Immune cell subtypes and their function in the testis

Autores
Bhushan, Sudhanshu; Theas, Maria Susana; Guazzone, Vanesa Anabella; Jacobo, Patricia Verónica; Wang, Ming; Fijak, Monika; Meinhardt, Andreas; Lustig, Livia
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Immunoregulation in the testis is characterized by a balance between immuno-suppression (or immune privilege) and the ability to react to infections and inflammation. In this review, we analyze the phenotypes of the various immune cell subtypes present in the testis, and how their functions change between homeostatic and inflammatory conditions. Starting with testicular macrophages, we explore how this heterogeneous population is shaped by the testicular microenvironment to ensure immune privilege. We then describe how dendritic cells exhibit a tolerogenic status under normal conditions, but proliferate, mature and then stimulate effector T-cell expansion under inflammatory conditions. Finally, we outline the two T-cell populations in the testis: CD4+/CD8+ αβ T cells and CD4+/CD8+ Foxp3+ regulatory T cells and describe the distribution and function of mast cells. All these cells help modulate innate immunity and regulate the immune response. By improving our understanding of immune cell behavior in the testis under normal and inflammatory conditions, we will be better placed to evaluate testis impairment due to immune mechanisms in affected patients.
Fil: Bhushan, Sudhanshu. Justus Liebig Universitat Giessen.; Alemania
Fil: Theas, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Guazzone, Vanesa Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Jacobo, Patricia Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Wang, Ming. The First Affiliated Hospital; China
Fil: Fijak, Monika. Justus Liebig Universitat Giessen.; Alemania
Fil: Meinhardt, Andreas. Justus Liebig Universitat Giessen.; Alemania
Fil: Lustig, Livia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Materia
DENDRITIC CELLS
IMMUNE PRIVILEGE
MACROPHAGES
MAST CELLS
T LYMPHOCYTES
TESTIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/136730
Acceder
id CONICETDig_b044d6cf0934bb564f0e92cbf53aaecd
oai_identifier_str oai:ri.conicet.gov.ar:11336/136730
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immune cell subtypes and their function in the testisBhushan, SudhanshuTheas, Maria SusanaGuazzone, Vanesa AnabellaJacobo, Patricia VerónicaWang, MingFijak, MonikaMeinhardt, AndreasLustig, LiviaDENDRITIC CELLSIMMUNE PRIVILEGEMACROPHAGESMAST CELLST LYMPHOCYTESTESTIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Immunoregulation in the testis is characterized by a balance between immuno-suppression (or immune privilege) and the ability to react to infections and inflammation. In this review, we analyze the phenotypes of the various immune cell subtypes present in the testis, and how their functions change between homeostatic and inflammatory conditions. Starting with testicular macrophages, we explore how this heterogeneous population is shaped by the testicular microenvironment to ensure immune privilege. We then describe how dendritic cells exhibit a tolerogenic status under normal conditions, but proliferate, mature and then stimulate effector T-cell expansion under inflammatory conditions. Finally, we outline the two T-cell populations in the testis: CD4+/CD8+ αβ T cells and CD4+/CD8+ Foxp3+ regulatory T cells and describe the distribution and function of mast cells. All these cells help modulate innate immunity and regulate the immune response. By improving our understanding of immune cell behavior in the testis under normal and inflammatory conditions, we will be better placed to evaluate testis impairment due to immune mechanisms in affected patients.Fil: Bhushan, Sudhanshu. Justus Liebig Universitat Giessen.; AlemaniaFil: Theas, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Guazzone, Vanesa Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Jacobo, Patricia Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Wang, Ming. The First Affiliated Hospital; ChinaFil: Fijak, Monika. Justus Liebig Universitat Giessen.; AlemaniaFil: Meinhardt, Andreas. Justus Liebig Universitat Giessen.; AlemaniaFil: Lustig, Livia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFrontiers Media S.A.2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/136730Bhushan, Sudhanshu; Theas, Maria Susana; Guazzone, Vanesa Anabella; Jacobo, Patricia Verónica; Wang, Ming; et al.; Immune cell subtypes and their function in the testis; Frontiers Media S.A.; Frontiers in Immunology; 11; 9-2020; 1-71664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fimmu.2020.583304/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2020.583304info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:18Zoai:ri.conicet.gov.ar:11336/136730instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:18.984CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immune cell subtypes and their function in the testis
title Immune cell subtypes and their function in the testis
