A global review on short peptides: Frontiers and perspectives
- Autores
- Apostolopoulos, Vasso; Bojarska, Joanna; Chai, Tsun Thai; Elnagdy, Sherif; Kaczmarek, Krzysztof; Matsoukas, John; New, Roger; Parang, Keykavous; Paredes Lopez, Octavio; Parhiz, Hamideh; Perera, Conrad O.; Pickholz, Mónica Andrea; Remko, Milan; Saviano, Michele; Skwarczynski, Mariusz; Tang, Yefeng; Wolf, Wojciech M.; Yoshiya, Taku; Zabrocki, Janusz; Zielenkiewicz, Piotr; AlKhazindar, Maha; Barriga, Vanessa; Kelaidonis, Konstantinos; Sarasia, Elham Mousavinezhad; Toth, Istvan
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.
Fil: Apostolopoulos, Vasso. Victoria University; Alemania
Fil: Bojarska, Joanna. Lodz University of Technology; Polonia
Fil: Chai, Tsun Thai. Universiti Tunku Abdul Rahman; Malasia
Fil: Elnagdy, Sherif. Cairo University; Egipto
Fil: Kaczmarek, Krzysztof. Lodz University of Technology; Polonia
Fil: Matsoukas, John. Patras Science Park; Canadá. Victoria University; Australia. University of Calgary; Canadá
Fil: New, Roger. Middlesex University; Reino Unido. London Bioscience Innovation Centre; Reino Unido
Fil: Parang, Keykavous. Chapman University; Estados Unidos
Fil: Paredes Lopez, Octavio. Centro de Investigacion y de Estudio Avanzados, Campus Guanajuato; México
Fil: Parhiz, Hamideh. University of Pennsylvania; Estados Unidos
Fil: Perera, Conrad O.. University of Auckland; Nueva Zelanda
Fil: Pickholz, Mónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Fil: Remko, Milan. Remedika; Eslovaquia
Fil: Saviano, Michele. Consiglio Nazionale delle Ricerche; Italia
Fil: Skwarczynski, Mariusz. University of Queensland; Australia. The University of Queensland; Australia
Fil: Tang, Yefeng. Tsinghua University; China
Fil: Wolf, Wojciech M.. Lodz University of Technology; Polonia
Fil: Yoshiya, Taku. Peptide Institute; Japón
Fil: Zabrocki, Janusz. Lodz University of Technology; Polonia
Fil: Zielenkiewicz, Piotr. Uniwersytet Warszawski; Argentina. Polish Academy of Sciences; Argentina
Fil: AlKhazindar, Maha. Cairo University; Egipto
Fil: Barriga, Vanessa. Victoria University; Australia
Fil: Kelaidonis, Konstantinos. Patras Science Park; Grecia
Fil: Sarasia, Elham Mousavinezhad. Middlesex University; Reino Unido
Fil: Toth, Istvan. University of Queensland; Australia. The University of Queensland; Australia - Materia
-
ALTERED PEPTIDE LIGANDS
ANT/SUPER/AGONISTS
APTAMERS
BILAYER INTERACTIONS
CANCER
CELL-PENETRATING PEPTIDES
CONSTRAINED AMINO ACIDS AND PEPTIDE (BIO)MIMETICS
COSMECEUTICALS
DIKETOPIPERAZINE
DRUG DESIGN AND DRUG/GENE DELIVERY
SARS-COV-2
SHORT PEPTIDES
SYNTHESIS
VACCINES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/182235
Ver los metadatos del registro completo
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A global review on short peptides: Frontiers and perspectivesApostolopoulos, VassoBojarska, JoannaChai, Tsun ThaiElnagdy, SherifKaczmarek, KrzysztofMatsoukas, JohnNew, RogerParang, KeykavousParedes Lopez, OctavioParhiz, HamidehPerera, Conrad O.Pickholz, Mónica AndreaRemko, MilanSaviano, MicheleSkwarczynski, MariuszTang, YefengWolf, Wojciech M.Yoshiya, TakuZabrocki, JanuszZielenkiewicz, PiotrAlKhazindar, MahaBarriga, VanessaKelaidonis, KonstantinosSarasia, Elham MousavinezhadToth, IstvanALTERED PEPTIDE LIGANDSANT/SUPER/AGONISTSAPTAMERSBILAYER INTERACTIONSCANCERCELL-PENETRATING PEPTIDESCONSTRAINED AMINO ACIDS AND PEPTIDE (BIO)MIMETICSCOSMECEUTICALSDIKETOPIPERAZINEDRUG DESIGN AND DRUG/GENE DELIVERYSARS-COV-2SHORT PEPTIDESSYNTHESISVACCINEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed.Fil: Apostolopoulos, Vasso. Victoria University; AlemaniaFil: Bojarska, Joanna. Lodz University of Technology; PoloniaFil: Chai, Tsun Thai. Universiti Tunku Abdul Rahman; MalasiaFil: Elnagdy, Sherif. Cairo University; EgiptoFil: Kaczmarek, Krzysztof. Lodz University of Technology; PoloniaFil: Matsoukas, John. Patras Science Park; Canadá. Victoria University; Australia. University of Calgary; CanadáFil: New, Roger. Middlesex University; Reino Unido. London Bioscience Innovation Centre; Reino UnidoFil: Parang, Keykavous. Chapman University; Estados UnidosFil: Paredes Lopez, Octavio. Centro de Investigacion y de Estudio Avanzados, Campus Guanajuato; MéxicoFil: Parhiz, Hamideh. University of Pennsylvania; Estados UnidosFil: Perera, Conrad O.. University of Auckland; Nueva ZelandaFil: Pickholz, Mónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Remko, Milan. Remedika; EslovaquiaFil: Saviano, Michele. Consiglio Nazionale delle Ricerche; ItaliaFil: Skwarczynski, Mariusz. University of Queensland; Australia. The University of Queensland; AustraliaFil: Tang, Yefeng. Tsinghua University; ChinaFil: Wolf, Wojciech M.. Lodz University of Technology; PoloniaFil: Yoshiya, Taku. Peptide Institute; JapónFil: Zabrocki, Janusz. Lodz University of Technology; PoloniaFil: Zielenkiewicz, Piotr. Uniwersytet Warszawski; Argentina. Polish Academy of Sciences; ArgentinaFil: AlKhazindar, Maha. Cairo University; EgiptoFil: Barriga, Vanessa. Victoria University; AustraliaFil: Kelaidonis, Konstantinos. Patras Science Park; GreciaFil: Sarasia, Elham Mousavinezhad. Middlesex University; Reino UnidoFil: Toth, Istvan. University of Queensland; Australia. The University of Queensland; AustraliaMolecular Diversity Preservation International2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182235Apostolopoulos, Vasso; Bojarska, Joanna; Chai, Tsun Thai; Elnagdy, Sherif; Kaczmarek, Krzysztof; et al.; A global review on short peptides: Frontiers and perspectives; Molecular Diversity Preservation International; Molecules; 26; 2; 1-2021; 1-451420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/molecules26020430info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/26/2/430info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T08:37:58Zoai:ri.conicet.gov.ar:11336/182235instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 08:37:58.236CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
A global review on short peptides: Frontiers and perspectives |
| title |
A global review on short peptides: Frontiers and perspectives |
| spellingShingle |
A global review on short peptides: Frontiers and perspectives Apostolopoulos, Vasso ALTERED PEPTIDE LIGANDS ANT/SUPER/AGONISTS APTAMERS BILAYER INTERACTIONS CANCER CELL-PENETRATING PEPTIDES CONSTRAINED AMINO ACIDS AND PEPTIDE (BIO)MIMETICS COSMECEUTICALS DIKETOPIPERAZINE DRUG DESIGN AND DRUG/GENE DELIVERY SARS-COV-2 SHORT PEPTIDES SYNTHESIS VACCINES |
| title_short |
A global review on short peptides: Frontiers and perspectives |
| title_full |
A global review on short peptides: Frontiers and perspectives |
| title_fullStr |
A global review on short peptides: Frontiers and perspectives |
| title_full_unstemmed |
A global review on short peptides: Frontiers and perspectives |
| title_sort |
A global review on short peptides: Frontiers and perspectives |
| dc.creator.none.fl_str_mv |
Apostolopoulos, Vasso Bojarska, Joanna Chai, Tsun Thai Elnagdy, Sherif Kaczmarek, Krzysztof Matsoukas, John New, Roger Parang, Keykavous Paredes Lopez, Octavio Parhiz, Hamideh Perera, Conrad O. Pickholz, Mónica Andrea Remko, Milan Saviano, Michele Skwarczynski, Mariusz Tang, Yefeng Wolf, Wojciech M. Yoshiya, Taku Zabrocki, Janusz Zielenkiewicz, Piotr AlKhazindar, Maha Barriga, Vanessa Kelaidonis, Konstantinos Sarasia, Elham Mousavinezhad Toth, Istvan |
| author |
Apostolopoulos, Vasso |
| author_facet |
Apostolopoulos, Vasso Bojarska, Joanna Chai, Tsun Thai Elnagdy, Sherif Kaczmarek, Krzysztof Matsoukas, John New, Roger Parang, Keykavous Paredes Lopez, Octavio Parhiz, Hamideh Perera, Conrad O. Pickholz, Mónica Andrea Remko, Milan Saviano, Michele Skwarczynski, Mariusz Tang, Yefeng Wolf, Wojciech M. Yoshiya, Taku Zabrocki, Janusz Zielenkiewicz, Piotr AlKhazindar, Maha Barriga, Vanessa Kelaidonis, Konstantinos Sarasia, Elham Mousavinezhad Toth, Istvan |
| author_role |
author |
| author2 |
Bojarska, Joanna Chai, Tsun Thai Elnagdy, Sherif Kaczmarek, Krzysztof Matsoukas, John New, Roger Parang, Keykavous Paredes Lopez, Octavio Parhiz, Hamideh Perera, Conrad O. Pickholz, Mónica Andrea Remko, Milan Saviano, Michele Skwarczynski, Mariusz Tang, Yefeng Wolf, Wojciech M. Yoshiya, Taku Zabrocki, Janusz Zielenkiewicz, Piotr AlKhazindar, Maha Barriga, Vanessa Kelaidonis, Konstantinos Sarasia, Elham Mousavinezhad Toth, Istvan |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ALTERED PEPTIDE LIGANDS ANT/SUPER/AGONISTS APTAMERS BILAYER INTERACTIONS CANCER CELL-PENETRATING PEPTIDES CONSTRAINED AMINO ACIDS AND PEPTIDE (BIO)MIMETICS COSMECEUTICALS DIKETOPIPERAZINE DRUG DESIGN AND DRUG/GENE DELIVERY SARS-COV-2 SHORT PEPTIDES SYNTHESIS VACCINES |
| topic |
