Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina

Autores
Von Specht, Martha Helena; Gardella, Noella Mariel; Ubeda, Clotilde; Grenon, Sandra Liliana; Gutkind, Gabriel Osvaldo; Mollerach, Marta Eugenia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) emerged at the Pediatric Hospital of Misiones Province, north Argentina, in 2003 as a cause of community-acquired (CA) infections, mostly associated with skin and soft tissue infections (SSTIs). This study aimed to assess the microbiological, epidemiological, and clinical features of CA-MRSA SSTIs treated at the hospital. Methodology: From 2003 through 2006, a longitudinal study on CA-MRSA SSTIs was conducted. Clinical, bacteriological, and molecular data were collected and analyzed by multiple correspondences and cluster analysis (MCCA). Results: A total of 138 children were enrolled; 55.8% of the children required hospitalization. The main clinical presentation was abscesses (51%). Antibiotic therapy in the previous six months was registered in 41% of the patients, and 72% of the patients had relatives with similar symptoms. Resistance to non-b-lactam antibiotics was found in less than 12% of patients. All 44 isolates carried staphylococcal cassette chromosomemec (SCCmec) type IV, and 30/44 had Panton-Valentine leucocidin (PVL) coding genes. Six pulsed-field gel electrophoresis (PFGE) patterns were detected from 17 isolates. MCCA hierarchic classification resulted in four distinctive patient classes (new variable). No relationship could be observed regarding the PVL detection, as PVL (+) isolates were detected in all classes; the same lack of significance was observed concerning the distribution of resistance to non-β-lactam antibiotics. Conclusions: This study increases the understanding and knowledge about CA-MRSA skin and soft tissue infections in pediatric patients. Continuous efforts should be made to control this significant public health problem.
Fil: Von Specht, Martha Helena. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital Publico Provincial de Pediatria de Autogestion Dr. Fernando Barreyro; Argentina. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; Argentina
Fil: Gardella, Noella Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Ubeda, Clotilde. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; Argentina
Fil: Grenon, Sandra Liliana. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; Argentina. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital Publico Provincial de Pediatria de Autogestion Dr. Fernando Barreyro; Argentina
Fil: Gutkind, Gabriel Osvaldo. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; Argentina
Materia
CA-MRSA
SKIN INFECTIONS
CHILDREN
EPIDEMIOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96010

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network_name_str CONICET Digital (CONICET)
spelling Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in ArgentinaVon Specht, Martha HelenaGardella, Noella MarielUbeda, ClotildeGrenon, Sandra LilianaGutkind, Gabriel OsvaldoMollerach, Marta EugeniaCA-MRSASKIN INFECTIONSCHILDRENEPIDEMIOLOGYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) emerged at the Pediatric Hospital of Misiones Province, north Argentina, in 2003 as a cause of community-acquired (CA) infections, mostly associated with skin and soft tissue infections (SSTIs). This study aimed to assess the microbiological, epidemiological, and clinical features of CA-MRSA SSTIs treated at the hospital. Methodology: From 2003 through 2006, a longitudinal study on CA-MRSA SSTIs was conducted. Clinical, bacteriological, and molecular data were collected and analyzed by multiple correspondences and cluster analysis (MCCA). Results: A total of 138 children were enrolled; 55.8% of the children required hospitalization. The main clinical presentation was abscesses (51%). Antibiotic therapy in the previous six months was registered in 41% of the patients, and 72% of the patients had relatives with similar symptoms. Resistance to non-b-lactam antibiotics was found in less than 12% of patients. All 44 isolates carried staphylococcal cassette chromosomemec (SCCmec) type IV, and 30/44 had Panton-Valentine leucocidin (PVL) coding genes. Six pulsed-field gel electrophoresis (PFGE) patterns were detected from 17 isolates. MCCA hierarchic classification resulted in four distinctive patient classes (new variable). No relationship could be observed regarding the PVL detection, as PVL (+) isolates were detected in all classes; the same lack of significance was observed concerning the distribution of resistance to non-β-lactam antibiotics. Conclusions: This study increases the understanding and knowledge about CA-MRSA skin and soft tissue infections in pediatric patients. Continuous efforts should be made to control this significant public health problem.Fil: Von Specht, Martha Helena. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital Publico Provincial de Pediatria de Autogestion Dr. Fernando Barreyro; Argentina. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; ArgentinaFil: Gardella, Noella Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Ubeda, Clotilde. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; ArgentinaFil: Grenon, Sandra Liliana. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; Argentina. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital Publico Provincial de Pediatria de Autogestion Dr. Fernando Barreyro; ArgentinaFil: Gutkind, Gabriel Osvaldo. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; ArgentinaThe Journal of Infection in Developing Countries2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96010Von Specht, Martha Helena; Gardella, Noella Mariel; Ubeda, Clotilde; Grenon, Sandra Liliana; Gutkind, Gabriel Osvaldo; et al.; Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina; The Journal of Infection in Developing Countries; The Journal of Infection in Developing Countries; 8; 9; 9-2014; 1119-11282036-65901972-2680CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jidc.org/index.php/journal/article/view/25212076info:eu-repo/semantics/altIdentifier/doi/10.3855/jidc.4271info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:21:18Zoai:ri.conicet.gov.ar:11336/96010instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:21:18.325CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina
title Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina
spellingShingle Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina
