Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation

Autores
Godino, Maria Andrea del Milagro; Margatho, Lisandra Oliveira; Caeiro, Ximena Elizabeth; Antunes Rodrigues, Jose; Vivas, Laura Marta
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Modulation of salt appetite involves interactions between the circumventricular organs (CVOs) receptive areas and inhibitory hindbrain serotonergic circuits. Recent studies provide support to the idea that the serotonin action in the lateral parabrachial nucleus (LPBN) plays an important inhibitory role in the modulation of sodium appetite. The aim of the present work was to identify the specific groups of neurons projecting to the LPBN that are activated in the course of sodium appetite regulation, and to analyze the associated endocrine response, specifically oxytocin (OT) and atrial natriuretic peptide (ANP) plasma release, since both hormones have been implicated in the regulatory response to fluid reestablishment. For this purpose we combined the detection of a retrograde transported dye, Fluorogold (FG) injected into the LPBN with the analysis of the Fos immunocytochemistry brain pattern after sodium intake induced by sodium depletion. We analyzed the Fos-FG immunoreactivity after sodium ingestion induced by peritoneal dialysis (PD). We also determined OT and ANP plasma concentration by radioimmunoassay (RIE) before and after sodium intake stimulated by PD. The present study identifies specific groups of neurons along the paraventricular nucleus, central extended amygdala, insular cortex, dorsal raphe nucleus, nucleus of the solitary tract and the CVOs that are activated during the modulation of sodium appetite and have direct connections with the LPBN. It also shows that OT and ANP are released during the course of sodium satiety and fluid reestablishment. The result of this brain network activity may enable appropriate responses that re-establish the body fluid balance after induced sodium consumption. © 2009 Elsevier Inc. All rights reserved.
Fil: Godino, Maria Andrea del Milagro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Margatho, Lisandra Oliveira. Universidade de Sao Paulo; Brasil
Fil: Caeiro, Ximena Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Antunes Rodrigues, Jose. Universidade de Sao Paulo; Brasil
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
ATRIAL NATRIURETIC PEPTIDE AND OXYTOCIN
FOS AND FLUOROGOLD IMMUNOREACTIVITY
LATERAL PARABRACHIAL NUCLEUS
SODIUM APPETITE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/186670
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/186670
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulationGodino, Maria Andrea del MilagroMargatho, Lisandra OliveiraCaeiro, Ximena ElizabethAntunes Rodrigues, JoseVivas, Laura MartaATRIAL NATRIURETIC PEPTIDE AND OXYTOCINFOS AND FLUOROGOLD IMMUNOREACTIVITYLATERAL PARABRACHIAL NUCLEUSSODIUM APPETITEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Modulation of salt appetite involves interactions between the circumventricular organs (CVOs) receptive areas and inhibitory hindbrain serotonergic circuits. Recent studies provide support to the idea that the serotonin action in the lateral parabrachial nucleus (LPBN) plays an important inhibitory role in the modulation of sodium appetite. The aim of the present work was to identify the specific groups of neurons projecting to the LPBN that are activated in the course of sodium appetite regulation, and to analyze the associated endocrine response, specifically oxytocin (OT) and atrial natriuretic peptide (ANP) plasma release, since both hormones have been implicated in the regulatory response to fluid reestablishment. For this purpose we combined the detection of a retrograde transported dye, Fluorogold (FG) injected into the LPBN with the analysis of the Fos immunocytochemistry brain pattern after sodium intake induced by sodium depletion. We analyzed the Fos-FG immunoreactivity after sodium ingestion induced by peritoneal dialysis (PD). We also determined OT and ANP plasma concentration by radioimmunoassay (RIE) before and after sodium intake stimulated by PD. The present study identifies specific groups of neurons along the paraventricular nucleus, central extended amygdala, insular cortex, dorsal raphe nucleus, nucleus of the solitary tract and the CVOs that are activated during the modulation of sodium appetite and have direct connections with the LPBN. It also shows that OT and ANP are released during the course of sodium satiety and fluid reestablishment. The result of this brain network activity may enable appropriate responses that re-establish the body fluid balance after induced sodium consumption. © 2009 Elsevier Inc. All rights reserved.Fil: Godino, Maria Andrea del Milagro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Margatho, Lisandra Oliveira. Universidade de Sao Paulo; BrasilFil: Caeiro, Ximena Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Antunes Rodrigues, Jose. Universidade de Sao Paulo; BrasilFil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaAcademic Press Inc Elsevier Science2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/186670Godino, Maria Andrea del Milagro; Margatho, Lisandra Oliveira; Caeiro, Ximena Elizabeth; Antunes Rodrigues, Jose; Vivas, Laura Marta; Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation; Academic Press Inc Elsevier Science; Experimental Neurology; 221; 2; 2-2010; 275-2840014-4886CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.expneurol.2009.11.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:47Zoai:ri.conicet.gov.ar:11336/186670instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:48.243CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation
title Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation
spellingShingle Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation
Godino, Maria Andrea del Milagro
ATRIAL NATRIURETIC PEPTIDE AND OXYTOCIN
FOS AND FLUOROGOLD IMMUNOREACTIVITY
LATERAL PARABRACHIAL NUCLEUS