ALTERED PEPTIDE LIGANDS ANT/SUPER/AGONISTS APTAMERS BILAYER INTERACTIONS CANCER CELL-PENETRATING PEPTIDES CONSTRAINED AMINO ACIDS AND PEPTIDE (BIO)MIMETICS COSMECEUTICALS DIKETOPIPERAZINE DRUG DESIGN AND DRUG/GENE DELIVERY SARS-COV-2 SHORT PEPTIDES SYNTHESIS VACCINES |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed. Fil: Apostolopoulos, Vasso. Victoria University; Alemania Fil: Bojarska, Joanna. Lodz University of Technology; Polonia Fil: Chai, Tsun Thai. Universiti Tunku Abdul Rahman; Malasia Fil: Elnagdy, Sherif. Cairo University; Egipto Fil: Kaczmarek, Krzysztof. Lodz University of Technology; Polonia Fil: Matsoukas, John. Patras Science Park; Canadá. Victoria University; Australia. University of Calgary; Canadá Fil: New, Roger. Middlesex University; Reino Unido. London Bioscience Innovation Centre; Reino Unido Fil: Parang, Keykavous. Chapman University; Estados Unidos Fil: Paredes Lopez, Octavio. Centro de Investigacion y de Estudio Avanzados, Campus Guanajuato; México Fil: Parhiz, Hamideh. University of Pennsylvania; Estados Unidos Fil: Perera, Conrad O.. University of Auckland; Nueva Zelanda Fil: Pickholz, Mónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina Fil: Remko, Milan. Remedika; Eslovaquia Fil: Saviano, Michele. Consiglio Nazionale delle Ricerche; Italia Fil: Skwarczynski, Mariusz. University of Queensland; Australia. The University of Queensland; Australia Fil: Tang, Yefeng. Tsinghua University; China Fil: Wolf, Wojciech M.. Lodz University of Technology; Polonia Fil: Yoshiya, Taku. Peptide Institute; Japón Fil: Zabrocki, Janusz. Lodz University of Technology; Polonia Fil: Zielenkiewicz, Piotr. Uniwersytet Warszawski; Argentina. Polish Academy of Sciences; Argentina Fil: AlKhazindar, Maha. Cairo University; Egipto Fil: Barriga, Vanessa. Victoria University; Australia Fil: Kelaidonis, Konstantinos. Patras Science Park; Grecia Fil: Sarasia, Elham Mousavinezhad. Middlesex University; Reino Unido Fil: Toth, Istvan. University of Queensland; Australia. The University of Queensland; Australia |
| description |
Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes. Short peptides include fundamental molecular information for a prelude to the symphony of life. They have aroused considerable interest due to their unique features and great promise in innovative bio-therapies. This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 1920s. Peptide “drugs” initially played only the role of hormone analogs to balance disorders. Nowadays, they achieve numerous biomedical tasks, can cross membranes, or reach intracellular targets. The role of peptides in bio-processes can hardly be mimicked by other chemical substances. The article is divided into independent sections, which are related to either the progress in short peptide-based theranostics or the problems posing challenge to bio-medicine. In particular, the SWOT analysis of short peptides, their relevance in therapies of diverse diseases, improvements in (bio)synthesis platforms, advanced nano-supramolecular technologies, aptamers, altered peptide ligands and in silico methodologies to overcome peptide limitations, modern smart bio-functional materials, vaccines, and drug/gene-targeted delivery systems are discussed. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-01 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/182235 Apostolopoulos, Vasso; Bojarska, Joanna; Chai, Tsun Thai; Elnagdy, Sherif; Kaczmarek, Krzysztof; et al.; A global review on short peptides: Frontiers and perspectives; Molecular Diversity Preservation International; Molecules; 26; 2; 1-2021; 1-45 1420-3049 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/182235 |
| identifier_str_mv |
Apostolopoulos, Vasso; Bojarska, Joanna; Chai, Tsun Thai; Elnagdy, Sherif; Kaczmarek, Krzysztof; et al.; A global review on short peptides: Frontiers and perspectives; Molecular Diversity Preservation International; Molecules; 26; 2; 1-2021; 1-45 1420-3049 CONICET Digital CONICET |
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eng |
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eng |
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Molecular Diversity Preservation International |
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Molecular Diversity Preservation International |
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