Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action

Autores
Soberon, Jose Rodolfo; Lizarraga, Emilio Fernando; Sgariglia, Melina Araceli; Carrasco Juarez, Marisa B.; Sampietro, Diego Alejandro; Ben Altabef, Aida; Catalan, Cesar Atilio Nazareno; Vattuone, Marta Amelia
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The main secondary metabolite of Senecio nutans is 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone (4HMBA). The antifungal activity of this compound and three derivatives was assessed using Candida albicans. 4HMBA exhibited the highest antifungal activity among the assayed compounds. The Fractional Inhibitory Concentration (FIC = 0.133) indicated a synergistic fungicidal effect of 4HMBA (5 mg L-1) and fluconazole (FLU) (0.5 mg L-1) against the C. albicans reference strain (ATCC 10231). Microscopy showed that 4HMBA inhibits filamentation and reduces cell wall thickness. Our findings s suggest that 4HMBA is an interesting compound to diminish resistance to commercial fungistatic drugs such as fluconazole
Fil: Soberon, Jose Rodolfo. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Quimica Fisica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lizarraga, Emilio Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán; Argentina
Fil: Sgariglia, Melina Araceli. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carrasco Juarez, Marisa B.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Sampietro, Diego Alejandro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ben Altabef, Aida. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán; Argentina
Fil: Vattuone, Marta Amelia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
4-Hydroxy-3-(3-Methyl-2- Butenyl)Acetophenone
Antifungal Activity
Candida Albicans
Filamentation
Fungal Cell Wall
Synergistic Effect
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6739
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6739
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of actionSoberon, Jose RodolfoLizarraga, Emilio FernandoSgariglia, Melina AraceliCarrasco Juarez, Marisa B.Sampietro, Diego AlejandroBen Altabef, AidaCatalan, Cesar Atilio NazarenoVattuone, Marta Amelia4-Hydroxy-3-(3-Methyl-2- Butenyl)AcetophenoneAntifungal ActivityCandida AlbicansFilamentationFungal Cell WallSynergistic Effecthttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The main secondary metabolite of Senecio nutans is 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone (4HMBA). The antifungal activity of this compound and three derivatives was assessed using Candida albicans. 4HMBA exhibited the highest antifungal activity among the assayed compounds. The Fractional Inhibitory Concentration (FIC = 0.133) indicated a synergistic fungicidal effect of 4HMBA (5 mg L-1) and fluconazole (FLU) (0.5 mg L-1) against the C. albicans reference strain (ATCC 10231). Microscopy showed that 4HMBA inhibits filamentation and reduces cell wall thickness. Our findings s suggest that 4HMBA is an interesting compound to diminish resistance to commercial fungistatic drugs such as fluconazoleFil: Soberon, Jose Rodolfo. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Quimica Fisica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lizarraga, Emilio Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán; ArgentinaFil: Sgariglia, Melina Araceli. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carrasco Juarez, Marisa B.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Sampietro, Diego Alejandro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ben Altabef, Aida. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán; ArgentinaFil: Vattuone, Marta Amelia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSpringer2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6739Soberon, Jose Rodolfo; Lizarraga, Emilio Fernando; Sgariglia, Melina Araceli; Carrasco Juarez, Marisa B.; Sampietro, Diego Alejandro; et al.; Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action; Springer; Anton Leeuw Int. J. G.; 108; 5; 10-2015; 1047-10570003-6072enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1007/s10482-015-0559-3info:eu-repo/semantics/altIdentifier/pmid/26342699info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs10482-015-0559-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:01:00Zoai:ri.conicet.gov.ar:11336/6739instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:01:00.49CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action
title Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action
spellingShingle Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action
Soberon, Jose Rodolfo
4-Hydroxy-3-(3-Methyl-2- Butenyl)Acetophenone
Antifungal Activity
Candida Albicans
Filamentation
Fungal Cell Wall
Synergistic Effect
title_short Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action
title_full Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action
title_fullStr Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action
title_full_unstemmed Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action
title_sort Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action
dc.creator.none.fl_str_mv Soberon, Jose Rodolfo
Lizarraga, Emilio Fernando
Sgariglia, Melina Araceli
Carrasco Juarez, Marisa B.
