Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone

Autores
Rojas García, Pedro P.; Recabarren, Mónica P.; Sir Petermann, Teresa; Rey, Rodolfo Alberto; Palma, Sergio; Carrasco, Albert; Pérez Marín, Carlos C.; Padmanabhan, Vasantha; Recabarren, Sergio E.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The reprograming effects of prenatal testosterone (T) treatment on postnatal reproductive parameters have been studied extensively in females of several species but similar studies in males are limited. We recently found that prenatal T treatment increases Sertoli cell number and reduced spermatogenesis in adult rams. If such disruptions are manifested early in life and involve changes in testicular paracrine environment remain to be explored. This study addresses the impact of prenatal T excess on testicular parameters in infant males, including Sertoli cell number and expression of critical genes [FSH receptor (FSHR), androgen receptor (AR), transforming growth factor beta 1 (TGFB1), 3 (TGFB3), transforming growth factor beta type 1 receptor, (TGFBR1), and anti-Mullerian hormone (AMH)] modulating testicular function. At 4 week of age, male lambs born to dams treated with 30 mg of T propionate twice weekly from day 30 to 90, followed by 40 mg of T propionate from day 90 to 120 of pregnancy (T-males), had a higher number of Sertoli cells/ testis compared to C-males. Expression level of AMH, TGFB1, and AR also tended to be lower in T-males. These findings provide evidence that impact of fetal exposure to T excess is evident early in postnatal life, mainly characterized by an increase in Sertoli cell number. This could explain the testicular dysfunction observed in adult rams.
Fil: Rojas García, Pedro P.. Universidad de Concepción; Chile
Fil: Recabarren, Mónica P.. Universidad de Concepción; Chile
Fil: Sir Petermann, Teresa. Universidad de Santiago de Chile; Chile
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Palma, Sergio. Universidad de Concepción; Chile
Fil: Carrasco, Albert. Universidad de Concepción; Chile
Fil: Pérez Marín, Carlos C.. Universidad de Córdoba; Argentina
Fil: Padmanabhan, Vasantha. University Of Michigan; Estados Unidos
Fil: Recabarren, Sergio E.. Universidad de Concepción; Chile
Materia
Developmental Programing
Ovine
Male Reproduction
Testes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8134
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/8134
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosteroneRojas García, Pedro P.Recabarren, Mónica P.Sir Petermann, TeresaRey, Rodolfo AlbertoPalma, SergioCarrasco, AlbertPérez Marín, Carlos C.Padmanabhan, VasanthaRecabarren, Sergio E.Developmental ProgramingOvineMale ReproductionTesteshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The reprograming effects of prenatal testosterone (T) treatment on postnatal reproductive parameters have been studied extensively in females of several species but similar studies in males are limited. We recently found that prenatal T treatment increases Sertoli cell number and reduced spermatogenesis in adult rams. If such disruptions are manifested early in life and involve changes in testicular paracrine environment remain to be explored. This study addresses the impact of prenatal T excess on testicular parameters in infant males, including Sertoli cell number and expression of critical genes [FSH receptor (FSHR), androgen receptor (AR), transforming growth factor beta 1 (TGFB1), 3 (TGFB3), transforming growth factor beta type 1 receptor, (TGFBR1), and anti-Mullerian hormone (AMH)] modulating testicular function. At 4 week of age, male lambs born to dams treated with 30 mg of T propionate twice weekly from day 30 to 90, followed by 40 mg of T propionate from day 90 to 120 of pregnancy (T-males), had a higher number of Sertoli cells/ testis compared to C-males. Expression level of AMH, TGFB1, and AR also tended to be lower in T-males. These findings provide evidence that impact of fetal exposure to T excess is evident early in postnatal life, mainly characterized by an increase in Sertoli cell number. This could explain the testicular dysfunction observed in adult rams.Fil: Rojas García, Pedro P.. Universidad de Concepción; ChileFil: Recabarren, Mónica P.. Universidad de Concepción; ChileFil: Sir Petermann, Teresa. Universidad de Santiago de Chile; ChileFil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Palma, Sergio. Universidad de Concepción; ChileFil: Carrasco, Albert. Universidad de Concepción; ChileFil: Pérez Marín, Carlos C.. Universidad de Córdoba; ArgentinaFil: Padmanabhan, Vasantha. University Of Michigan; Estados UnidosFil: Recabarren, Sergio E.. Universidad de Concepción; ChileHumana Press2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8134Rojas García, Pedro P.; Recabarren, Mónica P.; Sir Petermann, Teresa; Rey, Rodolfo Alberto; Palma, Sergio; et al.; Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone; Humana Press; Endocrine; 43; 3; 6-2013; 705-7130969-711Xenginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs12020-012-9818-5info:eu-repo/semantics/altIdentifier/doi/10.1007/s12020-012-9818-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:32:23Zoai:ri.conicet.gov.ar:11336/8134instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:32:23.431CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone
title Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone
spellingShingle Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone
Rojas García, Pedro P.
