Small GTPases as regulators of cell division

Autores
Militello, Rodrigo Damián; Colombo, Maria Isabel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The superfamily of small GTPases serves as a signal transducer to regulate a diverse array of cellular functions. The members of this superfamily are structurally and functionally classified into at least 5 groups (Ras, Rho/Rac, Rab, Arf, and Ran) and they are involved in the control of cell proliferation and differentiation, regulation of the actin cytoskeleton, membrane trafficking, and nuclear transport. It is widely reported that members of the Rab family participate in the control of intracellular membrane trafficking through the interaction with specific effector molecules. However, many Rabs and other small GTPases have also been shown to function in cell division. In this review, we discuss current knowledge about Rab proteins regulating different stages of the cell cycle, such as the congregation and segregation of chromosomes (during metaphase) and the final stage of cell division known as cytokinesis, in which a cell is cleaved originating 2 daughter cells.
Fil: Militello, Rodrigo Damián. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "dr. M. Burgos"; Argentina
Fil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "dr. M. Burgos"; Argentina
Materia
RAB GTPASES
MITOSIS
SMALL GTPASES
RABS
CELL DIVISION
CYTOKINESIS
CHROMOSOME SEGREGATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/9735
Acceder
id CONICETDig_b35fc5ee82dcdbafef050892723a4936
oai_identifier_str oai:ri.conicet.gov.ar:11336/9735
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Small GTPases as regulators of cell divisionMilitello, Rodrigo DamiánColombo, Maria IsabelRAB GTPASESMITOSISSMALL GTPASESRABSCELL DIVISIONCYTOKINESISCHROMOSOME SEGREGATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The superfamily of small GTPases serves as a signal transducer to regulate a diverse array of cellular functions. The members of this superfamily are structurally and functionally classified into at least 5 groups (Ras, Rho/Rac, Rab, Arf, and Ran) and they are involved in the control of cell proliferation and differentiation, regulation of the actin cytoskeleton, membrane trafficking, and nuclear transport. It is widely reported that members of the Rab family participate in the control of intracellular membrane trafficking through the interaction with specific effector molecules. However, many Rabs and other small GTPases have also been shown to function in cell division. In this review, we discuss current knowledge about Rab proteins regulating different stages of the cell cycle, such as the congregation and segregation of chromosomes (during metaphase) and the final stage of cell division known as cytokinesis, in which a cell is cleaved originating 2 daughter cells.Fil: Militello, Rodrigo Damián. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "dr. M. Burgos"; ArgentinaFil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "dr. M. Burgos"; ArgentinaLandes Bioscience2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9735Militello, Rodrigo Damián; Colombo, Maria Isabel; Small GTPases as regulators of cell division; Landes Bioscience; Communicative & Integrative Biology; 6; 5; 9-2013; 254601-2546041942-0889enginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/cib.25460info:eu-repo/semantics/altIdentifier/doi/10.4161/cib.25460info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:52:08Zoai:ri.conicet.gov.ar:11336/9735instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:52:08.558CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Small GTPases as regulators of cell division
title Small GTPases as regulators of cell division
spellingShingle Small GTPases as regulators of cell division
Militello, Rodrigo Damián
RAB GTPASES
MITOSIS
SMALL GTPASES
RABS
CELL DIVISION
CYTOKINESIS
CHROMOSOME SEGREGATION
title_short Small GTPases as regulators of cell division
title_full Small GTPases as regulators of cell division
title_fullStr Small GTPases as regulators of cell division
title_full_unstemmed Small GTPases as regulators of cell division
title_sort Small GTPases as regulators of cell division
dc.creator.none.fl_str_mv Militello, Rodrigo Damián
Colombo, Maria Isabel
author Militello, Rodrigo Damián
author_facet Militello, Rodrigo Damián
Colombo, Maria Isabel
author_role author
author2 Colombo, Maria Isabel
author2_role author
dc.subject.none.fl_str_mv RAB GTPASES
MITOSIS
SMALL GTPASES
RABS
CELL DIVISION
CYTOKINESIS
CHROMOSOME SEGREGATION
topic RAB GTPASES
MITOSIS
SMALL GTPASES
RABS
CELL DIVISION
CYTOKINESIS
CHROMOSOME SEGREGATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The superfamily of small GTPases serves as a signal transducer to regulate a diverse array of cellular functions. The members of this superfamily are structurally and functionally classified into at least 5 groups (Ras, Rho/Rac, Rab, Arf, and Ran) and they are involved in the control of cell proliferation and differentiation, regulation of the actin cytoskeleton, membrane trafficking, and nuclear transport. It is widely reported that members of the Rab family participate in the control of intracellular membrane trafficking through the interaction with specific effector molecules. However, many Rabs and other small GTPases have also been shown to function in cell division. In this review, we discuss current knowledge about Rab proteins regulating different stages of the cell cycle, such as the congregation and segregation of chromosomes (during metaphase) and the final stage of cell division known as cytokinesis, in which a cell is cleaved originating 2 daughter cells.
Fil: Militello, Rodrigo Damián. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "dr. M. Burgos"; Argentina
Fil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "dr. M. Burgos"; Argentina
description The superfamily of small GTPases serves as a signal transducer to regulate a diverse array of cellular functions. The members of this superfamily are structurally and functionally classified into at least 5 groups (Ras, Rho/Rac, Rab, Arf, and Ran) and they are involved in the control of cell proliferation and differentiation, regulation of the actin cytoskeleton, membrane trafficking, and nuclear transport. It is widely reported that members of the Rab family participate in the control of intracellular membrane trafficking through the interaction with specific effector molecules. However, many Rabs and other small GTPases have also been shown to function in cell division. In this review, we discuss current knowledge about Rab proteins regulating different stages of the cell cycle, such as the congregation and segregation of chromosomes (during metaphase) and the final stage of cell division known as cytokinesis, in which a cell is cleaved originating 2 daughter cells.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/9735
Militello, Rodrigo Damián; Colombo, Maria Isabel; Small GTPases as regulators of cell division; Landes Bioscience; Communicative & Integrative Biology; 6; 5; 9-2013; 254601-254604
1942-0889
url http://hdl.handle.net/11336/9735
identifier_str_mv Militello, Rodrigo Damián; Colombo, Maria Isabel; Small GTPases as regulators of cell division; Landes Bioscience; Communicative & Integrative Biology; 6; 5; 9-2013; 254601-254604
1942-0889
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/cib.25460
info:eu-repo/semantics/altIdentifier/doi/10.4161/cib.25460
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083048858189824
score 13.22299

Publicaciones similares