Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group

Autores
Halac, Eduardo; Dip, Marcelo; Quiñones, Emilio; Alvarez, Fernando; Leiva Espinoza, Johana; Romero, Pablo; Nievas, Franco; Maurette, Rafael; Luque, Carlos; Matus, Daniel; Surraco, Paz; Fauda, Martin; Mc Cormarck, Lucas; Mattera, Francisco J.; Gondolesi, Gabriel Eduardo; Imventarza, Oscar
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Grafts from split livers (SLs) constitute an accepted approach to expand the donor pool. Over the last 5 years, most Argentinean centers have shown significant interest in increasing the use of this technique. The purpose of this article is to describe and analyze the outcomes of right-side grafts (RSGs) and left-side grafts (LSGs) from a multicenter study. The multicenter retrospective study included data from 111 recipients of SL grafts from between January 1, 2009 and December 31, 2013. Incidence of surgical complications, patient and graft survival, and factors that affected RSG and LSG survival were analyzed. Grafts types were 57 LSG and 54 RSG. Median follow-up times for LSG and RSG were 46 and 42 months, respectively. The 36-month patient and graft survivals for LSG were 83% and 79%, respectively, and for RSG were 78% and 69%, respectively. Retransplantation rates for LSG and RSG were 3.5% and 11%, respectively. Arterial complications were the most common cause of early retransplantation (less than 12 months). Cold ischemia time (CIT) longer than 10 hours and the use of high-risk donors (age ≥ 40 years or body mass index ≥ 30 kg/m2 or ≥ 5 days intensive care unit stay) were independent factors for diminished graft survival in RSG. None of the analyzed variables were associated with worse graft survival in LSG. Biliary complications were the most frequent complications in both groups (57% in LSG and 33% in RSG). Partial grafts obtained from liver splitting are an excellent option for patients in need of liver transplantation and have the potential to alleviate the organ shortage. Adequate donor selection and reducing CIT are crucial for optimizing results.
Fil: Halac, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Dip, Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Quiñones, Emilio. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Alvarez, Fernando. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Leiva Espinoza, Johana. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Romero, Pablo. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Nievas, Franco. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Maurette, Rafael. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Luque, Carlos. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Matus, Daniel. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Surraco, Paz. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Fauda, Martin. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Mc Cormarck, Lucas. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Mattera, Francisco J.. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Gondolesi, Gabriel Eduardo. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Imventarza, Oscar. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Materia
Split Liver
Transplantation
Graft Survival
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42636
Acceder
id CONICETDig_8b31998fbf4f8cfcc006917ac837ed6b
oai_identifier_str oai:ri.conicet.gov.ar:11336/42636
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean GroupHalac, EduardoDip, MarceloQuiñones, EmilioAlvarez, FernandoLeiva Espinoza, JohanaRomero, PabloNievas, FrancoMaurette, RafaelLuque, CarlosMatus, DanielSurraco, PazFauda, MartinMc Cormarck, LucasMattera, Francisco J.Gondolesi, Gabriel EduardoImventarza, OscarSplit LiverTransplantationGraft Survivalhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Grafts from split livers (SLs) constitute an accepted approach to expand the donor pool. Over the last 5 years, most Argentinean centers have shown significant interest in increasing the use of this technique. The purpose of this article is to describe and analyze the outcomes of right-side grafts (RSGs) and left-side grafts (LSGs) from a multicenter study. The multicenter retrospective study included data from 111 recipients of SL grafts from between January 1, 2009 and December 31, 2013. Incidence of surgical complications, patient and graft survival, and factors that affected RSG and LSG survival were analyzed. Grafts types were 57 LSG and 54 RSG. Median follow-up times for LSG and RSG were 46 and 42 months, respectively. The 36-month patient and graft survivals for LSG were 83% and 79%, respectively, and for RSG were 78% and 69%, respectively. Retransplantation rates for LSG and RSG were 3.5% and 11%, respectively. Arterial complications were the most common cause of early retransplantation (less than 12 months). Cold ischemia time (CIT) longer than 10 hours and the use of high-risk donors (age ≥ 40 years or body mass index ≥ 30 kg/m2 or ≥ 5 days intensive care unit stay) were independent factors for diminished graft survival in RSG. None of the analyzed variables were associated with worse graft survival in LSG. Biliary complications were the most frequent complications in both groups (57% in LSG and 33% in RSG). Partial grafts obtained from liver splitting are an excellent option for patients in need of liver transplantation and have the potential to alleviate the organ shortage. Adequate donor selection and reducing CIT are crucial for optimizing results.Fil: Halac, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Dip, Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Quiñones, Emilio. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Alvarez, Fernando. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Leiva Espinoza, Johana. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Romero, Pablo. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Nievas, Franco. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Maurette, Rafael. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Luque, Carlos. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Matus, Daniel. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Surraco, Paz. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Fauda, Martin. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Mc Cormarck, Lucas. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Mattera, Francisco J.. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaFil: Gondolesi, Gabriel Eduardo. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Imventarza, Oscar. Capítulo Argentino de la International Hepato Pancreato Biliary Association; ArgentinaJohn Wiley & Sons Inc2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42636Halac, Eduardo; Dip, Marcelo; Quiñones, Emilio; Alvarez, Fernando; Leiva Espinoza, Johana; et al.; Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group; John Wiley & Sons Inc; Liver Transplantation; 22; 1; 1-2016; 63-701527-6465CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/lt.24338info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/lt.24338info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:21Zoai:ri.conicet.gov.ar:11336/42636instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:22.03CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group
title Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group
spellingShingle Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group
Halac, Eduardo
Split Liver
Transplantation
Graft Survival
title_short Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group
title_full Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group
title_fullStr Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group
title_full_unstemmed Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group
title_sort Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group
dc.creator.none.fl_str_mv Halac, Eduardo
Dip, Marcelo
Quiñones, Emilio
Alvarez, Fernando
Leiva Espinoza, Johana
Romero, Pablo
Nievas, Franco
Maurette, Rafael
Luque, Carlos
Matus, Daniel
Surraco, Paz
Fauda, Martin
Mc Cormarck, Lucas
Mattera, Francisco J.
