Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
- Autores
- Murer, Mario Gustavo; Yan, Q.; Raisman Vozari, Rita
- Año de publicación
- 2001
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance.
Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Yan, Q.. No especifíca;
Fil: Raisman Vozari, Rita. Inserm; Francia - Materia
- Brain-derived
- Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/162498
Ver los metadatos del registro completo
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Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's diseaseMurer, Mario GustavoYan, Q.Raisman Vozari, RitaBrain-derivedhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance.Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Yan, Q.. No especifíca;Fil: Raisman Vozari, Rita. Inserm; FranciaPergamon-Elsevier Science Ltd2001-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162498Murer, Mario Gustavo; Yan, Q.; Raisman Vozari, Rita; Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 63; 1; 1-2001; 71-1240301-0082CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0301008200000149info:eu-repo/semantics/altIdentifier/doi/10.1016/S0301-0082(00)00014-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:04:06Zoai:ri.conicet.gov.ar:11336/162498instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:04:06.957CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease |
title |
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease |
spellingShingle |
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease Murer, Mario Gustavo Brain-derived |
title_short |
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease |
title_full |
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease |
title_fullStr |
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease |
title_full_unstemmed |
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease |
title_sort |
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease |
dc.creator.none.fl_str_mv |
Murer, Mario Gustavo Yan, Q. Raisman Vozari, Rita |
author |
Murer, Mario Gustavo |
author_facet |
Murer, Mario Gustavo Yan, Q. Raisman Vozari, Rita |
author_role |
author |
author2 |
Yan, Q. Raisman Vozari, Rita |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Brain-derived |
topic |
Brain-derived |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.5 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance. Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina Fil: Yan, Q.. No especifíca; Fil: Raisman Vozari, Rita. Inserm; Francia |
description |
Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/162498 Murer, Mario Gustavo; Yan, Q.; Raisman Vozari, Rita; Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 63; 1; 1-2001; 71-124 0301-0082 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/162498 |
identifier_str_mv |
Murer, Mario Gustavo; Yan, Q.; Raisman Vozari, Rita; Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 63; 1; 1-2001; 71-124 0301-0082 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0301008200000149 info:eu-repo/semantics/altIdentifier/doi/10.1016/S0301-0082(00)00014-9 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |