EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom

Autores
Sagardia, J.; Valente, Mauro Andres; Mattea, Facundo; Villar, N.; Toro, C.; Jerez, F.; Flores, M.; Figueroa, R.
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A proof-of-concept is presented for an energy-dispersive X-ray fluorescence (EDXRF) system employing a 93 mCi ˆ241Am source (59.5 keV) to excite gadolinium (Gd) biomarkers embedded in water-equivalent phantoms. Monte Carlo simulations, based on adapted PENELOPE routines (109 primary histories), were used to optimize both source and detector collimation and to predict absorbed-dose distributions. For a 1 cm-diameter target located at 5 cm depth, simulations showed that a conical collimation geometry applied to both source and detector yields a signal-to-noise ratio (SNR) of 6000 ± 381 % at 0.5 mmol mL-1 Gd and 400 ± 95 % at 0.063 mmol mL-1. These represent 2-fold and 3.4-fold improvements, respectively, compared to single-collimator and fully divergent setups. Experimental validation confirmed these trends and established detection limits below 0.031 mmol mL-1 (approximately 0.5% w/w, equivalent to one-sixteenth the commercial OMNISCAN concentration). Tumor-sized volumes (≥1 cm) infused with ≥1% w/w Gd were reliably detected at 5 cm depth, while keeping the phantom-averaged absorbed dose below 1 mGy during a 15-minute acquisition. These findings demonstrate that a compact, radioisotope-based confocal EDXRF system can achieve clinically meaningful Gd sensitivity with sub-centimeter spatial resolution, establishing a foundation for accelerated imaging using large-area detector arrays.
Fil: Sagardia, J.. Universidad de La Frontera; Chile
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad de La Frontera; Chile
Fil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Villar, N.. Universidad de La Frontera; Chile
Fil: Toro, C.. Universidad de La Frontera; Chile
Fil: Jerez, F.. Universidad de La Frontera; Chile
Fil: Flores, M.. Universidad de La Frontera; Chile
Fil: Figueroa, R.. Universidad de La Frontera; Chile
Materia
Energy dispersive X-Ray Fluorescence
Confocal detection
Convergent photon beam
Gd-infused phantoms
Nivel de accesibilidad
acceso embargado
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/281856
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/281856
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantomSagardia, J.Valente, Mauro AndresMattea, FacundoVillar, N.Toro, C.Jerez, F.Flores, M.Figueroa, R.Energy dispersive X-Ray FluorescenceConfocal detectionConvergent photon beamGd-infused phantomshttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1A proof-of-concept is presented for an energy-dispersive X-ray fluorescence (EDXRF) system employing a 93 mCi ˆ241Am source (59.5 keV) to excite gadolinium (Gd) biomarkers embedded in water-equivalent phantoms. Monte Carlo simulations, based on adapted PENELOPE routines (109 primary histories), were used to optimize both source and detector collimation and to predict absorbed-dose distributions. For a 1 cm-diameter target located at 5 cm depth, simulations showed that a conical collimation geometry applied to both source and detector yields a signal-to-noise ratio (SNR) of 6000 ± 381 % at 0.5 mmol mL-1 Gd and 400 ± 95 % at 0.063 mmol mL-1. These represent 2-fold and 3.4-fold improvements, respectively, compared to single-collimator and fully divergent setups. Experimental validation confirmed these trends and established detection limits below 0.031 mmol mL-1 (approximately 0.5% w/w, equivalent to one-sixteenth the commercial OMNISCAN concentration). Tumor-sized volumes (≥1 cm) infused with ≥1% w/w Gd were reliably detected at 5 cm depth, while keeping the phantom-averaged absorbed dose below 1 mGy during a 15-minute acquisition. These findings demonstrate that a compact, radioisotope-based confocal EDXRF system can achieve clinically meaningful Gd sensitivity with sub-centimeter spatial resolution, establishing a foundation for accelerated imaging using large-area detector arrays.Fil: Sagardia, J.. Universidad de La Frontera; ChileFil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad de La Frontera; ChileFil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaFil: Villar, N.. Universidad de La Frontera; ChileFil: Toro, C.. Universidad de La Frontera; ChileFil: Jerez, F.. Universidad de La Frontera; ChileFil: Flores, M.. Universidad de La Frontera; ChileFil: Figueroa, R.. Universidad de La Frontera; ChilePergamon-Elsevier Science Ltd2025-12info:eu-repo/date/embargoEnd/2026-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/281856Sagardia, J.; Valente, Mauro Andres; Mattea, Facundo; Villar, N.; Toro, C.; et al.; EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 237; 12-2025; 1-290969-806XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0969806X25005092info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radphyschem.2025.113017info:eu-repo/semantics/embargoedAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-03-11T11:54:03Zoai:ri.conicet.gov.ar:11336/281856instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-03-11 11:54:03.761CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom
title EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom
spellingShingle EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom
Sagardia, J.
Energy dispersive X-Ray Fluorescence
Confocal detection
Convergent photon beam
Gd-infused phantoms
title_short EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom
title_full EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom
title_fullStr EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom
title_full_unstemmed EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom
title_sort EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom
dc.creator.none.fl_str_mv Sagardia, J.
