Chemical stability of veterinary drugs residues in feces: adverse environmental impact?

Autores
Lifschitz, Adrian Luis; Kolar, Lusija; Sallovitz, Juan Manuel; Suarez, Víctor Humberto; Cerkvenik Flajs, Vesna; Pogacnik, Milan; Kozuh Erzen, Nevenka; Lanusse, Carlos Edmundo
Año de publicación
2007
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The macrocyclic lactones (ML) are broad-spectrum antiparasitic drugs excreted in large concentrations as unchanged parent drugs in feces. The current work evaluated the comparative chemical stability of different ML drugs in feces from treated sheep and cattle exposed to environmental field conditions. Fecal depositions from sheep and cattle subcutaneously treated with different ML were kept in the field during different time periods (between 6 and 180 days). Drug fecal concentrations were measured by HPLC. The ML drugs showed a sustained chemical stability. Long persistence of fecal drug residues were observed in the feces exposed to field conditions. Although a rapid decrease in ML fecal concentrations were observed over the first 14 days (cattle) and 32 days (sheep) post-deposition, a slow chemical degradation accounting for the long persistence of the active parent molecules in the environment was registered. Doramectin was the ML compound recovered at the highest residual concentration in feces from both animal species. Even after 100 days of field exposure, doramectin concentrations were 308 (sheep) and 425 (cattle) ng/g dry faeces. The potential adverse effects of the fecal residual concentrations against nontarget organisms are under evaluation in an Argentina-Slovenia binational collaborative project.
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Kolar, Lusija. University of Ljubljana. Veterinary Faculty; Eslovenia
Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Suarez, Víctor Humberto. Instituto Nacional de Tecnología Agropecuaria. Centro Regional La Pampa-San Luis. Estación Experimental Agropecuaria Anguil; Argentina
Fil: Cerkvenik Flajs, Vesna. University of Ljubljana. Veterinary Faculty; Eslovenia
Fil: Pogacnik, Milan. University of Ljubljana. Veterinary Faculty; Eslovenia
Fil: Kozuh Erzen, Nevenka. University of Ljubljana. Veterinary Faculty; Eslovenia
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
XXXIX Reunión Anual de la Asociación Argentina de Farmacología Experimental
Ciudad Autónoma de Buenos Aires
Argentina
Asociación Argentina de Farmacología Experimental
Materia
Chemical stability
Faeces
Macrocyclic lactones
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/242059
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/242059
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Chemical stability of veterinary drugs residues in feces: adverse environmental impact?Lifschitz, Adrian LuisKolar, LusijaSallovitz, Juan ManuelSuarez, Víctor HumbertoCerkvenik Flajs, VesnaPogacnik, MilanKozuh Erzen, NevenkaLanusse, Carlos EdmundoChemical stabilityFaecesMacrocyclic lactoneshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The macrocyclic lactones (ML) are broad-spectrum antiparasitic drugs excreted in large concentrations as unchanged parent drugs in feces. The current work evaluated the comparative chemical stability of different ML drugs in feces from treated sheep and cattle exposed to environmental field conditions. Fecal depositions from sheep and cattle subcutaneously treated with different ML were kept in the field during different time periods (between 6 and 180 days). Drug fecal concentrations were measured by HPLC. The ML drugs showed a sustained chemical stability. Long persistence of fecal drug residues were observed in the feces exposed to field conditions. Although a rapid decrease in ML fecal concentrations were observed over the first 14 days (cattle) and 32 days (sheep) post-deposition, a slow chemical degradation accounting for the long persistence of the active parent molecules in the environment was registered. Doramectin was the ML compound recovered at the highest residual concentration in feces from both animal species. Even after 100 days of field exposure, doramectin concentrations were 308 (sheep) and 425 (cattle) ng/g dry faeces. The potential adverse effects of the fecal residual concentrations against nontarget organisms are under evaluation in an Argentina-Slovenia binational collaborative project.Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Kolar, Lusija. University of Ljubljana. Veterinary Faculty; EsloveniaFil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Suarez, Víctor Humberto. Instituto Nacional de Tecnología Agropecuaria. Centro Regional La Pampa-San Luis. Estación Experimental Agropecuaria Anguil; ArgentinaFil: Cerkvenik Flajs, Vesna. University of Ljubljana. Veterinary Faculty; EsloveniaFil: Pogacnik, Milan. University of Ljubljana. Veterinary Faculty; EsloveniaFil: Kozuh Erzen, Nevenka. University of Ljubljana. Veterinary Faculty; EsloveniaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaXXXIX Reunión Anual de la Asociación Argentina de Farmacología ExperimentalCiudad Autónoma de Buenos AiresArgentinaAsociación Argentina de Farmacología ExperimentalSociedad Argentina de Farmacología Experimental2007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/242059Chemical stability of veterinary drugs residues in feces: adverse environmental impact?; XXXIX Reunión Anual de la Asociación Argentina de Farmacología Experimental; Ciudad Autónoma de Buenos Aires; Argentina; 2007; 66-66CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/wp-content/uploads/2021/07/ACTA_2007.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:48Zoai:ri.conicet.gov.ar:11336/242059instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:48.577CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chemical stability of veterinary drugs residues in feces: adverse environmental impact?
title Chemical stability of veterinary drugs residues in feces: adverse environmental impact?
spellingShingle Chemical stability of veterinary drugs residues in feces: adverse environmental impact?