SODIUM APPETITE
title_short Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation
title_full Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation
title_fullStr Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation
title_full_unstemmed Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation
title_sort Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation
dc.creator.none.fl_str_mv Godino, Maria Andrea del Milagro
Margatho, Lisandra Oliveira
Caeiro, Ximena Elizabeth
Antunes Rodrigues, Jose
Vivas, Laura Marta
author Godino, Maria Andrea del Milagro
author_facet Godino, Maria Andrea del Milagro
Margatho, Lisandra Oliveira
Caeiro, Ximena Elizabeth
Antunes Rodrigues, Jose
Vivas, Laura Marta
author_role author
author2 Margatho, Lisandra Oliveira
Caeiro, Ximena Elizabeth
Antunes Rodrigues, Jose
Vivas, Laura Marta
author2_role author
author
author
author
dc.subject.none.fl_str_mv ATRIAL NATRIURETIC PEPTIDE AND OXYTOCIN
FOS AND FLUOROGOLD IMMUNOREACTIVITY
LATERAL PARABRACHIAL NUCLEUS
SODIUM APPETITE
topic ATRIAL NATRIURETIC PEPTIDE AND OXYTOCIN
FOS AND FLUOROGOLD IMMUNOREACTIVITY
LATERAL PARABRACHIAL NUCLEUS
SODIUM APPETITE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Modulation of salt appetite involves interactions between the circumventricular organs (CVOs) receptive areas and inhibitory hindbrain serotonergic circuits. Recent studies provide support to the idea that the serotonin action in the lateral parabrachial nucleus (LPBN) plays an important inhibitory role in the modulation of sodium appetite. The aim of the present work was to identify the specific groups of neurons projecting to the LPBN that are activated in the course of sodium appetite regulation, and to analyze the associated endocrine response, specifically oxytocin (OT) and atrial natriuretic peptide (ANP) plasma release, since both hormones have been implicated in the regulatory response to fluid reestablishment. For this purpose we combined the detection of a retrograde transported dye, Fluorogold (FG) injected into the LPBN with the analysis of the Fos immunocytochemistry brain pattern after sodium intake induced by sodium depletion. We analyzed the Fos-FG immunoreactivity after sodium ingestion induced by peritoneal dialysis (PD). We also determined OT and ANP plasma concentration by radioimmunoassay (RIE) before and after sodium intake stimulated by PD. The present study identifies specific groups of neurons along the paraventricular nucleus, central extended amygdala, insular cortex, dorsal raphe nucleus, nucleus of the solitary tract and the CVOs that are activated during the modulation of sodium appetite and have direct connections with the LPBN. It also shows that OT and ANP are released during the course of sodium satiety and fluid reestablishment. The result of this brain network activity may enable appropriate responses that re-establish the body fluid balance after induced sodium consumption. © 2009 Elsevier Inc. All rights reserved.
Fil: Godino, Maria Andrea del Milagro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Margatho, Lisandra Oliveira. Universidade de Sao Paulo; Brasil
Fil: Caeiro, Ximena Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Antunes Rodrigues, Jose. Universidade de Sao Paulo; Brasil
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description Modulation of salt appetite involves interactions between the circumventricular organs (CVOs) receptive areas and inhibitory hindbrain serotonergic circuits. Recent studies provide support to the idea that the serotonin action in the lateral parabrachial nucleus (LPBN) plays an important inhibitory role in the modulation of sodium appetite. The aim of the present work was to identify the specific groups of neurons projecting to the LPBN that are activated in the course of sodium appetite regulation, and to analyze the associated endocrine response, specifically oxytocin (OT) and atrial natriuretic peptide (ANP) plasma release, since both hormones have been implicated in the regulatory response to fluid reestablishment. For this purpose we combined the detection of a retrograde transported dye, Fluorogold (FG) injected into the LPBN with the analysis of the Fos immunocytochemistry brain pattern after sodium intake induced by sodium depletion. We analyzed the Fos-FG immunoreactivity after sodium ingestion induced by peritoneal dialysis (PD). We also determined OT and ANP plasma concentration by radioimmunoassay (RIE) before and after sodium intake stimulated by PD. The present study identifies specific groups of neurons along the paraventricular nucleus, central extended amygdala, insular cortex, dorsal raphe nucleus, nucleus of the solitary tract and the CVOs that are activated during the modulation of sodium appetite and have direct connections with the LPBN. It also shows that OT and ANP are released during the course of sodium satiety and fluid reestablishment. The result of this brain network activity may enable appropriate responses that re-establish the body fluid balance after induced sodium consumption. © 2009 Elsevier Inc. All rights reserved.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/186670
Godino, Maria Andrea del Milagro; Margatho, Lisandra Oliveira; Caeiro, Ximena Elizabeth; Antunes Rodrigues, Jose; Vivas, Laura Marta; Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation; Academic Press Inc Elsevier Science; Experimental Neurology; 221; 2; 2-2010; 275-284
0014-4886
CONICET Digital
CONICET
url http://hdl.handle.net/11336/186670
identifier_str_mv Godino, Maria Andrea del Milagro; Margatho, Lisandra Oliveira; Caeiro, Ximena Elizabeth; Antunes Rodrigues, Jose; Vivas, Laura Marta; Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation; Academic Press Inc Elsevier Science; Experimental Neurology; 221; 2; 2-2010; 275-284
0014-4886
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.expneurol.2009.11.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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