Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions

Autores
Figueroa, Rodolfo G.; Valente, Mauro Andres; Guarda, Jaime; Villar, Natalia; Sagardia, Joan; López, Adlin; Malano, Francisco; Cerna, Manuel; Leiva, Jorge; Casanelli, Bryan
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This short review showcases two innovative technological advances, culminating in more than a decade of research into advanced oncology devices: CONVERAY and COXIRIS. In this context, it is essential to evaluate how these technologies can optimize performance in specific applications. CONVERAY is a convergent beam radiotherapy system, adaptable to linear particle accelerators (LINACs), designed to deliver a focused megavoltage photon or electron beam to a precise tumor location. This innovative approach achieves depth-dose peaks comparable to proton therapy, optimizing therapeutic efficacy while minimizing exposure to surrounding healthy tissues. Following this line of analysis, the results obtained through advanced simulations are examined. Notably, CONVERAY is compatible with ultra-high dose rate FLASH technology, enabling faster and less toxic treatments. Its implementation requires minimal LINAC modifications, preserving precise physical dimensions and mechanical, electrical, magnetic, vacuum, and shielding conditions. These findings allow for a more detailed exploration of practical implications in clinical environments. Complementing CONVERAY, COXIRIS is a confocal system designed for theragnostic applications utilizing X-ray fluorescence (XRF) in specific biomarkers. This innovative device enables the detection of fluorescent radiation in biomarkers at depths of up to 10 cm, providing detailed tumor characterization. Its confocal configuration facilitates simultaneous therapeutic interventions, integrating real-time detection and treatment for precise oncological management. Finally, key aspects that may influence future implementations and clinical applications are highlighted. COXIRIS represents a significant advancement toward an integrated and efficient cancer treatment solution, harmonizing diagnosis and therapy. Building upon the presented findings, these technologies offer a pathway toward transforming cancer treatment strategies. In summary, both CONVERAY and COXIRIS technologies, currently in the prototype phase, represent substantial breakthroughs in radiotherapy and oncological theragnosis, holding promise as pivotal tools for enhancing precision and efficacy in future cancer treatments. Their innovative designs and integrated approaches position these technologies at the forefront of oncological care, poised to transform treatment paradigms and improve patient outcomes.
Fil: Figueroa, Rodolfo G.. Universidad de La Frontera; Chile
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Guarda, Jaime. Universidad de La Frontera; Chile
Fil: Villar, Natalia. Universidad de La Frontera; Chile
Fil: Sagardia, Joan. Universidad de La Frontera; Chile
Fil: López, Adlin. Universidad de La Frontera; Chile
Fil: Malano, Francisco. Universidad de La Frontera; Chile
Fil: Cerna, Manuel. Universidad de La Frontera; Chile
Fil: Leiva, Jorge. Universidad de La Frontera; Chile
Fil: Casanelli, Bryan. Universidad de La Frontera; Chile
Materia
Convergent beam radiotherapy
COXIRIS
CONVERAY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/282211
Acceder
id CONICETDig_bae807b142b7018d42ae16b2de45f350
oai_identifier_str oai:ri.conicet.gov.ar:11336/282211
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directionsFigueroa, Rodolfo G.Valente, Mauro AndresGuarda, JaimeVillar, NataliaSagardia, JoanLópez, AdlinMalano, FranciscoCerna, ManuelLeiva, JorgeCasanelli, BryanConvergent beam radiotherapyCOXIRISCONVERAYhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1This short review showcases two innovative technological advances, culminating in more than a decade of research into advanced oncology devices: CONVERAY and COXIRIS. In this context, it is essential to evaluate how these technologies can optimize performance in specific applications. CONVERAY is a convergent beam radiotherapy system, adaptable to linear particle accelerators (LINACs), designed to deliver a focused megavoltage photon or electron beam to a precise tumor location. This innovative approach achieves depth-dose peaks comparable to proton therapy, optimizing therapeutic efficacy while minimizing exposure to surrounding healthy tissues. Following this line of analysis, the results obtained through advanced simulations are examined. Notably, CONVERAY is compatible with ultra-high dose rate FLASH technology, enabling faster and less toxic treatments. Its implementation requires minimal LINAC modifications, preserving precise physical dimensions and mechanical, electrical, magnetic, vacuum, and shielding conditions. These findings allow for a more detailed exploration of practical implications in clinical environments. Complementing CONVERAY, COXIRIS is a confocal system designed for theragnostic applications utilizing X-ray fluorescence (XRF) in specific biomarkers. This innovative device enables the detection of fluorescent radiation in biomarkers at depths of up to 10 cm, providing detailed tumor characterization. Its confocal configuration facilitates simultaneous therapeutic interventions, integrating real-time detection and treatment for precise oncological management. Finally, key aspects that may influence future implementations and clinical applications are highlighted. COXIRIS represents a significant advancement toward an integrated and efficient