Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding
- Autores
- Berdakin, Matias; Steinmetz, Vicent; Maitre, Philippe; Pino, Gustavo Ariel
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artÃculo
- Estado
- versión publicada
- Descripción
- The study of metal ion–DNA interaction aiming to understand the stabilization of artificial base pairing and a number of noncanonical motifs is of current interest, due to their potential exploitation in developing new technological devices and expanding the genetic code. A successful strategy has been the synthesis of metal-mediated base pairs, in which a coordinative bond to a central metal cation replaces a H-bond in a natural pair. In this work, we characterized, for the first time, the gas phase structure of the cytosine···Ag+···cytosine (C–Ag+–C) complex by means of InfraRed-MultiPhoton-Dissociation (IR-MPD) spectroscopy and theoretical calculation. The IR-spectrum was confidently assigned to one structure with the Ag+ acting as a bridge between the heteronitrogen atoms in each cytosine (both in the keto-amino form). This structure is biologically relevant since it mimics the structure of the hemiprotonated C–H+–C dimer responsible for the stabilization of the i-motif structure in DNA, with the replacement of the NH···N bond by a stronger N···Ag+···N bond. Moreover, since the structure of the C–Ag+–C complex is planar, it allows an optimum intercalation between pairs of the two antiparallel strand duplex in the DNA i-motif structure.
Fil: Berdakin, Matias. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias QuÃmicas. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba; Argentina
Fil: Steinmetz, Vicent. Universite Paris Sud; Francia
Fil: Maitre, Philippe. Universite Paris Sud; Francia
Fil: Pino, Gustavo Ariel. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias QuÃmicas. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba; Argentina - Materia
-
Base-Pairing
Dna
Silver-Bound-Dimer - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones CientÃficas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/31495
Ver los metadatos del registro completo
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Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif FoldingBerdakin, MatiasSteinmetz, VicentMaitre, PhilippePino, Gustavo ArielBase-PairingDnaSilver-Bound-Dimerhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The study of metal ion–DNA interaction aiming to understand the stabilization of artificial base pairing and a number of noncanonical motifs is of current interest, due to their potential exploitation in developing new technological devices and expanding the genetic code. A successful strategy has been the synthesis of metal-mediated base pairs, in which a coordinative bond to a central metal cation replaces a H-bond in a natural pair. In this work, we characterized, for the first time, the gas phase structure of the cytosine···Ag+···cytosine (C–Ag+–C) complex by means of InfraRed-MultiPhoton-Dissociation (IR-MPD) spectroscopy and theoretical calculation. The IR-spectrum was confidently assigned to one structure with the Ag+ acting as a bridge between the heteronitrogen atoms in each cytosine (both in the keto-amino form). This structure is biologically relevant since it mimics the structure of the hemiprotonated C–H+–C dimer responsible for the stabilization of the i-motif structure in DNA, with the replacement of the NH···N bond by a stronger N···Ag+···N bond. Moreover, since the structure of the C–Ag+–C complex is planar, it allows an optimum intercalation between pairs of the two antiparallel strand duplex in the DNA i-motif structure.Fil: Berdakin, Matias. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias QuÃmicas. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba; ArgentinaFil: Steinmetz, Vicent. Universite Paris Sud; FranciaFil: Maitre, Philippe. Universite Paris Sud; FranciaFil: Pino, Gustavo Ariel. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias QuÃmicas. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba; ArgentinaAmerican Chemical Society2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31495Berdakin, Matias; Steinmetz, Vicent; Maitre, Philippe; Pino, Gustavo Ariel; Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding; American Chemical Society; Journal of Physical Chemistry A; 118; 21; 5-2014; 3804-38091089-5639CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.pubs.acs.org/doi/abs/10.1021/jp5038969info:eu-repo/semantics/altIdentifier/doi/10.1021/jp5038969info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones CientÃficas y Técnicas2025-10-22T11:04:31Zoai:ri.conicet.gov.ar:11336/31495instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo cientÃfico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:04:32.02CONICET Digital (CONICET) - Consejo Nacional de Investigaciones CientÃficas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding |
| title |
Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding |
| spellingShingle |
Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding Berdakin, Matias Base-Pairing Dna Silver-Bound-Dimer |
| title_short |
Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding |
| title_full |
Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding |
| title_fullStr |
Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding |
| title_full_unstemmed |
Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding |
| title_sort |
Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding |
| dc.creator.none.fl_str_mv |
Berdakin, Matias Steinmetz, Vicent Maitre, Philippe Pino, Gustavo Ariel |
| author |
Berdakin, Matias |
| author_facet |
Berdakin, Matias Steinmetz, Vicent Maitre, Philippe Pino, Gustavo Ariel |
| author_role |
author |
| author2 |
Steinmetz, Vicent Maitre, Philippe Pino, Gustavo Ariel |
| author2_role |
author author author |
| dc.subject.none.fl_str_mv |
Base-Pairing Dna Silver-Bound-Dimer |
| topic |
Base-Pairing Dna Silver-Bound-Dimer |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The study of metal ion–DNA interaction aiming to understand the stabilization of artificial base pairing and a number of noncanonical motifs is of current interest, due to their potential exploitation in developing new technological devices and expanding the genetic code. A successful strategy has been the synthesis of metal-mediated base pairs, in which a coordinative bond to a central metal cation replaces a H-bond in a natural pair. In this work, we characterized, for the first time, the gas phase structure of the cytosine···Ag+···cytosine (C–Ag+–C) complex by means of InfraRed-MultiPhoton-Dissociation (IR-MPD) spectroscopy and theoretical calculation. The IR-spectrum was confidently assigned to one structure with the Ag+ acting as a bridge between the heteronitrogen atoms in each cytosine (both in the keto-amino form). This structure is biologically relevant since it mimics the structure of the hemiprotonated C–H+–C dimer responsible for the stabilization of the i-motif structure in DNA, with the replacement of the NH···N bond by a stronger N···Ag+···N bond. Moreover, since the structure of the C–Ag+–C complex is planar, it allows an optimum intercalation between pairs of the two antiparallel strand duplex in the DNA i-motif structure. Fil: Berdakin, Matias. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias QuÃmicas. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba; Argentina Fil: Steinmetz, Vicent. Universite Paris Sud; Francia Fil: Maitre, Philippe. Universite Paris Sud; Francia Fil: Pino, Gustavo Ariel. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias QuÃmicas. Instituto de Investigaciones en FÃsico-quÃmica de Córdoba; Argentina |
| description |
The study of metal ion–DNA interaction aiming to understand the stabilization of artificial base pairing and a number of noncanonical motifs is of current interest, due to their potential exploitation in developing new technological devices and expanding the genetic code. A successful strategy has been the synthesis of metal-mediated base pairs, in which a coordinative bond to a central metal cation replaces a H-bond in a natural pair. In this work, we characterized, for the first time, the gas phase structure of the cytosine···Ag+···cytosine (C–Ag+–C) complex by means of InfraRed-MultiPhoton-Dissociation (IR-MPD) spectroscopy and theoretical calculation. The IR-spectrum was confidently assigned to one structure with the Ag+ acting as a bridge between the heteronitrogen atoms in each cytosine (both in the keto-amino form). This structure is biologically relevant since it mimics the structure of the hemiprotonated C–H+–C dimer responsible for the stabilization of the i-motif structure in DNA, with the replacement of the NH···N bond by a stronger N···Ag+···N bond. Moreover, since the structure of the C–Ag+–C complex is planar, it allows an optimum intercalation between pairs of the two antiparallel strand duplex in the DNA i-motif structure. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014-05 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/31495 Berdakin, Matias; Steinmetz, Vicent; Maitre, Philippe; Pino, Gustavo Ariel; Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding; American Chemical Society; Journal of Physical Chemistry A; 118; 21; 5-2014; 3804-3809 1089-5639 CONICET Digital CONICET |
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http://hdl.handle.net/11336/31495 |
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Berdakin, Matias; Steinmetz, Vicent; Maitre, Philippe; Pino, Gustavo Ariel; Gas Phase Structure of Metal Mediated (Cytosine)2Ag+Mimics theHemiprotonated (Cytosine)2H+Dimer ini‑Motif Folding; American Chemical Society; Journal of Physical Chemistry A; 118; 21; 5-2014; 3804-3809 1089-5639 CONICET Digital CONICET |
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eng |
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eng |
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openAccess |
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application/pdf application/pdf application/pdf |
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American Chemical Society |
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American Chemical Society |
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