Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries

Autores
Orrillo, Alfredo Gastón; Furlan, Ricardo Luis Eugenio
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The presence of a supramolecular network of interactions between library members can lead to very different responses when libraries with identical molecular composition are exposed to the same template. Numerical simulations demonstrate that supramolecular interactions between library members of covalent dynamic combinatorial libraries (DCLs) can affect both degree and selectivity of the response of the library when a template molecule is added.
Fil: Orrillo, Alfredo Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Fil: Furlan, Ricardo Luis Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Materia
Supramolecular network
Dynamic combinatorial libraries
DCLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/278371
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial LibrariesOrrillo, Alfredo GastónFurlan, Ricardo Luis EugenioSupramolecular networkDynamic combinatorial librariesDCLShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The presence of a supramolecular network of interactions between library members can lead to very different responses when libraries with identical molecular composition are exposed to the same template. Numerical simulations demonstrate that supramolecular interactions between library members of covalent dynamic combinatorial libraries (DCLs) can affect both degree and selectivity of the response of the library when a template molecule is added.Fil: Orrillo, Alfredo Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaFil: Furlan, Ricardo Luis Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaAmerican Chemical Society2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/278371Orrillo, Alfredo Gastón; Furlan, Ricardo Luis Eugenio; Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries; American Chemical Society; Journal of Organic Chemistry; 75; 1; 12-2010; 211-2140022-3263CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/jo902296hinfo:eu-repo/semantics/altIdentifier/doi/10.1021/jo902296hinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:21:06Zoai:ri.conicet.gov.ar:11336/278371instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:21:06.371CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries
title Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries
spellingShingle Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries
Orrillo, Alfredo Gastón
Supramolecular network
Dynamic combinatorial libraries
DCLS
title_short Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries
title_full Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries
title_fullStr Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries
title_full_unstemmed Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries
title_sort Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries
dc.creator.none.fl_str_mv Orrillo, Alfredo Gastón
Furlan, Ricardo Luis Eugenio
author Orrillo, Alfredo Gastón
author_facet Orrillo, Alfredo Gastón
Furlan, Ricardo Luis Eugenio
author_role author
author2 Furlan, Ricardo Luis Eugenio
author2_role author
dc.subject.none.fl_str_mv Supramolecular network
Dynamic combinatorial libraries
DCLS
topic Supramolecular network
Dynamic combinatorial libraries
DCLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The presence of a supramolecular network of interactions between library members can lead to very different responses when libraries with identical molecular composition are exposed to the same template. Numerical simulations demonstrate that supramolecular interactions between library members of covalent dynamic combinatorial libraries (DCLs) can affect both degree and selectivity of the response of the library when a template molecule is added.
Fil: Orrillo, Alfredo Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Fil: Furlan, Ricardo Luis Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
description The presence of a supramolecular network of interactions between library members can lead to very different responses when libraries with identical molecular composition are exposed to the same template. Numerical simulations demonstrate that supramolecular interactions between library members of covalent dynamic combinatorial libraries (DCLs) can affect both degree and selectivity of the response of the library when a template molecule is added.
publishDate 2010
dc.date.none.fl_str_mv 2010-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/278371
Orrillo, Alfredo Gastón; Furlan, Ricardo Luis Eugenio; Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries; American Chemical Society; Journal of Organic Chemistry; 75; 1; 12-2010; 211-214
0022-3263
CONICET Digital
CONICET
url http://hdl.handle.net/11336/278371
identifier_str_mv Orrillo, Alfredo Gastón; Furlan, Ricardo Luis Eugenio; Supramolecular Interactions between Library Members Modulate the Behavior of Dynamic Combinatorial Libraries; American Chemical Society; Journal of Organic Chemistry; 75; 1; 12-2010; 211-214
0022-3263
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/jo902296h
info:eu-repo/semantics/altIdentifier/doi/10.1021/jo902296h
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176822

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