AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features

Autores
Rodig, Scott J.; Ouyang, Jing; Juszczynski, Przemyslaw; Currie, Treeve; Law, Kenneth; Neuberg, Donna S.; Rabinovich, Gabriel Adrián; Shipp, Margaret A.; Kutok, Jeffery L.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Galectin-1 is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in Hodgkin Reed-Sternberg cells. We recently found that Reed Sternberg cell Gal-1 promotes the immunosuppressive T helper2/ T-regulatory cell-skewed microenvironment in classic Hodgkin lymphoma (cHL). We sought to investigate whether the the coordinate expression of activated AP1 pathway components and Gal-1 serves as a diagnostic signature of cHL. In addition, because there are common signaling and survival pahtways in cHL and additional non-Hodgkin lymphomas, we also evaluated whether the AP1/Gal1 signature is shared by other molecularly or morphologically related lymhomas. Our findings establish a functional AP1 signature that incluses Gal-1 expression in cHL and ALCL, and suggests a common mechanmism for tumor immunotolerance in these diseases. In addition, the combination of Gal1 and c-Jun serve as diagnostic biomarkers that delineate cHL and ALCL from other lymphomas with shared morphologic and/or molecular features.
Fil: Rodig, Scott J.. Harvard Medical School; Estados Unidos
Fil: Ouyang, Jing. Dana Farber Cancer Institute; Estados Unidos
Fil: Juszczynski, Przemyslaw. Dana Farber Cancer Institute; Estados Unidos
Fil: Currie, Treeve. Harvard Medical School; Estados Unidos
Fil: Law, Kenneth. Harvard Medical School; Estados Unidos
Fil: Neuberg, Donna S.. Dana Farber Cancer Institute; Estados Unidos
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Shipp, Margaret A.. Dana Farber Cancer Institute; Estados Unidos
Fil: Kutok, Jeffery L.. Harvard Medical School; Estados Unidos
Materia
Lymphomas
Galectin-1
Ap-1
Signature
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25866
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/25866
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular featuresRodig, Scott J.Ouyang, JingJuszczynski, PrzemyslawCurrie, TreeveLaw, KennethNeuberg, Donna S.Rabinovich, Gabriel AdriánShipp, Margaret A.Kutok, Jeffery L.LymphomasGalectin-1Ap-1Signaturehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Galectin-1 is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in Hodgkin Reed-Sternberg cells. We recently found that Reed Sternberg cell Gal-1 promotes the immunosuppressive T helper2/ T-regulatory cell-skewed microenvironment in classic Hodgkin lymphoma (cHL). We sought to investigate whether the the coordinate expression of activated AP1 pathway components and Gal-1 serves as a diagnostic signature of cHL. In addition, because there are common signaling and survival pahtways in cHL and additional non-Hodgkin lymphomas, we also evaluated whether the AP1/Gal1 signature is shared by other molecularly or morphologically related lymhomas. Our findings establish a functional AP1 signature that incluses Gal-1 expression in cHL and ALCL, and suggests a common mechanmism for tumor immunotolerance in these diseases. In addition, the combination of Gal1 and c-Jun serve as diagnostic biomarkers that delineate cHL and ALCL from other lymphomas with shared morphologic and/or molecular features.Fil: Rodig, Scott J.. Harvard Medical School; Estados UnidosFil: Ouyang, Jing. Dana Farber Cancer Institute; Estados UnidosFil: Juszczynski, Przemyslaw. Dana Farber Cancer Institute; Estados UnidosFil: Currie, Treeve. Harvard Medical School; Estados UnidosFil: Law, Kenneth. Harvard Medical School; Estados UnidosFil: Neuberg, Donna S.. Dana Farber Cancer Institute; Estados UnidosFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Shipp, Margaret A.. Dana Farber Cancer Institute; Estados UnidosFil: Kutok, Jeffery L.. Harvard Medical School; Estados UnidosAmerican Association for Cancer Research2008-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25866Rodig, Scott J.; Ouyang, Jing; Juszczynski, Przemyslaw; Currie, Treeve; Law, Kenneth; et al.; AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features; American Association for Cancer Research; Clinical Cancer Research; 14; 11; 6-2008; 3338-33441078-04321078-0432CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18519761info:eu-repo/semantics/altIdentifier/doi/10.1158/1078-0432.CCR-07-4709info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:27Zoai:ri.conicet.gov.ar:11336/25866instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:27.638CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features
title AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features
spellingShingle AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features
Rodig, Scott J.
