Hepatitis E virus infection in pregnant women, Argentina

Autores
Tissera, Gabriela; Lardizabal, María Cecilia; Torres, Sofía Belén; Fantilli, Anabella Clara; Martínez Wassaf, Maribel G.; Venezuela, Raul Fernando; Capra, Raul Horacio; Balderramo, Domingo; Travella, Claudia; Ré, Viviana Elizabeth; Pisano, María Belén
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Hepatitis E virus (HEV) infection is an important cause of acute hepatitis worldwide. In pregnant women, HEV can cause more severe symptoms, with high rates of fatal hepatic failure in endemic countries. However, HEV prevalence and circulation among pregnant women from South America is almost unknown. We aimed to investigate HEV infection in pregnant women for the first time in Argentina. Methods: IgG and IgM anti-HEV antibodies and RNA-HEV were investigated (by ELISA assays and RT-Nested-PCR, respectively) in 202 serum samples from pregnant women collected in the central region of Argentina between 2015 and 2017. A control group of 155 non-pregnant women was included (year 2018). Results: The IgG anti-HEV positivity rate was 8.4% (17/202), higher than the 2.6% (4/155) obtained for the non-pregnant women control group, and showing association between pregnancy and HEV infection (p = 0.023, OR = 3.5, CI95% = 1.1-10.5). Women younger than 25 years old presented higher levels of antibodies, and there were no differences in the prevalences between trimesters of pregnancy. Two samples were reactive for IgM anti-HEV, showing recent infections, although no symptoms were registered in these patients. All samples were negative for RNA-HEV amplification. Conclusions: HEV produces infections in pregnant women from Argentina, alerting health teams to consider it as a possible cause of liver disease.
Fil: Tissera, Gabriela. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Lardizabal, María Cecilia. Hospital Privado Universitario de Córdoba; Argentina
Fil: Torres, Sofía Belén. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Martínez Wassaf, Maribel G.. Laboratorio de Análisis Clínicos Especializados; Argentina
Fil: Venezuela, Raul Fernando. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Capra, Raul Horacio. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Balderramo, Domingo. Hospital Privado Centro Médico de Córdoba; Argentina. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina
Fil: Travella, Claudia. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Materia
ARGENTINA
HEPATITIS E VIRUS
PREGNANT WOMEN
PREVALENCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/140045
Acceder
id CONICETDig_b28d2979fe9b23e71d43e92c3ed6db13
oai_identifier_str oai:ri.conicet.gov.ar:11336/140045
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hepatitis E virus infection in pregnant women, ArgentinaTissera, GabrielaLardizabal, María CeciliaTorres, Sofía BelénFantilli, Anabella ClaraMartínez Wassaf, Maribel G.Venezuela, Raul FernandoCapra, Raul HoracioBalderramo, DomingoTravella, ClaudiaRé, Viviana ElizabethPisano, María BelénARGENTINAHEPATITIS E VIRUSPREGNANT WOMENPREVALENCEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Hepatitis E virus (HEV) infection is an important cause of acute hepatitis worldwide. In pregnant women, HEV can cause more severe symptoms, with high rates of fatal hepatic failure in endemic countries. However, HEV prevalence and circulation among pregnant women from South America is almost unknown. We aimed to investigate HEV infection in pregnant women for the first time in Argentina. Methods: IgG and IgM anti-HEV antibodies and RNA-HEV were investigated (by ELISA assays and RT-Nested-PCR, respectively) in 202 serum samples from pregnant women collected in the central region of Argentina between 2015 and 2017. A control group of 155 non-pregnant women was included (year 2018). Results: The IgG anti-HEV positivity rate was 8.4% (17/202), higher than the 2.6% (4/155) obtained for the non-pregnant women control group, and showing association between pregnancy and HEV infection (p = 0.023, OR = 3.5, CI95% = 1.1-10.5). Women younger than 25 years old presented higher levels of antibodies, and there were no differences in the prevalences between trimesters of pregnancy. Two samples were reactive for IgM anti-HEV, showing recent infections, although no symptoms were registered in these patients. All samples were negative for RNA-HEV amplification. Conclusions: HEV produces infections in pregnant women from Argentina, alerting health teams to consider it as a possible cause of liver disease.Fil: Tissera, Gabriela. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Lardizabal, María Cecilia. Hospital Privado Universitario de Córdoba; ArgentinaFil: Torres, Sofía Belén. Hospital Privado Centro Médico de Córdoba; ArgentinaFil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Martínez Wassaf, Maribel G.. Laboratorio de Análisis Clínicos Especializados; ArgentinaFil: Venezuela, Raul Fernando. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Capra, Raul Horacio. Hospital Privado Centro Médico de Córdoba; ArgentinaFil: Balderramo, Domingo. Hospital Privado Centro Médico de Córdoba; Argentina. Instituto Universitario de Ciencias Biomédicas de Córdoba; ArgentinaFil: Travella, Claudia. Hospital Privado Centro Médico de Córdoba; ArgentinaFil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaBioMed Central2020-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/140045Tissera, Gabriela; Lardizabal, María Cecilia; Torres, Sofía Belén; Fantilli, Anabella Clara; Martínez Wassaf, Maribel G.; et al.; Hepatitis E virus infection in pregnant women, Argentina; BioMed Central; BMC Infectious Diseases; 20; 1; 10-2020; 1-51471-2334CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05087-3info:eu-repo/semantics/altIdentifier/doi/10.1186/s12879-020-05087-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:32Zoai:ri.conicet.gov.ar:11336/140045instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:32.45CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hepatitis E virus infection in pregnant women, Argentina
title Hepatitis E virus infection in pregnant women, Argentina
spellingShingle Hepatitis E virus infection in pregnant women, Argentina
Tissera, Gabriela
ARGENTINA
HEPATITIS E VIRUS
PREGNANT WOMEN
PREVALENCE
title_short Hepatitis E virus infection in pregnant women, Argentina
title_full Hepatitis E virus infection in pregnant women, Argentina
title_fullStr Hepatitis E virus infection in pregnant women, Argentina
title_full_unstemmed Hepatitis E virus infection in pregnant women, Argentina
title_sort Hepatitis E virus infection in pregnant women, Argentina
dc.creator.none.fl_str_mv Tissera, Gabriela
Lardizabal, María Cecilia
Torres, Sofía Belén
Fantilli, Anabella Clara
Martínez Wassaf, Maribel G.