cancer treatment solution, harmonizing diagnosis and therapy. Building upon the presented findings, these technologies offer a pathway toward transforming cancer treatment strategies. In summary, both CONVERAY and COXIRIS technologies, currently in the prototype phase, represent substantial breakthroughs in radiotherapy and oncological theragnosis, holding promise as pivotal tools for enhancing precision and efficacy in future cancer treatments. Their innovative designs and integrated approaches position these technologies at the forefront of oncological care, poised to transform treatment paradigms and improve patient outcomes.Fil: Figueroa, Rodolfo G.. Universidad de La Frontera; ChileFil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Guarda, Jaime. Universidad de La Frontera; ChileFil: Villar, Natalia. Universidad de La Frontera; ChileFil: Sagardia, Joan. Universidad de La Frontera; ChileFil: López, Adlin. Universidad de La Frontera; ChileFil: Malano, Francisco. Universidad de La Frontera; ChileFil: Cerna, Manuel. Universidad de La Frontera; ChileFil: Leiva, Jorge. Universidad de La Frontera; ChileFil: Casanelli, Bryan. Universidad de La Frontera; ChilePergamon-Elsevier Science Ltd2025-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/282211Figueroa, Rodolfo G.; Valente, Mauro Andres; Guarda, Jaime; Villar, Natalia; Sagardia, Joan; et al.; Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 234; 4-2025; 1-200969-806XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0969806X25002804info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radphyschem.2025.112788info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-04-08T11:32:36Zoai:ri.conicet.gov.ar:11336/282211instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-04-08 11:32:37.414CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions
title Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions
spellingShingle Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions
Figueroa, Rodolfo G.
Convergent beam radiotherapy
COXIRIS
CONVERAY
title_short Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions
title_full Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions
title_fullStr Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions
title_full_unstemmed Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions
title_sort Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions
dc.creator.none.fl_str_mv Figueroa, Rodolfo G.
Valente, Mauro Andres
Guarda, Jaime
Villar, Natalia
Sagardia, Joan
López, Adlin
Malano, Francisco
Cerna, Manuel
Leiva, Jorge
Casanelli, Bryan
author Figueroa, Rodolfo G.
author_facet Figueroa, Rodolfo G.
Valente, Mauro Andres
Guarda, Jaime
Villar, Natalia
Sagardia, Joan
López, Adlin
Malano, Francisco
Cerna, Manuel
Leiva, Jorge
Casanelli, Bryan
author_role author
author2 Valente, Mauro Andres
Guarda, Jaime
Villar, Natalia
Sagardia, Joan
López, Adlin
Malano, Francisco
Cerna, Manuel
Leiva, Jorge
Casanelli, Bryan
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Convergent beam radiotherapy
COXIRIS
CONVERAY
topic Convergent beam radiotherapy
COXIRIS
CONVERAY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This short review showcases two innovative technological advances, culminating in more than a decade of research into advanced oncology devices: CONVERAY and COXIRIS. In this context, it is essential to evaluate how these technologies can optimize performance in specific applications. CONVERAY is a convergent beam radiotherapy system, adaptable to linear particle accelerators (LINACs), designed to deliver a focused megavoltage photon or electron beam to a precise tumor location. This innovative approach achieves depth-dose peaks comparable to proton therapy, optimizing therapeutic efficacy while minimizing exposure to surrounding healthy tissues. Following this line of analysis, the results obtained through advanced simulations are examined. Notably, CONVERAY is compatible with ultra-high dose rate FLASH technology, enabling faster and less toxic treatments. Its implementation requires minimal LINAC modifications, preserving precise physical dimensions and mechanical, electrical, magnetic, vacuum, and shielding conditions. These findings allow for a more detailed exploration of practical implications in clinical environments. Complementing CONVERAY, COXIRIS is a confocal system designed for theragnostic applications utilizing X-ray fluorescence (XRF) in specific biomarkers. This innovative device enables the detection of fluorescent radiation in biomarkers at depths of up to 10 cm, providing detailed tumor characterization. Its confocal configuration facilitates simultaneous therapeutic interventions, integrating real-time detection and treatment for precise oncological management. Finally, key aspects that may influence future implementations and clinical applications are highlighted. COXIRIS represents a significant advancement toward an integrated and efficient cancer treatment solution, harmonizing diagnosis and therapy. Building upon the presented findings, these technologies offer a pathway toward transforming cancer treatment strategies. In summary, both CONVERAY and COXIRIS technologies, currently in the prototype phase, represent substantial breakthroughs in radiotherapy and oncological theragnosis, holding promise as pivotal tools for enhancing precision and efficacy in future cancer treatments. Their innovative designs and integrated approaches position these technologies at the forefront of oncological care, poised to transform treatment paradigms and improve patient outcomes.