Lymphomas
Galectin-1
Ap-1
Signature
title_short AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features
title_full AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features
title_fullStr AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features
title_full_unstemmed AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features
title_sort AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features
dc.creator.none.fl_str_mv Rodig, Scott J.
Ouyang, Jing
Juszczynski, Przemyslaw
Currie, Treeve
Law, Kenneth
Neuberg, Donna S.
Rabinovich, Gabriel Adrián
Shipp, Margaret A.
Kutok, Jeffery L.
author Rodig, Scott J.
author_facet Rodig, Scott J.
Ouyang, Jing
Juszczynski, Przemyslaw
Currie, Treeve
Law, Kenneth
Neuberg, Donna S.
Rabinovich, Gabriel Adrián
Shipp, Margaret A.
Kutok, Jeffery L.
author_role author
author2 Ouyang, Jing
Juszczynski, Przemyslaw
Currie, Treeve
Law, Kenneth
Neuberg, Donna S.
Rabinovich, Gabriel Adrián
Shipp, Margaret A.
Kutok, Jeffery L.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lymphomas
Galectin-1
Ap-1
Signature
topic Lymphomas
Galectin-1
Ap-1
Signature
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Galectin-1 is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in Hodgkin Reed-Sternberg cells. We recently found that Reed Sternberg cell Gal-1 promotes the immunosuppressive T helper2/ T-regulatory cell-skewed microenvironment in classic Hodgkin lymphoma (cHL). We sought to investigate whether the the coordinate expression of activated AP1 pathway components and Gal-1 serves as a diagnostic signature of cHL. In addition, because there are common signaling and survival pahtways in cHL and additional non-Hodgkin lymphomas, we also evaluated whether the AP1/Gal1 signature is shared by other molecularly or morphologically related lymhomas. Our findings establish a functional AP1 signature that incluses Gal-1 expression in cHL and ALCL, and suggests a common mechanmism for tumor immunotolerance in these diseases. In addition, the combination of Gal1 and c-Jun serve as diagnostic biomarkers that delineate cHL and ALCL from other lymphomas with shared morphologic and/or molecular features.
Fil: Rodig, Scott J.. Harvard Medical School; Estados Unidos
Fil: Ouyang, Jing. Dana Farber Cancer Institute; Estados Unidos
Fil: Juszczynski, Przemyslaw. Dana Farber Cancer Institute; Estados Unidos
Fil: Currie, Treeve. Harvard Medical School; Estados Unidos
Fil: Law, Kenneth. Harvard Medical School; Estados Unidos
Fil: Neuberg, Donna S.. Dana Farber Cancer Institute; Estados Unidos
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Shipp, Margaret A.. Dana Farber Cancer Institute; Estados Unidos
Fil: Kutok, Jeffery L.. Harvard Medical School; Estados Unidos
description Galectin-1 is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in Hodgkin Reed-Sternberg cells. We recently found that Reed Sternberg cell Gal-1 promotes the immunosuppressive T helper2/ T-regulatory cell-skewed microenvironment in classic Hodgkin lymphoma (cHL). We sought to investigate whether the the coordinate expression of activated AP1 pathway components and Gal-1 serves as a diagnostic signature of cHL. In addition, because there are common signaling and survival pahtways in cHL and additional non-Hodgkin lymphomas, we also evaluated whether the AP1/Gal1 signature is shared by other molecularly or morphologically related lymhomas. Our findings establish a functional AP1 signature that incluses Gal-1 expression in cHL and ALCL, and suggests a common mechanmism for tumor immunotolerance in these diseases. In addition, the combination of Gal1 and c-Jun serve as diagnostic biomarkers that delineate cHL and ALCL from other lymphomas with shared morphologic and/or molecular features.
publishDate 2008
dc.date.none.fl_str_mv 2008-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25866
Rodig, Scott J.; Ouyang, Jing; Juszczynski, Przemyslaw; Currie, Treeve; Law, Kenneth; et al.; AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features; American Association for Cancer Research; Clinical Cancer Research; 14; 11; 6-2008; 3338-3344
1078-0432
1078-0432
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25866
identifier_str_mv Rodig, Scott J.; Ouyang, Jing; Juszczynski, Przemyslaw; Currie, Treeve; Law, Kenneth; et al.; AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features; American Association for Cancer Research; Clinical Cancer Research; 14; 11; 6-2008; 3338-3344
1078-0432
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18519761
info:eu-repo/semantics/altIdentifier/doi/10.1158/1078-0432.CCR-07-4709
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for Cancer Research
publisher.none.fl_str_mv American Association for Cancer Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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