1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution

Autores
Clop, Eduardo Matias; Perillo, Maria Angelica; Chattah, Ana Karina
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nuclear magnetic resonance spin–lattice relaxation times (T1) measurements were performed in aqueous solutions of poly(ethylene glycol) (PEG) of 6000 Da molecular mass to study the dynamical relation between PEG and water molecules at different solute concentrations. 1H–T1 experiments were carried on at a low magnetic field in the time domain (20 MHz) and at a high field (400 MHz) to obtain spectral resolution. Two contributing components were identified in each proton system, PEG and water, presenting values of T1 with very different orders of magnitude. The approximate matching between the shorter 1H–T1 values associated with water and PEG has lead us to conclude that there exists a network of interactions (hydrogen bonds) between the solute and the solvent, which results in the presence of an ordered and dehydrated structure of PEG folded or self-assembled in equilibrium with a more flexible monomer structure. Dynamic light scattering results were consistent with the formation of PEG aggregates, showing a mean size between 40 and 100 nm.
Fil: Clop, Eduardo Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Perillo, Maria Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Materia
Relaxation Times
Peg Aggregation
Dynamic Light Scattering
Water Dynamics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42449
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solutionClop, Eduardo MatiasPerillo, Maria AngelicaChattah, Ana KarinaRelaxation TimesPeg AggregationDynamic Light ScatteringWater Dynamicshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Nuclear magnetic resonance spin–lattice relaxation times (T1) measurements were performed in aqueous solutions of poly(ethylene glycol) (PEG) of 6000 Da molecular mass to study the dynamical relation between PEG and water molecules at different solute concentrations. 1H–T1 experiments were carried on at a low magnetic field in the time domain (20 MHz) and at a high field (400 MHz) to obtain spectral resolution. Two contributing components were identified in each proton system, PEG and water, presenting values of T1 with very different orders of magnitude. The approximate matching between the shorter 1H–T1 values associated with water and PEG has lead us to conclude that there exists a network of interactions (hydrogen bonds) between the solute and the solvent, which results in the presence of an ordered and dehydrated structure of PEG folded or self-assembled in equilibrium with a more flexible monomer structure. Dynamic light scattering results were consistent with the formation of PEG aggregates, showing a mean size between 40 and 100 nm.Fil: Clop, Eduardo Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Perillo, Maria Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaAmerican Chemical Society2012-09-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42449Clop, Eduardo Matias; Perillo, Maria Angelica; Chattah, Ana Karina; 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution; American Chemical Society; Journal of Physical Chemistry B; 116; 39; 7-9-2012; 11953-119581520-61061520-5207CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/jp304569ainfo:eu-repo/semantics/altIdentifier/doi/10.1021/jp304569ainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:06:40Zoai:ri.conicet.gov.ar:11336/42449instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:06:41.22CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution
title 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution
spellingShingle 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution
Clop, Eduardo Matias
Relaxation Times
Peg Aggregation
Dynamic Light Scattering
Water Dynamics
title_short 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution
title_full 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution
title_fullStr 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution
title_full_unstemmed 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution
title_sort 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution
dc.creator.none.fl_str_mv Clop, Eduardo Matias
Perillo, Maria Angelica
Chattah, Ana Karina
author Clop, Eduardo Matias
author_facet Clop, Eduardo Matias
Perillo, Maria Angelica
Chattah, Ana Karina
author_role author
author2 Perillo, Maria Angelica
Chattah, Ana Karina
author2_role author
author
dc.subject.none.fl_str_mv Relaxation Times
Peg Aggregation
Dynamic Light Scattering
Water Dynamics
topic Relaxation Times
Peg Aggregation
Dynamic Light Scattering
Water Dynamics
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Nuclear magnetic resonance spin–lattice relaxation times (T1) measurements were performed in aqueous solutions of poly(ethylene glycol) (PEG) of 6000 Da molecular mass to study the dynamical relation between PEG and water molecules at different solute concentrations. 1H–T1 experiments were carried on at a low magnetic field in the time domain (20 MHz) and at a high field (400 MHz) to obtain spectral resolution. Two contributing components were identified in each proton system, PEG and water, presenting values of T1 with very different orders of magnitude. The approximate matching between the shorter 1H–T1 values associated with water and PEG has lead us to conclude that there exists a network of interactions (hydrogen bonds) between the solute and the solvent, which results in the presence of an ordered and dehydrated structure of PEG folded or self-assembled in equilibrium with a more flexible monomer structure. Dynamic light scattering results were consistent with the formation of PEG aggregates, showing a mean size between 40 and 100 nm.
Fil: Clop, Eduardo Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Perillo, Maria Angelica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Chattah, Ana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
description Nuclear magnetic resonance spin–lattice relaxation times (T1) measurements were performed in aqueous solutions of poly(ethylene glycol) (PEG) of 6000 Da molecular mass to study the dynamical relation between PEG and water molecules at different solute concentrations. 1H–T1 experiments were carried on at a low magnetic field in the time domain (20 MHz) and at a high field (400 MHz) to obtain spectral resolution. Two contributing components were identified in each proton system, PEG and water, presenting values of T1 with very different orders of magnitude. The approximate matching between the shorter 1H–T1 values associated with water and PEG has lead us to conclude that there exists a network of interactions (hydrogen bonds) between the solute and the solvent, which results in the presence of an ordered and dehydrated structure of PEG folded or self-assembled in equilibrium with a more flexible monomer structure. Dynamic light scattering results were consistent with the formation of PEG aggregates, showing a mean size between 40 and 100 nm.
publishDate 2012
dc.date.none.fl_str_mv 2012-09-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42449
Clop, Eduardo Matias; Perillo, Maria Angelica; Chattah, Ana Karina; 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution; American Chemical Society; Journal of Physical Chemistry B; 116; 39; 7-9-2012; 11953-11958
1520-6106
1520-5207
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42449
identifier_str_mv Clop, Eduardo Matias; Perillo, Maria Angelica; Chattah, Ana Karina; 1H and 2H NMR spin–lattice relaxation probing water: PEG molecular dynamics in solution; American Chemical Society; Journal of Physical Chemistry B; 116; 39; 7-9-2012; 11953-11958
1520-6106
1520-5207
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/jp304569a
info:eu-repo/semantics/altIdentifier/doi/10.1021/jp304569a
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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