Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin

Autores
Fazzio, Luis Emilio; Streitenberger, Nicolás; Galvan, Walter Ruben; Sánchez, R. O.; Gimeno, Eduardo Juan; Sanabria, Rodrigo Eduardo Fabrizio
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Anthelmintic resistance (AR) of gastrointestinal nematodes to macrocyclic lactones is an increasingly common worldwide phenomenon limiting cattle production. This has motivated the search for alternatives, such as new active compounds, added drug synergisms, different doses, and alternate administration routes. The aim of this study was the assessment of moxidectin (MXD) performance in feedlot calves with a history of AR to ivermectin (IVM). Crossbred female calves aged 6-7 months and weighing 163 kg (SD = 34 kg) were divided into 3 groups of 35 animals each. They were assigned to the following antiparasitic treatment groups: IVM group (0.2 mg/kg IVM); MXD group (0.2 mg/kg MXD), and ricobendazole + levamisole (RBZ + LEV) group (7.5 mg/kg RBZ + 8 mg/kg LEV). On days 0, 26, and 47, fecal samples were taken and the weight of each animal was registered. Anthelmintic efficacy (by fecal egg count reduction), total weight gain (TWG) and average daily weight gain (AWG) were compared between the groups. A mixed SAS procedure was used for statistical analysis. Fecal egg count reduction 26 days post-treatment (PT) was calculated at 28% for the IVM group, 85% for the MXD group, and 99% for the RBZ + LEV group. AWGs (Standard Error) of 1.095 g (56), 1.264 g (49), and 1.340 g (52) were registered for the IVM, MXD, and RBZ + LEV groups, respectively (p < 0.05). Coprocultures revealed that MXD more effectively reduced Haemonchus spp. and Cooperia spp. egg counts than IVM. This resulted in higher AWGs and TWGs for this group; similar results were seen for the RBZ + LEV group as well. In this study, animals treated with MXD gained about 160 more g/day than animals treated with IVM. This represents a gain of 16 USD per animal over the 47 day trial.
Fil: Fazzio, Luis Emilio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Streitenberger, Nicolás. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Galvan, Walter Ruben. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Sánchez, R. O.. Laboratorio Mesopotámico de Diagnóstico Veterinario; Argentina
Fil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Sanabria, Rodrigo Eduardo Fabrizio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Materia
Average Weight Gain
Cattle
Cooperia
Haemonchus
Macrocyclic Lactones
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/54562
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/54562
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectinFazzio, Luis EmilioStreitenberger, NicolásGalvan, Walter RubenSánchez, R. O.Gimeno, Eduardo JuanSanabria, Rodrigo Eduardo FabrizioAverage Weight GainCattleCooperiaHaemonchusMacrocyclic Lactoneshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Anthelmintic resistance (AR) of gastrointestinal nematodes to macrocyclic lactones is an increasingly common worldwide phenomenon limiting cattle production. This has motivated the search for alternatives, such as new active compounds, added drug synergisms, different doses, and alternate administration routes. The aim of this study was the assessment of moxidectin (MXD) performance in feedlot calves with a history of AR to ivermectin (IVM). Crossbred female calves aged 6-7 months and weighing 163 kg (SD = 34 kg) were divided into 3 groups of 35 animals each. They were assigned to the following antiparasitic treatment groups: IVM group (0.2 mg/kg IVM); MXD group (0.2 mg/kg MXD), and ricobendazole + levamisole (RBZ + LEV) group (7.5 mg/kg RBZ + 8 mg/kg LEV). On days 0, 26, and 47, fecal samples were taken and the weight of each animal was registered. Anthelmintic efficacy (by fecal egg count reduction), total weight gain (TWG) and average daily weight gain (AWG) were compared between the groups. A mixed SAS procedure was used for statistical analysis. Fecal egg count reduction 26 days post-treatment (PT) was calculated at 28% for the IVM group, 85% for the MXD group, and 99% for the RBZ + LEV group. AWGs (Standard Error) of 1.095 g (56), 1.264 g (49), and 1.340 g (52) were registered for the IVM, MXD, and RBZ + LEV groups, respectively (p < 0.05). Coprocultures revealed that MXD more effectively reduced Haemonchus spp. and Cooperia spp. egg counts than IVM. This resulted in higher AWGs and TWGs for this group; similar results were seen for the RBZ + LEV group as well. In this study, animals treated with MXD gained about 160 more g/day than animals treated with IVM. This represents a gain of 16 USD per animal over the 47 day trial.Fil: Fazzio, Luis Emilio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Streitenberger, Nicolás. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Galvan, Walter Ruben. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Sánchez, R. O.. Laboratorio Mesopotámico de Diagnóstico Veterinario; ArgentinaFil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Sanabria, Rodrigo Eduardo Fabrizio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaElsevier Science2016-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/54562Fazzio, Luis Emilio; Streitenberger, Nicolás; Galvan, Walter Ruben; Sánchez, R. O.; Gimeno, Eduardo Juan; et al.; Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin; Elsevier Science; Veterinary Parasitology; 223; 6-2016; 26-290304-4017CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetpar.2016.04.003info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304401716300826info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:21Zoai:ri.conicet.gov.ar:11336/54562instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:22.021CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin
title Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin
spellingShingle Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin
Fazzio, Luis Emilio
Average Weight Gain
Cattle
Cooperia
Haemonchus
Macrocyclic Lactones
title_short Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin
title_full Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin
title_fullStr Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin
title_full_unstemmed Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin
title_sort Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin
dc.creator.none.fl_str_mv Fazzio, Luis Emilio
Streitenberger, Nicolás
Galvan, Walter Ruben
Sánchez, R. O.
