Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina

Autores
Salinas Ibañez, Angel Gabriel; Arismendi Sosa, Andrea Celeste; Ferramola, Florencia Fátima; Paredes, Jesica Daniela; Wendel, Graciela Haydée; María, Alejandra O.; Vega, Alba Edith
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The search of alternative anti-Helicobacter pylori agents obtained mainly of medicinal plants is a scientific area of great interest. The antimicrobial effects of Litrahea molleoides and Aristolochia argentina extracts against sensible and resistant H. pylori strains, were evaluated in vitro. Also, the urease inhibition activity and the effect on the ureA gene expression mRNA was evaluated. The L. molleoides and A. argentinae extracts showed antimicrobial activity against all strains assayed. Regardless of the extract assayed a decrease of viable count of approximately 2 log units on planktonic cell or established biofilms in H. pylori strains respect to the control was observed (p<0.05). Also, both extracts demonstrated strong urease inhibition activity on sensible H. pylori (p<0.05). In all strains, the ureA gene expression was down regulation independently of extracts used. The promising results of this work suggest that both L. molleoides and A. argentina, two traditional medicinal plant of Cuyo region, could be used as H. pylori alternative treatment that could attenuate virulence of bacterium and enable the host immune system to combat infection.
Fil: Salinas Ibañez, Angel Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
Fil: Arismendi Sosa, Andrea Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
Fil: Ferramola, Florencia Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
Fil: Paredes, Jesica Daniela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina
Fil: Wendel, Graciela Haydée. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina
Fil: María, Alejandra O.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina
Fil: Vega, Alba Edith. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
Materia
HELICOBACTER PYLORI
INHIBITION UREASE
LITRAHEA MOLLEOIDES
ARISTOLOCHIA ARGENTINA
PLANTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/158652

id CONICETDig_b3b64c77fd3d540d58c243c1fa955b18
oai_identifier_str oai:ri.conicet.gov.ar:11336/158652
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis ArgentinaSalinas Ibañez, Angel GabrielArismendi Sosa, Andrea CelesteFerramola, Florencia FátimaParedes, Jesica DanielaWendel, Graciela HaydéeMaría, Alejandra O.Vega, Alba EdithHELICOBACTER PYLORIINHIBITION UREASELITRAHEA MOLLEOIDESARISTOLOCHIA ARGENTINAPLANTShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The search of alternative anti-Helicobacter pylori agents obtained mainly of medicinal plants is a scientific area of great interest. The antimicrobial effects of Litrahea molleoides and Aristolochia argentina extracts against sensible and resistant H. pylori strains, were evaluated in vitro. Also, the urease inhibition activity and the effect on the ureA gene expression mRNA was evaluated. The L. molleoides and A. argentinae extracts showed antimicrobial activity against all strains assayed. Regardless of the extract assayed a decrease of viable count of approximately 2 log units on planktonic cell or established biofilms in H. pylori strains respect to the control was observed (p<0.05). Also, both extracts demonstrated strong urease inhibition activity on sensible H. pylori (p<0.05). In all strains, the ureA gene expression was down regulation independently of extracts used. The promising results of this work suggest that both L. molleoides and A. argentina, two traditional medicinal plant of Cuyo region, could be used as H. pylori alternative treatment that could attenuate virulence of bacterium and enable the host immune system to combat infection.Fil: Salinas Ibañez, Angel Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; ArgentinaFil: Arismendi Sosa, Andrea Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; ArgentinaFil: Ferramola, Florencia Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; ArgentinaFil: Paredes, Jesica Daniela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; ArgentinaFil: Wendel, Graciela Haydée. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; ArgentinaFil: María, Alejandra O.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; ArgentinaFil: Vega, Alba Edith. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; ArgentinaExcellent publishers2017-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/158652Salinas Ibañez, Angel Gabriel; Arismendi Sosa, Andrea Celeste; Ferramola, Florencia Fátima; Paredes, Jesica Daniela; Wendel, Graciela Haydée; et al.; Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina; Excellent publishers; International Journal of Current Microbiology and Applied Sciences; 6; 9; 12-2017; 2097-21062319-76922319-7706CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ijcmas.com/abstractview.php?ID=4169&vol=6-9-2017&SNo=258info:eu-repo/semantics/altIdentifier/doi/10.20546/ijcmas.2017.609.258info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:17Zoai:ri.conicet.gov.ar:11336/158652instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:17.778CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina
title Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina
spellingShingle Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina
Salinas Ibañez, Angel Gabriel
HELICOBACTER PYLORI
INHIBITION UREASE
LITRAHEA MOLLEOIDES
ARISTOLOCHIA ARGENTINA
PLANTS
title_short Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina
title_full Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina
title_fullStr Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina
title_full_unstemmed Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina
title_sort Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina
dc.creator.none.fl_str_mv Salinas Ibañez, Angel Gabriel
Arismendi Sosa, Andrea Celeste
Ferramola, Florencia Fátima
Paredes, Jesica Daniela
Wendel, Graciela Haydée
María, Alejandra O.
