Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization

Autores
Oceguera, Alfonso; Peralta, Andrea Verónica; Gustavo Martinez Delgado; Arias, Carlos F.; López, Susana
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cellular mRNAs cycle between translating and non-translating pools, polysomes compose the translating pool, while RNA granules contain translationally-silenced mRNAs, where the RNAs are either stored in stress granules, or accumulate in processing bodies (PBs) or GW-bodies, which have an important role in RNA degradation. Viruses have developed measures to prevent the deleterious effects of these structures during their replication. Rotavirus, the most common agent of viral gastroenteritis, is capable of establishing a successful infection by counteracting several of the antiviral responses of its host. Here, we describe that in rotavirus-infected cells the distribution of several RNA binding proteins is changed causing the disaggregation of PBs, the relocalization of GW-body proteins, and the cytoplasmic accumulation of HuR, a predominantly nuclear protein. We show that this redistribution of proteins is more likely caused by the accumulation of viral RNA in the cytoplasm of infected-cells, where it might be acting as an RBP sponge.
Fil: Oceguera, Alfonso. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
Fil: Peralta, Andrea Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
Fil: Gustavo Martinez Delgado. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México. Instituto Cumbres Lomas; México
Fil: Arias, Carlos F.. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
Fil: López, Susana. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
Materia
GW-BODIES
P-BODIES
RNA BINDING PROTEINS
RNA GRANULES
RNA SPONGES
ROTAVIRUS
VIRUS HOST CELL INTERACTIONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98242
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/98242
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localizationOceguera, AlfonsoPeralta, Andrea VerónicaGustavo Martinez DelgadoArias, Carlos F.López, SusanaGW-BODIESP-BODIESRNA BINDING PROTEINSRNA GRANULESRNA SPONGESROTAVIRUSVIRUS HOST CELL INTERACTIONShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cellular mRNAs cycle between translating and non-translating pools, polysomes compose the translating pool, while RNA granules contain translationally-silenced mRNAs, where the RNAs are either stored in stress granules, or accumulate in processing bodies (PBs) or GW-bodies, which have an important role in RNA degradation. Viruses have developed measures to prevent the deleterious effects of these structures during their replication. Rotavirus, the most common agent of viral gastroenteritis, is capable of establishing a successful infection by counteracting several of the antiviral responses of its host. Here, we describe that in rotavirus-infected cells the distribution of several RNA binding proteins is changed causing the disaggregation of PBs, the relocalization of GW-body proteins, and the cytoplasmic accumulation of HuR, a predominantly nuclear protein. We show that this redistribution of proteins is more likely caused by the accumulation of viral RNA in the cytoplasm of infected-cells, where it might be acting as an RBP sponge.Fil: Oceguera, Alfonso. Universidad Nacional Autónoma de México. Instituto de Biotecnología; MéxicoFil: Peralta, Andrea Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional Autónoma de México. Instituto de Biotecnología; MéxicoFil: Gustavo Martinez Delgado. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México. Instituto Cumbres Lomas; MéxicoFil: Arias, Carlos F.. Universidad Nacional Autónoma de México. Instituto de Biotecnología; MéxicoFil: López, Susana. Universidad Nacional Autónoma de México. Instituto de Biotecnología; MéxicoAcademic Press Inc Elsevier Science2018-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98242Oceguera, Alfonso; Peralta, Andrea Verónica; Gustavo Martinez Delgado; Arias, Carlos F.; López, Susana; Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization; Academic Press Inc Elsevier Science; Virology; 525; 12-2018; 96-1050042-6822CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.virol.2018.09.013info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0042682218302848info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:42Zoai:ri.conicet.gov.ar:11336/98242instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:42.434CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization
title Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization
spellingShingle Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization
Oceguera, Alfonso
GW-BODIES
P-BODIES
RNA BINDING PROTEINS
RNA GRANULES
RNA SPONGES
ROTAVIRUS
VIRUS HOST CELL INTERACTIONS
title_short Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization
title_full Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization
title_fullStr Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization
title_full_unstemmed Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization
title_sort Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization
dc.creator.none.fl_str_mv Oceguera, Alfonso
Peralta, Andrea Verónica
Gustavo Martinez Delgado
Arias, Carlos F.
López, Susana
author Oceguera, Alfonso
author_facet Oceguera, Alfonso
Peralta, Andrea Verónica
Gustavo Martinez Delgado
Arias, Carlos F.
López, Susana
author_role author
author2 Peralta, Andrea Verónica
Gustavo Martinez Delgado
Arias, Carlos F.
López, Susana
author2_role author
author
author
author
dc.subject.none.fl_str_mv GW-BODIES
P-BODIES
RNA BINDING PROTEINS
RNA GRANULES
RNA SPONGES
ROTAVIRUS
VIRUS HOST CELL INTERACTIONS
topic GW-BODIES
P-BODIES
RNA BINDING PROTEINS
RNA GRANULES
RNA SPONGES
ROTAVIRUS
VIRUS HOST CELL INTERACTIONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cellular mRNAs cycle between translating and non-translating pools, polysomes compose the translating pool, while RNA granules contain translationally-silenced mRNAs, where the RNAs are either stored in stress granules, or accumulate in processing bodies (PBs) or GW-bodies, which have an important role in RNA degradation. Viruses have developed measures to prevent the deleterious effects of these structures during their replication. Rotavirus, the most common agent of viral gastroenteritis, is capable of establishing a successful infection by counteracting several of the antiviral responses of its host. Here, we describe that in rotavirus-infected cells the distribution of several RNA binding proteins is changed causing the disaggregation of PBs, the relocalization of GW-body proteins, and the cytoplasmic accumulation of HuR, a predominantly nuclear protein. We show that this redistribution of proteins is more likely caused by the accumulation of viral RNA in the cytoplasm of infected-cells, where it might be acting as an RBP sponge.
Fil: Oceguera, Alfonso. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
Fil: Peralta, Andrea Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
Fil: Gustavo Martinez Delgado. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México. Instituto Cumbres Lomas; México
Fil: Arias, Carlos F.. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
Fil: López, Susana. Universidad Nacional Autónoma de México. Instituto de Biotecnología; México
description Cellular mRNAs cycle between translating and non-translating pools, polysomes compose the translating pool, while RNA granules contain translationally-silenced mRNAs, where the RNAs are either stored in stress granules, or accumulate in processing bodies (PBs) or GW-bodies, which have an important role in RNA degradation. Viruses have developed measures to prevent the deleterious effects of these structures during their replication. Rotavirus, the most common agent of viral gastroenteritis, is capable of establishing a successful infection by counteracting several of the antiviral responses of its host. Here, we describe that in rotavirus-infected cells the distribution of several RNA binding proteins is changed causing the disaggregation of PBs, the relocalization of GW-body proteins, and the cytoplasmic accumulation of HuR, a predominantly nuclear protein. We show that this redistribution of proteins is more likely caused by the accumulation of viral RNA in the cytoplasm of infected-cells, where it might be acting as an RBP sponge.
publishDate 2018
dc.date.none.fl_str_mv 2018-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98242
Oceguera, Alfonso; Peralta, Andrea Verónica; Gustavo Martinez Delgado; Arias, Carlos F.; López, Susana; Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization; Academic Press Inc Elsevier Science; Virology; 525; 12-2018; 96-105
0042-6822
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98242
identifier_str_mv Oceguera, Alfonso; Peralta, Andrea Verónica; Gustavo Martinez Delgado; Arias, Carlos F.; López, Susana; Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization; Academic Press Inc Elsevier Science; Virology; 525; 12-2018; 96-105
0042-6822
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.virol.2018.09.013
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0042682218302848
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270092039028736
score 13.13397

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