Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents

Autores
Mussin, Javier Esteban; Robles Botero, Viviana; Casañas-Pimentel, Rocío; Rojas, Florencia; Angiolella, Letizia; San Martín Martínez, Eduardo; Giusiano, Gustavo Emilio
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal plant used by indigenous peoples in northeastern Argentina to treat SSTIs. Spherical and stable silver nanoparticles (AgNPs) of 14 ± 2 nm were synthesized from the aqueous extract of A. australe and silver nitrate. The antimicrobial activity against main species causing SSTIs and cytotoxicity on peripheral blood mononuclear cells of AgNP solution and its synthesis components were evaluated. Compared to its synthesis components, AgNP solution showed greater antimicrobial activity and lower cytotoxicity. The antimicrobial activity of AgNPs was due to the silver and not to the metabolites of the aqueous extract present on the surface of the nanoparticles. The plant extract played an important role in the formation of stable AgNPs and acted as a modulator of cytotoxic and immune responses.
Fil: Mussin, Javier Esteban. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Robles Botero, Viviana. Consejo Nacional de Ciencia y Tecnología; México
Fil: Casañas-Pimentel, Rocío. Consejo Nacional de Ciencia y Tecnología; México
Fil: Rojas, Florencia. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina
Fil: Angiolella, Letizia. Università degli Studi di Roma "La Sapienza"; Italia
Fil: San Martín Martínez, Eduardo. Consejo Nacional de Ciencia y Tecnología; México
Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Materia
NANOPARTICLES
ANTIMICROBIAL
SKIN INFECTIONS
TRADITIONAL MEDICINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/146201
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/146201
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agentsMussin, Javier EstebanRobles Botero, VivianaCasañas-Pimentel, RocíoRojas, FlorenciaAngiolella, LetiziaSan Martín Martínez, EduardoGiusiano, Gustavo EmilioNANOPARTICLESANTIMICROBIALSKIN INFECTIONSTRADITIONAL MEDICINEhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal plant used by indigenous peoples in northeastern Argentina to treat SSTIs. Spherical and stable silver nanoparticles (AgNPs) of 14 ± 2 nm were synthesized from the aqueous extract of A. australe and silver nitrate. The antimicrobial activity against main species causing SSTIs and cytotoxicity on peripheral blood mononuclear cells of AgNP solution and its synthesis components were evaluated. Compared to its synthesis components, AgNP solution showed greater antimicrobial activity and lower cytotoxicity. The antimicrobial activity of AgNPs was due to the silver and not to the metabolites of the aqueous extract present on the surface of the nanoparticles. The plant extract played an important role in the formation of stable AgNPs and acted as a modulator of cytotoxic and immune responses.Fil: Mussin, Javier Esteban. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaFil: Robles Botero, Viviana. Consejo Nacional de Ciencia y Tecnología; MéxicoFil: Casañas-Pimentel, Rocío. Consejo Nacional de Ciencia y Tecnología; MéxicoFil: Rojas, Florencia. Universidad Nacional del Nordeste. Instituto de Medicina Regional; ArgentinaFil: Angiolella, Letizia. Università degli Studi di Roma "La Sapienza"; ItaliaFil: San Martín Martínez, Eduardo. Consejo Nacional de Ciencia y Tecnología; MéxicoFil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaNature2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146201Mussin, Javier Esteban; Robles Botero, Viviana; Casañas-Pimentel, Rocío; Rojas, Florencia; Angiolella, Letizia; et al.; Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents; Nature; Scientific Reports; 11; 1; 7-2021; 1-122045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-021-94012-yinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-021-94012-yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:15Zoai:ri.conicet.gov.ar:11336/146201instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:15.787CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
title Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
spellingShingle Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
Mussin, Javier Esteban
NANOPARTICLES
ANTIMICROBIAL
SKIN INFECTIONS
TRADITIONAL MEDICINE
title_short Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
title_full Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
title_fullStr Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
title_full_unstemmed Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
title_sort Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents
dc.creator.none.fl_str_mv Mussin, Javier Esteban
Robles Botero, Viviana
Casañas-Pimentel, Rocío
Rojas, Florencia
Angiolella, Letizia
San Martín Martínez, Eduardo
Giusiano, Gustavo Emilio
author Mussin, Javier Esteban
author_facet Mussin, Javier Esteban
Robles Botero, Viviana
Casañas-Pimentel, Rocío
Rojas, Florencia
Angiolella, Letizia
San Martín Martínez, Eduardo
Giusiano, Gustavo Emilio
author_role author
author2 Robles Botero, Viviana
Casañas-Pimentel, Rocío
Rojas, Florencia
Angiolella, Letizia
San Martín Martínez, Eduardo
Giusiano, Gustavo Emilio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv NANOPARTICLES
ANTIMICROBIAL
SKIN INFECTIONS
TRADITIONAL MEDICINE
topic NANOPARTICLES
ANTIMICROBIAL
SKIN INFECTIONS
TRADITIONAL MEDICINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal plant used by indigenous peoples in northeastern Argentina to treat SSTIs. Spherical and stable silver nanoparticles (AgNPs) of 14 ± 2 nm were synthesized from the aqueous extract of A. australe and silver nitrate. The antimicrobial activity against main species causing SSTIs and cytotoxicity on peripheral blood mononuclear cells of AgNP solution and its synthesis components were evaluated. Compared to its synthesis components, AgNP solution showed greater antimicrobial activity and lower cytotoxicity. The antimicrobial activity of AgNPs was due to the silver and not to the metabolites of the aqueous extract present on the surface of the nanoparticles. The plant extract played an important role in the formation of stable AgNPs and acted as a modulator of cytotoxic and immune responses.
Fil: Mussin, Javier Esteban. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Robles Botero, Viviana. Consejo Nacional de Ciencia y Tecnología; México
Fil: Casañas-Pimentel, Rocío. Consejo Nacional de Ciencia y Tecnología; México
Fil: Rojas, Florencia. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina
Fil: Angiolella, Letizia. Università degli Studi di Roma "La Sapienza"; Italia
Fil: San Martín Martínez, Eduardo. Consejo Nacional de Ciencia y Tecnología; México
Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
description Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal plant used by indigenous peoples in northeastern Argentina to treat SSTIs. Spherical and stable silver nanoparticles (AgNPs) of 14 ± 2 nm were synthesized from the aqueous extract of A. australe and silver nitrate. The antimicrobial activity against main species causing SSTIs and cytotoxicity on peripheral blood mononuclear cells of AgNP solution and its synthesis components were evaluated. Compared to its synthesis components, AgNP solution showed greater antimicrobial activity and lower cytotoxicity. The antimicrobial activity of AgNPs was due to the silver and not to the metabolites of the aqueous extract present on the surface of the nanoparticles. The plant extract played an important role in the formation of stable AgNPs and acted as a modulator of cytotoxic and immune responses.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/146201
Mussin, Javier Esteban; Robles Botero, Viviana; Casañas-Pimentel, Rocío; Rojas, Florencia; Angiolella, Letizia; et al.; Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents; Nature; Scientific Reports; 11; 1; 7-2021; 1-12
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/146201
identifier_str_mv Mussin, Javier Esteban; Robles Botero, Viviana; Casañas-Pimentel, Rocío; Rojas, Florencia; Angiolella, Letizia; et al.; Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents; Nature; Scientific Reports; 11; 1; 7-2021; 1-12
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-021-94012-y
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-021-94012-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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