Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome

Autores
Zambernardi König, María Agustina; Gondolesi, Gabriel Eduardo; Cabanne, Ana; Martínez, María Inés; Solar, Héctor; Rumbo, Martín; Rumbo, Carolina
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Exfoliative rejection is a severe complication after intestinal transplant. The assessment of mucosa histology is restricted to the area reached by endoscopy. We aim to evaluate the serum albumin (SA) value as a parameter of graft damage and clinical prognosis in intestinal exfoliative rejection (ExR). The present study is a retrospective analysis of 11 episodes of ExR occurred in a cohort of 26 patients. SA levels were measured 24 h after diagnosis and twice a week thereafter and then correlated with parameters of clinical and graft histological recovery (HR). During ExR, all patients had very low SA levels, reaching a minimum average of 1.9 0.3 g/dL. According to the value of albumin levels at ExR diagnosis, the patients were grouped finding a correlation with their clinical evolution. Six ExR episodes presented with severe hipoalbuminemia (<2.2 g/dL; p < 0.05) that correlated with worse patient and graft outcome, ranging from graft loss and need for retransplantation to delayed clinical and HR. SA at ExR diagnosis may be an indicator of the severity of the ExR process, and it could also be used as an early predictor of patient and graft outcome.
Fil: Zambernardi König, María Agustina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Favaloro; Argentina
Fil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cabanne, Ana. Fundación Favaloro; Argentina
Fil: Martínez, María Inés. Fundación Favaloro; Argentina
Fil: Solar, Héctor. Fundación Favaloro; Argentina
Fil: Rumbo, Martín. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rumbo, Carolina. Fundación Favaloro; Argentina
Materia
Intestinal Transplant
Rejection
Albumin
Biomarkers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23086
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23086
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcomeZambernardi König, María AgustinaGondolesi, Gabriel EduardoCabanne, AnaMartínez, María InésSolar, HéctorRumbo, MartínRumbo, CarolinaIntestinal TransplantRejectionAlbuminBiomarkershttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Exfoliative rejection is a severe complication after intestinal transplant. The assessment of mucosa histology is restricted to the area reached by endoscopy. We aim to evaluate the serum albumin (SA) value as a parameter of graft damage and clinical prognosis in intestinal exfoliative rejection (ExR). The present study is a retrospective analysis of 11 episodes of ExR occurred in a cohort of 26 patients. SA levels were measured 24 h after diagnosis and twice a week thereafter and then correlated with parameters of clinical and graft histological recovery (HR). During ExR, all patients had very low SA levels, reaching a minimum average of 1.9 0.3 g/dL. According to the value of albumin levels at ExR diagnosis, the patients were grouped finding a correlation with their clinical evolution. Six ExR episodes presented with severe hipoalbuminemia (<2.2 g/dL; p < 0.05) that correlated with worse patient and graft outcome, ranging from graft loss and need for retransplantation to delayed clinical and HR. SA at ExR diagnosis may be an indicator of the severity of the ExR process, and it could also be used as an early predictor of patient and graft outcome.Fil: Zambernardi König, María Agustina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Favaloro; ArgentinaFil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cabanne, Ana. Fundación Favaloro; ArgentinaFil: Martínez, María Inés. Fundación Favaloro; ArgentinaFil: Solar, Héctor. Fundación Favaloro; ArgentinaFil: Rumbo, Martín. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rumbo, Carolina. Fundación Favaloro; ArgentinaWiley2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23086Zambernardi König, María Agustina; Gondolesi, Gabriel Eduardo; Cabanne, Ana; Martínez, María Inés; Solar, Héctor; et al.; Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome; Wiley; Clinical Transplantation; 27; 2; 1-2013; 137-1420902-00631399-0012CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/ctr.12078info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/ctr.12078/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:37Zoai:ri.conicet.gov.ar:11336/23086instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:37.387CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome
title Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome
spellingShingle Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome
Zambernardi König, María Agustina
Intestinal Transplant
Rejection
