Placental oxidative status in rural residents environmentally exposed to organophosphates

Autores
Chiapella, Graciela; Genti de Raimondi, Susana; Magnarelli, Gladis Griselda
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The impact of environmental organophosphate pesticide exposure on the placenta oxidative status was assessed. Placental samples were collected from women residing in an agricultural area during pesticide pulverization period, non-pulverization period and from control group. Carboxylesterase activity was significantly decreased in pulverization period group. Enzymatic and non-enzymatic defense system, the oxidative stress biomarkers and the nuclear factor erythroid 2-related factor levels showed no differences among groups. However, in the pulverization period group, an inverse association between catalase activity and placental index, a useful metric for estimating placental inefficiency, was found. This result suggests that catalase may serve as a potential placental biomarker of susceptibility to pesticides. Further studies designed from a gene-environment perspective are needed.
Fil: Chiapella, Graciela. Universidad Nacional del Comahue. Facultad de Medicina; Argentina
Fil: Genti de Raimondi, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Magnarelli, Gladis Griselda. Universidad Nacional del Comahue. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CATALASE
PESTICIDES
PLACENTA
PLACENTAL INDEX
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/185940
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Placental oxidative status in rural residents environmentally exposed to organophosphatesChiapella, GracielaGenti de Raimondi, SusanaMagnarelli, Gladis GriseldaCATALASEPESTICIDESPLACENTAPLACENTAL INDEXhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The impact of environmental organophosphate pesticide exposure on the placenta oxidative status was assessed. Placental samples were collected from women residing in an agricultural area during pesticide pulverization period, non-pulverization period and from control group. Carboxylesterase activity was significantly decreased in pulverization period group. Enzymatic and non-enzymatic defense system, the oxidative stress biomarkers and the nuclear factor erythroid 2-related factor levels showed no differences among groups. However, in the pulverization period group, an inverse association between catalase activity and placental index, a useful metric for estimating placental inefficiency, was found. This result suggests that catalase may serve as a potential placental biomarker of susceptibility to pesticides. Further studies designed from a gene-environment perspective are needed.Fil: Chiapella, Graciela. Universidad Nacional del Comahue. Facultad de Medicina; ArgentinaFil: Genti de Raimondi, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Magnarelli, Gladis Griselda. Universidad Nacional del Comahue. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/185940Chiapella, Graciela; Genti de Raimondi, Susana; Magnarelli, Gladis Griselda; Placental oxidative status in rural residents environmentally exposed to organophosphates; Elsevier Science; Environmental Toxicology and Pharmacology; 38; 1; 7-2014; 220-2291382-6689CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1382668914001446?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2014.06.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:13:22Zoai:ri.conicet.gov.ar:11336/185940instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:13:22.994CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Placental oxidative status in rural residents environmentally exposed to organophosphates
title Placental oxidative status in rural residents environmentally exposed to organophosphates
spellingShingle Placental oxidative status in rural residents environmentally exposed to organophosphates
Chiapella, Graciela
CATALASE
PESTICIDES
PLACENTA
PLACENTAL INDEX
title_short Placental oxidative status in rural residents environmentally exposed to organophosphates
title_full Placental oxidative status in rural residents environmentally exposed to organophosphates
title_fullStr Placental oxidative status in rural residents environmentally exposed to organophosphates
title_full_unstemmed Placental oxidative status in rural residents environmentally exposed to organophosphates
title_sort Placental oxidative status in rural residents environmentally exposed to organophosphates
dc.creator.none.fl_str_mv Chiapella, Graciela
Genti de Raimondi, Susana
Magnarelli, Gladis Griselda
author Chiapella, Graciela
author_facet Chiapella, Graciela
Genti de Raimondi, Susana
Magnarelli, Gladis Griselda
author_role author
author2 Genti de Raimondi, Susana
Magnarelli, Gladis Griselda
author2_role author
author
dc.subject.none.fl_str_mv CATALASE
PESTICIDES
PLACENTA
PLACENTAL INDEX
topic CATALASE
PESTICIDES
PLACENTA
PLACENTAL INDEX
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The impact of environmental organophosphate pesticide exposure on the placenta oxidative status was assessed. Placental samples were collected from women residing in an agricultural area during pesticide pulverization period, non-pulverization period and from control group. Carboxylesterase activity was significantly decreased in pulverization period group. Enzymatic and non-enzymatic defense system, the oxidative stress biomarkers and the nuclear factor erythroid 2-related factor levels showed no differences among groups. However, in the pulverization period group, an inverse association between catalase activity and placental index, a useful metric for estimating placental inefficiency, was found. This result suggests that catalase may serve as a potential placental biomarker of susceptibility to pesticides. Further studies designed from a gene-environment perspective are needed.
Fil: Chiapella, Graciela. Universidad Nacional del Comahue. Facultad de Medicina; Argentina
Fil: Genti de Raimondi, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Magnarelli, Gladis Griselda. Universidad Nacional del Comahue. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The impact of environmental organophosphate pesticide exposure on the placenta oxidative status was assessed. Placental samples were collected from women residing in an agricultural area during pesticide pulverization period, non-pulverization period and from control group. Carboxylesterase activity was significantly decreased in pulverization period group. Enzymatic and non-enzymatic defense system, the oxidative stress biomarkers and the nuclear factor erythroid 2-related factor levels showed no differences among groups. However, in the pulverization period group, an inverse association between catalase activity and placental index, a useful metric for estimating placental inefficiency, was found. This result suggests that catalase may serve as a potential placental biomarker of susceptibility to pesticides. Further studies designed from a gene-environment perspective are needed.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/185940
Chiapella, Graciela; Genti de Raimondi, Susana; Magnarelli, Gladis Griselda; Placental oxidative status in rural residents environmentally exposed to organophosphates; Elsevier Science; Environmental Toxicology and Pharmacology; 38; 1; 7-2014; 220-229
1382-6689
CONICET Digital
CONICET
url http://hdl.handle.net/11336/185940
identifier_str_mv Chiapella, Graciela; Genti de Raimondi, Susana; Magnarelli, Gladis Griselda; Placental oxidative status in rural residents environmentally exposed to organophosphates; Elsevier Science; Environmental Toxicology and Pharmacology; 38; 1; 7-2014; 220-229
1382-6689
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1382668914001446?via%3Dihub
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2014.06.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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