Modulation of radiant oncological therapy through the intervention with substances of vegetable origin

Autores
Banega, Soledad; Bertoncini, Cintia; Pascuccio, Mercedes; Güerci, Alba Mabel
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: the search for substances that modulate the adverse effects of radiotherapy is key to optimizing the efficacy of these treatments and improving the patient´s quality of life. We consider the evaluation of green tea (Camellia Sinensis) opportune for its antioxidant and anti-inflammatory properties, while its composition in polyphenols would make it possible to reduce radiosensitivity and improve cell recovery. Thus, our objective was to assess the efficacy of this infusion in the management of mucositis developed during radiant treatment of patients with head and neck cancer. Materials and Methods: a prospective and controlled clinical trial was carried out on a population of 20 patients, under treatment with intensity modulated radiation (IMRT). The result of the intervention with green tea rinses (4 times/day) or compliance with the usual protocol, was assessed by detailed recording of radiotoxicity, using the RTOG scale. Statistical analysis was performed using the T-Test: Student´s t-Mann-Whitney U. Results: all the patients who adhered to and exhaustively complied with the protocol with the infusion, although they did not significantly recover the state of the oral cavity, demonstrated better control of the radio-induced acute effects (xerostomia and mucositis). Conclusion: although our results are preliminary, they allow us to suggest that from the intervention with green tea, the acute radiation-induced effects could be modulated. We believe intervention with this substance is opportune, given its easy administration, availability, cost, and lack of toxicity in a wide range of doses.
Fil: Banega, Soledad. Universidad Nacional de Entre Rios. Facultad de Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Bertoncini, Cintia. Centro de Medicina Nuclear Entre Rios (cemener);
Fil: Pascuccio, Mercedes. Universidad Nacional de Entre Rios. Facultad de Ciencias de la Salud; Argentina
Fil: Güerci, Alba Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Materia
GREEN TEA
RADIOMODULATOR
RADIOTHERAPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/253595
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/253595
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modulation of radiant oncological therapy through the intervention with substances of vegetable originBanega, SoledadBertoncini, CintiaPascuccio, MercedesGüerci, Alba MabelGREEN TEARADIOMODULATORRADIOTHERAPYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: the search for substances that modulate the adverse effects of radiotherapy is key to optimizing the efficacy of these treatments and improving the patient´s quality of life. We consider the evaluation of green tea (Camellia Sinensis) opportune for its antioxidant and anti-inflammatory properties, while its composition in polyphenols would make it possible to reduce radiosensitivity and improve cell recovery. Thus, our objective was to assess the efficacy of this infusion in the management of mucositis developed during radiant treatment of patients with head and neck cancer. Materials and Methods: a prospective and controlled clinical trial was carried out on a population of 20 patients, under treatment with intensity modulated radiation (IMRT). The result of the intervention with green tea rinses (4 times/day) or compliance with the usual protocol, was assessed by detailed recording of radiotoxicity, using the RTOG scale. Statistical analysis was performed using the T-Test: Student´s t-Mann-Whitney U. Results: all the patients who adhered to and exhaustively complied with the protocol with the infusion, although they did not significantly recover the state of the oral cavity, demonstrated better control of the radio-induced acute effects (xerostomia and mucositis). Conclusion: although our results are preliminary, they allow us to suggest that from the intervention with green tea, the acute radiation-induced effects could be modulated. We believe intervention with this substance is opportune, given its easy administration, availability, cost, and lack of toxicity in a wide range of doses.Fil: Banega, Soledad. Universidad Nacional de Entre Rios. Facultad de Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Bertoncini, Cintia. Centro de Medicina Nuclear Entre Rios (cemener);Fil: Pascuccio, Mercedes. Universidad Nacional de Entre Rios. Facultad de Ciencias de la Salud; ArgentinaFil: Güerci, Alba Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaSociedade Brasileira de Proteção Radiológica2023-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/253595Banega, Soledad; Bertoncini, Cintia; Pascuccio, Mercedes; Güerci, Alba Mabel; Modulation of radiant oncological therapy through the intervention with substances of vegetable origin; Sociedade Brasileira de Proteção Radiológica; Brazilian Journal of Radiation Sciences; 11; 4; 10-2023; 1-92319-0612CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.15392/2319-0612.2023.2261info:eu-repo/semantics/altIdentifier/url/https://bjrs.org.br/revista/index.php/REVISTA/article/view/2261info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:06:52Zoai:ri.conicet.gov.ar:11336/253595instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:06:52.328CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modulation of radiant oncological therapy through the intervention with substances of vegetable origin
title Modulation of radiant oncological therapy through the intervention with substances of vegetable origin
spellingShingle Modulation of radiant oncological therapy through the intervention with substances of vegetable origin
Banega, Soledad
GREEN TEA
RADIOMODULATOR
RADIOTHERAPY