Sampietro, Diego Alejandro
Ben Altabef, Aida
Catalan, Cesar Atilio Nazareno
Vattuone, Marta Amelia
author Soberon, Jose Rodolfo
author_facet Soberon, Jose Rodolfo
Lizarraga, Emilio Fernando
Sgariglia, Melina Araceli
Carrasco Juarez, Marisa B.
Sampietro, Diego Alejandro
Ben Altabef, Aida
Catalan, Cesar Atilio Nazareno
Vattuone, Marta Amelia
author_role author
author2 Lizarraga, Emilio Fernando
Sgariglia, Melina Araceli
Carrasco Juarez, Marisa B.
Sampietro, Diego Alejandro
Ben Altabef, Aida
Catalan, Cesar Atilio Nazareno
Vattuone, Marta Amelia
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 4-Hydroxy-3-(3-Methyl-2- Butenyl)Acetophenone
Antifungal Activity
Candida Albicans
Filamentation
Fungal Cell Wall
Synergistic Effect
topic 4-Hydroxy-3-(3-Methyl-2- Butenyl)Acetophenone
Antifungal Activity
Candida Albicans
Filamentation
Fungal Cell Wall
Synergistic Effect
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The main secondary metabolite of Senecio nutans is 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone (4HMBA). The antifungal activity of this compound and three derivatives was assessed using Candida albicans. 4HMBA exhibited the highest antifungal activity among the assayed compounds. The Fractional Inhibitory Concentration (FIC = 0.133) indicated a synergistic fungicidal effect of 4HMBA (5 mg L-1) and fluconazole (FLU) (0.5 mg L-1) against the C. albicans reference strain (ATCC 10231). Microscopy showed that 4HMBA inhibits filamentation and reduces cell wall thickness. Our findings s suggest that 4HMBA is an interesting compound to diminish resistance to commercial fungistatic drugs such as fluconazole
Fil: Soberon, Jose Rodolfo. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Quimica Fisica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lizarraga, Emilio Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán; Argentina
Fil: Sgariglia, Melina Araceli. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carrasco Juarez, Marisa B.. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Sampietro, Diego Alejandro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ben Altabef, Aida. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Universidad Nacional de Tucumán; Argentina
Fil: Vattuone, Marta Amelia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The main secondary metabolite of Senecio nutans is 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone (4HMBA). The antifungal activity of this compound and three derivatives was assessed using Candida albicans. 4HMBA exhibited the highest antifungal activity among the assayed compounds. The Fractional Inhibitory Concentration (FIC = 0.133) indicated a synergistic fungicidal effect of 4HMBA (5 mg L-1) and fluconazole (FLU) (0.5 mg L-1) against the C. albicans reference strain (ATCC 10231). Microscopy showed that 4HMBA inhibits filamentation and reduces cell wall thickness. Our findings s suggest that 4HMBA is an interesting compound to diminish resistance to commercial fungistatic drugs such as fluconazole
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6739
Soberon, Jose Rodolfo; Lizarraga, Emilio Fernando; Sgariglia, Melina Araceli; Carrasco Juarez, Marisa B.; Sampietro, Diego Alejandro; et al.; Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action; Springer; Anton Leeuw Int. J. G.; 108; 5; 10-2015; 1047-1057
0003-6072
url http://hdl.handle.net/11336/6739
identifier_str_mv Soberon, Jose Rodolfo; Lizarraga, Emilio Fernando; Sgariglia, Melina Araceli; Carrasco Juarez, Marisa B.; Sampietro, Diego Alejandro; et al.; Antifungal activity of 4-hydroxy-3-(3-methyl-2- butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action; Springer; Anton Leeuw Int. J. G.; 108; 5; 10-2015; 1047-1057
0003-6072
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10482-015-0559-3
info:eu-repo/semantics/altIdentifier/pmid/26342699
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs10482-015-0559-3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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