Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment

Autores
Anselmino Dieterle, Luciano Emanuel; Malizia, Florencia; Menacho Márquez, Mauricio Ariel
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Colorectal cancer is one of the most fatal cancers in the world because most of cases are diagnosed in advanced stages, when the development of resistance to chemotherapy is more frequent. To face this situation, new drugs and drug combinations would be necessary. Drug discovery is a very costly process; although efforts in drug discovery have been amplified in recent decades the success rate of approved FDA drugs continues being low. In response to this situation the repositioning of drugs proposes to delve into the genetic, epigenetic and metabolic differences to discover new targets and redirect drugs already approved to the treatment of other diseases and conditions. In this minireview we discuss the main avenues in which repositioning can occur and we cite some examples of repositioning drugs in colorectal cancer treatment that are being tested in clinical trials in the last years.
Fil: Anselmino Dieterle, Luciano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Malizia, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Menacho Márquez, Mauricio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Materia
COLORECTAL CANCER
DRUG REPOSITIONING
CLINICAL TRIALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/162564
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer TreatmentAnselmino Dieterle, Luciano EmanuelMalizia, FlorenciaMenacho Márquez, Mauricio ArielCOLORECTAL CANCERDRUG REPOSITIONINGCLINICAL TRIALShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Colorectal cancer is one of the most fatal cancers in the world because most of cases are diagnosed in advanced stages, when the development of resistance to chemotherapy is more frequent. To face this situation, new drugs and drug combinations would be necessary. Drug discovery is a very costly process; although efforts in drug discovery have been amplified in recent decades the success rate of approved FDA drugs continues being low. In response to this situation the repositioning of drugs proposes to delve into the genetic, epigenetic and metabolic differences to discover new targets and redirect drugs already approved to the treatment of other diseases and conditions. In this minireview we discuss the main avenues in which repositioning can occur and we cite some examples of repositioning drugs in colorectal cancer treatment that are being tested in clinical trials in the last years.Fil: Anselmino Dieterle, Luciano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Malizia, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Menacho Márquez, Mauricio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaCrimson Publisher2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162564Anselmino Dieterle, Luciano Emanuel; Malizia, Florencia; Menacho Márquez, Mauricio Ariel; Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment; Crimson Publisher; Novel Approaches in Cancer Study; 2; 4; 5-2019; 1-52637-773XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.31031/NACS.2019.02.000544info:eu-repo/semantics/altIdentifier/url/https://crimsonpublishers.com/nacs/fulltext/NACS.000544.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:27Zoai:ri.conicet.gov.ar:11336/162564instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:27.706CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
title Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
spellingShingle Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
Anselmino Dieterle, Luciano Emanuel
COLORECTAL CANCER
DRUG REPOSITIONING
CLINICAL TRIALS
title_short Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
title_full Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
title_fullStr Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
title_full_unstemmed Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
title_sort Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
dc.creator.none.fl_str_mv Anselmino Dieterle, Luciano Emanuel
Malizia, Florencia
Menacho Márquez, Mauricio Ariel
author Anselmino Dieterle, Luciano Emanuel
author_facet Anselmino Dieterle, Luciano Emanuel
Malizia, Florencia
Menacho Márquez, Mauricio Ariel
author_role author
author2 Malizia, Florencia
Menacho Márquez, Mauricio Ariel
author2_role author
author
dc.subject.none.fl_str_mv COLORECTAL CANCER
DRUG REPOSITIONING
CLINICAL TRIALS
topic COLORECTAL CANCER
DRUG REPOSITIONING
CLINICAL TRIALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Colorectal cancer is one of the most fatal cancers in the world because most of cases are diagnosed in advanced stages, when the development of resistance to chemotherapy is more frequent. To face this situation, new drugs and drug combinations would be necessary. Drug discovery is a very costly process; although efforts in drug discovery have been amplified in recent decades the success rate of approved FDA drugs continues being low. In response to this situation the repositioning of drugs proposes to delve into the genetic, epigenetic and metabolic differences to discover new targets and redirect drugs already approved to the treatment of other diseases and conditions. In this minireview we discuss the main avenues in which repositioning can occur and we cite some examples of repositioning drugs in colorectal cancer treatment that are being tested in clinical trials in the last years.
Fil: Anselmino Dieterle, Luciano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Malizia, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Menacho Márquez, Mauricio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
description Colorectal cancer is one of the most fatal cancers in the world because most of cases are diagnosed in advanced stages, when the development of resistance to chemotherapy is more frequent. To face this situation, new drugs and drug combinations would be necessary. Drug discovery is a very costly process; although efforts in drug discovery have been amplified in recent decades the success rate of approved FDA drugs continues being low. In response to this situation the repositioning of drugs proposes to delve into the genetic, epigenetic and metabolic differences to discover new targets and redirect drugs already approved to the treatment of other diseases and conditions. In this minireview we discuss the main avenues in which repositioning can occur and we cite some examples of repositioning drugs in colorectal cancer treatment that are being tested in clinical trials in the last years.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/162564
Anselmino Dieterle, Luciano Emanuel; Malizia, Florencia; Menacho Márquez, Mauricio Ariel; Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment; Crimson Publisher; Novel Approaches in Cancer Study; 2; 4; 5-2019; 1-5
2637-773X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/162564
identifier_str_mv Anselmino Dieterle, Luciano Emanuel; Malizia, Florencia; Menacho Márquez, Mauricio Ariel; Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment; Crimson Publisher; Novel Approaches in Cancer Study; 2; 4; 5-2019; 1-5
2637-773X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/https://crimsonpublishers.com/nacs/fulltext/NACS.000544.php
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Crimson Publisher
publisher.none.fl_str_mv Crimson Publisher
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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