Von Specht, Martha Helena
CA-MRSA
SKIN INFECTIONS
CHILDREN
EPIDEMIOLOGY
title_short Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina
title_full Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina
title_fullStr Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina
title_full_unstemmed Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina
title_sort Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina
dc.creator.none.fl_str_mv Von Specht, Martha Helena
Gardella, Noella Mariel
Ubeda, Clotilde
Grenon, Sandra Liliana
Gutkind, Gabriel Osvaldo
Mollerach, Marta Eugenia
author Von Specht, Martha Helena
author_facet Von Specht, Martha Helena
Gardella, Noella Mariel
Ubeda, Clotilde
Grenon, Sandra Liliana
Gutkind, Gabriel Osvaldo
Mollerach, Marta Eugenia
author_role author
author2 Gardella, Noella Mariel
Ubeda, Clotilde
Grenon, Sandra Liliana
Gutkind, Gabriel Osvaldo
Mollerach, Marta Eugenia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CA-MRSA
SKIN INFECTIONS
CHILDREN
EPIDEMIOLOGY
topic CA-MRSA
SKIN INFECTIONS
CHILDREN
EPIDEMIOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) emerged at the Pediatric Hospital of Misiones Province, north Argentina, in 2003 as a cause of community-acquired (CA) infections, mostly associated with skin and soft tissue infections (SSTIs). This study aimed to assess the microbiological, epidemiological, and clinical features of CA-MRSA SSTIs treated at the hospital. Methodology: From 2003 through 2006, a longitudinal study on CA-MRSA SSTIs was conducted. Clinical, bacteriological, and molecular data were collected and analyzed by multiple correspondences and cluster analysis (MCCA). Results: A total of 138 children were enrolled; 55.8% of the children required hospitalization. The main clinical presentation was abscesses (51%). Antibiotic therapy in the previous six months was registered in 41% of the patients, and 72% of the patients had relatives with similar symptoms. Resistance to non-b-lactam antibiotics was found in less than 12% of patients. All 44 isolates carried staphylococcal cassette chromosomemec (SCCmec) type IV, and 30/44 had Panton-Valentine leucocidin (PVL) coding genes. Six pulsed-field gel electrophoresis (PFGE) patterns were detected from 17 isolates. MCCA hierarchic classification resulted in four distinctive patient classes (new variable). No relationship could be observed regarding the PVL detection, as PVL (+) isolates were detected in all classes; the same lack of significance was observed concerning the distribution of resistance to non-β-lactam antibiotics. Conclusions: This study increases the understanding and knowledge about CA-MRSA skin and soft tissue infections in pediatric patients. Continuous efforts should be made to control this significant public health problem.
Fil: Von Specht, Martha Helena. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital Publico Provincial de Pediatria de Autogestion Dr. Fernando Barreyro; Argentina. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; Argentina
Fil: Gardella, Noella Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Ubeda, Clotilde. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; Argentina
Fil: Grenon, Sandra Liliana. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; Argentina. Provincia de Misiones. Ministerio de Salud de la Provincia de Misiones. Hospital Publico Provincial de Pediatria de Autogestion Dr. Fernando Barreyro; Argentina
Fil: Gutkind, Gabriel Osvaldo. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; Argentina
description Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) emerged at the Pediatric Hospital of Misiones Province, north Argentina, in 2003 as a cause of community-acquired (CA) infections, mostly associated with skin and soft tissue infections (SSTIs). This study aimed to assess the microbiological, epidemiological, and clinical features of CA-MRSA SSTIs treated at the hospital. Methodology: From 2003 through 2006, a longitudinal study on CA-MRSA SSTIs was conducted. Clinical, bacteriological, and molecular data were collected and analyzed by multiple correspondences and cluster analysis (MCCA). Results: A total of 138 children were enrolled; 55.8% of the children required hospitalization. The main clinical presentation was abscesses (51%). Antibiotic therapy in the previous six months was registered in 41% of the patients, and 72% of the patients had relatives with similar symptoms. Resistance to non-b-lactam antibiotics was found in less than 12% of patients. All 44 isolates carried staphylococcal cassette chromosomemec (SCCmec) type IV, and 30/44 had Panton-Valentine leucocidin (PVL) coding genes. Six pulsed-field gel electrophoresis (PFGE) patterns were detected from 17 isolates. MCCA hierarchic classification resulted in four distinctive patient classes (new variable). No relationship could be observed regarding the PVL detection, as PVL (+) isolates were detected in all classes; the same lack of significance was observed concerning the distribution of resistance to non-β-lactam antibiotics. Conclusions: This study increases the understanding and knowledge about CA-MRSA skin and soft tissue infections in pediatric patients. Continuous efforts should be made to control this significant public health problem.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96010
Von Specht, Martha Helena; Gardella, Noella Mariel; Ubeda, Clotilde; Grenon, Sandra Liliana; Gutkind, Gabriel Osvaldo; et al.; Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina; The Journal of Infection in Developing Countries; The Journal of Infection in Developing Countries; 8; 9; 9-2014; 1119-1128
2036-6590
1972-2680
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96010
identifier_str_mv Von Specht, Martha Helena; Gardella, Noella Mariel; Ubeda, Clotilde; Grenon, Sandra Liliana; Gutkind, Gabriel Osvaldo; et al.; Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina; The Journal of Infection in Developing Countries; The Journal of Infection in Developing Countries; 8; 9; 9-2014; 1119-1128
2036-6590
1972-2680
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.3855/jidc.4271
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
application/pdf
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dc.publisher.none.fl_str_mv The Journal of Infection in Developing Countries
publisher.none.fl_str_mv The Journal of Infection in Developing Countries
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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