Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response
- Autores
- Desai, Radha; East, Daniel A.; Hardy, Liana; Faccenda, Danilo; Rigon, Manuel; Crosby, James; Alvarez, Maria Soledad; Singh, Aarti; Mainenti, Marta; Hussey, Laura Kuhlman; Bentham, Robert; Szabadkai, Gyorgy; Zappulli, Valentina; Dhoot, Gurtej K.; Romano, Lisa E.; Xia, Dong; Coppens, Isabelle; Hamacher Brady, Anne; Paul Chapple, J.; Abeti, Rosella; Fleck, Roland A.; Vizcay Barrena, Gema; Smith, Kenneth; Campanella, Michelangelo
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as mitochondrial retrograde response (MRR) and is induced by mitochondrial dysfunction. MRR results in the nuclear stabilization of prosurvival transcription factors such as the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB). Here, we demonstrate that MRR is facilitated by contact sites between mitochondria and the nucleus. The translocator protein (TSPO) by preventing the mitophagy-mediated segregation o mitochonria is required for this interaction. The complex formed by TSPO with the protein kinase A (PKA), via the A-kinase anchoring protein acyl-CoA binding domain containing 3 (ACBD3), established the tethering. The latter allows for cholesterol redistribution of cholesterol in the nucleus to sustain the prosurvival response by blocking NF-кB deacetylation. This work proposes a previously unidentified paradigm in MRR: the formation of contact sites between mitochondria and nucleus to aid communication.
Fil: Desai, Radha. University of London; Reino Unido
Fil: East, Daniel A.. University of London; Reino Unido
Fil: Hardy, Liana. University of London; Reino Unido
Fil: Faccenda, Danilo. University of London; Reino Unido
Fil: Rigon, Manuel. University of London; Reino Unido
Fil: Crosby, James. University of London; Reino Unido
Fil: Alvarez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Singh, Aarti. University of London; Reino Unido
Fil: Mainenti, Marta. University of London; Reino Unido
Fil: Hussey, Laura Kuhlman. University of London; Reino Unido
Fil: Bentham, Robert. Colegio Universitario de Londres; Reino Unido
Fil: Szabadkai, Gyorgy. Colegio Universitario de Londres; Reino Unido. The Francis Crick Institute; Reino Unido. Università di Padova; Italia
Fil: Zappulli, Valentina. Università di Padova; Italia
Fil: Dhoot, Gurtej K.. University of London; Reino Unido
Fil: Romano, Lisa E.. Queen Mary University of London; Reino Unido
Fil: Xia, Dong. University of London; Reino Unido
Fil: Coppens, Isabelle. University Johns Hopkins; Estados Unidos
Fil: Hamacher Brady, Anne. University Johns Hopkins; Estados Unidos
Fil: Paul Chapple, J.. Queen Mary University of London; Reino Unido
Fil: Abeti, Rosella. Queen Square Institute Of Neurology; Reino Unido
Fil: Fleck, Roland A.. King's College London; Reino Unido
Fil: Vizcay Barrena, Gema. King's College London; Reino Unido
Fil: Smith, Kenneth. Royal Veterinary College University Of London; Reino Unido
Fil: Campanella, Michelangelo. Colegio Universitario de Londres; Reino Unido. University of London; Reino Unido - Materia
-
mitochondrial retrograde response
NF-KB
TSPO
ACBD3 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/142121
Ver los metadatos del registro completo
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Mitochondria form contact sites with the nucleus to couple prosurvival retrograde responseDesai, RadhaEast, Daniel A.Hardy, LianaFaccenda, DaniloRigon, ManuelCrosby, JamesAlvarez, Maria SoledadSingh, AartiMainenti, MartaHussey, Laura KuhlmanBentham, RobertSzabadkai, GyorgyZappulli, ValentinaDhoot, Gurtej K.Romano, Lisa E.Xia, DongCoppens, IsabelleHamacher Brady, AnnePaul Chapple, J.Abeti, RosellaFleck, Roland A.Vizcay Barrena, GemaSmith, KennethCampanella, Michelangelomitochondrial retrograde responseNF-KBTSPOACBD3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as mitochondrial retrograde response (MRR) and is induced by mitochondrial dysfunction. MRR results in the nuclear stabilization of prosurvival transcription factors such as the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB). Here, we demonstrate that MRR is facilitated by contact sites between mitochondria and the nucleus. The translocator protein (TSPO) by preventing the mitophagy-mediated segregation o mitochonria is required for this interaction. The complex formed by TSPO with the protein kinase A (PKA), via the A-kinase anchoring protein acyl-CoA binding domain containing 3 (ACBD3), established the tethering. The latter allows for cholesterol redistribution of cholesterol in the nucleus to sustain the prosurvival response by blocking NF-кB deacetylation. This work proposes a previously unidentified paradigm in