Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells

Autores
Naso, Luciana Gissella; Varcarcel, Maria; Villace, Patricia; Roura Ferrer, Meritxell; Salado, Clarisa; Ferrer, Evelina Gloria; Williams, Patricia Ana María
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The structure–activity relationships of the natural flavonoids quercetin, chrysin and silibinin have revealed that they meet the key structural requirements for killing tumor cells. When the structures of these three flavonoids are modified by complexation using the oxovanadium(IV) cation their cytotoxic properties in human breast cancer cell lines are enhanced. Breast epithelial cells are used to determine the selectivity of these compounds. The mechanisms of action of the flavonoids and the oxovanadium(IV) cation in the MDA-MB231 cell line seem to be different to the apoptotic mechanisms of cell death exerted by the oxovanadium(IV) complexes. These results showed the mechanisms of the antitumoral effect of these complexes, making them promising compounds for cancer treatment.
Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Varcarcel, Maria. Innoprot SL; España
Fil: Villace, Patricia. Innoprot SL; España
Fil: Roura Ferrer, Meritxell. Innoprot SL; España
Fil: Salado, Clarisa. Innoprot SL; España
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Materia
Flavonoids
Oxovanadium(Iv) Complexes
Breast Cancer Cell
Cytotoxicity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24966
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cellsNaso, Luciana GissellaVarcarcel, MariaVillace, PatriciaRoura Ferrer, MeritxellSalado, ClarisaFerrer, Evelina GloriaWilliams, Patricia Ana MaríaFlavonoidsOxovanadium(Iv) ComplexesBreast Cancer CellCytotoxicityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The structure–activity relationships of the natural flavonoids quercetin, chrysin and silibinin have revealed that they meet the key structural requirements for killing tumor cells. When the structures of these three flavonoids are modified by complexation using the oxovanadium(IV) cation their cytotoxic properties in human breast cancer cell lines are enhanced. Breast epithelial cells are used to determine the selectivity of these compounds. The mechanisms of action of the flavonoids and the oxovanadium(IV) cation in the MDA-MB231 cell line seem to be different to the apoptotic mechanisms of cell death exerted by the oxovanadium(IV) complexes. These results showed the mechanisms of the antitumoral effect of these complexes, making them promising compounds for cancer treatment.Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Varcarcel, Maria. Innoprot SL; EspañaFil: Villace, Patricia. Innoprot SL; EspañaFil: Roura Ferrer, Meritxell. Innoprot SL; EspañaFil: Salado, Clarisa. Innoprot SL; EspañaFil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaRoyal Society of Chemistry2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24966Naso, Luciana Gissella; Varcarcel, Maria; Villace, Patricia; Roura Ferrer, Meritxell; Salado, Clarisa; et al.; Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells; Royal Society of Chemistry; New Journal of Chemistry; 6; 3-2014; 2414-24211144-0546CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c3nj01649hinfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/NJ/c3nj01649hinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:34:27Zoai:ri.conicet.gov.ar:11336/24966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:34:27.524CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells
title Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells
spellingShingle Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells
Naso, Luciana Gissella
Flavonoids
Oxovanadium(Iv) Complexes
Breast Cancer Cell
Cytotoxicity
title_short Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells
title_full Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells
title_fullStr Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells
title_full_unstemmed Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells
title_sort Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells
dc.creator.none.fl_str_mv Naso, Luciana Gissella
Varcarcel, Maria
Villace, Patricia
Roura Ferrer, Meritxell
Salado, Clarisa
Ferrer, Evelina Gloria
Williams, Patricia Ana María
author Naso, Luciana Gissella
author_facet Naso, Luciana Gissella
Varcarcel, Maria
Villace, Patricia
Roura Ferrer, Meritxell
Salado, Clarisa
Ferrer, Evelina Gloria
Williams, Patricia Ana María
author_role author
author2 Varcarcel, Maria
Villace, Patricia
Roura Ferrer, Meritxell
Salado, Clarisa
Ferrer, Evelina Gloria
Williams, Patricia Ana María
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Flavonoids
Oxovanadium(Iv) Complexes
Breast Cancer Cell
Cytotoxicity
topic Flavonoids
Oxovanadium(Iv) Complexes
Breast Cancer Cell
Cytotoxicity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The structure–activity relationships of the natural flavonoids quercetin, chrysin and silibinin have revealed that they meet the key structural requirements for killing tumor cells. When the structures of these three flavonoids are modified by complexation using the oxovanadium(IV) cation their cytotoxic properties in human breast cancer cell lines are enhanced. Breast epithelial cells are used to determine the selectivity of these compounds. The mechanisms of action of the flavonoids and the oxovanadium(IV) cation in the MDA-MB231 cell line seem to be different to the apoptotic mechanisms of cell death exerted by the oxovanadium(IV) complexes. These results showed the mechanisms of the antitumoral effect of these complexes, making them promising compounds for cancer treatment.
Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Varcarcel, Maria. Innoprot SL; España
Fil: Villace, Patricia. Innoprot SL; España
Fil: Roura Ferrer, Meritxell. Innoprot SL; España
Fil: Salado, Clarisa. Innoprot SL; España
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
description The structure–activity relationships of the natural flavonoids quercetin, chrysin and silibinin have revealed that they meet the key structural requirements for killing tumor cells. When the structures of these three flavonoids are modified by complexation using the oxovanadium(IV) cation their cytotoxic properties in human breast cancer cell lines are enhanced. Breast epithelial cells are used to determine the selectivity of these compounds. The mechanisms of action of the flavonoids and the oxovanadium(IV) cation in the MDA-MB231 cell line seem to be different to the apoptotic mechanisms of cell death exerted by the oxovanadium(IV) complexes. These results showed the mechanisms of the antitumoral effect of these complexes, making them promising compounds for cancer treatment.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24966
Naso, Luciana Gissella; Varcarcel, Maria; Villace, Patricia; Roura Ferrer, Meritxell; Salado, Clarisa; et al.; Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells; Royal Society of Chemistry; New Journal of Chemistry; 6; 3-2014; 2414-2421
1144-0546
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24966
identifier_str_mv Naso, Luciana Gissella; Varcarcel, Maria; Villace, Patricia; Roura Ferrer, Meritxell; Salado, Clarisa; et al.; Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells; Royal Society of Chemistry; New Journal of Chemistry; 6; 3-2014; 2414-2421
1144-0546
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/c3nj01649h
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2014/NJ/c3nj01649h
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083472906518528
score 13.22299

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