Venezuela, Raul Fernando
Capra, Raul Horacio
Balderramo, Domingo
Travella, Claudia
Ré, Viviana Elizabeth
Pisano, María Belén
author Tissera, Gabriela
author_facet Tissera, Gabriela
Lardizabal, María Cecilia
Torres, Sofía Belén
Fantilli, Anabella Clara
Martínez Wassaf, Maribel G.
Venezuela, Raul Fernando
Capra, Raul Horacio
Balderramo, Domingo
Travella, Claudia
Ré, Viviana Elizabeth
Pisano, María Belén
author_role author
author2 Lardizabal, María Cecilia
Torres, Sofía Belén
Fantilli, Anabella Clara
Martínez Wassaf, Maribel G.
Venezuela, Raul Fernando
Capra, Raul Horacio
Balderramo, Domingo
Travella, Claudia
Ré, Viviana Elizabeth
Pisano, María Belén
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ARGENTINA
HEPATITIS E VIRUS
PREGNANT WOMEN
PREVALENCE
topic ARGENTINA
HEPATITIS E VIRUS
PREGNANT WOMEN
PREVALENCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Hepatitis E virus (HEV) infection is an important cause of acute hepatitis worldwide. In pregnant women, HEV can cause more severe symptoms, with high rates of fatal hepatic failure in endemic countries. However, HEV prevalence and circulation among pregnant women from South America is almost unknown. We aimed to investigate HEV infection in pregnant women for the first time in Argentina. Methods: IgG and IgM anti-HEV antibodies and RNA-HEV were investigated (by ELISA assays and RT-Nested-PCR, respectively) in 202 serum samples from pregnant women collected in the central region of Argentina between 2015 and 2017. A control group of 155 non-pregnant women was included (year 2018). Results: The IgG anti-HEV positivity rate was 8.4% (17/202), higher than the 2.6% (4/155) obtained for the non-pregnant women control group, and showing association between pregnancy and HEV infection (p = 0.023, OR = 3.5, CI95% = 1.1-10.5). Women younger than 25 years old presented higher levels of antibodies, and there were no differences in the prevalences between trimesters of pregnancy. Two samples were reactive for IgM anti-HEV, showing recent infections, although no symptoms were registered in these patients. All samples were negative for RNA-HEV amplification. Conclusions: HEV produces infections in pregnant women from Argentina, alerting health teams to consider it as a possible cause of liver disease.
Fil: Tissera, Gabriela. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Lardizabal, María Cecilia. Hospital Privado Universitario de Córdoba; Argentina
Fil: Torres, Sofía Belén. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Martínez Wassaf, Maribel G.. Laboratorio de Análisis Clínicos Especializados; Argentina
Fil: Venezuela, Raul Fernando. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Capra, Raul Horacio. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Balderramo, Domingo. Hospital Privado Centro Médico de Córdoba; Argentina. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina
Fil: Travella, Claudia. Hospital Privado Centro Médico de Córdoba; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
description Background: Hepatitis E virus (HEV) infection is an important cause of acute hepatitis worldwide. In pregnant women, HEV can cause more severe symptoms, with high rates of fatal hepatic failure in endemic countries. However, HEV prevalence and circulation among pregnant women from South America is almost unknown. We aimed to investigate HEV infection in pregnant women for the first time in Argentina. Methods: IgG and IgM anti-HEV antibodies and RNA-HEV were investigated (by ELISA assays and RT-Nested-PCR, respectively) in 202 serum samples from pregnant women collected in the central region of Argentina between 2015 and 2017. A control group of 155 non-pregnant women was included (year 2018). Results: The IgG anti-HEV positivity rate was 8.4% (17/202), higher than the 2.6% (4/155) obtained for the non-pregnant women control group, and showing association between pregnancy and HEV infection (p = 0.023, OR = 3.5, CI95% = 1.1-10.5). Women younger than 25 years old presented higher levels of antibodies, and there were no differences in the prevalences between trimesters of pregnancy. Two samples were reactive for IgM anti-HEV, showing recent infections, although no symptoms were registered in these patients. All samples were negative for RNA-HEV amplification. Conclusions: HEV produces infections in pregnant women from Argentina, alerting health teams to consider it as a possible cause of liver disease.
publishDate 2020
dc.date.none.fl_str_mv 2020-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/140045
Tissera, Gabriela; Lardizabal, María Cecilia; Torres, Sofía Belén; Fantilli, Anabella Clara; Martínez Wassaf, Maribel G.; et al.; Hepatitis E virus infection in pregnant women, Argentina; BioMed Central; BMC Infectious Diseases; 20; 1; 10-2020; 1-5
1471-2334
CONICET Digital
CONICET
url http://hdl.handle.net/11336/140045
identifier_str_mv Tissera, Gabriela; Lardizabal, María Cecilia; Torres, Sofía Belén; Fantilli, Anabella Clara; Martínez Wassaf, Maribel G.; et al.; Hepatitis E virus infection in pregnant women, Argentina; BioMed Central; BMC Infectious Diseases; 20; 1; 10-2020; 1-5
1471-2334
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1186/s12879-020-05087-3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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