Gondolesi, Gabriel Eduardo
Imventarza, Oscar
author Halac, Eduardo
author_facet Halac, Eduardo
Dip, Marcelo
Quiñones, Emilio
Alvarez, Fernando
Leiva Espinoza, Johana
Romero, Pablo
Nievas, Franco
Maurette, Rafael
Luque, Carlos
Matus, Daniel
Surraco, Paz
Fauda, Martin
Mc Cormarck, Lucas
Mattera, Francisco J.
Gondolesi, Gabriel Eduardo
Imventarza, Oscar
author_role author
author2 Dip, Marcelo
Quiñones, Emilio
Alvarez, Fernando
Leiva Espinoza, Johana
Romero, Pablo
Nievas, Franco
Maurette, Rafael
Luque, Carlos
Matus, Daniel
Surraco, Paz
Fauda, Martin
Mc Cormarck, Lucas
Mattera, Francisco J.
Gondolesi, Gabriel Eduardo
Imventarza, Oscar
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Split Liver
Transplantation
Graft Survival
topic Split Liver
Transplantation
Graft Survival
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Grafts from split livers (SLs) constitute an accepted approach to expand the donor pool. Over the last 5 years, most Argentinean centers have shown significant interest in increasing the use of this technique. The purpose of this article is to describe and analyze the outcomes of right-side grafts (RSGs) and left-side grafts (LSGs) from a multicenter study. The multicenter retrospective study included data from 111 recipients of SL grafts from between January 1, 2009 and December 31, 2013. Incidence of surgical complications, patient and graft survival, and factors that affected RSG and LSG survival were analyzed. Grafts types were 57 LSG and 54 RSG. Median follow-up times for LSG and RSG were 46 and 42 months, respectively. The 36-month patient and graft survivals for LSG were 83% and 79%, respectively, and for RSG were 78% and 69%, respectively. Retransplantation rates for LSG and RSG were 3.5% and 11%, respectively. Arterial complications were the most common cause of early retransplantation (less than 12 months). Cold ischemia time (CIT) longer than 10 hours and the use of high-risk donors (age ≥ 40 years or body mass index ≥ 30 kg/m2 or ≥ 5 days intensive care unit stay) were independent factors for diminished graft survival in RSG. None of the analyzed variables were associated with worse graft survival in LSG. Biliary complications were the most frequent complications in both groups (57% in LSG and 33% in RSG). Partial grafts obtained from liver splitting are an excellent option for patients in need of liver transplantation and have the potential to alleviate the organ shortage. Adequate donor selection and reducing CIT are crucial for optimizing results.
Fil: Halac, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Dip, Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Quiñones, Emilio. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Alvarez, Fernando. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Leiva Espinoza, Johana. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Romero, Pablo. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Nievas, Franco. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Maurette, Rafael. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Luque, Carlos. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Matus, Daniel. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Surraco, Paz. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Fauda, Martin. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Mc Cormarck, Lucas. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Mattera, Francisco J.. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
Fil: Gondolesi, Gabriel Eduardo. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Imventarza, Oscar. Capítulo Argentino de la International Hepato Pancreato Biliary Association; Argentina
description Grafts from split livers (SLs) constitute an accepted approach to expand the donor pool. Over the last 5 years, most Argentinean centers have shown significant interest in increasing the use of this technique. The purpose of this article is to describe and analyze the outcomes of right-side grafts (RSGs) and left-side grafts (LSGs) from a multicenter study. The multicenter retrospective study included data from 111 recipients of SL grafts from between January 1, 2009 and December 31, 2013. Incidence of surgical complications, patient and graft survival, and factors that affected RSG and LSG survival were analyzed. Grafts types were 57 LSG and 54 RSG. Median follow-up times for LSG and RSG were 46 and 42 months, respectively. The 36-month patient and graft survivals for LSG were 83% and 79%, respectively, and for RSG were 78% and 69%, respectively. Retransplantation rates for LSG and RSG were 3.5% and 11%, respectively. Arterial complications were the most common cause of early retransplantation (less than 12 months). Cold ischemia time (CIT) longer than 10 hours and the use of high-risk donors (age ≥ 40 years or body mass index ≥ 30 kg/m2 or ≥ 5 days intensive care unit stay) were independent factors for diminished graft survival in RSG. None of the analyzed variables were associated with worse graft survival in LSG. Biliary complications were the most frequent complications in both groups (57% in LSG and 33% in RSG). Partial grafts obtained from liver splitting are an excellent option for patients in need of liver transplantation and have the potential to alleviate the organ shortage. Adequate donor selection and reducing CIT are crucial for optimizing results.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42636
Halac, Eduardo; Dip, Marcelo; Quiñones, Emilio; Alvarez, Fernando; Leiva Espinoza, Johana; et al.; Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group; John Wiley & Sons Inc; Liver Transplantation; 22; 1; 1-2016; 63-70
1527-6465
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42636
identifier_str_mv Halac, Eduardo; Dip, Marcelo; Quiñones, Emilio; Alvarez, Fernando; Leiva Espinoza, Johana; et al.; Split-Liver Transplantation: Report of Right- and Left-Graft Outcomes from a Multicenter Argentinean Group; John Wiley & Sons Inc; Liver Transplantation; 22; 1; 1-2016; 63-70
1527-6465
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/lt.24338
info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/lt.24338
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc
publisher.none.fl_str_mv John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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