Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches

Autores
Ramos Elizagaray, Sabrina I.; Soria, Elio Andres
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Arsenic (As) contaminates drinking water worldwide, and As exposure, hypersensitivity and deficiency are involved in the immunopathogenesis of various health problems. Its chemoprevention thus has a high health impact. Given its oxidative potential, antioxidant compounds are good candidates to counteract arsenic's deleterious effects on humans. Phytochemicals (e.g., phenolics, carotenoids, etc.) act through free radical chelation activity and regulation of cellular targets. Consequently, they are appropriate for developing anti-As strategies derived from plants, and Argentinean flora is rich in useful species. Several molecular pathways involved in immune regulation are at the same time targets of exogenous agents, and oxidative stress itself is a modulating phenomenon of immunity. Since xenohormesis has been described as the organic enhancement of resistance to stress conditions (e.g., oxidation, pollution, etc.) by consuming xenobiotics, immunoxenohormesis implies also defense improvement. This review focuses on recent patents on the development of vegetable redox-related immunomodulating agents, which might be applied in As-induced dysfunctions, with their scientific basis being reviewed.
Fil: Ramos Elizagaray, Sabrina I.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina. Consejo Interuniversitario Nacional; Argentina
Fil: Soria, Elio Andres. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina
Materia
Antioxidant
Arsenicosis
Chemoprevention
Phytomedicine
Immunomodulation
Polyphenol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11539
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approachesRamos Elizagaray, Sabrina I.Soria, Elio AndresAntioxidantArsenicosisChemopreventionPhytomedicineImmunomodulationPolyphenolhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Arsenic (As) contaminates drinking water worldwide, and As exposure, hypersensitivity and deficiency are involved in the immunopathogenesis of various health problems. Its chemoprevention thus has a high health impact. Given its oxidative potential, antioxidant compounds are good candidates to counteract arsenic's deleterious effects on humans. Phytochemicals (e.g., phenolics, carotenoids, etc.) act through free radical chelation activity and regulation of cellular targets. Consequently, they are appropriate for developing anti-As strategies derived from plants, and Argentinean flora is rich in useful species. Several molecular pathways involved in immune regulation are at the same time targets of exogenous agents, and oxidative stress itself is a modulating phenomenon of immunity. Since xenohormesis has been described as the organic enhancement of resistance to stress conditions (e.g., oxidation, pollution, etc.) by consuming xenobiotics, immunoxenohormesis implies also defense improvement. This review focuses on recent patents on the development of vegetable redox-related immunomodulating agents, which might be applied in As-induced dysfunctions, with their scientific basis being reviewed.Fil: Ramos Elizagaray, Sabrina I.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina. Consejo Interuniversitario Nacional; ArgentinaFil: Soria, Elio Andres. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; ArgentinaBentham Science Publishers2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11539Ramos Elizagaray, Sabrina I.; Soria, Elio Andres; Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches; Bentham Science Publishers; Recent Patents on Inflammation and Allergy Drug Discovery; 8; 2; 7-2014; 92-1031872-213X2212-2710enginfo:eu-repo/semantics/altIdentifier/url/http://benthamscience.com/journals/recent-patents-on-inflammation-and-allergy-drug-discovery/volume/8/issue/2/page/92/info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.2174/1872213X08666140619104944info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:30:47Zoai:ri.conicet.gov.ar:11336/11539instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:30:47.533CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches
title Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches
spellingShingle Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches
Ramos Elizagaray, Sabrina I.
Antioxidant
Arsenicosis
Chemoprevention
Phytomedicine
Immunomodulation
Polyphenol
title_short Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches
title_full Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches
title_fullStr Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches
title_full_unstemmed Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches
title_sort Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches
dc.creator.none.fl_str_mv Ramos Elizagaray, Sabrina I.
Soria, Elio Andres
author Ramos Elizagaray, Sabrina I.
author_facet Ramos Elizagaray, Sabrina I.
Soria, Elio Andres
author_role author
author2 Soria, Elio Andres
author2_role author
dc.subject.none.fl_str_mv Antioxidant
Arsenicosis
Chemoprevention
Phytomedicine
Immunomodulation
Polyphenol
topic Antioxidant
Arsenicosis
Chemoprevention
Phytomedicine
Immunomodulation
Polyphenol
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Arsenic (As) contaminates drinking water worldwide, and As exposure, hypersensitivity and deficiency are involved in the immunopathogenesis of various health problems. Its chemoprevention thus has a high health impact. Given its oxidative potential, antioxidant compounds are good candidates to counteract arsenic's deleterious effects on humans. Phytochemicals (e.g., phenolics, carotenoids, etc.) act through free radical chelation activity and regulation of cellular targets. Consequently, they are appropriate for developing anti-As strategies derived from plants, and Argentinean flora is rich in useful species. Several molecular pathways involved in immune regulation are at the same time targets of exogenous agents, and oxidative stress itself is a modulating phenomenon of immunity. Since xenohormesis has been described as the organic enhancement of resistance to stress conditions (e.g., oxidation, pollution, etc.) by consuming xenobiotics, immunoxenohormesis implies also defense improvement. This review focuses on recent patents on the development of vegetable redox-related immunomodulating agents, which might be applied in As-induced dysfunctions, with their scientific basis being reviewed.
Fil: Ramos Elizagaray, Sabrina I.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina. Consejo Interuniversitario Nacional; Argentina
Fil: Soria, Elio Andres. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; Argentina
description Arsenic (As) contaminates drinking water worldwide, and As exposure, hypersensitivity and deficiency are involved in the immunopathogenesis of various health problems. Its chemoprevention thus has a high health impact. Given its oxidative potential, antioxidant compounds are good candidates to counteract arsenic's deleterious effects on humans. Phytochemicals (e.g., phenolics, carotenoids, etc.) act through free radical chelation activity and regulation of cellular targets. Consequently, they are appropriate for developing anti-As strategies derived from plants, and Argentinean flora is rich in useful species. Several molecular pathways involved in immune regulation are at the same time targets of exogenous agents, and oxidative stress itself is a modulating phenomenon of immunity. Since xenohormesis has been described as the organic enhancement of resistance to stress conditions (e.g., oxidation, pollution, etc.) by consuming xenobiotics, immunoxenohormesis implies also defense improvement. This review focuses on recent patents on the development of vegetable redox-related immunomodulating agents, which might be applied in As-induced dysfunctions, with their scientific basis being reviewed.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11539
Ramos Elizagaray, Sabrina I.; Soria, Elio Andres; Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches; Bentham Science Publishers; Recent Patents on Inflammation and Allergy Drug Discovery; 8; 2; 7-2014; 92-103
1872-213X
2212-2710
url http://hdl.handle.net/11336/11539
identifier_str_mv Ramos Elizagaray, Sabrina I.; Soria, Elio Andres; Arsenic immunotoxicity and immunomodulation by Phytochemicals: potential relations to develop chemopreventive approaches; Bentham Science Publishers; Recent Patents on Inflammation and Allergy Drug Discovery; 8; 2; 7-2014; 92-103
1872-213X
2212-2710
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://benthamscience.com/journals/recent-patents-on-inflammation-and-allergy-drug-discovery/volume/8/issue/2/page/92/
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.2174/1872213X08666140619104944
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082786291613696
score 13.22299

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