Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor
- Autores
- German, Olga Lorena; Monaco, Sandra Tanya; Agnolazza, Daniela Luciana; Rotstein, Nora Patricia; Politi, Luis Enrique
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Docosahexaenoic acid (DHA), the major omega-3 polyunsaturated fatty acid in the retina, promotes the survival of rat retina photoreceptors (PR) during early development in vitro and upon oxidative stress by activating the ERK/MAPK signaling pathway. We investigated if DHA activates this pathway by direct activation of tyrosine kinase receptors (TRK) or of retinoid nuclear receptors (RXR). Using retinal neuronal cultures we determined that DHA prevented PR apoptosis at early culture times in spite of the presence of a TRK inhibitor (K252a), implying TRK are not involved in its effects. On the contrary, RXR antagonists (HX531 or PA452) inhibited DHA protection during early development in vitro and upon paraquat and H2O2-induced apoptosis. Moreover, RXR agonists (HX630 or PA024) decreased photoreceptors apoptosis in H2O2-treated neuronal cultures, as we previously showed for DHA. To evaluate whether DHA has to be released from phospholipids to exert its protective effect, DHA-supplemented cultures were treated with a phospholipase A2 inhibitor (BEL) prior to H2O2 treatment; BEL addition blocked DHA protection on PR upon oxidative stress. These results suggest a new pathway for DHA actions in PR: it is first released from phospholipids and then activates RXR to promote PR survival.
Fil: German, Olga Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Monaco, Sandra Tanya. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Agnolazza, Daniela Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Rotstein, Nora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Politi, Luis Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XLI Reuniao Anual da Sociedade Brasileira de Bioquimica e Biologia Molecular
Foz do Iguacu
Brasil
Sociedade Brasileira de Bioquimica e Biologia Molecular - Materia
-
PHOTORECEPTOR
DHA
APOPTOSIS
RXR - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/253064
Ver los metadatos del registro completo
id |
CONICETDig_bb2bc5de648fe7d311583daab16c0d2a |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/253064 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptorGerman, Olga LorenaMonaco, Sandra TanyaAgnolazza, Daniela LucianaRotstein, Nora PatriciaPoliti, Luis EnriquePHOTORECEPTORDHAAPOPTOSISRXRhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Docosahexaenoic acid (DHA), the major omega-3 polyunsaturated fatty acid in the retina, promotes the survival of rat retina photoreceptors (PR) during early development in vitro and upon oxidative stress by activating the ERK/MAPK signaling pathway. We investigated if DHA activates this pathway by direct activation of tyrosine kinase receptors (TRK) or of retinoid nuclear receptors (RXR). Using retinal neuronal cultures we determined that DHA prevented PR apoptosis at early culture times in spite of the presence of a TRK inhibitor (K252a), implying TRK are not involved in its effects. On the contrary, RXR antagonists (HX531 or PA452) inhibited DHA protection during early development in vitro and upon paraquat and H2O2-induced apoptosis. Moreover, RXR agonists (HX630 or PA024) decreased photoreceptors apoptosis in H2O2-treated neuronal cultures, as we previously showed for DHA. To evaluate whether DHA has to be released from phospholipids to exert its protective effect, DHA-supplemented cultures were treated with a phospholipase A2 inhibitor (BEL) prior to H2O2 treatment; BEL addition blocked DHA protection on PR upon oxidative stress. These results suggest a new pathway for DHA actions in PR: it is first released from phospholipids and then activates RXR to promote PR survival.Fil: German, Olga Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Monaco, Sandra Tanya. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Agnolazza, Daniela Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Rotstein, Nora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Politi, Luis Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaXLI Reuniao Anual da Sociedade Brasileira de Bioquimica e Biologia MolecularFoz do IguacuBrasilSociedade Brasileira de Bioquimica e Biologia MolecularSociedade Brasileira de Bioquimica e Biologia Molecular2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/253064Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor; XLI Reuniao Anual da Sociedade Brasileira de Bioquimica e Biologia Molecular; Foz do Iguacu; Brasil; 2012; 1-1CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www2.sbbq.org.br/reuniao/reuniao2012.htmlinfo:eu-repo/semantics/altIdentifier/url/https://www2.sbbq.org.br/reuniao/cdrom/ra2012/abstract.htmInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:28Zoai:ri.conicet.gov.ar:11336/253064instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:28.458CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor |
title |
Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor |
spellingShingle |
Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor German, Olga Lorena PHOTORECEPTOR DHA APOPTOSIS RXR |
title_short |
Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor |
title_full |
Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor |
title_fullStr |
Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor |
title_full_unstemmed |
Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor |
title_sort |
Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor |
dc.creator.none.fl_str_mv |
German, Olga Lorena Monaco, Sandra Tanya Agnolazza, Daniela Luciana Rotstein, Nora Patricia Politi, Luis Enrique |
author |
German, Olga Lorena |
author_facet |
German, Olga Lorena Monaco, Sandra Tanya Agnolazza, Daniela Luciana Rotstein, Nora Patricia Politi, Luis Enrique |
author_role |
author |
author2 |
Monaco, Sandra Tanya Agnolazza, Daniela Luciana Rotstein, Nora Patricia Politi, Luis Enrique |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
PHOTORECEPTOR DHA APOPTOSIS RXR |
topic |
PHOTORECEPTOR DHA APOPTOSIS RXR |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.5 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Docosahexaenoic acid (DHA), the major omega-3 polyunsaturated fatty acid in the retina, promotes the survival of rat retina photoreceptors (PR) during early development in vitro and upon oxidative stress by activating the ERK/MAPK signaling pathway. We investigated if DHA activates this pathway by direct activation of tyrosine kinase receptors (TRK) or of retinoid nuclear receptors (RXR). Using retinal neuronal cultures we determined that DHA prevented PR apoptosis at early culture times in spite of the presence of a TRK inhibitor (K252a), implying TRK are not involved in its effects. On the contrary, RXR antagonists (HX531 or PA452) inhibited DHA protection during early development in vitro and upon paraquat and H2O2-induced apoptosis. Moreover, RXR agonists (HX630 or PA024) decreased photoreceptors apoptosis in H2O2-treated neuronal cultures, as we previously showed for DHA. To evaluate whether DHA has to be released from phospholipids to exert its protective effect, DHA-supplemented cultures were treated with a phospholipase A2 inhibitor (BEL) prior to H2O2 treatment; BEL addition blocked DHA protection on PR upon oxidative stress. These results suggest a new pathway for DHA actions in PR: it is first released from phospholipids and then activates RXR to promote PR survival. Fil: German, Olga Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Monaco, Sandra Tanya. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Agnolazza, Daniela Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Rotstein, Nora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Politi, Luis Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina XLI Reuniao Anual da Sociedade Brasileira de Bioquimica e Biologia Molecular Foz do Iguacu Brasil Sociedade Brasileira de Bioquimica e Biologia Molecular |
description |
Docosahexaenoic acid (DHA), the major omega-3 polyunsaturated fatty acid in the retina, promotes the survival of rat retina photoreceptors (PR) during early development in vitro and upon oxidative stress by activating the ERK/MAPK signaling pathway. We investigated if DHA activates this pathway by direct activation of tyrosine kinase receptors (TRK) or of retinoid nuclear receptors (RXR). Using retinal neuronal cultures we determined that DHA prevented PR apoptosis at early culture times in spite of the presence of a TRK inhibitor (K252a), implying TRK are not involved in its effects. On the contrary, RXR antagonists (HX531 or PA452) inhibited DHA protection during early development in vitro and upon paraquat and H2O2-induced apoptosis. Moreover, RXR agonists (HX630 or PA024) decreased photoreceptors apoptosis in H2O2-treated neuronal cultures, as we previously showed for DHA. To evaluate whether DHA has to be released from phospholipids to exert its protective effect, DHA-supplemented cultures were treated with a phospholipase A2 inhibitor (BEL) prior to H2O2 treatment; BEL addition blocked DHA protection on PR upon oxidative stress. These results suggest a new pathway for DHA actions in PR: it is first released from phospholipids and then activates RXR to promote PR survival. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Book http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/253064 Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor; XLI Reuniao Anual da Sociedade Brasileira de Bioquimica e Biologia Molecular; Foz do Iguacu; Brasil; 2012; 1-1 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/253064 |
identifier_str_mv |
Unesterified docosahexaenoic acid promotes photoreceptors survival activating a retinoid orphan receptor; XLI Reuniao Anual da Sociedade Brasileira de Bioquimica e Biologia Molecular; Foz do Iguacu; Brasil; 2012; 1-1 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www2.sbbq.org.br/reuniao/reuniao2012.html info:eu-repo/semantics/altIdentifier/url/https://www2.sbbq.org.br/reuniao/cdrom/ra2012/abstract.htm |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.coverage.none.fl_str_mv |
Internacional |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Bioquimica e Biologia Molecular |
publisher.none.fl_str_mv |
Sociedade Brasileira de Bioquimica e Biologia Molecular |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842268796696395776 |
score |
13.13397 |