spellingShingle Immune cell subtypes and their function in the testis
Bhushan, Sudhanshu
DENDRITIC CELLS
IMMUNE PRIVILEGE
MACROPHAGES
MAST CELLS
T LYMPHOCYTES
TESTIS
title_short Immune cell subtypes and their function in the testis
title_full Immune cell subtypes and their function in the testis
title_fullStr Immune cell subtypes and their function in the testis
title_full_unstemmed Immune cell subtypes and their function in the testis
title_sort Immune cell subtypes and their function in the testis
dc.creator.none.fl_str_mv Bhushan, Sudhanshu
Theas, Maria Susana
Guazzone, Vanesa Anabella
Jacobo, Patricia Verónica
Wang, Ming
Fijak, Monika
Meinhardt, Andreas
Lustig, Livia
author Bhushan, Sudhanshu
author_facet Bhushan, Sudhanshu
Theas, Maria Susana
Guazzone, Vanesa Anabella
Jacobo, Patricia Verónica
Wang, Ming
Fijak, Monika
Meinhardt, Andreas
Lustig, Livia
author_role author
author2 Theas, Maria Susana
Guazzone, Vanesa Anabella
Jacobo, Patricia Verónica
Wang, Ming
Fijak, Monika
Meinhardt, Andreas
Lustig, Livia
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DENDRITIC CELLS
IMMUNE PRIVILEGE
MACROPHAGES
MAST CELLS
T LYMPHOCYTES
TESTIS
topic DENDRITIC CELLS
IMMUNE PRIVILEGE
MACROPHAGES
MAST CELLS
T LYMPHOCYTES
TESTIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Immunoregulation in the testis is characterized by a balance between immuno-suppression (or immune privilege) and the ability to react to infections and inflammation. In this review, we analyze the phenotypes of the various immune cell subtypes present in the testis, and how their functions change between homeostatic and inflammatory conditions. Starting with testicular macrophages, we explore how this heterogeneous population is shaped by the testicular microenvironment to ensure immune privilege. We then describe how dendritic cells exhibit a tolerogenic status under normal conditions, but proliferate, mature and then stimulate effector T-cell expansion under inflammatory conditions. Finally, we outline the two T-cell populations in the testis: CD4+/CD8+ αβ T cells and CD4+/CD8+ Foxp3+ regulatory T cells and describe the distribution and function of mast cells. All these cells help modulate innate immunity and regulate the immune response. By improving our understanding of immune cell behavior in the testis under normal and inflammatory conditions, we will be better placed to evaluate testis impairment due to immune mechanisms in affected patients.
Fil: Bhushan, Sudhanshu. Justus Liebig Universitat Giessen.; Alemania
Fil: Theas, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Guazzone, Vanesa Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Jacobo, Patricia Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Wang, Ming. The First Affiliated Hospital; China
Fil: Fijak, Monika. Justus Liebig Universitat Giessen.; Alemania
Fil: Meinhardt, Andreas. Justus Liebig Universitat Giessen.; Alemania
Fil: Lustig, Livia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
description Immunoregulation in the testis is characterized by a balance between immuno-suppression (or immune privilege) and the ability to react to infections and inflammation. In this review, we analyze the phenotypes of the various immune cell subtypes present in the testis, and how their functions change between homeostatic and inflammatory conditions. Starting with testicular macrophages, we explore how this heterogeneous population is shaped by the testicular microenvironment to ensure immune privilege. We then describe how dendritic cells exhibit a tolerogenic status under normal conditions, but proliferate, mature and then stimulate effector T-cell expansion under inflammatory conditions. Finally, we outline the two T-cell populations in the testis: CD4+/CD8+ αβ T cells and CD4+/CD8+ Foxp3+ regulatory T cells and describe the distribution and function of mast cells. All these cells help modulate innate immunity and regulate the immune response. By improving our understanding of immune cell behavior in the testis under normal and inflammatory conditions, we will be better placed to evaluate testis impairment due to immune mechanisms in affected patients.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/136730
Bhushan, Sudhanshu; Theas, Maria Susana; Guazzone, Vanesa Anabella; Jacobo, Patricia Verónica; Wang, Ming; et al.; Immune cell subtypes and their function in the testis; Frontiers Media S.A.; Frontiers in Immunology; 11; 9-2020; 1-7
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/136730
identifier_str_mv Bhushan, Sudhanshu; Theas, Maria Susana; Guazzone, Vanesa Anabella; Jacobo, Patricia Verónica; Wang, Ming; et al.; Immune cell subtypes and their function in the testis; Frontiers Media S.A.; Frontiers in Immunology; 11; 9-2020; 1-7
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fimmu.2020.583304/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2020.583304
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269750132998144
score 13.13397

Publicaciones similares