Fil: Figueroa, Rodolfo G.. Universidad de La Frontera; Chile
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Guarda, Jaime. Universidad de La Frontera; Chile
Fil: Villar, Natalia. Universidad de La Frontera; Chile
Fil: Sagardia, Joan. Universidad de La Frontera; Chile
Fil: López, Adlin. Universidad de La Frontera; Chile
Fil: Malano, Francisco. Universidad de La Frontera; Chile
Fil: Cerna, Manuel. Universidad de La Frontera; Chile
Fil: Leiva, Jorge. Universidad de La Frontera; Chile
Fil: Casanelli, Bryan. Universidad de La Frontera; Chile
description This short review showcases two innovative technological advances, culminating in more than a decade of research into advanced oncology devices: CONVERAY and COXIRIS. In this context, it is essential to evaluate how these technologies can optimize performance in specific applications. CONVERAY is a convergent beam radiotherapy system, adaptable to linear particle accelerators (LINACs), designed to deliver a focused megavoltage photon or electron beam to a precise tumor location. This innovative approach achieves depth-dose peaks comparable to proton therapy, optimizing therapeutic efficacy while minimizing exposure to surrounding healthy tissues. Following this line of analysis, the results obtained through advanced simulations are examined. Notably, CONVERAY is compatible with ultra-high dose rate FLASH technology, enabling faster and less toxic treatments. Its implementation requires minimal LINAC modifications, preserving precise physical dimensions and mechanical, electrical, magnetic, vacuum, and shielding conditions. These findings allow for a more detailed exploration of practical implications in clinical environments. Complementing CONVERAY, COXIRIS is a confocal system designed for theragnostic applications utilizing X-ray fluorescence (XRF) in specific biomarkers. This innovative device enables the detection of fluorescent radiation in biomarkers at depths of up to 10 cm, providing detailed tumor characterization. Its confocal configuration facilitates simultaneous therapeutic interventions, integrating real-time detection and treatment for precise oncological management. Finally, key aspects that may influence future implementations and clinical applications are highlighted. COXIRIS represents a significant advancement toward an integrated and efficient cancer treatment solution, harmonizing diagnosis and therapy. Building upon the presented findings, these technologies offer a pathway toward transforming cancer treatment strategies. In summary, both CONVERAY and COXIRIS technologies, currently in the prototype phase, represent substantial breakthroughs in radiotherapy and oncological theragnosis, holding promise as pivotal tools for enhancing precision and efficacy in future cancer treatments. Their innovative designs and integrated approaches position these technologies at the forefront of oncological care, poised to transform treatment paradigms and improve patient outcomes.
publishDate 2025
dc.date.none.fl_str_mv 2025-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/282211
Figueroa, Rodolfo G.; Valente, Mauro Andres; Guarda, Jaime; Villar, Natalia; Sagardia, Joan; et al.; Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 234; 4-2025; 1-20
0969-806X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/282211
identifier_str_mv Figueroa, Rodolfo G.; Valente, Mauro Andres; Guarda, Jaime; Villar, Natalia; Sagardia, Joan; et al.; Advances in cancer diagnosis and treatment: A review of CONVERAY and COXIRIS radiation technologies - Current state and future directions; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 234; 4-2025; 1-20
0969-806X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0969806X25002804
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radphyschem.2025.112788
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1861931013726273536
score 13.018236

Publicaciones similares