Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption

Autores
Rodriguez, Valeria Andrea; Rivoira, María Angélica; Marchionatti, Ana María; del Valle Perez, Adriana; Tolosa, Nori Graciela
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to investigate the effect of ursodeoxycholic acid (UDCA) on intestinal Ca2+ absorption and to find out whether the inhibition of this process caused by NaDOC could be prevented by UDCA. Chicks were employed and divided into four groups: (a) controls, (b) treated with 10 mM NaDOC, (c) treated with 60 lg UDCA/100 g of b.w., and (d) treated with 10 mM NaDOC and 60 lg UDCA/100 g of b.w. UDCA enhanced intestinal Ca2+ absorption, which was time and dose-dependent. UDCA avoided the inhibition of intestinal Ca2+ absorption caused by NaDOC. Both bile acids altered protein and gene expression of molecules involved in the transcellular pathway of intestinal Ca2+ absorption, but in the opposite way. UDCA aborted the oxidative stress produced by NaDOC in the intestine. UDCA and UDCA plus NaDOC increased vitamin D receptor protein expression. In conclusion, UDCA is a bene- ficial bile acid for intestinal Ca2+ absorption. Contrarily, NaDOC inhibits the intestinal cation absorption through triggering oxidative stress. The use of UDCA in patients with cholestasis would be benefited because of the protective effect on the intestinal Ca2+ absorption, avoiding the inhibition caused by hydrophobic bile acids and neutralizing the oxidative stress.
Fil: Rodriguez, Valeria Andrea. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Rivoira, María Angélica. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Marchionatti, Ana María. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: del Valle Perez, Adriana. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Tolosa, Nori Graciela. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Materia
Udca
Nadoc
Intestinal Ca2+ Absorption
Ca2+-Atpase
Na+/Ca2+ Exchange
Calbindin D28k
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11407
Acceder
id CONICETDig_af99416dbacf2444b950208f7a6876e6
oai_identifier_str oai:ri.conicet.gov.ar:11336/11407
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorptionRodriguez, Valeria AndreaRivoira, María AngélicaMarchionatti, Ana Maríadel Valle Perez, AdrianaTolosa, Nori GracielaUdcaNadocIntestinal Ca2+ AbsorptionCa2+-AtpaseNa+/Ca2+ ExchangeCalbindin D28khttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The aim of this study was to investigate the effect of ursodeoxycholic acid (UDCA) on intestinal Ca2+ absorption and to find out whether the inhibition of this process caused by NaDOC could be prevented by UDCA. Chicks were employed and divided into four groups: (a) controls, (b) treated with 10 mM NaDOC, (c) treated with 60 lg UDCA/100 g of b.w., and (d) treated with 10 mM NaDOC and 60 lg UDCA/100 g of b.w. UDCA enhanced intestinal Ca2+ absorption, which was time and dose-dependent. UDCA avoided the inhibition of intestinal Ca2+ absorption caused by NaDOC. Both bile acids altered protein and gene expression of molecules involved in the transcellular pathway of intestinal Ca2+ absorption, but in the opposite way. UDCA aborted the oxidative stress produced by NaDOC in the intestine. UDCA and UDCA plus NaDOC increased vitamin D receptor protein expression. In conclusion, UDCA is a bene- ficial bile acid for intestinal Ca2+ absorption. Contrarily, NaDOC inhibits the intestinal cation absorption through triggering oxidative stress. The use of UDCA in patients with cholestasis would be benefited because of the protective effect on the intestinal Ca2+ absorption, avoiding the inhibition caused by hydrophobic bile acids and neutralizing the oxidative stress.Fil: Rodriguez, Valeria Andrea. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Rivoira, María Angélica. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Marchionatti, Ana María. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: del Valle Perez, Adriana. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Tolosa, Nori Graciela. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaElsevier Science Inc2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11407Rodriguez, Valeria Andrea; Rivoira, María Angélica; Marchionatti, Ana María; del Valle Perez, Adriana; Tolosa, Nori Graciela; Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption; Elsevier Science Inc; Archives Of Biochemistry And Biophysics; 540; 1-2; 12-2013; 19-250003-9861enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.abb.2013.09.018info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0003986113003019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:10Zoai:ri.conicet.gov.ar:11336/11407instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:10.868CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption
title Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption
spellingShingle Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption
Rodriguez, Valeria Andrea
Udca
Nadoc
Intestinal Ca2+ Absorption
Ca2+-Atpase
Na+/Ca2+ Exchange
