Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility

Autores
Ramos, R. A.; Zapata, Jair; Condat, Carlos; Deisboeck, Thomas S.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A mesoscopic model is used to describe the effects of lymphocyte activity on a growing tumor. The model yields novel insights into the tumor–immune system interaction. In particular, we found that the presence of a putative chemotactic messenger that helps guide the lymphocytes towards the tumor is not critical to elicit the anti-tumor effects of the immune system, while lymphocytes that block tumor cell migration contribute to limit cancer expansion and thus have a more significant therapeutic impact.
Fil: Ramos, R. A.. Universidad de Puerto Rico; Puerto Rico
Fil: Zapata, Jair. Universidad de Puerto Rico; Puerto Rico
Fil: Condat, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Deisboeck, Thomas S.. Harvard University; Estados Unidos. Massachusetts Institute of Technology; Estados Unidos
Materia
Cancer
Immunotherapy
Tumor Growth
Cell Motility
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25407
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motilityRamos, R. A.Zapata, JairCondat, CarlosDeisboeck, Thomas S.CancerImmunotherapyTumor GrowthCell Motilityhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A mesoscopic model is used to describe the effects of lymphocyte activity on a growing tumor. The model yields novel insights into the tumor–immune system interaction. In particular, we found that the presence of a putative chemotactic messenger that helps guide the lymphocytes towards the tumor is not critical to elicit the anti-tumor effects of the immune system, while lymphocytes that block tumor cell migration contribute to limit cancer expansion and thus have a more significant therapeutic impact.Fil: Ramos, R. A.. Universidad de Puerto Rico; Puerto RicoFil: Zapata, Jair. Universidad de Puerto Rico; Puerto RicoFil: Condat, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Deisboeck, Thomas S.. Harvard University; Estados Unidos. Massachusetts Institute of Technology; Estados UnidosElsevier Science2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25407Ramos, R. A.; Zapata, Jair; Condat, Carlos; Deisboeck, Thomas S.; Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility; Elsevier Science; Physica A: Statistical Mechanics and its Applications; 392; 10; 2-2013; 2415-24250378-4371CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.physa.2013.01.047info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S037843711300099Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:43:34Zoai:ri.conicet.gov.ar:11336/25407instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:43:35.051CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility
title Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility
spellingShingle Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility
Ramos, R. A.
Cancer
Immunotherapy
Tumor Growth
Cell Motility
title_short Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility
title_full Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility
title_fullStr Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility
title_full_unstemmed Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility
title_sort Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility
dc.creator.none.fl_str_mv Ramos, R. A.
Zapata, Jair
Condat, Carlos
Deisboeck, Thomas S.
author Ramos, R. A.
author_facet Ramos, R. A.
Zapata, Jair
Condat, Carlos
Deisboeck, Thomas S.
author_role author
author2 Zapata, Jair
Condat, Carlos
Deisboeck, Thomas S.
author2_role author
author
author
dc.subject.none.fl_str_mv Cancer
Immunotherapy
Tumor Growth
Cell Motility
topic Cancer
Immunotherapy
Tumor Growth
Cell Motility
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A mesoscopic model is used to describe the effects of lymphocyte activity on a growing tumor. The model yields novel insights into the tumor–immune system interaction. In particular, we found that the presence of a putative chemotactic messenger that helps guide the lymphocytes towards the tumor is not critical to elicit the anti-tumor effects of the immune system, while lymphocytes that block tumor cell migration contribute to limit cancer expansion and thus have a more significant therapeutic impact.
Fil: Ramos, R. A.. Universidad de Puerto Rico; Puerto Rico
Fil: Zapata, Jair. Universidad de Puerto Rico; Puerto Rico
Fil: Condat, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Deisboeck, Thomas S.. Harvard University; Estados Unidos. Massachusetts Institute of Technology; Estados Unidos
description A mesoscopic model is used to describe the effects of lymphocyte activity on a growing tumor. The model yields novel insights into the tumor–immune system interaction. In particular, we found that the presence of a putative chemotactic messenger that helps guide the lymphocytes towards the tumor is not critical to elicit the anti-tumor effects of the immune system, while lymphocytes that block tumor cell migration contribute to limit cancer expansion and thus have a more significant therapeutic impact.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25407
Ramos, R. A.; Zapata, Jair; Condat, Carlos; Deisboeck, Thomas S.; Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility; Elsevier Science; Physica A: Statistical Mechanics and its Applications; 392; 10; 2-2013; 2415-2425
0378-4371
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25407
identifier_str_mv Ramos, R. A.; Zapata, Jair; Condat, Carlos; Deisboeck, Thomas S.; Modeling cancer immunotherapy: Assessing the effects of lymphocytes on cancer cell growth and motility; Elsevier Science; Physica A: Statistical Mechanics and its Applications; 392; 10; 2-2013; 2415-2425
0378-4371
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.physa.2013.01.047
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S037843711300099X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614471381680128
score 13.069144

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