Cholesterol in brain disease: sometimesdeterminant and frequently implicated

Autores
Martín, Mauricio Gerardo; Pfrieger, Frank; Dotti, Carlos G.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cholesterol is essential for neuronal physiology, both during development and in the adult life: as a major component of cell membranes and precursor of steroid hormones, it contributes to the regulation of ion permeability, cell shape, cell–cell interaction, and transmembrane signaling. Consistently, hereditary diseases with mutations in cholesterol‐related genes result in impaired brain function during early life. In addition, defects in brain cholesterol metabolism may contribute to neurological syndromes, such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD), and even to the cognitive deficits typical of the old age. In these cases, brain cholesterol defects may be secondary to disease‐causing elements and contribute to the functional deficits by altering synaptic functions. In the first part of this review, we will describe hereditary and non‐hereditary causes of cholesterol dyshomeostasis and the relationship to brain diseases. In the second part, we will focus on the mechanisms by which perturbation of cholesterol metabolism can affect synaptic function.
Fil: Martín, Mauricio Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Pfrieger, Frank. Université de Strasbourg; Francia
Fil: Dotti, Carlos G.. Universidad Autónoma de Madrid; España
Materia
Brain Disease
Cholesterol Metabolism
Cognition
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31626
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Cholesterol in brain disease: sometimesdeterminant and frequently implicatedMartín, Mauricio GerardoPfrieger, FrankDotti, Carlos G.Brain DiseaseCholesterol MetabolismCognitionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cholesterol is essential for neuronal physiology, both during development and in the adult life: as a major component of cell membranes and precursor of steroid hormones, it contributes to the regulation of ion permeability, cell shape, cell–cell interaction, and transmembrane signaling. Consistently, hereditary diseases with mutations in cholesterol‐related genes result in impaired brain function during early life. In addition, defects in brain cholesterol metabolism may contribute to neurological syndromes, such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD), and even to the cognitive deficits typical of the old age. In these cases, brain cholesterol defects may be secondary to disease‐causing elements and contribute to the functional deficits by altering synaptic functions. In the first part of this review, we will describe hereditary and non‐hereditary causes of cholesterol dyshomeostasis and the relationship to brain diseases. In the second part, we will focus on the mechanisms by which perturbation of cholesterol metabolism can affect synaptic function.Fil: Martín, Mauricio Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Pfrieger, Frank. Université de Strasbourg; FranciaFil: Dotti, Carlos G.. Universidad Autónoma de Madrid; EspañaNature Publishing Group2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31626Martín, Mauricio Gerardo; Pfrieger, Frank; Dotti, Carlos G.; Cholesterol in brain disease: sometimesdeterminant and frequently implicated; Nature Publishing Group; Embo Reports; 15; 10; 9-2014; 1036-10521469-221XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.15252/embr.201439225info:eu-repo/semantics/altIdentifier/url/http://embor.embopress.org/content/15/10/1036info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:24Zoai:ri.conicet.gov.ar:11336/31626instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:24.904CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cholesterol in brain disease: sometimesdeterminant and frequently implicated
title Cholesterol in brain disease: sometimesdeterminant and frequently implicated
spellingShingle Cholesterol in brain disease: sometimesdeterminant and frequently implicated
Martín, Mauricio Gerardo
Brain Disease
Cholesterol Metabolism
Cognition
title_short Cholesterol in brain disease: sometimesdeterminant and frequently implicated
title_full Cholesterol in brain disease: sometimesdeterminant and frequently implicated
title_fullStr Cholesterol in brain disease: sometimesdeterminant and frequently implicated
title_full_unstemmed Cholesterol in brain disease: sometimesdeterminant and frequently implicated
title_sort Cholesterol in brain disease: sometimesdeterminant and frequently implicated
dc.creator.none.fl_str_mv Martín, Mauricio Gerardo
Pfrieger, Frank
Dotti, Carlos G.
author Martín, Mauricio Gerardo
author_facet Martín, Mauricio Gerardo
Pfrieger, Frank
Dotti, Carlos G.
author_role author
author2 Pfrieger, Frank
Dotti, Carlos G.
author2_role author
author
dc.subject.none.fl_str_mv Brain Disease
Cholesterol Metabolism
Cognition
topic Brain Disease
Cholesterol Metabolism
Cognition
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cholesterol is essential for neuronal physiology, both during development and in the adult life: as a major component of cell membranes and precursor of steroid hormones, it contributes to the regulation of ion permeability, cell shape, cell–cell interaction, and transmembrane signaling. Consistently, hereditary diseases with mutations in cholesterol‐related genes result in impaired brain function during early life. In addition, defects in brain cholesterol metabolism may contribute to neurological syndromes, such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD), and even to the cognitive deficits typical of the old age. In these cases, brain cholesterol defects may be secondary to disease‐causing elements and contribute to the functional deficits by altering synaptic functions. In the first part of this review, we will describe hereditary and non‐hereditary causes of cholesterol dyshomeostasis and the relationship to brain diseases. In the second part, we will focus on the mechanisms by which perturbation of cholesterol metabolism can affect synaptic function.
Fil: Martín, Mauricio Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Pfrieger, Frank. Université de Strasbourg; Francia
Fil: Dotti, Carlos G.. Universidad Autónoma de Madrid; España
description Cholesterol is essential for neuronal physiology, both during development and in the adult life: as a major component of cell membranes and precursor of steroid hormones, it contributes to the regulation of ion permeability, cell shape, cell–cell interaction, and transmembrane signaling. Consistently, hereditary diseases with mutations in cholesterol‐related genes result in impaired brain function during early life. In addition, defects in brain cholesterol metabolism may contribute to neurological syndromes, such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD), and even to the cognitive deficits typical of the old age. In these cases, brain cholesterol defects may be secondary to disease‐causing elements and contribute to the functional deficits by altering synaptic functions. In the first part of this review, we will describe hereditary and non‐hereditary causes of cholesterol dyshomeostasis and the relationship to brain diseases. In the second part, we will focus on the mechanisms by which perturbation of cholesterol metabolism can affect synaptic function.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31626
Martín, Mauricio Gerardo; Pfrieger, Frank; Dotti, Carlos G.; Cholesterol in brain disease: sometimesdeterminant and frequently implicated; Nature Publishing Group; Embo Reports; 15; 10; 9-2014; 1036-1052
1469-221X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31626
identifier_str_mv Martín, Mauricio Gerardo; Pfrieger, Frank; Dotti, Carlos G.; Cholesterol in brain disease: sometimesdeterminant and frequently implicated; Nature Publishing Group; Embo Reports; 15; 10; 9-2014; 1036-1052
1469-221X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.15252/embr.201439225
info:eu-repo/semantics/altIdentifier/url/http://embor.embopress.org/content/15/10/1036
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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