Calbindin D28k
title_short Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption
title_full Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption
title_fullStr Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption
title_full_unstemmed Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption
title_sort Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption
dc.creator.none.fl_str_mv Rodriguez, Valeria Andrea
Rivoira, María Angélica
Marchionatti, Ana María
del Valle Perez, Adriana
Tolosa, Nori Graciela
author Rodriguez, Valeria Andrea
author_facet Rodriguez, Valeria Andrea
Rivoira, María Angélica
Marchionatti, Ana María
del Valle Perez, Adriana
Tolosa, Nori Graciela
author_role author
author2 Rivoira, María Angélica
Marchionatti, Ana María
del Valle Perez, Adriana
Tolosa, Nori Graciela
author2_role author
author
author
author
dc.subject.none.fl_str_mv Udca
Nadoc
Intestinal Ca2+ Absorption
Ca2+-Atpase
Na+/Ca2+ Exchange
Calbindin D28k
topic Udca
Nadoc
Intestinal Ca2+ Absorption
Ca2+-Atpase
Na+/Ca2+ Exchange
Calbindin D28k
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The aim of this study was to investigate the effect of ursodeoxycholic acid (UDCA) on intestinal Ca2+ absorption and to find out whether the inhibition of this process caused by NaDOC could be prevented by UDCA. Chicks were employed and divided into four groups: (a) controls, (b) treated with 10 mM NaDOC, (c) treated with 60 lg UDCA/100 g of b.w., and (d) treated with 10 mM NaDOC and 60 lg UDCA/100 g of b.w. UDCA enhanced intestinal Ca2+ absorption, which was time and dose-dependent. UDCA avoided the inhibition of intestinal Ca2+ absorption caused by NaDOC. Both bile acids altered protein and gene expression of molecules involved in the transcellular pathway of intestinal Ca2+ absorption, but in the opposite way. UDCA aborted the oxidative stress produced by NaDOC in the intestine. UDCA and UDCA plus NaDOC increased vitamin D receptor protein expression. In conclusion, UDCA is a bene- ficial bile acid for intestinal Ca2+ absorption. Contrarily, NaDOC inhibits the intestinal cation absorption through triggering oxidative stress. The use of UDCA in patients with cholestasis would be benefited because of the protective effect on the intestinal Ca2+ absorption, avoiding the inhibition caused by hydrophobic bile acids and neutralizing the oxidative stress.
Fil: Rodriguez, Valeria Andrea. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Rivoira, María Angélica. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Marchionatti, Ana María. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: del Valle Perez, Adriana. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Tolosa, Nori Graciela. Universidad Nacional de Cordoba. Facultad de Medicina. Catedra de Bioquimica y Biologia Molecular; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
description The aim of this study was to investigate the effect of ursodeoxycholic acid (UDCA) on intestinal Ca2+ absorption and to find out whether the inhibition of this process caused by NaDOC could be prevented by UDCA. Chicks were employed and divided into four groups: (a) controls, (b) treated with 10 mM NaDOC, (c) treated with 60 lg UDCA/100 g of b.w., and (d) treated with 10 mM NaDOC and 60 lg UDCA/100 g of b.w. UDCA enhanced intestinal Ca2+ absorption, which was time and dose-dependent. UDCA avoided the inhibition of intestinal Ca2+ absorption caused by NaDOC. Both bile acids altered protein and gene expression of molecules involved in the transcellular pathway of intestinal Ca2+ absorption, but in the opposite way. UDCA aborted the oxidative stress produced by NaDOC in the intestine. UDCA and UDCA plus NaDOC increased vitamin D receptor protein expression. In conclusion, UDCA is a bene- ficial bile acid for intestinal Ca2+ absorption. Contrarily, NaDOC inhibits the intestinal cation absorption through triggering oxidative stress. The use of UDCA in patients with cholestasis would be benefited because of the protective effect on the intestinal Ca2+ absorption, avoiding the inhibition caused by hydrophobic bile acids and neutralizing the oxidative stress.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11407
Rodriguez, Valeria Andrea; Rivoira, María Angélica; Marchionatti, Ana María; del Valle Perez, Adriana; Tolosa, Nori Graciela; Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption; Elsevier Science Inc; Archives Of Biochemistry And Biophysics; 540; 1-2; 12-2013; 19-25
0003-9861
url http://hdl.handle.net/11336/11407
identifier_str_mv Rodriguez, Valeria Andrea; Rivoira, María Angélica; Marchionatti, Ana María; del Valle Perez, Adriana; Tolosa, Nori Graciela; Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption; Elsevier Science Inc; Archives Of Biochemistry And Biophysics; 540; 1-2; 12-2013; 19-25
0003-9861
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.abb.2013.09.018
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0003986113003019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269078572498944
score 13.13397

Publicaciones similares