Peptide imprinted polymer synthesized by radiation-induced graft polymerization

Autores
Wolman, Federico Javier; Smolko, Eduardo; Cascone, Osvaldo; Grasselli, Mariano
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The design of polymer surfaces with molecular recognition capabilities is an exciting subject with potential application in the analytical and biotechnological fields. Molecular imprinted polymers (MIPs) are still in their infancy and new methodologies are required to broaden their application. In this paper, MIPs were synthesized by simultaneous radiation-induced graft polymerisation in a polar medium. Bacitracin, a cyclic decapeptide, was used as the target molecule to develop MIP grafted onto macroporous membranes. Soluble ternary complexes of vinyl pyridine, bacitracin and copper (II) were obtained and characterized by visible spectroscopy in an aqueous medium. These complexes were grafted onto macroporous polyethylene membranes. MIP materials showed ability to adsorb bacitracin in a higher amount than non-printed polymers. In addition, these materials showed a 5-fold greater selectivity to bacitracin than that of chemically modified bacitracins.
Fil: Wolman, Federico Javier. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Smolko, Eduardo. Comisión Nacional de Energía Atómica; Argentina
Fil: Cascone, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Grasselli, Mariano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
PEPTIDE IMPRINTED
MEMBRANES
RADIATION-INDUCED
GRAFT POLYMERISATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/111651
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Peptide imprinted polymer synthesized by radiation-induced graft polymerizationWolman, Federico JavierSmolko, EduardoCascone, OsvaldoGrasselli, MarianoPEPTIDE IMPRINTEDMEMBRANESRADIATION-INDUCEDGRAFT POLYMERISATIONhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2The design of polymer surfaces with molecular recognition capabilities is an exciting subject with potential application in the analytical and biotechnological fields. Molecular imprinted polymers (MIPs) are still in their infancy and new methodologies are required to broaden their application. In this paper, MIPs were synthesized by simultaneous radiation-induced graft polymerisation in a polar medium. Bacitracin, a cyclic decapeptide, was used as the target molecule to develop MIP grafted onto macroporous membranes. Soluble ternary complexes of vinyl pyridine, bacitracin and copper (II) were obtained and characterized by visible spectroscopy in an aqueous medium. These complexes were grafted onto macroporous polyethylene membranes. MIP materials showed ability to adsorb bacitracin in a higher amount than non-printed polymers. In addition, these materials showed a 5-fold greater selectivity to bacitracin than that of chemically modified bacitracins.Fil: Wolman, Federico Javier. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Smolko, Eduardo. Comisión Nacional de Energía Atómica; ArgentinaFil: Cascone, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Grasselli, Mariano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2006-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/111651Wolman, Federico Javier; Smolko, Eduardo; Cascone, Osvaldo; Grasselli, Mariano; Peptide imprinted polymer synthesized by radiation-induced graft polymerization; Elsevier Science; Reactive & Functional Polymers; 66; 11; 11-2006; 1199-12051381-5148CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2006.03.002info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S138151480600054Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:53:46Zoai:ri.conicet.gov.ar:11336/111651instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:53:46.39CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Peptide imprinted polymer synthesized by radiation-induced graft polymerization
title Peptide imprinted polymer synthesized by radiation-induced graft polymerization
spellingShingle Peptide imprinted polymer synthesized by radiation-induced graft polymerization
Wolman, Federico Javier
PEPTIDE IMPRINTED
MEMBRANES
RADIATION-INDUCED
GRAFT POLYMERISATION
title_short Peptide imprinted polymer synthesized by radiation-induced graft polymerization
title_full Peptide imprinted polymer synthesized by radiation-induced graft polymerization
title_fullStr Peptide imprinted polymer synthesized by radiation-induced graft polymerization
title_full_unstemmed Peptide imprinted polymer synthesized by radiation-induced graft polymerization
title_sort Peptide imprinted polymer synthesized by radiation-induced graft polymerization
dc.creator.none.fl_str_mv Wolman, Federico Javier
Smolko, Eduardo
Cascone, Osvaldo
Grasselli, Mariano
author Wolman, Federico Javier
author_facet Wolman, Federico Javier
Smolko, Eduardo
Cascone, Osvaldo
Grasselli, Mariano
author_role author
author2 Smolko, Eduardo
Cascone, Osvaldo
Grasselli, Mariano
author2_role author
author
author
dc.subject.none.fl_str_mv PEPTIDE IMPRINTED
MEMBRANES
RADIATION-INDUCED
GRAFT POLYMERISATION
topic PEPTIDE IMPRINTED
MEMBRANES
RADIATION-INDUCED
GRAFT POLYMERISATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The design of polymer surfaces with molecular recognition capabilities is an exciting subject with potential application in the analytical and biotechnological fields. Molecular imprinted polymers (MIPs) are still in their infancy and new methodologies are required to broaden their application. In this paper, MIPs were synthesized by simultaneous radiation-induced graft polymerisation in a polar medium. Bacitracin, a cyclic decapeptide, was used as the target molecule to develop MIP grafted onto macroporous membranes. Soluble ternary complexes of vinyl pyridine, bacitracin and copper (II) were obtained and characterized by visible spectroscopy in an aqueous medium. These complexes were grafted onto macroporous polyethylene membranes. MIP materials showed ability to adsorb bacitracin in a higher amount than non-printed polymers. In addition, these materials showed a 5-fold greater selectivity to bacitracin than that of chemically modified bacitracins.
Fil: Wolman, Federico Javier. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Smolko, Eduardo. Comisión Nacional de Energía Atómica; Argentina
Fil: Cascone, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Grasselli, Mariano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The design of polymer surfaces with molecular recognition capabilities is an exciting subject with potential application in the analytical and biotechnological fields. Molecular imprinted polymers (MIPs) are still in their infancy and new methodologies are required to broaden their application. In this paper, MIPs were synthesized by simultaneous radiation-induced graft polymerisation in a polar medium. Bacitracin, a cyclic decapeptide, was used as the target molecule to develop MIP grafted onto macroporous membranes. Soluble ternary complexes of vinyl pyridine, bacitracin and copper (II) were obtained and characterized by visible spectroscopy in an aqueous medium. These complexes were grafted onto macroporous polyethylene membranes. MIP materials showed ability to adsorb bacitracin in a higher amount than non-printed polymers. In addition, these materials showed a 5-fold greater selectivity to bacitracin than that of chemically modified bacitracins.
publishDate 2006
dc.date.none.fl_str_mv 2006-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/111651
Wolman, Federico Javier; Smolko, Eduardo; Cascone, Osvaldo; Grasselli, Mariano; Peptide imprinted polymer synthesized by radiation-induced graft polymerization; Elsevier Science; Reactive & Functional Polymers; 66; 11; 11-2006; 1199-1205
1381-5148
CONICET Digital
CONICET
url http://hdl.handle.net/11336/111651
identifier_str_mv Wolman, Federico Javier; Smolko, Eduardo; Cascone, Osvaldo; Grasselli, Mariano; Peptide imprinted polymer synthesized by radiation-induced graft polymerization; Elsevier Science; Reactive & Functional Polymers; 66; 11; 11-2006; 1199-1205
1381-5148
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2006.03.002
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S138151480600054X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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