Steroid molecular properties influence the biophysical state of steroid-containing membranes

Autores
Wenz, Jorge Javier
Año de publicación
2015
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The effects of steroids on the biophysical state of membranes were investigated by analyzing the ordering, rigidifying, condensing and/or raft promoting activity on membranes of a library of 82 steroids. Based on the documented membrane activity, steroids were classified by means of a categorical variable [1] into three possible categories: disrupters, neutrals or promoters of such activity. All steroids were subjected to geometry optimization using the semi-empirical procedure AM1 and 245 molecular descriptors were next computed [2] on the low energy conformations. After the removal of the invariant descriptors, the remaining 93 were correlated with membrane activity through principal component analysis (PCA) [3] and mean contrasting.
Fil: Wenz, Jorge Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XV Congress of the Spanish Biophysical Society
Granada
España
Sociedad Biophyica de España
Materia
STEROIDS
MOLECULAR PROPERTIES
BIOPHYSICAL PROPERTIES
MULATIVARIATE ANALYSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/238519
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/238519
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Steroid molecular properties influence the biophysical state of steroid-containing membranesWenz, Jorge JavierSTEROIDSMOLECULAR PROPERTIESBIOPHYSICAL PROPERTIESMULATIVARIATE ANALYSIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The effects of steroids on the biophysical state of membranes were investigated by analyzing the ordering, rigidifying, condensing and/or raft promoting activity on membranes of a library of 82 steroids. Based on the documented membrane activity, steroids were classified by means of a categorical variable [1] into three possible categories: disrupters, neutrals or promoters of such activity. All steroids were subjected to geometry optimization using the semi-empirical procedure AM1 and 245 molecular descriptors were next computed [2] on the low energy conformations. After the removal of the invariant descriptors, the remaining 93 were correlated with membrane activity through principal component analysis (PCA) [3] and mean contrasting.Fil: Wenz, Jorge Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaXV Congress of the Spanish Biophysical SocietyGranadaEspañaSociedad Biophyica de EspañaSociedad Biophyica de España2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/238519Steroid molecular properties influence the biophysical state of steroid-containing membranes; XV Congress of the Spanish Biophysical Society; Granada; España; 2015; 173-173CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.uv.es/biophys/sbe/S/book_of_abstracts_Granada2015.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:45Zoai:ri.conicet.gov.ar:11336/238519instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:02:45.417CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Steroid molecular properties influence the biophysical state of steroid-containing membranes
title Steroid molecular properties influence the biophysical state of steroid-containing membranes
spellingShingle Steroid molecular properties influence the biophysical state of steroid-containing membranes
Wenz, Jorge Javier
STEROIDS
MOLECULAR PROPERTIES
BIOPHYSICAL PROPERTIES
MULATIVARIATE ANALYSIS
title_short Steroid molecular properties influence the biophysical state of steroid-containing membranes
title_full Steroid molecular properties influence the biophysical state of steroid-containing membranes
title_fullStr Steroid molecular properties influence the biophysical state of steroid-containing membranes
title_full_unstemmed Steroid molecular properties influence the biophysical state of steroid-containing membranes
title_sort Steroid molecular properties influence the biophysical state of steroid-containing membranes
dc.creator.none.fl_str_mv Wenz, Jorge Javier
author Wenz, Jorge Javier
author_facet Wenz, Jorge Javier
author_role author
dc.subject.none.fl_str_mv STEROIDS
MOLECULAR PROPERTIES
BIOPHYSICAL PROPERTIES
MULATIVARIATE ANALYSIS
topic STEROIDS
MOLECULAR PROPERTIES
BIOPHYSICAL PROPERTIES
MULATIVARIATE ANALYSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The effects of steroids on the biophysical state of membranes were investigated by analyzing the ordering, rigidifying, condensing and/or raft promoting activity on membranes of a library of 82 steroids. Based on the documented membrane activity, steroids were classified by means of a categorical variable [1] into three possible categories: disrupters, neutrals or promoters of such activity. All steroids were subjected to geometry optimization using the semi-empirical procedure AM1 and 245 molecular descriptors were next computed [2] on the low energy conformations. After the removal of the invariant descriptors, the remaining 93 were correlated with membrane activity through principal component analysis (PCA) [3] and mean contrasting.
Fil: Wenz, Jorge Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XV Congress of the Spanish Biophysical Society
Granada
España
Sociedad Biophyica de España
description The effects of steroids on the biophysical state of membranes were investigated by analyzing the ordering, rigidifying, condensing and/or raft promoting activity on membranes of a library of 82 steroids. Based on the documented membrane activity, steroids were classified by means of a categorical variable [1] into three possible categories: disrupters, neutrals or promoters of such activity. All steroids were subjected to geometry optimization using the semi-empirical procedure AM1 and 245 molecular descriptors were next computed [2] on the low energy conformations. After the removal of the invariant descriptors, the remaining 93 were correlated with membrane activity through principal component analysis (PCA) [3] and mean contrasting.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/238519
Steroid molecular properties influence the biophysical state of steroid-containing membranes; XV Congress of the Spanish Biophysical Society; Granada; España; 2015; 173-173
CONICET Digital
CONICET
url http://hdl.handle.net/11336/238519
identifier_str_mv Steroid molecular properties influence the biophysical state of steroid-containing membranes; XV Congress of the Spanish Biophysical Society; Granada; España; 2015; 173-173
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.uv.es/biophys/sbe/S/book_of_abstracts_Granada2015.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Sociedad Biophyica de España
publisher.none.fl_str_mv Sociedad Biophyica de España
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613835290312704
score 13.070432

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