Valente, Mauro Andres
Mattea, Facundo
Villar, N.
Toro, C.
Jerez, F.
Flores, M.
Figueroa, R.
author Sagardia, J.
author_facet Sagardia, J.
Valente, Mauro Andres
Mattea, Facundo
Villar, N.
Toro, C.
Jerez, F.
Flores, M.
Figueroa, R.
author_role author
author2 Valente, Mauro Andres
Mattea, Facundo
Villar, N.
Toro, C.
Jerez, F.
Flores, M.
Figueroa, R.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Energy dispersive X-Ray Fluorescence
Confocal detection
Convergent photon beam
Gd-infused phantoms
topic Energy dispersive X-Ray Fluorescence
Confocal detection
Convergent photon beam
Gd-infused phantoms
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A proof-of-concept is presented for an energy-dispersive X-ray fluorescence (EDXRF) system employing a 93 mCi ˆ241Am source (59.5 keV) to excite gadolinium (Gd) biomarkers embedded in water-equivalent phantoms. Monte Carlo simulations, based on adapted PENELOPE routines (109 primary histories), were used to optimize both source and detector collimation and to predict absorbed-dose distributions. For a 1 cm-diameter target located at 5 cm depth, simulations showed that a conical collimation geometry applied to both source and detector yields a signal-to-noise ratio (SNR) of 6000 ± 381 % at 0.5 mmol mL-1 Gd and 400 ± 95 % at 0.063 mmol mL-1. These represent 2-fold and 3.4-fold improvements, respectively, compared to single-collimator and fully divergent setups. Experimental validation confirmed these trends and established detection limits below 0.031 mmol mL-1 (approximately 0.5% w/w, equivalent to one-sixteenth the commercial OMNISCAN concentration). Tumor-sized volumes (≥1 cm) infused with ≥1% w/w Gd were reliably detected at 5 cm depth, while keeping the phantom-averaged absorbed dose below 1 mGy during a 15-minute acquisition. These findings demonstrate that a compact, radioisotope-based confocal EDXRF system can achieve clinically meaningful Gd sensitivity with sub-centimeter spatial resolution, establishing a foundation for accelerated imaging using large-area detector arrays.
Fil: Sagardia, J.. Universidad de La Frontera; Chile
Fil: Valente, Mauro Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad de La Frontera; Chile
Fil: Mattea, Facundo. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Villar, N.. Universidad de La Frontera; Chile
Fil: Toro, C.. Universidad de La Frontera; Chile
Fil: Jerez, F.. Universidad de La Frontera; Chile
Fil: Flores, M.. Universidad de La Frontera; Chile
Fil: Figueroa, R.. Universidad de La Frontera; Chile
description A proof-of-concept is presented for an energy-dispersive X-ray fluorescence (EDXRF) system employing a 93 mCi ˆ241Am source (59.5 keV) to excite gadolinium (Gd) biomarkers embedded in water-equivalent phantoms. Monte Carlo simulations, based on adapted PENELOPE routines (109 primary histories), were used to optimize both source and detector collimation and to predict absorbed-dose distributions. For a 1 cm-diameter target located at 5 cm depth, simulations showed that a conical collimation geometry applied to both source and detector yields a signal-to-noise ratio (SNR) of 6000 ± 381 % at 0.5 mmol mL-1 Gd and 400 ± 95 % at 0.063 mmol mL-1. These represent 2-fold and 3.4-fold improvements, respectively, compared to single-collimator and fully divergent setups. Experimental validation confirmed these trends and established detection limits below 0.031 mmol mL-1 (approximately 0.5% w/w, equivalent to one-sixteenth the commercial OMNISCAN concentration). Tumor-sized volumes (≥1 cm) infused with ≥1% w/w Gd were reliably detected at 5 cm depth, while keeping the phantom-averaged absorbed dose below 1 mGy during a 15-minute acquisition. These findings demonstrate that a compact, radioisotope-based confocal EDXRF system can achieve clinically meaningful Gd sensitivity with sub-centimeter spatial resolution, establishing a foundation for accelerated imaging using large-area detector arrays.
publishDate 2025
dc.date.none.fl_str_mv 2025-12
info:eu-repo/date/embargoEnd/2026-06-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/281856
Sagardia, J.; Valente, Mauro Andres; Mattea, Facundo; Villar, N.; Toro, C.; et al.; EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 237; 12-2025; 1-29
0969-806X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/281856
identifier_str_mv Sagardia, J.; Valente, Mauro Andres; Mattea, Facundo; Villar, N.; Toro, C.; et al.; EDXRF analysis of Gd-based Tumoral biomarker using a collimated 241Am source in a Bioequivalent phantom; Pergamon-Elsevier Science Ltd; Radiation Physics and Chemistry (Oxford); 237; 12-2025; 1-29
0969-806X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0969806X25005092
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.radphyschem.2025.113017
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
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eu_rights_str_mv embargoedAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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