Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis

Autores
Botta, Eliana Elizabeth; Meroño, Tomás; Saucedo, Carla; Martin, Maximiliano Emanuel; Tetzlaff, Walter Francisco; Sorroche, Patricia Beatriz; Boero, Laura; Malah, Verónica; Menafra, Martín; Gomez Rosso, Leonardo Adrián; Chapman, John M.; Kontush, Anatol; Soriano, Enrique; Brites, Fernando Daniel
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background and aims Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular disease (CVD). Measures of HDL metabolism/function were shown to be altered in RA patients with high disease activity. We aimed at evaluating the effect of HDL characteristics on arterial stiffness in RA patients classified according to the inflammatory disease activity. Methods RA patients were classified according to disease activity (DAS-28) into active RA (n = 27; DAS-28 > 3.2) and inactive RA patients (n = 17; DAS-28 < 3.2). A control group of healthy individuals was also studied (n = 33). Clinical and biochemical characteristics, cholesteryl ester transfer protein (CETP) and paraoxonase 1 (phenylacetate and paraoxonase) activities and carotid-femoral pulse wave velocity (cf-PWV) were determined. Results Anthropometric characteristics were similar in all groups. In accordance with the inflammatory status, active RA patients presented elevated hsCRP levels (p < 0.001). There were no differences in the lipid profile between groups. Similarly, features of insulin resistance were absent in RA patients (p = non-significant). Active RA patients presented higher CETP activity than the other two groups (p = 0.026). Phenylacetate and paraoxonase activities were altered in active RA patients in comparison with the other groups (p = 0.034 and p = 0.041, respectively). Cf-PWV was significantly higher in active RA patients in comparison with controls, following adjustment by age (p = 0.030). Age (βst = 0.468, p = 0.013) and apo A-I levels (βst = −0.405, p = 0.029) were independent predictors of cf-PWV in a model including hsCRP, HOMA-IR, and phenylacetate activity (r2 = 0.42). Conclusions High DAS-28 identifies patients with alterations in HDL characteristics. Plasma levels of apo A-I can be used as a marker of arterial stiffness in RA.
Fil: Botta, Eliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Meroño, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Hospital Nacional "Profesor Alejandro Posadas"; Argentina
Fil: Saucedo, Carla. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
Fil: Martin, Maximiliano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Tetzlaff, Walter Francisco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Sorroche, Patricia Beatriz. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
Fil: Boero, Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Malah, Verónica. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Menafra, Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Gomez Rosso, Leonardo Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Chapman, John M.. Inserm; Francia
Fil: Kontush, Anatol. Inserm; Francia
Fil: Soriano, Enrique. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
Fil: Brites, Fernando Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Materia
Arterial Rigidity
Atherosclerosis
Cholesteryl Ester Transfer Protein
Hdl
Paraoxonase
Pulse Wave Velocity
Rheumatoid Arthritis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67268
Acceder
id CONICETDig_b2860086f95a04d91168036edab496a9
oai_identifier_str oai:ri.conicet.gov.ar:11336/67268
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritisBotta, Eliana ElizabethMeroño, TomásSaucedo, CarlaMartin, Maximiliano EmanuelTetzlaff, Walter FranciscoSorroche, Patricia BeatrizBoero, LauraMalah, VerónicaMenafra, MartínGomez Rosso, Leonardo AdriánChapman, John M.Kontush, AnatolSoriano, EnriqueBrites, Fernando DanielArterial RigidityAtherosclerosisCholesteryl Ester Transfer ProteinHdlParaoxonasePulse Wave VelocityRheumatoid Arthritishttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background and aims Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular disease (CVD). Measures of HDL metabolism/function were shown to be altered in RA patients with high disease activity. We aimed at evaluating the effect of HDL characteristics on arterial stiffness in RA patients classified according to the inflammatory disease activity. Methods RA patients were classified according to disease activity (DAS-28) into active RA (n = 27; DAS-28 > 3.2) and inactive RA patients (n = 17; DAS-28 < 3.2). A control group of healthy individuals was also studied (n = 33). Clinical and biochemical characteristics, cholesteryl ester transfer protein (CETP) and paraoxonase 1 (phenylacetate and paraoxonase) activities and carotid-femoral pulse wave velocity (cf-PWV) were determined. Results Anthropometric characteristics were similar in all groups. In accordance with the inflammatory status, active RA patients presented elevated hsCRP levels (p < 0.001). There were no differences in the lipid profile between groups. Similarly, features of insulin resistance were absent in RA patients (p = non-significant). Active RA patients presented higher CETP activity than the other two groups (p = 0.026). Phenylacetate and paraoxonase activities were altered in active RA patients in comparison with the other groups (p = 0.034 and p = 0.041, respectively). Cf-PWV was significantly higher in active RA patients in comparison with controls, following adjustment by age (p = 0.030). Age (βst = 0.468, p = 0.013) and apo A-I levels (βst = −0.405, p = 0.029) were independent predictors of cf-PWV in a model including hsCRP, HOMA-IR, and phenylacetate activity (r2 = 0.42). Conclusions High DAS-28 identifies patients with alterations in HDL characteristics. Plasma levels of apo A-I can be used as a marker of arterial stiffness in RA.Fil: Botta, Eliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Meroño, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Hospital Nacional "Profesor Alejandro Posadas"; ArgentinaFil: Saucedo, Carla. Instituto Universidad Escuela de Medicina del Hospital Italiano; ArgentinaFil: Martin, Maximiliano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Tetzlaff, Walter Francisco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Sorroche, Patricia Beatriz. Instituto Universidad Escuela de Medicina del Hospital Italiano; ArgentinaFil: Boero, Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Malah, Verónica. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Menafra, Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Gomez Rosso, Leonardo Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Chapman, John M.. Inserm; FranciaFil: Kontush, Anatol. Inserm; FranciaFil: Soriano, Enrique. Instituto Universidad Escuela de Medicina del Hospital Italiano; ArgentinaFil: Brites, Fernando Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaElsevier Ireland2016-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67268Botta, Eliana Elizabeth; Meroño, Tomás; Saucedo, Carla; Martin, Maximiliano Emanuel; Tetzlaff, Walter Francisco; et al.; Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis; Elsevier Ireland; Atherosclerosis; 251; 8-2016; 438-4440021-9150CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.atherosclerosis.2016.06.009info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0021915016302544info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:14Zoai:ri.conicet.gov.ar:11336/67268instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:14.38CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis
title Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis
spellingShingle Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis
Botta, Eliana Elizabeth
Arterial Rigidity
Atherosclerosis
Cholesteryl Ester Transfer Protein
Hdl
Paraoxonase
Pulse Wave Velocity
Rheumatoid Arthritis
title_short Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis
title_full Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis
title_fullStr Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis
title_full_unstemmed Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis
title_sort Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis
dc.creator.none.fl_str_mv Botta, Eliana Elizabeth
Meroño, Tomás
Saucedo, Carla
Martin, Maximiliano Emanuel
Tetzlaff, Walter Francisco
Sorroche, Patricia Beatriz
Boero, Laura
Malah, Verónica
Menafra, Martín
Gomez Rosso, Leonardo Adrián
Chapman, John M.
Kontush, Anatol
Soriano, Enrique
Brites, Fernando Daniel
author Botta, Eliana Elizabeth
author_facet Botta, Eliana Elizabeth
Meroño, Tomás
Saucedo, Carla
Martin, Maximiliano Emanuel
Tetzlaff, Walter Francisco
Sorroche, Patricia Beatriz
Boero, Laura
Malah, Verónica
Menafra, Martín
Gomez Rosso, Leonardo Adrián
Chapman, John M.
Kontush, Anatol
Soriano, Enrique
Brites, Fernando Daniel
author_role author
author2 Meroño, Tomás
Saucedo, Carla
Martin, Maximiliano Emanuel
Tetzlaff, Walter Francisco
Sorroche, Patricia Beatriz
Boero, Laura
Malah, Verónica
Menafra, Martín
Gomez Rosso, Leonardo Adrián
Chapman, John M.
