Acute kidney injury: what part do toll-like receptors play?

Autores
Vallés, Patricia G.; Gil Lorenzo, Andrea Fernanda; Bocanegra, María Victoria; Valles, Roberto
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The innate immune system plays an important role as a first response to tissue injury. This first response is carried out via germline-encoded receptors. Toll-like receptors (TLRs) are the first identified and best studied family of pattern recognition receptors. TLRs are expressed on a variety of cell types, including epithelial cells, endothelia, dendritic cells, monocytes/macrophages, and B- and T-cells. TLRs initiate innate immune responses and concurrently shape the subsequent adaptive immune response. They are sensors of both pathogens, through the exogenous pathogen-associated molecular patterns (PAMPs), and tissue injury, through the endogenous danger-associated molecular patterns (DAMPs). TLR signaling is critical in defending against invading microorganisms; however, sustained receptor activation is also implicated in the pathogenesis of inflammatory diseases. Ischemic kidney injury involves early TLR-driven immunopathology, and the resolution of inflammation is needed for rapid regeneration of injured tubule cells. Notably, the activation of TLRs also has been implicated in epithelial repair. This review focuses on the role of TLRs and their endogenous ligands within the inflammatory response of acute kidney injury.
Fil: Vallés, Patricia G.. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gil Lorenzo, Andrea Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Bocanegra, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Valles, Roberto. Universidad Nacional de Cuyo; Argentina
Materia
TOLL-LIKE RECEPTORS
Pathogen-Associated Molecular Patterns
Danger-Associated Molecular Patterns
Ischemic Kidney Injury
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32214
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Acute kidney injury: what part do toll-like receptors play?Vallés, Patricia G.Gil Lorenzo, Andrea FernandaBocanegra, María VictoriaValles, RobertoTOLL-LIKE RECEPTORSPathogen-Associated Molecular PatternsDanger-Associated Molecular PatternsIschemic Kidney Injuryhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The innate immune system plays an important role as a first response to tissue injury. This first response is carried out via germline-encoded receptors. Toll-like receptors (TLRs) are the first identified and best studied family of pattern recognition receptors. TLRs are expressed on a variety of cell types, including epithelial cells, endothelia, dendritic cells, monocytes/macrophages, and B- and T-cells. TLRs initiate innate immune responses and concurrently shape the subsequent adaptive immune response. They are sensors of both pathogens, through the exogenous pathogen-associated molecular patterns (PAMPs), and tissue injury, through the endogenous danger-associated molecular patterns (DAMPs). TLR signaling is critical in defending against invading microorganisms; however, sustained receptor activation is also implicated in the pathogenesis of inflammatory diseases. Ischemic kidney injury involves early TLR-driven immunopathology, and the resolution of inflammation is needed for rapid regeneration of injured tubule cells. Notably, the activation of TLRs also has been implicated in epithelial repair. This review focuses on the role of TLRs and their endogenous ligands within the inflammatory response of acute kidney injury.Fil: Vallés, Patricia G.. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gil Lorenzo, Andrea Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Bocanegra, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Valles, Roberto. Universidad Nacional de Cuyo; ArgentinaDove Press2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32214Valles, Roberto; Bocanegra, María Victoria; Gil Lorenzo, Andrea Fernanda; Vallés, Patricia G.; Acute kidney injury: what part do toll-like receptors play?; Dove Press; International Journal of Nephrology and Renovascular Disease; 2014; 7; 6-2014; 241-2511178-7058CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/ 10.2147/IJNRD.S37891info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069137/info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/acute-kidney-injury-what-part-do-toll-like-receptors-play-peer-reviewed-article-IJNRDinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:36Zoai:ri.conicet.gov.ar:11336/32214instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:36.616CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Acute kidney injury: what part do toll-like receptors play?
title Acute kidney injury: what part do toll-like receptors play?
spellingShingle Acute kidney injury: what part do toll-like receptors play?
Vallés, Patricia G.
TOLL-LIKE RECEPTORS
Pathogen-Associated Molecular Patterns
Danger-Associated Molecular Patterns
Ischemic Kidney Injury
title_short Acute kidney injury: what part do toll-like receptors play?
title_full Acute kidney injury: what part do toll-like receptors play?
title_fullStr Acute kidney injury: what part do toll-like receptors play?
title_full_unstemmed Acute kidney injury: what part do toll-like receptors play?
title_sort Acute kidney injury: what part do toll-like receptors play?
dc.creator.none.fl_str_mv Vallés, Patricia G.