title_short Modulation of radiant oncological therapy through the intervention with substances of vegetable origin
title_full Modulation of radiant oncological therapy through the intervention with substances of vegetable origin
title_fullStr Modulation of radiant oncological therapy through the intervention with substances of vegetable origin
title_full_unstemmed Modulation of radiant oncological therapy through the intervention with substances of vegetable origin
title_sort Modulation of radiant oncological therapy through the intervention with substances of vegetable origin
dc.creator.none.fl_str_mv Banega, Soledad
Bertoncini, Cintia
Pascuccio, Mercedes
Güerci, Alba Mabel
author Banega, Soledad
author_facet Banega, Soledad
Bertoncini, Cintia
Pascuccio, Mercedes
Güerci, Alba Mabel
author_role author
author2 Bertoncini, Cintia
Pascuccio, Mercedes
Güerci, Alba Mabel
author2_role author
author
author
dc.subject.none.fl_str_mv GREEN TEA
RADIOMODULATOR
RADIOTHERAPY
topic GREEN TEA
RADIOMODULATOR
RADIOTHERAPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: the search for substances that modulate the adverse effects of radiotherapy is key to optimizing the efficacy of these treatments and improving the patient´s quality of life. We consider the evaluation of green tea (Camellia Sinensis) opportune for its antioxidant and anti-inflammatory properties, while its composition in polyphenols would make it possible to reduce radiosensitivity and improve cell recovery. Thus, our objective was to assess the efficacy of this infusion in the management of mucositis developed during radiant treatment of patients with head and neck cancer. Materials and Methods: a prospective and controlled clinical trial was carried out on a population of 20 patients, under treatment with intensity modulated radiation (IMRT). The result of the intervention with green tea rinses (4 times/day) or compliance with the usual protocol, was assessed by detailed recording of radiotoxicity, using the RTOG scale. Statistical analysis was performed using the T-Test: Student´s t-Mann-Whitney U. Results: all the patients who adhered to and exhaustively complied with the protocol with the infusion, although they did not significantly recover the state of the oral cavity, demonstrated better control of the radio-induced acute effects (xerostomia and mucositis). Conclusion: although our results are preliminary, they allow us to suggest that from the intervention with green tea, the acute radiation-induced effects could be modulated. We believe intervention with this substance is opportune, given its easy administration, availability, cost, and lack of toxicity in a wide range of doses.
Fil: Banega, Soledad. Universidad Nacional de Entre Rios. Facultad de Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Bertoncini, Cintia. Centro de Medicina Nuclear Entre Rios (cemener);
Fil: Pascuccio, Mercedes. Universidad Nacional de Entre Rios. Facultad de Ciencias de la Salud; Argentina
Fil: Güerci, Alba Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
description Introduction: the search for substances that modulate the adverse effects of radiotherapy is key to optimizing the efficacy of these treatments and improving the patient´s quality of life. We consider the evaluation of green tea (Camellia Sinensis) opportune for its antioxidant and anti-inflammatory properties, while its composition in polyphenols would make it possible to reduce radiosensitivity and improve cell recovery. Thus, our objective was to assess the efficacy of this infusion in the management of mucositis developed during radiant treatment of patients with head and neck cancer. Materials and Methods: a prospective and controlled clinical trial was carried out on a population of 20 patients, under treatment with intensity modulated radiation (IMRT). The result of the intervention with green tea rinses (4 times/day) or compliance with the usual protocol, was assessed by detailed recording of radiotoxicity, using the RTOG scale. Statistical analysis was performed using the T-Test: Student´s t-Mann-Whitney U. Results: all the patients who adhered to and exhaustively complied with the protocol with the infusion, although they did not significantly recover the state of the oral cavity, demonstrated better control of the radio-induced acute effects (xerostomia and mucositis). Conclusion: although our results are preliminary, they allow us to suggest that from the intervention with green tea, the acute radiation-induced effects could be modulated. We believe intervention with this substance is opportune, given its easy administration, availability, cost, and lack of toxicity in a wide range of doses.
publishDate 2023
dc.date.none.fl_str_mv 2023-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/253595
Banega, Soledad; Bertoncini, Cintia; Pascuccio, Mercedes; Güerci, Alba Mabel; Modulation of radiant oncological therapy through the intervention with substances of vegetable origin; Sociedade Brasileira de Proteção Radiológica; Brazilian Journal of Radiation Sciences; 11; 4; 10-2023; 1-9
2319-0612
CONICET Digital
CONICET
url http://hdl.handle.net/11336/253595
identifier_str_mv Banega, Soledad; Bertoncini, Cintia; Pascuccio, Mercedes; Güerci, Alba Mabel; Modulation of radiant oncological therapy through the intervention with substances of vegetable origin; Sociedade Brasileira de Proteção Radiológica; Brazilian Journal of Radiation Sciences; 11; 4; 10-2023; 1-9
2319-0612
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.15392/2319-0612.2023.2261
info:eu-repo/semantics/altIdentifier/url/https://bjrs.org.br/revista/index.php/REVISTA/article/view/2261
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Proteção Radiológica
publisher.none.fl_str_mv Sociedade Brasileira de Proteção Radiológica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083211735597056
score 13.22299

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