Lifschitz, Adrian Luis
Chemical stability
Faeces
Macrocyclic lactones
title_short Chemical stability of veterinary drugs residues in feces: adverse environmental impact?
title_full Chemical stability of veterinary drugs residues in feces: adverse environmental impact?
title_fullStr Chemical stability of veterinary drugs residues in feces: adverse environmental impact?
title_full_unstemmed Chemical stability of veterinary drugs residues in feces: adverse environmental impact?
title_sort Chemical stability of veterinary drugs residues in feces: adverse environmental impact?
dc.creator.none.fl_str_mv Lifschitz, Adrian Luis
Kolar, Lusija
Sallovitz, Juan Manuel
Suarez, Víctor Humberto
Cerkvenik Flajs, Vesna
Pogacnik, Milan
Kozuh Erzen, Nevenka
Lanusse, Carlos Edmundo
author Lifschitz, Adrian Luis
author_facet Lifschitz, Adrian Luis
Kolar, Lusija
Sallovitz, Juan Manuel
Suarez, Víctor Humberto
Cerkvenik Flajs, Vesna
Pogacnik, Milan
Kozuh Erzen, Nevenka
Lanusse, Carlos Edmundo
author_role author
author2 Kolar, Lusija
Sallovitz, Juan Manuel
Suarez, Víctor Humberto
Cerkvenik Flajs, Vesna
Pogacnik, Milan
Kozuh Erzen, Nevenka
Lanusse, Carlos Edmundo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chemical stability
Faeces
Macrocyclic lactones
topic Chemical stability
Faeces
Macrocyclic lactones
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The macrocyclic lactones (ML) are broad-spectrum antiparasitic drugs excreted in large concentrations as unchanged parent drugs in feces. The current work evaluated the comparative chemical stability of different ML drugs in feces from treated sheep and cattle exposed to environmental field conditions. Fecal depositions from sheep and cattle subcutaneously treated with different ML were kept in the field during different time periods (between 6 and 180 days). Drug fecal concentrations were measured by HPLC. The ML drugs showed a sustained chemical stability. Long persistence of fecal drug residues were observed in the feces exposed to field conditions. Although a rapid decrease in ML fecal concentrations were observed over the first 14 days (cattle) and 32 days (sheep) post-deposition, a slow chemical degradation accounting for the long persistence of the active parent molecules in the environment was registered. Doramectin was the ML compound recovered at the highest residual concentration in feces from both animal species. Even after 100 days of field exposure, doramectin concentrations were 308 (sheep) and 425 (cattle) ng/g dry faeces. The potential adverse effects of the fecal residual concentrations against nontarget organisms are under evaluation in an Argentina-Slovenia binational collaborative project.
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Kolar, Lusija. University of Ljubljana. Veterinary Faculty; Eslovenia
Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Suarez, Víctor Humberto. Instituto Nacional de Tecnología Agropecuaria. Centro Regional La Pampa-San Luis. Estación Experimental Agropecuaria Anguil; Argentina
Fil: Cerkvenik Flajs, Vesna. University of Ljubljana. Veterinary Faculty; Eslovenia
Fil: Pogacnik, Milan. University of Ljubljana. Veterinary Faculty; Eslovenia
Fil: Kozuh Erzen, Nevenka. University of Ljubljana. Veterinary Faculty; Eslovenia
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
XXXIX Reunión Anual de la Asociación Argentina de Farmacología Experimental
Ciudad Autónoma de Buenos Aires
Argentina
Asociación Argentina de Farmacología Experimental
description The macrocyclic lactones (ML) are broad-spectrum antiparasitic drugs excreted in large concentrations as unchanged parent drugs in feces. The current work evaluated the comparative chemical stability of different ML drugs in feces from treated sheep and cattle exposed to environmental field conditions. Fecal depositions from sheep and cattle subcutaneously treated with different ML were kept in the field during different time periods (between 6 and 180 days). Drug fecal concentrations were measured by HPLC. The ML drugs showed a sustained chemical stability. Long persistence of fecal drug residues were observed in the feces exposed to field conditions. Although a rapid decrease in ML fecal concentrations were observed over the first 14 days (cattle) and 32 days (sheep) post-deposition, a slow chemical degradation accounting for the long persistence of the active parent molecules in the environment was registered. Doramectin was the ML compound recovered at the highest residual concentration in feces from both animal species. Even after 100 days of field exposure, doramectin concentrations were 308 (sheep) and 425 (cattle) ng/g dry faeces. The potential adverse effects of the fecal residual concentrations against nontarget organisms are under evaluation in an Argentina-Slovenia binational collaborative project.
publishDate 2007
dc.date.none.fl_str_mv 2007
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/242059
Chemical stability of veterinary drugs residues in feces: adverse environmental impact?; XXXIX Reunión Anual de la Asociación Argentina de Farmacología Experimental; Ciudad Autónoma de Buenos Aires; Argentina; 2007; 66-66
CONICET Digital
CONICET
url http://hdl.handle.net/11336/242059
identifier_str_mv Chemical stability of veterinary drugs residues in feces: adverse environmental impact?; XXXIX Reunión Anual de la Asociación Argentina de Farmacología Experimental; Ciudad Autónoma de Buenos Aires; Argentina; 2007; 66-66
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/wp-content/uploads/2021/07/ACTA_2007.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Farmacología Experimental
publisher.none.fl_str_mv Sociedad Argentina de Farmacología Experimental
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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