Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina
- Autores
- Salinas Ibañez, Angel Gabriel; Arismendi Sosa, Andrea Celeste; Ferramola, Florencia Fátima; Paredes, Jesica Daniela; Wendel, Graciela Haydée; María, Alejandra O.; Vega, Alba Edith
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The search of alternative anti-Helicobacter pylori agents obtained mainly of medicinal plants is a scientific area of great interest. The antimicrobial effects of Litrahea molleoides and Aristolochia argentina extracts against sensible and resistant H. pylori strains, were evaluated in vitro. Also, the urease inhibition activity and the effect on the ureA gene expression mRNA was evaluated. The L. molleoides and A. argentinae extracts showed antimicrobial activity against all strains assayed. Regardless of the extract assayed a decrease of viable count of approximately 2 log units on planktonic cell or established biofilms in H. pylori strains respect to the control was observed (p<0.05). Also, both extracts demonstrated strong urease inhibition activity on sensible H. pylori (p<0.05). In all strains, the ureA gene expression was down regulation independently of extracts used. The promising results of this work suggest that both L. molleoides and A. argentina, two traditional medicinal plant of Cuyo region, could be used as H. pylori alternative treatment that could attenuate virulence of bacterium and enable the host immune system to combat infection.
Fil: Salinas Ibañez, Angel Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
Fil: Arismendi Sosa, Andrea Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
Fil: Ferramola, Florencia Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
Fil: Paredes, Jesica Daniela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina
Fil: Wendel, Graciela Haydée. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina
Fil: María, Alejandra O.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina
Fil: Vega, Alba Edith. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina - Materia
-
HELICOBACTER PYLORI
INHIBITION UREASE
LITRAHEA MOLLEOIDES
ARISTOLOCHIA ARGENTINA
PLANTS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/158652
Ver los metadatos del registro completo
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Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis ArgentinaSalinas Ibañez, Angel GabrielArismendi Sosa, Andrea CelesteFerramola, Florencia FátimaParedes, Jesica DanielaWendel, Graciela HaydéeMaría, Alejandra O.Vega, Alba EdithHELICOBACTER PYLORIINHIBITION UREASELITRAHEA MOLLEOIDESARISTOLOCHIA ARGENTINAPLANTShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The search of alternative anti-Helicobacter pylori agents obtained mainly of medicinal plants is a scientific area of great interest. The antimicrobial effects of Litrahea molleoides and Aristolochia argentina extracts against sensible and resistant H. pylori strains, were evaluated in vitro. Also, the urease inhibition activity and the effect on the ureA gene expression mRNA was evaluated. The L. molleoides and A. argentinae extracts showed antimicrobial activity against all strains assayed. Regardless of the extract assayed a decrease of viable count of approximately 2 log units on planktonic cell or established biofilms in H. pylori strains respect to the control was observed (p<0.05). Also, both extracts demonstrated strong urease inhibition activity on sensible H. pylori (p<0.05). In all strains, the ureA gene expression was down regulation independently of extracts used. The promising results of this work suggest that both L. molleoides and A. argentina, two traditional medicinal plant of Cuyo region, could be used as H. pylori alternative treatment that could attenuate virulence of bacterium and enable the host immune system to combat infection.Fil: Salinas Ibañez, Angel Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; ArgentinaFil: Arismendi Sosa, Andrea Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; ArgentinaFil: Ferramola, Florencia Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; ArgentinaFil: Paredes, Jesica Daniela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; ArgentinaFil: Wendel, Graciela Haydée. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; ArgentinaFil: María, Alejandra O.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; ArgentinaFil: Vega, Alba Edith. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; ArgentinaExcellent publishers2017-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/158652Salinas Ibañez, Angel Gabriel; Arismendi Sosa, Andrea Celeste; Ferramola, Florencia Fátima; Paredes, Jesica Daniela; Wendel, Graciela Haydée; et al.; Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina; Excellent publishers; International Journal of Current Microbiology and Applied Sciences; 6; 9; 12-2017; 2097-21062319-76922319-7706CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ijcmas.com/abstractview.php?ID=4169&vol=6-9-2017&SNo=258info:eu-repo/semantics/altIdentifier/doi/10.20546/ijcmas.2017.609.258info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:09:22Zoai:ri.conicet.gov.ar:11336/158652instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:09:22.853CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina |
| title |
Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina |
| spellingShingle |
Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina Salinas Ibañez, Angel Gabriel HELICOBACTER PYLORI INHIBITION UREASE LITRAHEA MOLLEOIDES ARISTOLOCHIA ARGENTINA PLANTS |
| title_short |
Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina |
| title_full |
Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina |
| title_fullStr |
Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina |
| title_full_unstemmed |
Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina |
| title_sort |
Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina |
| dc.creator.none.fl_str_mv |
Salinas Ibañez, Angel Gabriel Arismendi Sosa, Andrea Celeste Ferramola, Florencia Fátima Paredes, Jesica Daniela Wendel, Graciela Haydée María, Alejandra O. Vega, Alba Edith |
| author |
Salinas Ibañez, Angel Gabriel |
| author_facet |
Salinas Ibañez, Angel Gabriel Arismendi Sosa, Andrea Celeste Ferramola, Florencia Fátima Paredes, Jesica Daniela Wendel, Graciela Haydée María, Alejandra O. Vega, Alba Edith |
| author_role |
author |
| author2 |
Arismendi Sosa, Andrea Celeste Ferramola, Florencia Fátima Paredes, Jesica Daniela Wendel, Graciela Haydée María, Alejandra O. Vega, Alba Edith |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
HELICOBACTER PYLORI INHIBITION UREASE LITRAHEA MOLLEOIDES ARISTOLOCHIA ARGENTINA PLANTS |
| topic |
HELICOBACTER PYLORI INHIBITION UREASE LITRAHEA MOLLEOIDES ARISTOLOCHIA ARGENTINA PLANTS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The search of alternative anti-Helicobacter pylori agents obtained mainly of medicinal plants is a scientific area of great interest. The antimicrobial effects of Litrahea molleoides and Aristolochia argentina extracts against sensible and resistant H. pylori strains, were evaluated in vitro. Also, the urease inhibition activity and the effect on the ureA gene expression mRNA was evaluated. The L. molleoides and A. argentinae extracts showed antimicrobial activity against all strains assayed. Regardless of the extract assayed a decrease of viable count of approximately 2 log units on planktonic cell or established biofilms in H. pylori strains respect to the control was observed (p<0.05). Also, both extracts demonstrated strong urease inhibition activity on sensible H. pylori (p<0.05). In all strains, the ureA gene expression was down regulation independently of extracts used. The promising results of this work suggest that both L. molleoides and A. argentina, two traditional medicinal plant of Cuyo region, could be used as H. pylori alternative treatment that could attenuate virulence of bacterium and enable the host immune system to combat infection. Fil: Salinas Ibañez, Angel Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina Fil: Arismendi Sosa, Andrea Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina Fil: Ferramola, Florencia Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina Fil: Paredes, Jesica Daniela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina Fil: Wendel, Graciela Haydée. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina Fil: María, Alejandra O.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina Fil: Vega, Alba Edith. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina |
| description |
The search of alternative anti-Helicobacter pylori agents obtained mainly of medicinal plants is a scientific area of great interest. The antimicrobial effects of Litrahea molleoides and Aristolochia argentina extracts against sensible and resistant H. pylori strains, were evaluated in vitro. Also, the urease inhibition activity and the effect on the ureA gene expression mRNA was evaluated. The L. molleoides and A. argentinae extracts showed antimicrobial activity against all strains assayed. Regardless of the extract assayed a decrease of viable count of approximately 2 log units on planktonic cell or established biofilms in H. pylori strains respect to the control was observed (p<0.05). Also, both extracts demonstrated strong urease inhibition activity on sensible H. pylori (p<0.05). In all strains, the ureA gene expression was down regulation independently of extracts used. The promising results of this work suggest that both L. molleoides and A. argentina, two traditional medicinal plant of Cuyo region, could be used as H. pylori alternative treatment that could attenuate virulence of bacterium and enable the host immune system to combat infection. |
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2017 |
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2017-12 |
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http://hdl.handle.net/11336/158652 Salinas Ibañez, Angel Gabriel; Arismendi Sosa, Andrea Celeste; Ferramola, Florencia Fátima; Paredes, Jesica Daniela; Wendel, Graciela Haydée; et al.; Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina; Excellent publishers; International Journal of Current Microbiology and Applied Sciences; 6; 9; 12-2017; 2097-2106 2319-7692 2319-7706 CONICET Digital CONICET |
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Salinas Ibañez, Angel Gabriel; Arismendi Sosa, Andrea Celeste; Ferramola, Florencia Fátima; Paredes, Jesica Daniela; Wendel, Graciela Haydée; et al.; Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina; Excellent publishers; International Journal of Current Microbiology and Applied Sciences; 6; 9; 12-2017; 2097-2106 2319-7692 2319-7706 CONICET Digital CONICET |
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