Local actions of melatonin in somatic cells of the testis

Autores
Frungieri, Monica Beatriz; Calandra, Ricardo Saul; Rossi, Soledad Paola
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The pineal hormone melatonin regulates testicular function through the hypothalamic- adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis have been described. Melatonin acts as a local modulator of the endocrine activity in Leydig cells. In Sertoli cells, melatonin influences cellular growth, proliferation, energy metabolism and the oxidation state, and consequently may regulate spermatogenesis. These data pinpoint melatonin as a key player in the regulation of testicular physiology (i.e., steroidogenesis, spermatogenesis) mostly in seasonal breeders. In patients with idiopathic infertility, melatonin exerts anti-proliferative and anti-inflammatory effects on testicular macrophages, and provides protective effects against oxidative stress in testicular mast cells. Consequently, melatonin is also involved in the modulation of inflammatory and oxidant/anti-oxidant states in testicular pathology. Overall, the literature data indicate that melatonin has important effects on testicular function and male reproduction.
Fil: Frungieri, Monica Beatriz. Universidad de Buenos Aires. Ciclo Básico Común; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rossi, Soledad Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Materia
ANDROGEN PRODUCTION
INFERTILITY
INFLAMMATION
LEYDIG CELLS
MACROPHAGES
MAST CELLS
MELATONIN
OXIDATIVE STRESS
SERTOLI CELLS
TESTIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/63588
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/63588
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Local actions of melatonin in somatic cells of the testisFrungieri, Monica BeatrizCalandra, Ricardo SaulRossi, Soledad PaolaANDROGEN PRODUCTIONINFERTILITYINFLAMMATIONLEYDIG CELLSMACROPHAGESMAST CELLSMELATONINOXIDATIVE STRESSSERTOLI CELLSTESTIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The pineal hormone melatonin regulates testicular function through the hypothalamic- adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis have been described. Melatonin acts as a local modulator of the endocrine activity in Leydig cells. In Sertoli cells, melatonin influences cellular growth, proliferation, energy metabolism and the oxidation state, and consequently may regulate spermatogenesis. These data pinpoint melatonin as a key player in the regulation of testicular physiology (i.e., steroidogenesis, spermatogenesis) mostly in seasonal breeders. In patients with idiopathic infertility, melatonin exerts anti-proliferative and anti-inflammatory effects on testicular macrophages, and provides protective effects against oxidative stress in testicular mast cells. Consequently, melatonin is also involved in the modulation of inflammatory and oxidant/anti-oxidant states in testicular pathology. Overall, the literature data indicate that melatonin has important effects on testicular function and male reproduction.Fil: Frungieri, Monica Beatriz. Universidad de Buenos Aires. Ciclo Básico Común; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rossi, Soledad Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaMDPI AG2017-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/63588Frungieri, Monica Beatriz; Calandra, Ricardo Saul; Rossi, Soledad Paola; Local actions of melatonin in somatic cells of the testis; MDPI AG; International Journal of Molecular Sciences; 18; 6; 6-20171422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/18/6/1170info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms18061170info:eu-repo/semantics/altIdentifier/pmid/28561756info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:10Zoai:ri.conicet.gov.ar:11336/63588instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:11.052CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Local actions of melatonin in somatic cells of the testis
title Local actions of melatonin in somatic cells of the testis
spellingShingle Local actions of melatonin in somatic cells of the testis
Frungieri, Monica Beatriz
ANDROGEN PRODUCTION
INFERTILITY
INFLAMMATION
LEYDIG CELLS
MACROPHAGES
MAST CELLS
MELATONIN
OXIDATIVE STRESS
SERTOLI CELLS
TESTIS
title_short Local actions of melatonin in somatic cells of the testis
title_full Local actions of melatonin in somatic cells of the testis
title_fullStr Local actions of melatonin in somatic cells of the testis
title_full_unstemmed Local actions of melatonin in somatic cells of the testis
title_sort Local actions of melatonin in somatic cells of the testis
dc.creator.none.fl_str_mv Frungieri, Monica Beatriz
Calandra, Ricardo Saul
Rossi, Soledad Paola
author Frungieri, Monica Beatriz
author_facet Frungieri, Monica Beatriz
Calandra, Ricardo Saul
Rossi, Soledad Paola
author_role author
author2 Calandra, Ricardo Saul
Rossi, Soledad Paola
author2_role author
author
dc.subject.none.fl_str_mv ANDROGEN PRODUCTION
INFERTILITY
INFLAMMATION
LEYDIG CELLS
MACROPHAGES
MAST CELLS
MELATONIN
OXIDATIVE STRESS
SERTOLI CELLS
TESTIS
topic ANDROGEN PRODUCTION
INFERTILITY
INFLAMMATION
LEYDIG CELLS
MACROPHAGES
MAST CELLS
MELATONIN
OXIDATIVE STRESS
SERTOLI CELLS
TESTIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The pineal hormone melatonin regulates testicular function through the hypothalamic- adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis have been described. Melatonin acts as a local modulator of the endocrine activity in Leydig cells. In Sertoli cells, melatonin influences cellular growth, proliferation, energy metabolism and the oxidation state, and consequently may regulate spermatogenesis. These data pinpoint melatonin as a key player in the regulation of testicular physiology (i.e., steroidogenesis, spermatogenesis) mostly in seasonal breeders. In patients with idiopathic infertility, melatonin exerts anti-proliferative and anti-inflammatory effects on testicular macrophages, and provides protective effects against oxidative stress in testicular mast cells. Consequently, melatonin is also involved in the modulation of inflammatory and oxidant/anti-oxidant states in testicular pathology. Overall, the literature data indicate that melatonin has important effects on testicular function and male reproduction.
Fil: Frungieri, Monica Beatriz. Universidad de Buenos Aires. Ciclo Básico Común; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rossi, Soledad Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
description The pineal hormone melatonin regulates testicular function through the hypothalamic- adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis have been described. Melatonin acts as a local modulator of the endocrine activity in Leydig cells. In Sertoli cells, melatonin influences cellular growth, proliferation, energy metabolism and the oxidation state, and consequently may regulate spermatogenesis. These data pinpoint melatonin as a key player in the regulation of testicular physiology (i.e., steroidogenesis, spermatogenesis) mostly in seasonal breeders. In patients with idiopathic infertility, melatonin exerts anti-proliferative and anti-inflammatory effects on testicular macrophages, and provides protective effects against oxidative stress in testicular mast cells. Consequently, melatonin is also involved in the modulation of inflammatory and oxidant/anti-oxidant states in testicular pathology. Overall, the literature data indicate that melatonin has important effects on testicular function and male reproduction.
publishDate 2017
dc.date.none.fl_str_mv 2017-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/63588
Frungieri, Monica Beatriz; Calandra, Ricardo Saul; Rossi, Soledad Paola; Local actions of melatonin in somatic cells of the testis; MDPI AG; International Journal of Molecular Sciences; 18; 6; 6-2017
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/63588
identifier_str_mv Frungieri, Monica Beatriz; Calandra, Ricardo Saul; Rossi, Soledad Paola; Local actions of melatonin in somatic cells of the testis; MDPI AG; International Journal of Molecular Sciences; 18; 6; 6-2017
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/18/6/1170
info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms18061170
info:eu-repo/semantics/altIdentifier/pmid/28561756
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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