Vega, Alba Edith
author Salinas Ibañez, Angel Gabriel
author_facet Salinas Ibañez, Angel Gabriel
Arismendi Sosa, Andrea Celeste
Ferramola, Florencia Fátima
Paredes, Jesica Daniela
Wendel, Graciela Haydée
María, Alejandra O.
Vega, Alba Edith
author_role author
author2 Arismendi Sosa, Andrea Celeste
Ferramola, Florencia Fátima
Paredes, Jesica Daniela
Wendel, Graciela Haydée
María, Alejandra O.
Vega, Alba Edith
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv HELICOBACTER PYLORI
INHIBITION UREASE
LITRAHEA MOLLEOIDES
ARISTOLOCHIA ARGENTINA
PLANTS
topic HELICOBACTER PYLORI
INHIBITION UREASE
LITRAHEA MOLLEOIDES
ARISTOLOCHIA ARGENTINA
PLANTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The search of alternative anti-Helicobacter pylori agents obtained mainly of medicinal plants is a scientific area of great interest. The antimicrobial effects of Litrahea molleoides and Aristolochia argentina extracts against sensible and resistant H. pylori strains, were evaluated in vitro. Also, the urease inhibition activity and the effect on the ureA gene expression mRNA was evaluated. The L. molleoides and A. argentinae extracts showed antimicrobial activity against all strains assayed. Regardless of the extract assayed a decrease of viable count of approximately 2 log units on planktonic cell or established biofilms in H. pylori strains respect to the control was observed (p<0.05). Also, both extracts demonstrated strong urease inhibition activity on sensible H. pylori (p<0.05). In all strains, the ureA gene expression was down regulation independently of extracts used. The promising results of this work suggest that both L. molleoides and A. argentina, two traditional medicinal plant of Cuyo region, could be used as H. pylori alternative treatment that could attenuate virulence of bacterium and enable the host immune system to combat infection.
Fil: Salinas Ibañez, Angel Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
Fil: Arismendi Sosa, Andrea Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
Fil: Ferramola, Florencia Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
Fil: Paredes, Jesica Daniela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina
Fil: Wendel, Graciela Haydée. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina
Fil: María, Alejandra O.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Farmacología; Argentina
Fil: Vega, Alba Edith. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Microbiología; Argentina
description The search of alternative anti-Helicobacter pylori agents obtained mainly of medicinal plants is a scientific area of great interest. The antimicrobial effects of Litrahea molleoides and Aristolochia argentina extracts against sensible and resistant H. pylori strains, were evaluated in vitro. Also, the urease inhibition activity and the effect on the ureA gene expression mRNA was evaluated. The L. molleoides and A. argentinae extracts showed antimicrobial activity against all strains assayed. Regardless of the extract assayed a decrease of viable count of approximately 2 log units on planktonic cell or established biofilms in H. pylori strains respect to the control was observed (p<0.05). Also, both extracts demonstrated strong urease inhibition activity on sensible H. pylori (p<0.05). In all strains, the ureA gene expression was down regulation independently of extracts used. The promising results of this work suggest that both L. molleoides and A. argentina, two traditional medicinal plant of Cuyo region, could be used as H. pylori alternative treatment that could attenuate virulence of bacterium and enable the host immune system to combat infection.
publishDate 2017
dc.date.none.fl_str_mv 2017-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/158652
Salinas Ibañez, Angel Gabriel; Arismendi Sosa, Andrea Celeste; Ferramola, Florencia Fátima; Paredes, Jesica Daniela; Wendel, Graciela Haydée; et al.; Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina; Excellent publishers; International Journal of Current Microbiology and Applied Sciences; 6; 9; 12-2017; 2097-2106
2319-7692
2319-7706
CONICET Digital
CONICET
url http://hdl.handle.net/11336/158652
identifier_str_mv Salinas Ibañez, Angel Gabriel; Arismendi Sosa, Andrea Celeste; Ferramola, Florencia Fátima; Paredes, Jesica Daniela; Wendel, Graciela Haydée; et al.; Inhibition of helicobacter pylori and its associated urease by two regional plants of San Luis Argentina; Excellent publishers; International Journal of Current Microbiology and Applied Sciences; 6; 9; 12-2017; 2097-2106
2319-7692
2319-7706
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ijcmas.com/abstractview.php?ID=4169&vol=6-9-2017&SNo=258
info:eu-repo/semantics/altIdentifier/doi/10.20546/ijcmas.2017.609.258
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Excellent publishers
publisher.none.fl_str_mv Excellent publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614029290504192
score 13.070432