Gil Lorenzo, Andrea Fernanda
Bocanegra, María Victoria
Valles, Roberto
author Vallés, Patricia G.
author_facet Vallés, Patricia G.
Gil Lorenzo, Andrea Fernanda
Bocanegra, María Victoria
Valles, Roberto
author_role author
author2 Gil Lorenzo, Andrea Fernanda
Bocanegra, María Victoria
Valles, Roberto
author2_role author
author
author
dc.subject.none.fl_str_mv TOLL-LIKE RECEPTORS
Pathogen-Associated Molecular Patterns
Danger-Associated Molecular Patterns
Ischemic Kidney Injury
topic TOLL-LIKE RECEPTORS
Pathogen-Associated Molecular Patterns
Danger-Associated Molecular Patterns
Ischemic Kidney Injury
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The innate immune system plays an important role as a first response to tissue injury. This first response is carried out via germline-encoded receptors. Toll-like receptors (TLRs) are the first identified and best studied family of pattern recognition receptors. TLRs are expressed on a variety of cell types, including epithelial cells, endothelia, dendritic cells, monocytes/macrophages, and B- and T-cells. TLRs initiate innate immune responses and concurrently shape the subsequent adaptive immune response. They are sensors of both pathogens, through the exogenous pathogen-associated molecular patterns (PAMPs), and tissue injury, through the endogenous danger-associated molecular patterns (DAMPs). TLR signaling is critical in defending against invading microorganisms; however, sustained receptor activation is also implicated in the pathogenesis of inflammatory diseases. Ischemic kidney injury involves early TLR-driven immunopathology, and the resolution of inflammation is needed for rapid regeneration of injured tubule cells. Notably, the activation of TLRs also has been implicated in epithelial repair. This review focuses on the role of TLRs and their endogenous ligands within the inflammatory response of acute kidney injury.
Fil: Vallés, Patricia G.. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gil Lorenzo, Andrea Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Bocanegra, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Valles, Roberto. Universidad Nacional de Cuyo; Argentina
description The innate immune system plays an important role as a first response to tissue injury. This first response is carried out via germline-encoded receptors. Toll-like receptors (TLRs) are the first identified and best studied family of pattern recognition receptors. TLRs are expressed on a variety of cell types, including epithelial cells, endothelia, dendritic cells, monocytes/macrophages, and B- and T-cells. TLRs initiate innate immune responses and concurrently shape the subsequent adaptive immune response. They are sensors of both pathogens, through the exogenous pathogen-associated molecular patterns (PAMPs), and tissue injury, through the endogenous danger-associated molecular patterns (DAMPs). TLR signaling is critical in defending against invading microorganisms; however, sustained receptor activation is also implicated in the pathogenesis of inflammatory diseases. Ischemic kidney injury involves early TLR-driven immunopathology, and the resolution of inflammation is needed for rapid regeneration of injured tubule cells. Notably, the activation of TLRs also has been implicated in epithelial repair. This review focuses on the role of TLRs and their endogenous ligands within the inflammatory response of acute kidney injury.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32214
Valles, Roberto; Bocanegra, María Victoria; Gil Lorenzo, Andrea Fernanda; Vallés, Patricia G.; Acute kidney injury: what part do toll-like receptors play?; Dove Press; International Journal of Nephrology and Renovascular Disease; 2014; 7; 6-2014; 241-251
1178-7058
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32214
identifier_str_mv Valles, Roberto; Bocanegra, María Victoria; Gil Lorenzo, Andrea Fernanda; Vallés, Patricia G.; Acute kidney injury: what part do toll-like receptors play?; Dove Press; International Journal of Nephrology and Renovascular Disease; 2014; 7; 6-2014; 241-251
1178-7058
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/ 10.2147/IJNRD.S37891
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069137/
info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/acute-kidney-injury-what-part-do-toll-like-receptors-play-peer-reviewed-article-IJNRD
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Dove Press
publisher.none.fl_str_mv Dove Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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