Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications

Autores
Aranda, Federico; Udry, Sebastián; Perés Wingeyer, Silvia; Amshoff, Lea Christina; Bogdanova, Nadja; Wieacker, Peter; Latino, José Omar; Markoff, Arseni; de Larrañaga, Gabriela Fernanda
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. Consequently, this study aimed to assess the potential association of M2 maternal carrier status with the risk of recurrent pregnancy loss (RPL), the timing of miscarriages, and other obstetric complications, for the first time in a population from Latin America. Methods This study was designed as a prospective recruitment of RPL patients with post hoc analysis. The distribution of the M2/ANXA5 haplotype was compared between a group of 229 Argentine women with RPL and 100 parous controls, and was further analyzed in subgroups of patients stratified according to the timing of miscarriages and in relation to other obstetric complications. Results No significant differences were found in the distribution of M2 haplotype among either RPL patients or the subgroups with embryonic, early fetal, or late fetal losses compared to parous controls. Notwithstanding, maternal M2/ANXA5 was found to be independently associated with a higher risk of suffering intrauterine growth restriction (IUGR) and/or preeclampsia (PE). Simultaneously, the presence of inherited and/or acquired thrombophilia also proved to be an independent risk factor for these. Conclusions The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications.
Fil: Aranda, Federico. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Udry, Sebastián. Hospital General de Agudos"Dr Carlos G. Durand"; Argentina
Fil: Perés Wingeyer, Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Amshoff, Lea Christina. University Hospital Munster; Alemania
Fil: Bogdanova, Nadja. University Hospital Munster; Alemania
Fil: Wieacker, Peter. University Hospital Munster; Alemania
Fil: Latino, José Omar. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Markoff, Arseni. University Hospital Munster; Alemania
Fil: de Larrañaga, Gabriela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Materia
ANNEXIN A5
IUGR
M2/ANXA5
PRE-ECLAMPSIA
RECURRENT PREGNANCY LOSS
RISK FACTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98552
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/98552
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complicationsAranda, FedericoUdry, SebastiánPerés Wingeyer, SilviaAmshoff, Lea ChristinaBogdanova, NadjaWieacker, PeterLatino, José OmarMarkoff, Arsenide Larrañaga, Gabriela FernandaANNEXIN A5IUGRM2/ANXA5PRE-ECLAMPSIARECURRENT PREGNANCY LOSSRISK FACTORhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. Consequently, this study aimed to assess the potential association of M2 maternal carrier status with the risk of recurrent pregnancy loss (RPL), the timing of miscarriages, and other obstetric complications, for the first time in a population from Latin America. Methods This study was designed as a prospective recruitment of RPL patients with post hoc analysis. The distribution of the M2/ANXA5 haplotype was compared between a group of 229 Argentine women with RPL and 100 parous controls, and was further analyzed in subgroups of patients stratified according to the timing of miscarriages and in relation to other obstetric complications. Results No significant differences were found in the distribution of M2 haplotype among either RPL patients or the subgroups with embryonic, early fetal, or late fetal losses compared to parous controls. Notwithstanding, maternal M2/ANXA5 was found to be independently associated with a higher risk of suffering intrauterine growth restriction (IUGR) and/or preeclampsia (PE). Simultaneously, the presence of inherited and/or acquired thrombophilia also proved to be an independent risk factor for these. Conclusions The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications.Fil: Aranda, Federico. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Udry, Sebastián. Hospital General de Agudos"Dr Carlos G. Durand"; ArgentinaFil: Perés Wingeyer, Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Amshoff, Lea Christina. University Hospital Munster; AlemaniaFil: Bogdanova, Nadja. University Hospital Munster; AlemaniaFil: Wieacker, Peter. University Hospital Munster; AlemaniaFil: Latino, José Omar. Hospital General de Agudos "Carlos G. Durand"; ArgentinaFil: Markoff, Arseni. University Hospital Munster; AlemaniaFil: de Larrañaga, Gabriela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaSpringer/Plenum Publishers2018-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98552Aranda, Federico; Udry, Sebastián; Perés Wingeyer, Silvia; Amshoff, Lea Christina; Bogdanova, Nadja; et al.; Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications; Springer/Plenum Publishers; Journal of Assisted Reproduction and Genetics; 35; 5; 3-2018; 921-9281058-0468CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s10815-018-1142-4info:eu-repo/semantics/altIdentifier/doi/10.1007/s10815-018-1142-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:17Zoai:ri.conicet.gov.ar:11336/98552instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:18.184CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications
title Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications
spellingShingle Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications
Aranda, Federico
ANNEXIN A5