Albumin
Biomarkers
title_short Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome
title_full Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome
title_fullStr Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome
title_full_unstemmed Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome
title_sort Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome
dc.creator.none.fl_str_mv Zambernardi König, María Agustina
Gondolesi, Gabriel Eduardo
Cabanne, Ana
Martínez, María Inés
Solar, Héctor
Rumbo, Martín
Rumbo, Carolina
author Zambernardi König, María Agustina
author_facet Zambernardi König, María Agustina
Gondolesi, Gabriel Eduardo
Cabanne, Ana
Martínez, María Inés
Solar, Héctor
Rumbo, Martín
Rumbo, Carolina
author_role author
author2 Gondolesi, Gabriel Eduardo
Cabanne, Ana
Martínez, María Inés
Solar, Héctor
Rumbo, Martín
Rumbo, Carolina
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Intestinal Transplant
Rejection
Albumin
Biomarkers
topic Intestinal Transplant
Rejection
Albumin
Biomarkers
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Exfoliative rejection is a severe complication after intestinal transplant. The assessment of mucosa histology is restricted to the area reached by endoscopy. We aim to evaluate the serum albumin (SA) value as a parameter of graft damage and clinical prognosis in intestinal exfoliative rejection (ExR). The present study is a retrospective analysis of 11 episodes of ExR occurred in a cohort of 26 patients. SA levels were measured 24 h after diagnosis and twice a week thereafter and then correlated with parameters of clinical and graft histological recovery (HR). During ExR, all patients had very low SA levels, reaching a minimum average of 1.9 0.3 g/dL. According to the value of albumin levels at ExR diagnosis, the patients were grouped finding a correlation with their clinical evolution. Six ExR episodes presented with severe hipoalbuminemia (<2.2 g/dL; p < 0.05) that correlated with worse patient and graft outcome, ranging from graft loss and need for retransplantation to delayed clinical and HR. SA at ExR diagnosis may be an indicator of the severity of the ExR process, and it could also be used as an early predictor of patient and graft outcome.
Fil: Zambernardi König, María Agustina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Favaloro; Argentina
Fil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cabanne, Ana. Fundación Favaloro; Argentina
Fil: Martínez, María Inés. Fundación Favaloro; Argentina
Fil: Solar, Héctor. Fundación Favaloro; Argentina
Fil: Rumbo, Martín. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biologicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rumbo, Carolina. Fundación Favaloro; Argentina
description Exfoliative rejection is a severe complication after intestinal transplant. The assessment of mucosa histology is restricted to the area reached by endoscopy. We aim to evaluate the serum albumin (SA) value as a parameter of graft damage and clinical prognosis in intestinal exfoliative rejection (ExR). The present study is a retrospective analysis of 11 episodes of ExR occurred in a cohort of 26 patients. SA levels were measured 24 h after diagnosis and twice a week thereafter and then correlated with parameters of clinical and graft histological recovery (HR). During ExR, all patients had very low SA levels, reaching a minimum average of 1.9 0.3 g/dL. According to the value of albumin levels at ExR diagnosis, the patients were grouped finding a correlation with their clinical evolution. Six ExR episodes presented with severe hipoalbuminemia (<2.2 g/dL; p < 0.05) that correlated with worse patient and graft outcome, ranging from graft loss and need for retransplantation to delayed clinical and HR. SA at ExR diagnosis may be an indicator of the severity of the ExR process, and it could also be used as an early predictor of patient and graft outcome.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23086
Zambernardi König, María Agustina; Gondolesi, Gabriel Eduardo; Cabanne, Ana; Martínez, María Inés; Solar, Héctor; et al.; Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome; Wiley; Clinical Transplantation; 27; 2; 1-2013; 137-142
0902-0063
1399-0012
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23086
identifier_str_mv Zambernardi König, María Agustina; Gondolesi, Gabriel Eduardo; Cabanne, Ana; Martínez, María Inés; Solar, Héctor; et al.; Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome; Wiley; Clinical Transplantation; 27; 2; 1-2013; 137-142
0902-0063
1399-0012
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/ctr.12078
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/ctr.12078/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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