Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers

Autores
Dulce, Raul; Hurtado, Cecilia; Ennis, Irene Lucia; Garciarena, Carolina Denis; Alvarez, María Cecilia; Caldiz, Claudia Irma; Pierce, Grant N.; Portiansky, Enrique Leo; Chiappe, Gladys Ethel; Camilion, Maria Cristina
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Endothelin-1 (ET-1) is a potent agonist of cell growth that also stimulates Na+/H+ exchanger isoform 1 (NHE-1) activity. It was hypothesized that the increase in intracellular Na+ ([Na+]i) mediated by NHE-1 activity may induce the reverse mode of Na+/Ca2+ exchanger (NCXrev) increasing intracellular Ca2+ ([Ca2+]i) which in turn will induce hypertrophy. The objective of this work was to test whether the inhibition of NHE-1 or NCXrev prevents ET-1 induced hypertrophy in neonatal rat cardiomyocytes (NRVMs). NRVMs were cultured (24 h) in the absence (control) and presence of 5 nmol/L ET-1 alone, or combined with 1 μmol/L HOE 642 or 5 μmol/L KB-R7943. Cell surface area, 3H-phenylalanine incorporation and atrial natriuretic factor (ANF) mRNA expression were increased to 131 ± 3, 220 ± 12 and 190 ± 25% of control, respectively (P < 0.05) by ET-1. [Na+]i and total [Ca2+]i were higher (8.1 ± 1.2 mmol/L and 636 ± 117 nmol/L, respectively) in ET-1-treated than in control NRVMs (4.2 ± 1.3 and 346 ± 85, respectively, P < 0.05), effects that were cancelled by NHE-1 inhibition with HOE 642. The rise in [Ca2+]i induced by extracellular Na+ removal (NCXrev) was higher in ET-1-treated than in control NRVMs and the effect was prevented by co-treatment with HOE 642 or KB-R7943 (NCXrev inhibitor). The ET-1-induced increase in cell area, ANF mRNA expression and 3H-phenylalanine incorporation in ET-1-treated NRVM were decreased by NHE-1 or NCXrev inhibition. Our results provide the first evidence that NCXrev is, secondarily to NHE-1 activation, involved in ET-1-induced hypertrophy in NRVMs.
Fil: Dulce, Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Hurtado, Cecilia. St. Boniface Hospital Research Center; Canadá
Fil: Ennis, Irene Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Garciarena, Carolina Denis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Alvarez, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Caldiz, Claudia Irma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Pierce, Grant N.. St. Boniface Hospital Research Center; Canadá
Fil: Portiansky, Enrique Leo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chiappe, Gladys Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Camilion, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Materia
Endothelin-1
Na+/H+ Exchanger
Na+/Ca2+ Exchanger
Intracellular Na+
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/29372
Acceder
id CONICETDig_bda8417d155272bfbd03ce676da0fe61
oai_identifier_str oai:ri.conicet.gov.ar:11336/29372
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network_name_str CONICET Digital (CONICET)
spelling Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangersDulce, RaulHurtado, CeciliaEnnis, Irene LuciaGarciarena, Carolina DenisAlvarez, María CeciliaCaldiz, Claudia IrmaPierce, Grant N.Portiansky, Enrique LeoChiappe, Gladys EthelCamilion, Maria CristinaEndothelin-1Na+/H+ ExchangerNa+/Ca2+ ExchangerIntracellular Na+https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Endothelin-1 (ET-1) is a potent agonist of cell growth that also stimulates Na+/H+ exchanger isoform 1 (NHE-1) activity. It was hypothesized that the increase in intracellular Na+ ([Na+]i) mediated by NHE-1 activity may induce the reverse mode of Na+/Ca2+ exchanger (NCXrev) increasing intracellular Ca2+ ([Ca2+]i) which in turn will induce hypertrophy. The objective of this work was to test whether the inhibition of NHE-1 or NCXrev prevents ET-1 induced hypertrophy in neonatal rat cardiomyocytes (NRVMs). NRVMs were cultured (24 h) in the absence (control) and presence of 5 nmol/L ET-1 alone, or combined with 1 μmol/L HOE 642 or 5 μmol/L KB-R7943. Cell surface area, 3H-phenylalanine incorporation and atrial natriuretic factor (ANF) mRNA expression were increased to 131 ± 3, 220 ± 12 and 190 ± 25% of control, respectively (P < 0.05) by ET-1. [Na+]i and total [Ca2+]i were higher (8.1 ± 1.2 mmol/L and 636 ± 117 nmol/L, respectively) in ET-1-treated than in control NRVMs (4.2 ± 1.3 and 346 ± 85, respectively, P < 0.05), effects that were cancelled by NHE-1 inhibition with HOE 642. The rise in [Ca2+]i induced by extracellular Na+ removal (NCXrev) was higher in ET-1-treated than in control NRVMs and the effect was prevented by co-treatment with HOE 642 or KB-R7943 (NCXrev inhibitor). The ET-1-induced increase in cell area, ANF mRNA expression and 