MRR: the formation of contact sites between mitochondria and nucleus to aid communication.Fil: Desai, Radha. University of London; Reino UnidoFil: East, Daniel A.. University of London; Reino UnidoFil: Hardy, Liana. University of London; Reino UnidoFil: Faccenda, Danilo. University of London; Reino UnidoFil: Rigon, Manuel. University of London; Reino UnidoFil: Crosby, James. University of London; Reino UnidoFil: Alvarez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Singh, Aarti. University of London; Reino UnidoFil: Mainenti, Marta. University of London; Reino UnidoFil: Hussey, Laura Kuhlman. University of London; Reino UnidoFil: Bentham, Robert. Colegio Universitario de Londres; Reino UnidoFil: Szabadkai, Gyorgy. Colegio Universitario de Londres; Reino Unido. The Francis Crick Institute; Reino Unido. Università di Padova; ItaliaFil: Zappulli, Valentina. Università di Padova; ItaliaFil: Dhoot, Gurtej K.. University of London; Reino UnidoFil: Romano, Lisa E.. Queen Mary University of London; Reino UnidoFil: Xia, Dong. University of London; Reino UnidoFil: Coppens, Isabelle. University Johns Hopkins; Estados UnidosFil: Hamacher Brady, Anne. University Johns Hopkins; Estados UnidosFil: Paul Chapple, J.. Queen Mary University of London; Reino UnidoFil: Abeti, Rosella. Queen Square Institute Of Neurology; Reino UnidoFil: Fleck, Roland A.. King's College London; Reino UnidoFil: Vizcay Barrena, Gema. King's College London; Reino UnidoFil: Smith, Kenneth. Royal Veterinary College University Of London; Reino UnidoFil: Campanella, Michelangelo. Colegio Universitario de Londres; Reino Unido. University of London; Reino UnidoScience Advances is the American Association for the Advancement of Science2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/142121Desai, Radha; East, Daniel A.; Hardy, Liana; Faccenda, Danilo; Rigon, Manuel; et al.; Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response; Science Advances is the American Association for the Advancement of Science; Science Advances; 6; 51; 12-2020; 1-152375-2548CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1126/SCIADV.ABC9955info:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/10.1126/sciadv.abc9955info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:11Zoai:ri.conicet.gov.ar:11336/142121instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:12.218CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response |
| title |
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response |
| spellingShingle |
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response Desai, Radha mitochondrial retrograde response NF-KB TSPO ACBD3 |
| title_short |
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response |
| title_full |
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response |
| title_fullStr |
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response |
| title_full_unstemmed |
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response |
| title_sort |
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response |
| dc.creator.none.fl_str_mv |
Desai, Radha East, Daniel A. Hardy, Liana Faccenda, Danilo Rigon, Manuel Crosby, James Alvarez, Maria Soledad Singh, Aarti Mainenti, Marta Hussey, Laura Kuhlman Bentham, Robert Szabadkai, Gyorgy Zappulli, Valentina Dhoot, Gurtej K. Romano, Lisa E. Xia, Dong Coppens, Isabelle Hamacher Brady, Anne Paul Chapple, J. Abeti, Rosella Fleck, Roland A. Vizcay Barrena, Gema Smith, Kenneth Campanella, Michelangelo |
| author |
Desai, Radha |
| author_facet |
Desai, Radha East, Daniel A. Hardy, Liana Faccenda, Danilo Rigon, Manuel Crosby, James Alvarez, Maria Soledad Singh, Aarti Mainenti, Marta Hussey, Laura Kuhlman Bentham, Robert Szabadkai, Gyorgy Zappulli, Valentina Dhoot, Gurtej K. Romano, Lisa E. Xia, Dong Coppens, Isabelle Hamacher Brady, Anne Paul Chapple, J. Abeti, Rosella Fleck, Roland A. Vizcay Barrena, Gema Smith, Kenneth Campanella, Michelangelo |
| author_role |
author |
| author2 |
East, Daniel A. Hardy, Liana Faccenda, Danilo Rigon, Manuel Crosby, James Alvarez, Maria Soledad Singh, Aarti Mainenti, Marta Hussey, Laura Kuhlman Bentham, Robert Szabadkai, Gyorgy Zappulli, Valentina Dhoot, Gurtej K. Romano, Lisa E. Xia, Dong Coppens, Isabelle Hamacher Brady, Anne Paul Chapple, J. Abeti, Rosella Fleck, Roland A. Vizcay Barrena, Gema Smith, Kenneth Campanella, Michelangelo |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
mitochondrial retrograde response NF-KB TSPO ACBD3 |
| topic |