Gimeno, Eduardo Juan
Sanabria, Rodrigo Eduardo Fabrizio
author Fazzio, Luis Emilio
author_facet Fazzio, Luis Emilio
Streitenberger, Nicolás
Galvan, Walter Ruben
Sánchez, R. O.
Gimeno, Eduardo Juan
Sanabria, Rodrigo Eduardo Fabrizio
author_role author
author2 Streitenberger, Nicolás
Galvan, Walter Ruben
Sánchez, R. O.
Gimeno, Eduardo Juan
Sanabria, Rodrigo Eduardo Fabrizio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Average Weight Gain
Cattle
Cooperia
Haemonchus
Macrocyclic Lactones
topic Average Weight Gain
Cattle
Cooperia
Haemonchus
Macrocyclic Lactones
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Anthelmintic resistance (AR) of gastrointestinal nematodes to macrocyclic lactones is an increasingly common worldwide phenomenon limiting cattle production. This has motivated the search for alternatives, such as new active compounds, added drug synergisms, different doses, and alternate administration routes. The aim of this study was the assessment of moxidectin (MXD) performance in feedlot calves with a history of AR to ivermectin (IVM). Crossbred female calves aged 6-7 months and weighing 163 kg (SD = 34 kg) were divided into 3 groups of 35 animals each. They were assigned to the following antiparasitic treatment groups: IVM group (0.2 mg/kg IVM); MXD group (0.2 mg/kg MXD), and ricobendazole + levamisole (RBZ + LEV) group (7.5 mg/kg RBZ + 8 mg/kg LEV). On days 0, 26, and 47, fecal samples were taken and the weight of each animal was registered. Anthelmintic efficacy (by fecal egg count reduction), total weight gain (TWG) and average daily weight gain (AWG) were compared between the groups. A mixed SAS procedure was used for statistical analysis. Fecal egg count reduction 26 days post-treatment (PT) was calculated at 28% for the IVM group, 85% for the MXD group, and 99% for the RBZ + LEV group. AWGs (Standard Error) of 1.095 g (56), 1.264 g (49), and 1.340 g (52) were registered for the IVM, MXD, and RBZ + LEV groups, respectively (p < 0.05). Coprocultures revealed that MXD more effectively reduced Haemonchus spp. and Cooperia spp. egg counts than IVM. This resulted in higher AWGs and TWGs for this group; similar results were seen for the RBZ + LEV group as well. In this study, animals treated with MXD gained about 160 more g/day than animals treated with IVM. This represents a gain of 16 USD per animal over the 47 day trial.
Fil: Fazzio, Luis Emilio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Streitenberger, Nicolás. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Galvan, Walter Ruben. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Sánchez, R. O.. Laboratorio Mesopotámico de Diagnóstico Veterinario; Argentina
Fil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Sanabria, Rodrigo Eduardo Fabrizio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
description Anthelmintic resistance (AR) of gastrointestinal nematodes to macrocyclic lactones is an increasingly common worldwide phenomenon limiting cattle production. This has motivated the search for alternatives, such as new active compounds, added drug synergisms, different doses, and alternate administration routes. The aim of this study was the assessment of moxidectin (MXD) performance in feedlot calves with a history of AR to ivermectin (IVM). Crossbred female calves aged 6-7 months and weighing 163 kg (SD = 34 kg) were divided into 3 groups of 35 animals each. They were assigned to the following antiparasitic treatment groups: IVM group (0.2 mg/kg IVM); MXD group (0.2 mg/kg MXD), and ricobendazole + levamisole (RBZ + LEV) group (7.5 mg/kg RBZ + 8 mg/kg LEV). On days 0, 26, and 47, fecal samples were taken and the weight of each animal was registered. Anthelmintic efficacy (by fecal egg count reduction), total weight gain (TWG) and average daily weight gain (AWG) were compared between the groups. A mixed SAS procedure was used for statistical analysis. Fecal egg count reduction 26 days post-treatment (PT) was calculated at 28% for the IVM group, 85% for the MXD group, and 99% for the RBZ + LEV group. AWGs (Standard Error) of 1.095 g (56), 1.264 g (49), and 1.340 g (52) were registered for the IVM, MXD, and RBZ + LEV groups, respectively (p < 0.05). Coprocultures revealed that MXD more effectively reduced Haemonchus spp. and Cooperia spp. egg counts than IVM. This resulted in higher AWGs and TWGs for this group; similar results were seen for the RBZ + LEV group as well. In this study, animals treated with MXD gained about 160 more g/day than animals treated with IVM. This represents a gain of 16 USD per animal over the 47 day trial.
publishDate 2016
dc.date.none.fl_str_mv 2016-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/54562
Fazzio, Luis Emilio; Streitenberger, Nicolás; Galvan, Walter Ruben; Sánchez, R. O.; Gimeno, Eduardo Juan; et al.; Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin; Elsevier Science; Veterinary Parasitology; 223; 6-2016; 26-29
0304-4017
CONICET Digital
CONICET
url http://hdl.handle.net/11336/54562
identifier_str_mv Fazzio, Luis Emilio; Streitenberger, Nicolás; Galvan, Walter Ruben; Sánchez, R. O.; Gimeno, Eduardo Juan; et al.; Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin; Elsevier Science; Veterinary Parasitology; 223; 6-2016; 26-29
0304-4017
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetpar.2016.04.003
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304401716300826
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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