Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation

Autores
Benseñor, Lorena Betsabe; Vazquez, Maria Soledad; Boccaccio, Graciela Lidia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Control of protein synthesis and quality are critical steps to support eukaryotic cells’ maintenance and survival. Two very distinctive mechanisms emerge as key checkpoints of protein synthesis regulation. The first one is the delivery of mRNA molecules, packed into ribonucleoprotein (mRNP) granules, to specific subcellular regions in order to restrict protein synthesis to distinct cytoplasmic domains. In the presence of cellular stress or injury, translation is aborted by sequestering mRNA molecules into a sub-type of RNP particles called stress granules (SGs). The second mechanism deals with the folding state and further processing of synthesized proteins. Misbehavior of a particular protein, affecting its processing, functioning, and/or conformation can cause the formation of protein inclusions called aggresomes. Interestingly, self-aggregation of abnormal proteins is one of the leading causes of neurodegenerative disorders. Recently, intracellular transport directed by microtubule-motors, has emerged as an important step in the assembly and dynamic of SGs and aggresomes. This mechanism allows for a precise temporal and spatial trafficking of RNA and protein complexes. Furthermore, it facilitates the regulation of the RNA silencing domains and targets abnormal protein aggregates for degradation. In this review we will explore the specific and common features of mRNA transport and of SG and aggresome formation, and will provide details on the role of the microtubule network and motors in their movement and dynamics.
Fil: Benseñor, Lorena Betsabe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Vazquez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Boccaccio, Graciela Lidia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Materia
Stress granule
aggresome
neurodegeneration
P Bodies
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/100832
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/100832
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein AggregationBenseñor, Lorena BetsabeVazquez, Maria SoledadBoccaccio, Graciela LidiaStress granuleaggresomeneurodegenerationP Bodieshttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Control of protein synthesis and quality are critical steps to support eukaryotic cells’ maintenance and survival. Two very distinctive mechanisms emerge as key checkpoints of protein synthesis regulation. The first one is the delivery of mRNA molecules, packed into ribonucleoprotein (mRNP) granules, to specific subcellular regions in order to restrict protein synthesis to distinct cytoplasmic domains. In the presence of cellular stress or injury, translation is aborted by sequestering mRNA molecules into a sub-type of RNP particles called stress granules (SGs). The second mechanism deals with the folding state and further processing of synthesized proteins. Misbehavior of a particular protein, affecting its processing, functioning, and/or conformation can cause the formation of protein inclusions called aggresomes. Interestingly, self-aggregation of abnormal proteins is one of the leading causes of neurodegenerative disorders. Recently, intracellular transport directed by microtubule-motors, has emerged as an important step in the assembly and dynamic of SGs and aggresomes. This mechanism allows for a precise temporal and spatial trafficking of RNA and protein complexes. Furthermore, it facilitates the regulation of the RNA silencing domains and targets abnormal protein aggregates for degradation. In this review we will explore the specific and common features of mRNA transport and of SG and aggresome formation, and will provide details on the role of the microtubule network and motors in their movement and dynamics.Fil: Benseñor, Lorena Betsabe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Vazquez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Boccaccio, Graciela Lidia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaBentham Science Publishers2011-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/100832Benseñor, Lorena Betsabe; Vazquez, Maria Soledad; Boccaccio, Graciela Lidia; Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation; Bentham Science Publishers; Current Chemical Biology; 5; 2; 5-2011; 77-892212-79681872-3136CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/94397/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/2212796811105020077info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:22:57Zoai:ri.conicet.gov.ar:11336/100832instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:22:58.259CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation
title Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation
spellingShingle Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation
Benseñor, Lorena Betsabe
Stress granule
aggresome
neurodegeneration
P Bodies
title_short Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation
title_full Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation
title_fullStr Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation
title_full_unstemmed Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation
title_sort Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation
dc.creator.none.fl_str_mv Benseñor, Lorena Betsabe
Vazquez, Maria Soledad
Boccaccio, Graciela Lidia
author Benseñor, Lorena Betsabe
author_facet Benseñor, Lorena Betsabe
Vazquez, Maria Soledad
Boccaccio, Graciela Lidia
author_role author
author2 Vazquez, Maria Soledad
Boccaccio, Graciela Lidia
author2_role author
author
dc.subject.none.fl_str_mv Stress granule
aggresome
neurodegeneration
P Bodies
topic Stress granule
aggresome
neurodegeneration
P Bodies
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Control of protein synthesis and quality are critical steps to support eukaryotic cells’ maintenance and survival. Two very distinctive mechanisms emerge as key checkpoints of protein synthesis regulation. The first one is the delivery of mRNA molecules, packed into ribonucleoprotein (mRNP) granules, to specific subcellular regions in order to restrict protein synthesis to distinct cytoplasmic domains. In the presence of cellular stress or injury, translation is aborted by sequestering mRNA molecules into a sub-type of RNP particles called stress granules (SGs). The second mechanism deals with the folding state and further processing of synthesized proteins. Misbehavior of a particular protein, affecting its processing, functioning, and/or conformation can cause the formation of protein inclusions called aggresomes. Interestingly, self-aggregation of abnormal proteins is one of the leading causes of neurodegenerative disorders. Recently, intracellular transport directed by microtubule-motors, has emerged as an important step in the assembly and dynamic of SGs and aggresomes. This mechanism allows for a precise temporal and spatial trafficking of RNA and protein complexes. Furthermore, it facilitates the regulation of the RNA silencing domains and targets abnormal protein aggregates for degradation. In this review we will explore the specific and common features of mRNA transport and of SG and aggresome formation, and will provide details on the role of the microtubule network and motors in their movement and dynamics.
Fil: Benseñor, Lorena Betsabe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Vazquez, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Boccaccio, Graciela Lidia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
description Control of protein synthesis and quality are critical steps to support eukaryotic cells’ maintenance and survival. Two very distinctive mechanisms emerge as key checkpoints of protein synthesis regulation. The first one is the delivery of mRNA molecules, packed into ribonucleoprotein (mRNP) granules, to specific subcellular regions in order to restrict protein synthesis to distinct cytoplasmic domains. In the presence of cellular stress or injury, translation is aborted by sequestering mRNA molecules into a sub-type of RNP particles called stress granules (SGs). The second mechanism deals with the folding state and further processing of synthesized proteins. Misbehavior of a particular protein, affecting its processing, functioning, and/or conformation can cause the formation of protein inclusions called aggresomes. Interestingly, self-aggregation of abnormal proteins is one of the leading causes of neurodegenerative disorders. Recently, intracellular transport directed by microtubule-motors, has emerged as an important step in the assembly and dynamic of SGs and aggresomes. This mechanism allows for a precise temporal and spatial trafficking of RNA and protein complexes. Furthermore, it facilitates the regulation of the RNA silencing domains and targets abnormal protein aggregates for degradation. In this review we will explore the specific and common features of mRNA transport and of SG and aggresome formation, and will provide details on the role of the microtubule network and motors in their movement and dynamics.
publishDate 2011
dc.date.none.fl_str_mv 2011-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/100832
Benseñor, Lorena Betsabe; Vazquez, Maria Soledad; Boccaccio, Graciela Lidia; Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation; Bentham Science Publishers; Current Chemical Biology; 5; 2; 5-2011; 77-89
2212-7968
1872-3136
CONICET Digital
CONICET
url http://hdl.handle.net/11336/100832
identifier_str_mv Benseñor, Lorena Betsabe; Vazquez, Maria Soledad; Boccaccio, Graciela Lidia; Common Themes in RNA Subcellular Transport, Stress Granule Formation and Abnormal Protein Aggregation; Bentham Science Publishers; Current Chemical Biology; 5; 2; 5-2011; 77-89
2212-7968
1872-3136
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/94397/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/2212796811105020077
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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