SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma

Autores
Roisman, Alejandro; Huamán Garaicoa, Fuad; Metrebian, Fernanda; Narbaitz, Marina; Kohan, Dana; Garcia Rivello, Hernan Jorge; Fernandez, Isolda; Pavlovsky, Astrid; Pavlovsky, Miguel; Hernández, Luis; Slavutsky, Irma Rosa
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mantle cell lymphoma (MCL) is a heterogeneous B-cell lymphoid malignancy where most patients follow an aggressive clinical course whereas others are associated with an indolent performance. SOX4, SOX11, and SOX12 belong to SOXC family of transcription factors involved in embryonic neurogenesis and tissue remodeling. Among them, SOX11 has been found aberrantly expressed in most aggressive MCL patients, being considered a reliable biomarker in the pathology. Several studies have revealed that microRNAs (miRs) from the miR-17-92 cluster are among the most deregulated miRNAs in human cancers, still little is known about this cluster in MCL. In this study we screened the transcriptional profiles of 70 MCL patients for SOXC cluster and miR17, miR18a, miR19b and miR92a, from the miR-17-92 cluster. Gene expression analysis showed higher SOX11 and SOX12 levels compared to SOX4 (P≤0.0026). Moreover we found a negative correlation between the expression of SOX11 and SOX4 (P<0.0001). miR17-92 cluster analysis showed that miR19b and miR92a exhibited higher levels than miR17 and miR18a (P<0.0001). Unsupervised hierarchical clustering revealed two subgroups with significant differences in relation to aggressive MCL features, such as blastoid morphological variant (P=0.0412), nodal presentation (P=0.0492), CD5+ (P=0.0004) and shorter overall survival (P<0.0001). Together, our findings show for the first time an association between the differential expression profiles of SOXC and miR17-92 clusters in MCL and also relate them to different clinical subtypes of the disease adding new biological information that may contribute to a better understanding of this pathology.
Fil: Roisman, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Huamán Garaicoa, Fuad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. FUNDALEU; Argentina
Fil: Metrebian, Fernanda. Instituto de Investigaciones Hematologicas; Argentina
Fil: Narbaitz, Marina. FUNDALEU; Argentina. Instituto de Investigaciones Hematologicas; Argentina
Fil: Kohan, Dana. Hospital Italiano; Argentina
Fil: Garcia Rivello, Hernan Jorge. Hospital Italiano; Argentina
Fil: Fernandez, Isolda. FUNDALEU; Argentina
Fil: Pavlovsky, Astrid. FUNDALEU; Argentina
Fil: Pavlovsky, Miguel. FUNDALEU; Argentina
Fil: Hernández, Luis. Institut d’Investigacions Biome'diques August Pii Sunyer; España
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
Mantle Cell Lymphoma
Soxc Transcription Factors
Mir-17-92 Cluster
Gene Expression
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52608
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/52608
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphomaRoisman, AlejandroHuamán Garaicoa, FuadMetrebian, FernandaNarbaitz, MarinaKohan, DanaGarcia Rivello, Hernan JorgeFernandez, IsoldaPavlovsky, AstridPavlovsky, MiguelHernández, LuisSlavutsky, Irma RosaMantle Cell LymphomaSoxc Transcription FactorsMir-17-92 ClusterGene Expressionhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Mantle cell lymphoma (MCL) is a heterogeneous B-cell lymphoid malignancy where most patients follow an aggressive clinical course whereas others are associated with an indolent performance. SOX4, SOX11, and SOX12 belong to SOXC family of transcription factors involved in embryonic neurogenesis and tissue remodeling. Among them, SOX11 has been found aberrantly expressed in most aggressive MCL patients, being considered a reliable biomarker in the pathology. Several studies have revealed that microRNAs (miRs) from the miR-17-92 cluster are among the most deregulated miRNAs in human cancers, still little is known about this cluster in MCL. In this study we screened the transcriptional profiles of 70 MCL patients for SOXC cluster and miR17, miR18a, miR19b and miR92a, from the miR-17-92 cluster. Gene expression analysis showed higher SOX11 and SOX12 levels compared to SOX4 (P≤0.0026). Moreover we found a negative correlation between the expression of SOX11 and SOX4 (P<0.0001). miR17-92 cluster analysis showed that miR19b and miR92a exhibited higher levels than miR17 and miR18a (P<0.0001). Unsupervised hierarchical clustering revealed two subgroups with significant differences in relation to aggressive MCL features, such as blastoid morphological variant (P=0.0412), nodal presentation (P=0.0492), CD5+ (P=0.0004) and shorter overall survival (P<0.0001). Together, our findings show for the first time an association between the differential expression profiles of SOXC and miR17-92 clusters in