Kontush, Anatol
Soriano, Enrique
Brites, Fernando Daniel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Arterial Rigidity
Atherosclerosis
Cholesteryl Ester Transfer Protein
Hdl
Paraoxonase
Pulse Wave Velocity
Rheumatoid Arthritis
topic Arterial Rigidity
Atherosclerosis
Cholesteryl Ester Transfer Protein
Hdl
Paraoxonase
Pulse Wave Velocity
Rheumatoid Arthritis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background and aims Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular disease (CVD). Measures of HDL metabolism/function were shown to be altered in RA patients with high disease activity. We aimed at evaluating the effect of HDL characteristics on arterial stiffness in RA patients classified according to the inflammatory disease activity. Methods RA patients were classified according to disease activity (DAS-28) into active RA (n = 27; DAS-28 > 3.2) and inactive RA patients (n = 17; DAS-28 < 3.2). A control group of healthy individuals was also studied (n = 33). Clinical and biochemical characteristics, cholesteryl ester transfer protein (CETP) and paraoxonase 1 (phenylacetate and paraoxonase) activities and carotid-femoral pulse wave velocity (cf-PWV) were determined. Results Anthropometric characteristics were similar in all groups. In accordance with the inflammatory status, active RA patients presented elevated hsCRP levels (p < 0.001). There were no differences in the lipid profile between groups. Similarly, features of insulin resistance were absent in RA patients (p = non-significant). Active RA patients presented higher CETP activity than the other two groups (p = 0.026). Phenylacetate and paraoxonase activities were altered in active RA patients in comparison with the other groups (p = 0.034 and p = 0.041, respectively). Cf-PWV was significantly higher in active RA patients in comparison with controls, following adjustment by age (p = 0.030). Age (βst = 0.468, p = 0.013) and apo A-I levels (βst = −0.405, p = 0.029) were independent predictors of cf-PWV in a model including hsCRP, HOMA-IR, and phenylacetate activity (r2 = 0.42). Conclusions High DAS-28 identifies patients with alterations in HDL characteristics. Plasma levels of apo A-I can be used as a marker of arterial stiffness in RA.
Fil: Botta, Eliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Meroño, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Hospital Nacional "Profesor Alejandro Posadas"; Argentina
Fil: Saucedo, Carla. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
Fil: Martin, Maximiliano Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Tetzlaff, Walter Francisco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Sorroche, Patricia Beatriz. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
Fil: Boero, Laura. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Malah, Verónica. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Menafra, Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Gomez Rosso, Leonardo Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Chapman, John M.. Inserm; Francia
Fil: Kontush, Anatol. Inserm; Francia
Fil: Soriano, Enrique. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina
Fil: Brites, Fernando Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
description Background and aims Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular disease (CVD). Measures of HDL metabolism/function were shown to be altered in RA patients with high disease activity. We aimed at evaluating the effect of HDL characteristics on arterial stiffness in RA patients classified according to the inflammatory disease activity. Methods RA patients were classified according to disease activity (DAS-28) into active RA (n = 27; DAS-28 > 3.2) and inactive RA patients (n = 17; DAS-28 < 3.2). A control group of healthy individuals was also studied (n = 33). Clinical and biochemical characteristics, cholesteryl ester transfer protein (CETP) and paraoxonase 1 (phenylacetate and paraoxonase) activities and carotid-femoral pulse wave velocity (cf-PWV) were determined. Results Anthropometric characteristics were similar in all groups. In accordance with the inflammatory status, active RA patients presented elevated hsCRP levels (p < 0.001). There were no differences in the lipid profile between groups. Similarly, features of insulin resistance were absent in RA patients (p = non-significant). Active RA patients presented higher CETP activity than the other two groups (p = 0.026). Phenylacetate and paraoxonase activities were altered in active RA patients in comparison with the other groups (p = 0.034 and p = 0.041, respectively). Cf-PWV was significantly higher in active RA patients in comparison with controls, following adjustment by age (p = 0.030). Age (βst = 0.468, p = 0.013) and apo A-I levels (βst = −0.405, p = 0.029) were independent predictors of cf-PWV in a model including hsCRP, HOMA-IR, and phenylacetate activity (r2 = 0.42). Conclusions High DAS-28 identifies patients with alterations in HDL characteristics. Plasma levels of apo A-I can be used as a marker of arterial stiffness in RA.
publishDate 2016
dc.date.none.fl_str_mv 2016-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67268
Botta, Eliana Elizabeth; Meroño, Tomás; Saucedo, Carla; Martin, Maximiliano Emanuel; Tetzlaff, Walter Francisco; et al.; Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis; Elsevier Ireland; Atherosclerosis; 251; 8-2016; 438-444
0021-9150
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67268
identifier_str_mv Botta, Eliana Elizabeth; Meroño, Tomás; Saucedo, Carla; Martin, Maximiliano Emanuel; Tetzlaff, Walter Francisco; et al.; Associations between disease activity, markers of HDL functionality and arterial stiffness in patients with rheumatoid arthritis; Elsevier Ireland; Atherosclerosis; 251; 8-2016; 438-444
0021-9150
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.atherosclerosis.2016.06.009
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0021915016302544
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268961694023680
score 13.13397

Publicaciones similares