New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe

Autores
Vitale, Arturo Alberto; Bernatene, Eduardo Alberto; Vitale, Martín Gustavo; Pomilio, Alicia Beatriz
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The use of iron ions as catalyst of oxidation with hydrogen peroxide, known as the Fenton reaction, is important for industry and biological systems. It has been widely studied since its discovery in the 19th century, but important aspects of the reaction as which is the oxidant, the role of oxygen, and the oxidation state of Fe still remain unclear. In this work new mechanistic insights of the oxidation of carbohydrates by the Fenton reaction using glycerol as experimental model are described. The reaction was studied by means of oxidation reduction potential (ORP) measures. The stoichiometry was measured, showing the important role of oxygen for lowering H2O2 consumption under aerobic conditions. Evidence is provided to demonstrate that in this system Fe2+ generates a catalyst by reacting with a substrate to produce a complex, which gives rise to singlet oxygen after reacting with H2O2. This is the first time that the inhibitor effect of Mg2+ is reported in this reaction, and its participation in the mechanism is described. A rational mechanism for the oxidation of glycerol using the Fenton reaction under these specific conditions is proposed. The role of oxygen, the participation of Fe2+, and the inhibition by Mg2+ are fully demonstrated experimentally.
Fil: Vitale, Arturo Alberto. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bernatene, Eduardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Vitale, Martín Gustavo. Ciudad Autónoma de Buenos Aires. Hospital Infanto Juvenil ; Argentina
Fil: Pomilio, Alicia Beatriz. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Materia
FENTON REACTION
ORP
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47356
Acceder
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spelling New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of FeVitale, Arturo AlbertoBernatene, Eduardo AlbertoVitale, Martín GustavoPomilio, Alicia BeatrizFENTON REACTIONORPhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The use of iron ions as catalyst of oxidation with hydrogen peroxide, known as the Fenton reaction, is important for industry and biological systems. It has been widely studied since its discovery in the 19th century, but important aspects of the reaction as which is the oxidant, the role of oxygen, and the oxidation state of Fe still remain unclear. In this work new mechanistic insights of the oxidation of carbohydrates by the Fenton reaction using glycerol as experimental model are described. The reaction was studied by means of oxidation reduction potential (ORP) measures. The stoichiometry was measured, showing the important role of oxygen for lowering H2O2 consumption under aerobic conditions. Evidence is provided to demonstrate that in this system Fe2+ generates a catalyst by reacting with a substrate to produce a complex, which gives rise to singlet oxygen after reacting with H2O2. This is the first time that the inhibitor effect of Mg2+ is reported in this reaction, and its participation in the mechanism is described. A rational mechanism for the oxidation of glycerol using the Fenton reaction under these specific conditions is proposed. The role of oxygen, the participation of Fe2+, and the inhibition by Mg2+ are fully demonstrated experimentally.Fil: Vitale, Arturo Alberto. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bernatene, Eduardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Vitale, Martín Gustavo. Ciudad Autónoma de Buenos Aires. Hospital Infanto Juvenil ; ArgentinaFil: Pomilio, Alicia Beatriz. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaAmerican Chemical Society2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47356Vitale, Arturo Alberto; Bernatene, Eduardo Alberto; Vitale, Martín Gustavo; Pomilio, Alicia Beatriz; New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe; American Chemical Society; Journal of Physical Chemistry A; 120; 28; 7-2016; 5435-54451089-5639CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jpca.6b03805info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/acs.jpca.6b03805info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:23:07Zoai:ri.conicet.gov.ar:11336/47356instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:23:07.539CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe
title New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe
spellingShingle New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe
Vitale, Arturo Alberto
FENTON REACTION
ORP
title_short New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe
title_full New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe
title_fullStr New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe
title_full_unstemmed New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe
title_sort New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe
dc.creator.none.fl_str_mv Vitale, Arturo Alberto
Bernatene, Eduardo Alberto
Vitale, Martín Gustavo
Pomilio, Alicia Beatriz
author Vitale, Arturo Alberto
author_facet Vitale, Arturo Alberto
Bernatene, Eduardo Alberto
Vitale, Martín Gustavo
Pomilio, Alicia Beatriz
author_role author
author2 Bernatene, Eduardo Alberto
Vitale, Martín Gustavo
Pomilio, Alicia Beatriz
author2_role author
author
author
dc.subject.none.fl_str_mv FENTON REACTION
ORP
topic FENTON REACTION
ORP
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The use of iron ions as catalyst of oxidation with hydrogen peroxide, known as the Fenton reaction, is important for industry and biological systems. It has been widely studied since its discovery in the 19th century, but important aspects of the reaction as which is the oxidant, the role of oxygen, and the oxidation state of Fe still remain unclear. In this work new mechanistic insights of the oxidation of carbohydrates by the Fenton reaction using glycerol as experimental model are described. The reaction was studied by means of oxidation reduction potential (ORP) measures. The stoichiometry was measured, showing the important role of oxygen for lowering H2O2 consumption under aerobic conditions. Evidence is provided to demonstrate that in this system Fe2+ generates a catalyst by reacting with a substrate to produce a complex, which gives rise to singlet oxygen after reacting with H2O2. This is the first time that the inhibitor effect of Mg2+ is reported in this reaction, and its participation in the mechanism is described. A rational mechanism for the oxidation of glycerol using the Fenton reaction under these specific conditions is proposed. The role of oxygen, the participation of Fe2+, and the inhibition by Mg2+ are fully demonstrated experimentally.
Fil: Vitale, Arturo Alberto. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bernatene, Eduardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Vitale, Martín Gustavo. Ciudad Autónoma de Buenos Aires. Hospital Infanto Juvenil ; Argentina
Fil: Pomilio, Alicia Beatriz. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
description The use of iron ions as catalyst of oxidation with hydrogen peroxide, known as the Fenton reaction, is important for industry and biological systems. It has been widely studied since its discovery in the 19th century, but important aspects of the reaction as which is the oxidant, the role of oxygen, and the oxidation state of Fe still remain unclear. In this work new mechanistic insights of the oxidation of carbohydrates by the Fenton reaction using glycerol as experimental model are described. The reaction was studied by means of oxidation reduction potential (ORP) measures. The stoichiometry was measured, showing the important role of oxygen for lowering H2O2 consumption under aerobic conditions. Evidence is provided to demonstrate that in this system Fe2+ generates a catalyst by reacting with a substrate to produce a complex, which gives rise to singlet oxygen after reacting with H2O2. This is the first time that the inhibitor effect of Mg2+ is reported in this reaction, and its participation in the mechanism is described. A rational mechanism for the oxidation of glycerol using the Fenton reaction under these specific conditions is proposed. The role of oxygen, the participation of Fe2+, and the inhibition by Mg2+ are fully demonstrated experimentally.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47356
Vitale, Arturo Alberto; Bernatene, Eduardo Alberto; Vitale, Martín Gustavo; Pomilio, Alicia Beatriz; New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe; American Chemical Society; Journal of Physical Chemistry A; 120; 28; 7-2016; 5435-5445
1089-5639
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47356
identifier_str_mv Vitale, Arturo Alberto; Bernatene, Eduardo Alberto; Vitale, Martín Gustavo; Pomilio, Alicia Beatriz; New Insights of the Fenton Reaction Using Glycerol as the Experimental Model. Effect of O 2 , Inhibition by Mg 2+ , and Oxidation State of Fe; American Chemical Society; Journal of Physical Chemistry A; 120; 28; 7-2016; 5435-5445
1089-5639
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jpca.6b03805
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/acs.jpca.6b03805
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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