MCL and also relate them to different clinical subtypes of the disease adding new biological information that may contribute to a better understanding of this pathology.Fil: Roisman, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Huamán Garaicoa, Fuad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. FUNDALEU; ArgentinaFil: Metrebian, Fernanda. Instituto de Investigaciones Hematologicas; ArgentinaFil: Narbaitz, Marina. FUNDALEU; Argentina. Instituto de Investigaciones Hematologicas; ArgentinaFil: Kohan, Dana. Hospital Italiano; ArgentinaFil: Garcia Rivello, Hernan Jorge. Hospital Italiano; ArgentinaFil: Fernandez, Isolda. FUNDALEU; ArgentinaFil: Pavlovsky, Astrid. FUNDALEU; ArgentinaFil: Pavlovsky, Miguel. FUNDALEU; ArgentinaFil: Hernández, Luis. Institut d’Investigacions Biome'diques August Pii Sunyer; EspañaFil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaWiley-liss, Div John Wiley & Sons Inc2016-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52608Roisman, Alejandro; Huamán Garaicoa, Fuad; Metrebian, Fernanda; Narbaitz, Marina; Kohan, Dana; et al.; SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma; Wiley-liss, Div John Wiley & Sons Inc; Genes, Chromosomes & Cancer.; 55; 6; 6-2016; 531-5401045-2257CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/gcc.22355info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.22355info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:17Zoai:ri.conicet.gov.ar:11336/52608instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:18.029CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma
title SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma
spellingShingle SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma
Roisman, Alejandro
Mantle Cell Lymphoma
Soxc Transcription Factors
Mir-17-92 Cluster
Gene Expression
title_short SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma
title_full SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma
title_fullStr SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma
title_full_unstemmed SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma
title_sort SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma
dc.creator.none.fl_str_mv Roisman, Alejandro
Huamán Garaicoa, Fuad
Metrebian, Fernanda
Narbaitz, Marina
Kohan, Dana
Garcia Rivello, Hernan Jorge
Fernandez, Isolda
Pavlovsky, Astrid
Pavlovsky, Miguel
Hernández, Luis
Slavutsky, Irma Rosa
author Roisman, Alejandro
author_facet Roisman, Alejandro
Huamán Garaicoa, Fuad
Metrebian, Fernanda
Narbaitz, Marina
Kohan, Dana
Garcia Rivello, Hernan Jorge
Fernandez, Isolda
Pavlovsky, Astrid
Pavlovsky, Miguel
Hernández, Luis
Slavutsky, Irma Rosa
author_role author
author2 Huamán Garaicoa, Fuad
Metrebian, Fernanda
Narbaitz, Marina
Kohan, Dana
Garcia Rivello, Hernan Jorge
Fernandez, Isolda
Pavlovsky, Astrid
Pavlovsky, Miguel
Hernández, Luis
Slavutsky, Irma Rosa
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mantle Cell Lymphoma
Soxc Transcription Factors
Mir-17-92 Cluster
Gene Expression
topic Mantle Cell Lymphoma
Soxc Transcription Factors
Mir-17-92 Cluster
Gene Expression
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mantle cell lymphoma (MCL) is a heterogeneous B-cell lymphoid malignancy where most patients follow an aggressive clinical course whereas others are associated with an indolent performance. SOX4, SOX11, and SOX12 belong to SOXC family of transcription factors involved in embryonic neurogenesis and tissue remodeling. Among them, SOX11 has been found aberrantly expressed in most aggressive MCL patients, being considered a reliable biomarker in the pathology. Several studies have revealed that microRNAs (miRs) from the miR-17-92 cluster are among the most deregulated miRNAs in human cancers, still little is known about this cluster in MCL. In this study we screened the transcriptional profiles of 70 MCL patients for SOXC cluster and miR17, miR18a, miR19b and miR92a, from the miR-17-92 cluster. Gene expression analysis showed higher SOX11 and SOX12 levels compared to SOX4 (P≤0.0026). Moreover we found a negative correlation between the expression of SOX11 and SOX4 (P<0.0001). miR17-92 cluster analysis showed that miR19b and miR92a exhibited higher levels than miR17 and miR18a (P<0.0001). Unsupervised hierarchical clustering revealed two subgroups with significant differences in relation to aggressive MCL features, such as blastoid morphological variant (P=0.0412), nodal presentation (P=0.0492), CD5+ (P=0.0004) and shorter overall survival (P<0.0001). Together, our findings show for the first time an association between the differential expression profiles of SOXC and miR17-92 clusters in MCL and also relate them to different clinical subtypes of the disease adding new biological information that may contribute to a better understanding of this pathology.
