Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study

Autores
de Lucas, José Julio; Rodríguez, Casilda; Martella, Monica Beatriz; Lábaque, María Carla; Navarro, Joaquin Luis; San Andrés, Manuel
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (Vss = 5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t1/2β = 2.66 h and MRT = 1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR + CIP).
Fil: de Lucas, José Julio. Universidad Complutense de Madrid; España
Fil: Rodríguez, Casilda. Universidad Complutense de Madrid; España
Fil: Martella, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina
Fil: Lábaque, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Navarro, Joaquin Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina
Fil: San Andrés, Manuel. Universidad Complutense de Madrid; España
Materia
AVIAN
CIPROFLOXACIN
ENROFLOXACIN
FLUOROQUINOLONES
PHARMACOKINETIC
RHEA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/115735
Acceder
id CONICETDig_bdf58979a3f8f2807f60876d75032514
oai_identifier_str oai:ri.conicet.gov.ar:11336/115735
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary studyde Lucas, José JulioRodríguez, CasildaMartella, Monica BeatrizLábaque, María CarlaNavarro, Joaquin LuisSan Andrés, ManuelAVIANCIPROFLOXACINENROFLOXACINFLUOROQUINOLONESPHARMACOKINETICRHEAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (Vss = 5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t1/2β = 2.66 h and MRT = 1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR + CIP).Fil: de Lucas, José Julio. Universidad Complutense de Madrid; EspañaFil: Rodríguez, Casilda. Universidad Complutense de Madrid; EspañaFil: Martella, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; ArgentinaFil: Lábaque, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Navarro, Joaquin Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; ArgentinaFil: San Andrés, Manuel. Universidad Complutense de Madrid; EspañaElsevier2005-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115735de Lucas, José Julio; Rodríguez, Casilda; Martella, Monica Beatriz; Lábaque, María Carla; Navarro, Joaquin Luis; et al.; Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study; Elsevier; Research in Veterinary Science; 78; 3; 6-2005; 265-2670034-5288CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0034528804001870info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2004.09.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:10:28Zoai:ri.conicet.gov.ar:11336/115735instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:10:28.913CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study
title Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study
spellingShingle Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study
de Lucas, José Julio
AVIAN
CIPROFLOXACIN
ENROFLOXACIN
FLUOROQUINOLONES
PHARMACOKINETIC
RHEA
title_short Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study
title_full Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study
title_fullStr Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study
title_full_unstemmed Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study
title_sort Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study
dc.creator.none.fl_str_mv de Lucas, José Julio
Rodríguez, Casilda
Martella, Monica Beatriz
Lábaque, María Carla
Navarro, Joaquin Luis
San Andrés, Manuel
author de Lucas, José Julio
author_facet de Lucas, José Julio
Rodríguez, Casilda
Martella, Monica Beatriz
Lábaque, María Carla
Navarro, Joaquin Luis
San Andrés, Manuel
author_role author
author2 Rodríguez, Casilda
Martella, Monica Beatriz
Lábaque, María Carla
Navarro, Joaquin Luis
San Andrés, Manuel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv AVIAN
CIPROFLOXACIN
ENROFLOXACIN
FLUOROQUINOLONES
PHARMACOKINETIC
RHEA
topic AVIAN
CIPROFLOXACIN
ENROFLOXACIN
FLUOROQUINOLONES
PHARMACOKINETIC
RHEA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (Vss = 5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t1/2β = 2.66 h and MRT = 1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR + CIP).
Fil: de Lucas, José Julio. Universidad Complutense de Madrid; España
Fil: Rodríguez, Casilda. Universidad Complutense de Madrid; España
Fil: Martella, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina
Fil: Lábaque, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Navarro, Joaquin Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina
Fil: San Andrés, Manuel. Universidad Complutense de Madrid; España
description The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open two-compartment model with a rapid distribution phase. The high volume of distribution (Vss = 5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t1/2β = 2.66 h and MRT = 1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR + CIP).
publishDate 2005
dc.date.none.fl_str_mv 2005-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/115735
de Lucas, José Julio; Rodríguez, Casilda; Martella, Monica Beatriz; Lábaque, María Carla; Navarro, Joaquin Luis; et al.; Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study; Elsevier; Research in Veterinary Science; 78; 3; 6-2005; 265-267
0034-5288
CONICET Digital
CONICET
url http://hdl.handle.net/11336/115735
identifier_str_mv de Lucas, José Julio; Rodríguez, Casilda; Martella, Monica Beatriz; Lábaque, María Carla; Navarro, Joaquin Luis; et al.; Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study; Elsevier; Research in Veterinary Science; 78; 3; 6-2005; 265-267
0034-5288
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0034528804001870
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2004.09.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613994327834624
score 13.070432

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