mitochondrial retrograde response NF-KB TSPO ACBD3 |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as mitochondrial retrograde response (MRR) and is induced by mitochondrial dysfunction. MRR results in the nuclear stabilization of prosurvival transcription factors such as the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB). Here, we demonstrate that MRR is facilitated by contact sites between mitochondria and the nucleus. The translocator protein (TSPO) by preventing the mitophagy-mediated segregation o mitochonria is required for this interaction. The complex formed by TSPO with the protein kinase A (PKA), via the A-kinase anchoring protein acyl-CoA binding domain containing 3 (ACBD3), established the tethering. The latter allows for cholesterol redistribution of cholesterol in the nucleus to sustain the prosurvival response by blocking NF-кB deacetylation. This work proposes a previously unidentified paradigm in MRR: the formation of contact sites between mitochondria and nucleus to aid communication. Fil: Desai, Radha. University of London; Reino Unido Fil: East, Daniel A.. University of London; Reino Unido Fil: Hardy, Liana. University of London; Reino Unido Fil: Faccenda, Danilo. University of London; Reino Unido Fil: Rigon, Manuel. University of London; Reino Unido Fil: Crosby, James. University of London; Reino Unido Fil: Alvarez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Singh, Aarti. University of London; Reino Unido Fil: Mainenti, Marta. University of London; Reino Unido Fil: Hussey, Laura Kuhlman. University of London; Reino Unido Fil: Bentham, Robert. Colegio Universitario de Londres; Reino Unido Fil: Szabadkai, Gyorgy. Colegio Universitario de Londres; Reino Unido. The Francis Crick Institute; Reino Unido. Università di Padova; Italia Fil: Zappulli, Valentina. Università di Padova; Italia Fil: Dhoot, Gurtej K.. University of London; Reino Unido Fil: Romano, Lisa E.. Queen Mary University of London; Reino Unido Fil: Xia, Dong. University of London; Reino Unido Fil: Coppens, Isabelle. University Johns Hopkins; Estados Unidos Fil: Hamacher Brady, Anne. University Johns Hopkins; Estados Unidos Fil: Paul Chapple, J.. Queen Mary University of London; Reino Unido Fil: Abeti, Rosella. Queen Square Institute Of Neurology; Reino Unido Fil: Fleck, Roland A.. King's College London; Reino Unido Fil: Vizcay Barrena, Gema. King's College London; Reino Unido Fil: Smith, Kenneth. Royal Veterinary College University Of London; Reino Unido Fil: Campanella, Michelangelo. Colegio Universitario de Londres; Reino Unido. University of London; Reino Unido |
| description |
Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as mitochondrial retrograde response (MRR) and is induced by mitochondrial dysfunction. MRR results in the nuclear stabilization of prosurvival transcription factors such as the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB). Here, we demonstrate that MRR is facilitated by contact sites between mitochondria and the nucleus. The translocator protein (TSPO) by preventing the mitophagy-mediated segregation o mitochonria is required for this interaction. The complex formed by TSPO with the protein kinase A (PKA), via the A-kinase anchoring protein acyl-CoA binding domain containing 3 (ACBD3), established the tethering. The latter allows for cholesterol redistribution of cholesterol in the nucleus to sustain the prosurvival response by blocking NF-кB deacetylation. This work proposes a previously unidentified paradigm in MRR: the formation of contact sites between mitochondria and nucleus to aid communication. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-12 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/142121 Desai, Radha; East, Daniel A.; Hardy, Liana; Faccenda, Danilo; Rigon, Manuel; et al.; Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response; Science Advances is the American Association for the Advancement of Science; Science Advances; 6; 51; 12-2020; 1-15 2375-2548 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/142121 |
| identifier_str_mv |
Desai, Radha; East, Daniel A.; Hardy, Liana; Faccenda, Danilo; Rigon, Manuel; et al.; Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response; Science Advances is the American Association for the Advancement of Science; Science Advances; 6; 51; 12-2020; 1-15 2375-2548 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1126/SCIADV.ABC9955 info:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/10.1126/sciadv.abc9955 |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Science Advances is the American Association for the Advancement of Science |
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Science Advances is the American Association for the Advancement of Science |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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