Fil: Roisman, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Huamán Garaicoa, Fuad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. FUNDALEU; Argentina
Fil: Metrebian, Fernanda. Instituto de Investigaciones Hematologicas; Argentina
Fil: Narbaitz, Marina. FUNDALEU; Argentina. Instituto de Investigaciones Hematologicas; Argentina
Fil: Kohan, Dana. Hospital Italiano; Argentina
Fil: Garcia Rivello, Hernan Jorge. Hospital Italiano; Argentina
Fil: Fernandez, Isolda. FUNDALEU; Argentina
Fil: Pavlovsky, Astrid. FUNDALEU; Argentina
Fil: Pavlovsky, Miguel. FUNDALEU; Argentina
Fil: Hernández, Luis. Institut d’Investigacions Biome'diques August Pii Sunyer; España
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description Mantle cell lymphoma (MCL) is a heterogeneous B-cell lymphoid malignancy where most patients follow an aggressive clinical course whereas others are associated with an indolent performance. SOX4, SOX11, and SOX12 belong to SOXC family of transcription factors involved in embryonic neurogenesis and tissue remodeling. Among them, SOX11 has been found aberrantly expressed in most aggressive MCL patients, being considered a reliable biomarker in the pathology. Several studies have revealed that microRNAs (miRs) from the miR-17-92 cluster are among the most deregulated miRNAs in human cancers, still little is known about this cluster in MCL. In this study we screened the transcriptional profiles of 70 MCL patients for SOXC cluster and miR17, miR18a, miR19b and miR92a, from the miR-17-92 cluster. Gene expression analysis showed higher SOX11 and SOX12 levels compared to SOX4 (P≤0.0026). Moreover we found a negative correlation between the expression of SOX11 and SOX4 (P<0.0001). miR17-92 cluster analysis showed that miR19b and miR92a exhibited higher levels than miR17 and miR18a (P<0.0001). Unsupervised hierarchical clustering revealed two subgroups with significant differences in relation to aggressive MCL features, such as blastoid morphological variant (P=0.0412), nodal presentation (P=0.0492), CD5+ (P=0.0004) and shorter overall survival (P<0.0001). Together, our findings show for the first time an association between the differential expression profiles of SOXC and miR17-92 clusters in MCL and also relate them to different clinical subtypes of the disease adding new biological information that may contribute to a better understanding of this pathology.
publishDate 2016
dc.date.none.fl_str_mv 2016-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52608
Roisman, Alejandro; Huamán Garaicoa, Fuad; Metrebian, Fernanda; Narbaitz, Marina; Kohan, Dana; et al.; SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma; Wiley-liss, Div John Wiley & Sons Inc; Genes, Chromosomes & Cancer.; 55; 6; 6-2016; 531-540
1045-2257
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52608
identifier_str_mv Roisman, Alejandro; Huamán Garaicoa, Fuad; Metrebian, Fernanda; Narbaitz, Marina; Kohan, Dana; et al.; SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma; Wiley-liss, Div John Wiley & Sons Inc; Genes, Chromosomes & Cancer.; 55; 6; 6-2016; 531-540
1045-2257
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/gcc.22355
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.22355
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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