3H-phenylalanine incorporation in ET-1-treated NRVM were decreased by NHE-1 or NCXrev inhibition. Our results provide the first evidence that NCXrev is, secondarily to NHE-1 activation, involved in ET-1-induced hypertrophy in NRVMs.Fil: Dulce, Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Hurtado, Cecilia. St. Boniface Hospital Research Center; CanadáFil: Ennis, Irene Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Garciarena, Carolina Denis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Alvarez, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Caldiz, Claudia Irma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Pierce, Grant N.. St. Boniface Hospital Research Center; CanadáFil: Portiansky, Enrique Leo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chiappe, Gladys Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Camilion, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaElsevier Inc2006-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29372Dulce, Raul; Hurtado, Cecilia; Ennis, Irene Lucia; Garciarena, Carolina Denis; Alvarez, María Cecilia; et al.; Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers; Elsevier Inc; Journal Of Molecular And Cellular Cardiology; 41; 5; 7-2006; 807-8150022-2828CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.yjmcc.2006.05.016info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022282806005815info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:49Zoai:ri.conicet.gov.ar:11336/29372instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:49.843CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers
title Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers
spellingShingle Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers
Dulce, Raul
Endothelin-1
Na+/H+ Exchanger
Na+/Ca2+ Exchanger
Intracellular Na+
title_short Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers
title_full Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers
title_fullStr Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers
title_full_unstemmed Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers
title_sort Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers
dc.creator.none.fl_str_mv Dulce, Raul
Hurtado, Cecilia
Ennis, Irene Lucia
Garciarena, Carolina Denis
Alvarez, María Cecilia
Caldiz, Claudia Irma
Pierce, Grant N.
Portiansky, Enrique Leo
Chiappe, Gladys Ethel
Camilion, Maria Cristina
author Dulce, Raul
author_facet Dulce, Raul
Hurtado, Cecilia
Ennis, Irene Lucia
Garciarena, Carolina Denis
Alvarez, María Cecilia
Caldiz, Claudia Irma
Pierce, Grant N.
Portiansky, Enrique Leo
Chiappe, Gladys Ethel
Camilion, Maria Cristina
author_role author
author2 Hurtado, Cecilia
Ennis, Irene Lucia
Garciarena, Carolina Denis
Alvarez, María Cecilia
Caldiz, Claudia Irma
Pierce, Grant N.
Portiansky, Enrique Leo
Chiappe, Gladys Ethel
Camilion, Maria Cristina
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Endothelin-1
Na+/H+ Exchanger
Na+/Ca2+ Exchanger
Intracellular Na+
topic Endothelin-1
Na+/H+ Exchanger
Na+/Ca2+ Exchanger
Intracellular Na+
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Endothelin-1 (ET-1) is a potent agonist of cell growth that also stimulates Na+/H+ exchanger isoform 1 (NHE-1) activity. It was hypothesized that the increase in intracellular Na+ ([Na+]i) mediated by NHE-1 activity may induce the reverse mode of Na+/Ca2+ exchanger (NCXrev) increasing intracellular Ca2+ ([Ca2+]i) which in turn will induce hypertrophy. The objective of this work was to test whether the inhibition of NHE-1 or NCXrev prevents ET-1 induced hypertrophy in neonatal rat cardiomyocytes (NRVMs). NRVMs were cultured (24 h) in the absence (control) and presence of 5 nmol/L ET-1 alone, or combined with 1 μmol/L HOE 642 or 5 μmol/L KB-R7943. Cell surface area, 3H-phenylalanine incorporation and atrial natriuretic factor (ANF) mRNA expression were increased to 131 ± 3, 220 ± 12 and 190 ± 25% of control, respectively (P < 0.05) by ET-1. [Na+]i and total [Ca2+]i were higher (8.1 ± 1.2 mmol/L and 636 ± 117 nmol/L, respectively) in ET-1-treated than in control NRVMs (4.2 ± 1.3 and 346 ± 85, respectively, P < 0.05), effects that were cancelled by NHE-1 inhibition with HOE 642. The rise in [Ca2+]i induced by extracellular Na+ removal (NCXrev) was higher in ET-1-treated than in control NRVMs and the effect was prevented by co-treatment with HOE 642 or KB-R7943 (NCXrev inhibitor). The ET-1-induced increase in cell area, ANF mRNA expression and 3H-phenylalanine incorporation in ET-1-treated NRVM were decreased by NHE-1 or NCXrev inhibition. Our results provide the first evidence that NCXrev is, secondarily to NHE-1 activation, involved in ET-1-induced hypertrophy in NRVMs.
