Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis

Autores
Martín, Andrea P.; Vieira de Moraes, Luciana; Tadokoro, Carlos E.; Commodaro, Alessandra G.; Urrets Zavalia, Enrique; Rabinovich, Gabriel Adrián; Urrets Zavalía, Julio Alberto; Rizzo, Luiz V.; Serra, Horacio Marcelo
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. alpha4 Integrins and their receptors play an important role during homing of cells to the inflammatory site. In the present study, the effect of alpha4-integrin inhibitor on the development of EAU was investigated.
Fil: Martín, Andrea P.. Universidade de Sao Paulo; Brasil
Fil: Vieira de Moraes, Luciana. Universidade de Sao Paulo; Brasil
Fil: Tadokoro, Carlos E.. Universidade de Sao Paulo; Brasil
Fil: Commodaro, Alessandra G.. Universidade de Sao Paulo; Brasil
Fil: Urrets Zavalia, Enrique. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Urrets Zavalía, Julio Alberto. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Rizzo, Luiz V.. Universidade de Sao Paulo; Brasil. Fundação Zerbini; Brasil
Fil: Serra, Horacio Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
Materia
Uveitis
Suppression
Peptide
Anti Integrin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31474
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitisMartín, Andrea P.Vieira de Moraes, LucianaTadokoro, Carlos E.Commodaro, Alessandra G.Urrets Zavalia, EnriqueRabinovich, Gabriel AdriánUrrets Zavalía, Julio AlbertoRizzo, Luiz V.Serra, Horacio MarceloUveitisSuppressionPeptideAnti Integrinhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. alpha4 Integrins and their receptors play an important role during homing of cells to the inflammatory site. In the present study, the effect of alpha4-integrin inhibitor on the development of EAU was investigated.Fil: Martín, Andrea P.. Universidade de Sao Paulo; BrasilFil: Vieira de Moraes, Luciana. Universidade de Sao Paulo; BrasilFil: Tadokoro, Carlos E.. Universidade de Sao Paulo; BrasilFil: Commodaro, Alessandra G.. Universidade de Sao Paulo; BrasilFil: Urrets Zavalia, Enrique. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Urrets Zavalía, Julio Alberto. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; ArgentinaFil: Rizzo, Luiz V.. Universidade de Sao Paulo; Brasil. Fundação Zerbini; BrasilFil: Serra, Horacio Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; ArgentinaAssociation for Research in Vision and Ophthalmology2005-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31474Martín, Andrea P.; Vieira de Moraes, Luciana; Tadokoro, Carlos E.; Commodaro, Alessandra G.; Urrets Zavalia, Enrique; et al.; Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis; Association for Research in Vision and Ophthalmology; Investigative Ophthalmology & Visual Science; 46; 6; 6-2005; 2056-20630146-04041552-5783CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://iovs.arvojournals.org/article.aspx?articleid=2163505info:eu-repo/semantics/altIdentifier/doi/10.1167/iovs.04-0418info:eu-repo/semantics/altIdentifier/pmid/15914623info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/15914623info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:07:05Zoai:ri.conicet.gov.ar:11336/31474instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:07:05.934CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis
title Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis
spellingShingle Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis
Martín, Andrea P.
Uveitis
Suppression
Peptide
Anti Integrin
title_short Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis
title_full Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis
title_fullStr Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis
title_full_unstemmed Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis
title_sort Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis
dc.creator.none.fl_str_mv Martín, Andrea P.
Vieira de Moraes, Luciana
Tadokoro, Carlos E.
Commodaro, Alessandra G.
Urrets Zavalia, Enrique
Rabinovich, Gabriel Adrián
Urrets Zavalía, Julio Alberto
Rizzo, Luiz V.
Serra, Horacio Marcelo
author Martín, Andrea P.
author_facet Martín, Andrea P.
Vieira de Moraes, Luciana
Tadokoro, Carlos E.
Commodaro, Alessandra G.
Urrets Zavalia, Enrique
Rabinovich, Gabriel Adrián
Urrets Zavalía, Julio Alberto
Rizzo, Luiz V.
Serra, Horacio Marcelo
author_role author
author2 Vieira de Moraes, Luciana
Tadokoro, Carlos E.
Commodaro, Alessandra G.
Urrets Zavalia, Enrique
Rabinovich, Gabriel Adrián
Urrets Zavalía, Julio Alberto
Rizzo, Luiz V.
Serra, Horacio Marcelo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Uveitis
Suppression
Peptide
Anti Integrin
topic Uveitis
Suppression
Peptide
Anti Integrin
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. alpha4 Integrins and their receptors play an important role during homing of cells to the inflammatory site. In the present study, the effect of alpha4-integrin inhibitor on the development of EAU was investigated.
Fil: Martín, Andrea P.. Universidade de Sao Paulo; Brasil
Fil: Vieira de Moraes, Luciana. Universidade de Sao Paulo; Brasil
Fil: Tadokoro, Carlos E.. Universidade de Sao Paulo; Brasil
Fil: Commodaro, Alessandra G.. Universidade de Sao Paulo; Brasil
Fil: Urrets Zavalia, Enrique. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Urrets Zavalía, Julio Alberto. Universidad Catolica de Córdoba. Facultad de Medicina. Clinica Universitaria Reina Fabiola; Argentina
Fil: Rizzo, Luiz V.. Universidade de Sao Paulo; Brasil. Fundação Zerbini; Brasil
Fil: Serra, Horacio Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
description Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. alpha4 Integrins and their receptors play an important role during homing of cells to the inflammatory site. In the present study, the effect of alpha4-integrin inhibitor on the development of EAU was investigated.
publishDate 2005
dc.date.none.fl_str_mv 2005-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31474
Martín, Andrea P.; Vieira de Moraes, Luciana; Tadokoro, Carlos E.; Commodaro, Alessandra G.; Urrets Zavalia, Enrique; et al.; Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis; Association for Research in Vision and Ophthalmology; Investigative Ophthalmology & Visual Science; 46; 6; 6-2005; 2056-2063
0146-0404
1552-5783
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31474
identifier_str_mv Martín, Andrea P.; Vieira de Moraes, Luciana; Tadokoro, Carlos E.; Commodaro, Alessandra G.; Urrets Zavalia, Enrique; et al.; Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis; Association for Research in Vision and Ophthalmology; Investigative Ophthalmology & Visual Science; 46; 6; 6-2005; 2056-2063
0146-0404
1552-5783
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://iovs.arvojournals.org/article.aspx?articleid=2163505
info:eu-repo/semantics/altIdentifier/doi/10.1167/iovs.04-0418
info:eu-repo/semantics/altIdentifier/pmid/15914623
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/15914623
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Association for Research in Vision and Ophthalmology
publisher.none.fl_str_mv Association for Research in Vision and Ophthalmology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980310663299072
score 13.004268

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