IUGR
M2/ANXA5
PRE-ECLAMPSIA
RECURRENT PREGNANCY LOSS
RISK FACTOR
title_short Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications
title_full Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications
title_fullStr Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications
title_full_unstemmed Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications
title_sort Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications
dc.creator.none.fl_str_mv Aranda, Federico
Udry, Sebastián
Perés Wingeyer, Silvia
Amshoff, Lea Christina
Bogdanova, Nadja
Wieacker, Peter
Latino, José Omar
Markoff, Arseni
de Larrañaga, Gabriela Fernanda
author Aranda, Federico
author_facet Aranda, Federico
Udry, Sebastián
Perés Wingeyer, Silvia
Amshoff, Lea Christina
Bogdanova, Nadja
Wieacker, Peter
Latino, José Omar
Markoff, Arseni
de Larrañaga, Gabriela Fernanda
author_role author
author2 Udry, Sebastián
Perés Wingeyer, Silvia
Amshoff, Lea Christina
Bogdanova, Nadja
Wieacker, Peter
Latino, José Omar
Markoff, Arseni
de Larrañaga, Gabriela Fernanda
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANNEXIN A5
IUGR
M2/ANXA5
PRE-ECLAMPSIA
RECURRENT PREGNANCY LOSS
RISK FACTOR
topic ANNEXIN A5
IUGR
M2/ANXA5
PRE-ECLAMPSIA
RECURRENT PREGNANCY LOSS
RISK FACTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. Consequently, this study aimed to assess the potential association of M2 maternal carrier status with the risk of recurrent pregnancy loss (RPL), the timing of miscarriages, and other obstetric complications, for the first time in a population from Latin America. Methods This study was designed as a prospective recruitment of RPL patients with post hoc analysis. The distribution of the M2/ANXA5 haplotype was compared between a group of 229 Argentine women with RPL and 100 parous controls, and was further analyzed in subgroups of patients stratified according to the timing of miscarriages and in relation to other obstetric complications. Results No significant differences were found in the distribution of M2 haplotype among either RPL patients or the subgroups with embryonic, early fetal, or late fetal losses compared to parous controls. Notwithstanding, maternal M2/ANXA5 was found to be independently associated with a higher risk of suffering intrauterine growth restriction (IUGR) and/or preeclampsia (PE). Simultaneously, the presence of inherited and/or acquired thrombophilia also proved to be an independent risk factor for these. Conclusions The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications.
Fil: Aranda, Federico. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Udry, Sebastián. Hospital General de Agudos"Dr Carlos G. Durand"; Argentina
Fil: Perés Wingeyer, Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Amshoff, Lea Christina. University Hospital Munster; Alemania
Fil: Bogdanova, Nadja. University Hospital Munster; Alemania
Fil: Wieacker, Peter. University Hospital Munster; Alemania
Fil: Latino, José Omar. Hospital General de Agudos "Carlos G. Durand"; Argentina
Fil: Markoff, Arseni. University Hospital Munster; Alemania
Fil: de Larrañaga, Gabriela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
description Purpose Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. Consequently, this study aimed to assess the potential association of M2 maternal carrier status with the risk of recurrent pregnancy loss (RPL), the timing of miscarriages, and other obstetric complications, for the first time in a population from Latin America. Methods This study was designed as a prospective recruitment of RPL patients with post hoc analysis. The distribution of the M2/ANXA5 haplotype was compared between a group of 229 Argentine women with RPL and 100 parous controls, and was further analyzed in subgroups of patients stratified according to the timing of miscarriages and in relation to other obstetric complications. Results No significant differences were found in the distribution of M2 haplotype among either RPL patients or the subgroups with embryonic, early fetal, or late fetal losses compared to parous controls. Notwithstanding, maternal M2/ANXA5 was found to be independently associated with a higher risk of suffering intrauterine growth restriction (IUGR) and/or preeclampsia (PE). Simultaneously, the presence of inherited and/or acquired thrombophilia also proved to be an independent risk factor for these. Conclusions The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98552
Aranda, Federico; Udry, Sebastián; Perés Wingeyer, Silvia; Amshoff, Lea Christina; Bogdanova, Nadja; et al.; Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications; Springer/Plenum Publishers; Journal of Assisted Reproduction and Genetics; 35; 5; 3-2018; 921-928
1058-0468
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98552
identifier_str_mv Aranda, Federico; Udry, Sebastián; Perés Wingeyer, Silvia; Amshoff, Lea Christina; Bogdanova, Nadja; et al.; Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications; Springer/Plenum Publishers; Journal of Assisted Reproduction and Genetics; 35; 5; 3-2018; 921-928
1058-0468
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s10815-018-1142-4
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10815-018-1142-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer/Plenum Publishers
publisher.none.fl_str_mv Springer/Plenum Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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