Developmental Programing
Ovine
Male Reproduction
Testes
title_short Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone
title_full Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone
title_fullStr Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone
title_full_unstemmed Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone
title_sort Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone
dc.creator.none.fl_str_mv Rojas García, Pedro P.
Recabarren, Mónica P.
Sir Petermann, Teresa
Rey, Rodolfo Alberto
Palma, Sergio
Carrasco, Albert
Pérez Marín, Carlos C.
Padmanabhan, Vasantha
Recabarren, Sergio E.
author Rojas García, Pedro P.
author_facet Rojas García, Pedro P.
Recabarren, Mónica P.
Sir Petermann, Teresa
Rey, Rodolfo Alberto
Palma, Sergio
Carrasco, Albert
Pérez Marín, Carlos C.
Padmanabhan, Vasantha
Recabarren, Sergio E.
author_role author
author2 Recabarren, Mónica P.
Sir Petermann, Teresa
Rey, Rodolfo Alberto
Palma, Sergio
Carrasco, Albert
Pérez Marín, Carlos C.
Padmanabhan, Vasantha
Recabarren, Sergio E.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Developmental Programing
Ovine
Male Reproduction
Testes
topic Developmental Programing
Ovine
Male Reproduction
Testes
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The reprograming effects of prenatal testosterone (T) treatment on postnatal reproductive parameters have been studied extensively in females of several species but similar studies in males are limited. We recently found that prenatal T treatment increases Sertoli cell number and reduced spermatogenesis in adult rams. If such disruptions are manifested early in life and involve changes in testicular paracrine environment remain to be explored. This study addresses the impact of prenatal T excess on testicular parameters in infant males, including Sertoli cell number and expression of critical genes [FSH receptor (FSHR), androgen receptor (AR), transforming growth factor beta 1 (TGFB1), 3 (TGFB3), transforming growth factor beta type 1 receptor, (TGFBR1), and anti-Mullerian hormone (AMH)] modulating testicular function. At 4 week of age, male lambs born to dams treated with 30 mg of T propionate twice weekly from day 30 to 90, followed by 40 mg of T propionate from day 90 to 120 of pregnancy (T-males), had a higher number of Sertoli cells/ testis compared to C-males. Expression level of AMH, TGFB1, and AR also tended to be lower in T-males. These findings provide evidence that impact of fetal exposure to T excess is evident early in postnatal life, mainly characterized by an increase in Sertoli cell number. This could explain the testicular dysfunction observed in adult rams.
Fil: Rojas García, Pedro P.. Universidad de Concepción; Chile
Fil: Recabarren, Mónica P.. Universidad de Concepción; Chile
Fil: Sir Petermann, Teresa. Universidad de Santiago de Chile; Chile
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Palma, Sergio. Universidad de Concepción; Chile
Fil: Carrasco, Albert. Universidad de Concepción; Chile
Fil: Pérez Marín, Carlos C.. Universidad de Córdoba; Argentina
Fil: Padmanabhan, Vasantha. University Of Michigan; Estados Unidos
Fil: Recabarren, Sergio E.. Universidad de Concepción; Chile
description The reprograming effects of prenatal testosterone (T) treatment on postnatal reproductive parameters have been studied extensively in females of several species but similar studies in males are limited. We recently found that prenatal T treatment increases Sertoli cell number and reduced spermatogenesis in adult rams. If such disruptions are manifested early in life and involve changes in testicular paracrine environment remain to be explored. This study addresses the impact of prenatal T excess on testicular parameters in infant males, including Sertoli cell number and expression of critical genes [FSH receptor (FSHR), androgen receptor (AR), transforming growth factor beta 1 (TGFB1), 3 (TGFB3), transforming growth factor beta type 1 receptor, (TGFBR1), and anti-Mullerian hormone (AMH)] modulating testicular function. At 4 week of age, male lambs born to dams treated with 30 mg of T propionate twice weekly from day 30 to 90, followed by 40 mg of T propionate from day 90 to 120 of pregnancy (T-males), had a higher number of Sertoli cells/ testis compared to C-males. Expression level of AMH, TGFB1, and AR also tended to be lower in T-males. These findings provide evidence that impact of fetal exposure to T excess is evident early in postnatal life, mainly characterized by an increase in Sertoli cell number. This could explain the testicular dysfunction observed in adult rams.
publishDate 2013
dc.date.none.fl_str_mv 2013-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8134
Rojas García, Pedro P.; Recabarren, Mónica P.; Sir Petermann, Teresa; Rey, Rodolfo Alberto; Palma, Sergio; et al.; Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone; Humana Press; Endocrine; 43; 3; 6-2013; 705-713
0969-711X
url http://hdl.handle.net/11336/8134
identifier_str_mv Rojas García, Pedro P.; Recabarren, Mónica P.; Sir Petermann, Teresa; Rey, Rodolfo Alberto; Palma, Sergio; et al.; Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone; Humana Press; Endocrine; 43; 3; 6-2013; 705-713
0969-711X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs12020-012-9818-5
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12020-012-9818-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Humana Press
publisher.none.fl_str_mv Humana Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.665996

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