Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease

Autores
Murer, Mario Gustavo; Yan, Q.; Raisman Vozari, Rita
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance.
Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Yan, Q.. No especifíca;
Fil: Raisman Vozari, Rita. Inserm; Francia
Materia
Brain-derived
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/162498

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spelling Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's diseaseMurer, Mario GustavoYan, Q.Raisman Vozari, RitaBrain-derivedhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance.Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Yan, Q.. No especifíca;Fil: Raisman Vozari, Rita. Inserm; FranciaPergamon-Elsevier Science Ltd2001-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162498Murer, Mario Gustavo; Yan, Q.; Raisman Vozari, Rita; Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 63; 1; 1-2001; 71-1240301-0082CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0301008200000149info:eu-repo/semantics/altIdentifier/doi/10.1016/S0301-0082(00)00014-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:04:06Zoai:ri.conicet.gov.ar:11336/162498instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:04:06.957CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
title Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
spellingShingle Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
Murer, Mario Gustavo
Brain-derived
title_short Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
title_full Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
title_fullStr Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
title_full_unstemmed Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
title_sort Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
dc.creator.none.fl_str_mv Murer, Mario Gustavo
Yan, Q.
Raisman Vozari, Rita
author Murer, Mario Gustavo
author_facet Murer, Mario Gustavo
Yan, Q.
Raisman Vozari, Rita
author_role author
author2 Yan, Q.
Raisman Vozari, Rita
author2_role author
author
dc.subject.none.fl_str_mv Brain-derived
topic Brain-derived
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance.
Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Yan, Q.. No especifíca;
Fil: Raisman Vozari, Rita. Inserm; Francia
description Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to nerve growth factor, which is abundantly and widely expressed in the adult mammalian brain. BDNF has been found to promote survival of all major neuronal types affected in Alzheimer's disease and Parkinson's disease, like hippocampal and neocortical neurons, cholinergic septal and basal forebrain neurons, and nigral dopaminergic neurons. In this article, we summarize recent work on the molecular and cellular biology of BDNF, including current ideas about its intracellular trafficking, regulated synthesis and release, and actions at the synaptic level, which have considerably expanded our conception of BDNF actions in the central nervous system. But our primary aim is to review the literature regarding BDNF distribution in the human brain, and the modifications of BDNF expression which occur in the brain of individuals with Alzheimer's disease and Parkinson's disease. Our knowledge concerning BDNF actions on the neuronal populations affected in these pathological states is also reviewed, with an aim at understanding its pathogenic and pathophysiological relevance.
publishDate 2001
dc.date.none.fl_str_mv 2001-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/162498
Murer, Mario Gustavo; Yan, Q.; Raisman Vozari, Rita; Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 63; 1; 1-2001; 71-124
0301-0082
CONICET Digital
CONICET
url http://hdl.handle.net/11336/162498
identifier_str_mv Murer, Mario Gustavo; Yan, Q.; Raisman Vozari, Rita; Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 63; 1; 1-2001; 71-124
0301-0082
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0301008200000149
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0301-0082(00)00014-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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