Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution

Autores
Frankel, Nicolás; Wang, Shu; Stern, David L.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Similar morphological, physiological, and behavioral features have evolved independently in different species, a pattern known as convergence. It is known that morphological convergence can occur through changes in orthologous genes. In some cases of convergence, cis-regulatory changes generate parallel modifications in the expression patterns of orthologous genes. Our understanding of how changes in cis-regulatory regions contribute to convergence is hampered, usually, by a limited understanding of the global cis-regulatory structure of the evolving genes. Here we examine the genetic causes of a case of precise phenotypic convergence between Drosophila sechellia and Drosophila ezoana, species that diverged ?40 Mya. Previous studies revealed that changes in multiple transcriptional enhancers of shavenbaby (svb, a transcript of the ovo locus) caused phenotypic evolution in the D. sechellia lineage. It has also been shown that the convergent phenotype of D. ezoana was likely caused by cis-regulatory evolution of svb. Here we show that the large-scale cis-regulatory architecture of svb is conserved between these Drosophila species. Furthermore, we show that the D. ezoana orthologs of the evolved D. sechellia enhancers have also evolved expression patterns that correlate precisely with the changes in the phenotype. Our results suggest that phenotypic convergence resulted frommultiple noncoding changes that occurred in parallel in the D. sechellia and D. ezoana lineages.
Fil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. University of Princeton; Estados Unidos
Fil: Wang, Shu. University of Princeton; Estados Unidos. JFK Medical Center; Estados Unidos
Fil: Stern, David L.. University of Princeton; Estados Unidos. Howard Hughes Medical Institute; Estados Unidos
Materia
ENHANCER FUNCTION
EVOLUTIONARY DEVELOPMENTAL BIOLOGY
PARALLEL DEVELOPMENTAL EVOLUTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/217392
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolutionFrankel, NicolásWang, ShuStern, David L.ENHANCER FUNCTIONEVOLUTIONARY DEVELOPMENTAL BIOLOGYPARALLEL DEVELOPMENTAL EVOLUTIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Similar morphological, physiological, and behavioral features have evolved independently in different species, a pattern known as convergence. It is known that morphological convergence can occur through changes in orthologous genes. In some cases of convergence, cis-regulatory changes generate parallel modifications in the expression patterns of orthologous genes. Our understanding of how changes in cis-regulatory regions contribute to convergence is hampered, usually, by a limited understanding of the global cis-regulatory structure of the evolving genes. Here we examine the genetic causes of a case of precise phenotypic convergence between Drosophila sechellia and Drosophila ezoana, species that diverged ?40 Mya. Previous studies revealed that changes in multiple transcriptional enhancers of shavenbaby (svb, a transcript of the ovo locus) caused phenotypic evolution in the D. sechellia lineage. It has also been shown that the convergent phenotype of D. ezoana was likely caused by cis-regulatory evolution of svb. Here we show that the large-scale cis-regulatory architecture of svb is conserved between these Drosophila species. Furthermore, we show that the D. ezoana orthologs of the evolved D. sechellia enhancers have also evolved expression patterns that correlate precisely with the changes in the phenotype. Our results suggest that phenotypic convergence resulted frommultiple noncoding changes that occurred in parallel in the D. sechellia and D. ezoana lineages.Fil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. University of Princeton; Estados UnidosFil: Wang, Shu. University of Princeton; Estados Unidos. JFK Medical Center; Estados UnidosFil: Stern, David L.. University of Princeton; Estados Unidos. Howard Hughes Medical Institute; Estados UnidosNational Academy of Sciences2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/217392Frankel, Nicolás; Wang, Shu; Stern, David L.; Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 109; 51; 12-2012; 20975-209790027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/doi/full/10.1073/pnas.1207715109info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1207715109info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:35Zoai:ri.conicet.gov.ar:11336/217392instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:35.333CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution
title Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution
spellingShingle Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution
Frankel, Nicolás
ENHANCER FUNCTION
EVOLUTIONARY DEVELOPMENTAL BIOLOGY
PARALLEL DEVELOPMENTAL EVOLUTION
title_short Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution
title_full Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution
title_fullStr Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution
title_full_unstemmed Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution
title_sort Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution
dc.creator.none.fl_str_mv Frankel, Nicolás
Wang, Shu
Stern, David L.
author Frankel, Nicolás
author_facet Frankel, Nicolás
Wang, Shu
Stern, David L.
author_role author
author2 Wang, Shu
Stern, David L.
author2_role author
author
dc.subject.none.fl_str_mv ENHANCER FUNCTION
EVOLUTIONARY DEVELOPMENTAL BIOLOGY
PARALLEL DEVELOPMENTAL EVOLUTION
topic ENHANCER FUNCTION
EVOLUTIONARY DEVELOPMENTAL BIOLOGY
PARALLEL DEVELOPMENTAL EVOLUTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Similar morphological, physiological, and behavioral features have evolved independently in different species, a pattern known as convergence. It is known that morphological convergence can occur through changes in orthologous genes. In some cases of convergence, cis-regulatory changes generate parallel modifications in the expression patterns of orthologous genes. Our understanding of how changes in cis-regulatory regions contribute to convergence is hampered, usually, by a limited understanding of the global cis-regulatory structure of the evolving genes. Here we examine the genetic causes of a case of precise phenotypic convergence between Drosophila sechellia and Drosophila ezoana, species that diverged ?40 Mya. Previous studies revealed that changes in multiple transcriptional enhancers of shavenbaby (svb, a transcript of the ovo locus) caused phenotypic evolution in the D. sechellia lineage. It has also been shown that the convergent phenotype of D. ezoana was likely caused by cis-regulatory evolution of svb. Here we show that the large-scale cis-regulatory architecture of svb is conserved between these Drosophila species. Furthermore, we show that the D. ezoana orthologs of the evolved D. sechellia enhancers have also evolved expression patterns that correlate precisely with the changes in the phenotype. Our results suggest that phenotypic convergence resulted frommultiple noncoding changes that occurred in parallel in the D. sechellia and D. ezoana lineages.
Fil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina. University of Princeton; Estados Unidos
Fil: Wang, Shu. University of Princeton; Estados Unidos. JFK Medical Center; Estados Unidos
Fil: Stern, David L.. University of Princeton; Estados Unidos. Howard Hughes Medical Institute; Estados Unidos
description Similar morphological, physiological, and behavioral features have evolved independently in different species, a pattern known as convergence. It is known that morphological convergence can occur through changes in orthologous genes. In some cases of convergence, cis-regulatory changes generate parallel modifications in the expression patterns of orthologous genes. Our understanding of how changes in cis-regulatory regions contribute to convergence is hampered, usually, by a limited understanding of the global cis-regulatory structure of the evolving genes. Here we examine the genetic causes of a case of precise phenotypic convergence between Drosophila sechellia and Drosophila ezoana, species that diverged ?40 Mya. Previous studies revealed that changes in multiple transcriptional enhancers of shavenbaby (svb, a transcript of the ovo locus) caused phenotypic evolution in the D. sechellia lineage. It has also been shown that the convergent phenotype of D. ezoana was likely caused by cis-regulatory evolution of svb. Here we show that the large-scale cis-regulatory architecture of svb is conserved between these Drosophila species. Furthermore, we show that the D. ezoana orthologs of the evolved D. sechellia enhancers have also evolved expression patterns that correlate precisely with the changes in the phenotype. Our results suggest that phenotypic convergence resulted frommultiple noncoding changes that occurred in parallel in the D. sechellia and D. ezoana lineages.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/217392
Frankel, Nicolás; Wang, Shu; Stern, David L.; Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 109; 51; 12-2012; 20975-20979
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/217392
identifier_str_mv Frankel, Nicolás; Wang, Shu; Stern, David L.; Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 109; 51; 12-2012; 20975-20979
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/doi/full/10.1073/pnas.1207715109
info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1207715109
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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