Fil: Dulce, Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Hurtado, Cecilia. St. Boniface Hospital Research Center; Canadá
Fil: Ennis, Irene Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Garciarena, Carolina Denis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Alvarez, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Caldiz, Claudia Irma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Pierce, Grant N.. St. Boniface Hospital Research Center; Canadá
Fil: Portiansky, Enrique Leo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chiappe, Gladys Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Camilion, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
description Endothelin-1 (ET-1) is a potent agonist of cell growth that also stimulates Na+/H+ exchanger isoform 1 (NHE-1) activity. It was hypothesized that the increase in intracellular Na+ ([Na+]i) mediated by NHE-1 activity may induce the reverse mode of Na+/Ca2+ exchanger (NCXrev) increasing intracellular Ca2+ ([Ca2+]i) which in turn will induce hypertrophy. The objective of this work was to test whether the inhibition of NHE-1 or NCXrev prevents ET-1 induced hypertrophy in neonatal rat cardiomyocytes (NRVMs). NRVMs were cultured (24 h) in the absence (control) and presence of 5 nmol/L ET-1 alone, or combined with 1 μmol/L HOE 642 or 5 μmol/L KB-R7943. Cell surface area, 3H-phenylalanine incorporation and atrial natriuretic factor (ANF) mRNA expression were increased to 131 ± 3, 220 ± 12 and 190 ± 25% of control, respectively (P < 0.05) by ET-1. [Na+]i and total [Ca2+]i were higher (8.1 ± 1.2 mmol/L and 636 ± 117 nmol/L, respectively) in ET-1-treated than in control NRVMs (4.2 ± 1.3 and 346 ± 85, respectively, P < 0.05), effects that were cancelled by NHE-1 inhibition with HOE 642. The rise in [Ca2+]i induced by extracellular Na+ removal (NCXrev) was higher in ET-1-treated than in control NRVMs and the effect was prevented by co-treatment with HOE 642 or KB-R7943 (NCXrev inhibitor). The ET-1-induced increase in cell area, ANF mRNA expression and 3H-phenylalanine incorporation in ET-1-treated NRVM were decreased by NHE-1 or NCXrev inhibition. Our results provide the first evidence that NCXrev is, secondarily to NHE-1 activation, involved in ET-1-induced hypertrophy in NRVMs.
publishDate 2006
dc.date.none.fl_str_mv 2006-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/29372
Dulce, Raul; Hurtado, Cecilia; Ennis, Irene Lucia; Garciarena, Carolina Denis; Alvarez, María Cecilia; et al.; Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers; Elsevier Inc; Journal Of Molecular And Cellular Cardiology; 41; 5; 7-2006; 807-815
0022-2828
CONICET Digital
CONICET
url http://hdl.handle.net/11336/29372
identifier_str_mv Dulce, Raul; Hurtado, Cecilia; Ennis, Irene Lucia; Garciarena, Carolina Denis; Alvarez, María Cecilia; et al.; Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers; Elsevier Inc; Journal Of Molecular And Cellular Cardiology; 41; 5; 7-2006; 807-815
0022-2828
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.yjmcc.2006.05.016
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022282806005815
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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