Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta

Autores
Marino, Gabriela Inés; Kotsias, Basilio Aristides
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aldosterone modulates the activity of the epithelial sodium channel (ENaC) through changes in its trafficking, membrane expression and open probability. Plasma levels of aldosterone are decreased in preeclampsia. Herein we postulated that if aldosterone regulates ENaC expression then its expression should be decreased in preeclampsia. We found a diminished expression of the three subunits of the ENaC in the membranes of preeclamptic placentas in comparison with the normal ones. Although the role of ENaC in placental tissues is poorly understood, these differences may have consequences for the ion transport involved in the pathophysiology of preeclampsia.
Fil: Marino, Gabriela Inés. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Kotsias, Basilio Aristides. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires; Argentina
Materia
Enac
Human Placenta
Preeclampsia
Syncytiotrophoblast
Immunostaining
Western Blot
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11564
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/11564
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placentaMarino, Gabriela InésKotsias, Basilio AristidesEnacHuman PlacentaPreeclampsiaSyncytiotrophoblastImmunostainingWestern Blothttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Aldosterone modulates the activity of the epithelial sodium channel (ENaC) through changes in its trafficking, membrane expression and open probability. Plasma levels of aldosterone are decreased in preeclampsia. Herein we postulated that if aldosterone regulates ENaC expression then its expression should be decreased in preeclampsia. We found a diminished expression of the three subunits of the ENaC in the membranes of preeclamptic placentas in comparison with the normal ones. Although the role of ENaC in placental tissues is poorly understood, these differences may have consequences for the ion transport involved in the pathophysiology of preeclampsia.Fil: Marino, Gabriela Inés. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Kotsias, Basilio Aristides. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires; ArgentinaElsevier2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11564Marino, Gabriela Inés; Kotsias, Basilio Aristides; Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta; Elsevier; Placenta; 34; 2; 2-2013; 197-2000143-4004enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0143400412004432info:eu-repo/semantics/altIdentifier/doi/10.1016/j.placenta.2012.11.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:35Zoai:ri.conicet.gov.ar:11336/11564instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:35.369CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta
title Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta
spellingShingle Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta
Marino, Gabriela Inés
Enac
Human Placenta
Preeclampsia
Syncytiotrophoblast
Immunostaining
Western Blot
title_short Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta
title_full Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta
title_fullStr Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta
title_full_unstemmed Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta
title_sort Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta
dc.creator.none.fl_str_mv Marino, Gabriela Inés
Kotsias, Basilio Aristides
author Marino, Gabriela Inés
author_facet Marino, Gabriela Inés
Kotsias, Basilio Aristides
author_role author
author2 Kotsias, Basilio Aristides
author2_role author
dc.subject.none.fl_str_mv Enac
Human Placenta
Preeclampsia
Syncytiotrophoblast
Immunostaining
Western Blot
topic Enac
Human Placenta
Preeclampsia
Syncytiotrophoblast
Immunostaining
Western Blot
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aldosterone modulates the activity of the epithelial sodium channel (ENaC) through changes in its trafficking, membrane expression and open probability. Plasma levels of aldosterone are decreased in preeclampsia. Herein we postulated that if aldosterone regulates ENaC expression then its expression should be decreased in preeclampsia. We found a diminished expression of the three subunits of the ENaC in the membranes of preeclamptic placentas in comparison with the normal ones. Although the role of ENaC in placental tissues is poorly understood, these differences may have consequences for the ion transport involved in the pathophysiology of preeclampsia.
Fil: Marino, Gabriela Inés. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Kotsias, Basilio Aristides. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires; Argentina
description Aldosterone modulates the activity of the epithelial sodium channel (ENaC) through changes in its trafficking, membrane expression and open probability. Plasma levels of aldosterone are decreased in preeclampsia. Herein we postulated that if aldosterone regulates ENaC expression then its expression should be decreased in preeclampsia. We found a diminished expression of the three subunits of the ENaC in the membranes of preeclamptic placentas in comparison with the normal ones. Although the role of ENaC in placental tissues is poorly understood, these differences may have consequences for the ion transport involved in the pathophysiology of preeclampsia.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11564
Marino, Gabriela Inés; Kotsias, Basilio Aristides; Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta; Elsevier; Placenta; 34; 2; 2-2013; 197-200
0143-4004
url http://hdl.handle.net/11336/11564
identifier_str_mv Marino, Gabriela Inés; Kotsias, Basilio Aristides; Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta; Elsevier; Placenta; 34; 2; 2-2013; 197-200
0143-4004
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0143400412004432
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.placenta.2012.11.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268804628873216
score 13.13397

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