Human consciousness is supported by dynamic complex patterns of brain signal coordination

Autores
Demertzi, A.; Tagliazucchi, Enzo Rodolfo; Dehaene, Stanislas; Deco, G.; Barttfeld, Pablo; Raimondo, Federico; Martial, C.; Fernández Espejo, D.; Rohaut, Benjamin; Voss, H. U.; Schiff, N. D.; Owen, A. M.; Laureys, S.; Naccache, L.; Sitt, J. D.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined whether dynamic signal coordination provides specific and generalizable patterns pertaining to conscious and unconscious states after brain damage. A dynamic pattern of coordinated and anticoordinated functional magnetic resonance imaging signals characterized healthy individuals and minimally conscious patients. The brains of unresponsive patients showed primarily a pattern of low interareal phase coherence mainly mediated by structural connectivity, and had smaller chances to transition between patterns. The complex pattern was further corroborated in patients with covert cognition, who could perform neuroimaging mental imagery tasks, validating this pattern’s implication in consciousness. Anesthesia increased the probability of the less complex pattern to equal levels, validating its implication in unconsciousness. Our results establish that consciousness rests on the brain’s ability to sustain rich brain dynamics and pave the way for determining specific and generalizable fingerprints of conscious and unconscious states.
Fil: Demertzi, A.. Université de Liège; Bélgica. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia
Fil: Tagliazucchi, Enzo Rodolfo. Hôpital Pitié Salpêtrière; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Dehaene, Stanislas. Inserm; Francia. Collège de France; Francia
Fil: Deco, G.. Universitat Pompeu Fabra; España
Fil: Barttfeld, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Raimondo, Federico. Université de Liège; Bélgica. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia. Universidad de Buenos Aires; Argentina. Sorbonne University; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martial, C.. Université de Liège; Bélgica
Fil: Fernández Espejo, D.. University of Birmingham; Reino Unido. Western University; Canadá
Fil: Rohaut, Benjamin. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia. Columbia University; Estados Unidos
Fil: Voss, H. U.. Weill Cornell Medical College; Estados Unidos
Fil: Schiff, N. D.. Weill Cornell Medical College; Estados Unidos
Fil: Owen, A. M.. Western University; Canadá
Fil: Laureys, S.. Université de Liège; Bélgica
Fil: Naccache, L.. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia
Fil: Sitt, J. D.. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia
Materia
Consciousness
Neuroimaging
Dynamics
Neurology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147539
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/147539
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Human consciousness is supported by dynamic complex patterns of brain signal coordinationDemertzi, A.Tagliazucchi, Enzo RodolfoDehaene, StanislasDeco, G.Barttfeld, PabloRaimondo, FedericoMartial, C.Fernández Espejo, D.Rohaut, BenjaminVoss, H. U.Schiff, N. D.Owen, A. M.Laureys, S.Naccache, L.Sitt, J. D.ConsciousnessNeuroimagingDynamicsNeurologyhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined whether dynamic signal coordination provides specific and generalizable patterns pertaining to conscious and unconscious states after brain damage. A dynamic pattern of coordinated and anticoordinated functional magnetic resonance imaging signals characterized healthy individuals and minimally conscious patients. The brains of unresponsive patients showed primarily a pattern of low interareal phase coherence mainly mediated by structural connectivity, and had smaller chances to transition between patterns. The complex pattern was further corroborated in patients with covert cognition, who could perform neuroimaging mental imagery tasks, validating this pattern’s implication in consciousness. Anesthesia increased the probability of the less complex pattern to equal levels, validating its implication in unconsciousness. Our results establish that consciousness rests on the brain’s ability to sustain rich brain dynamics and pave the way for determining specific and generalizable fingerprints of conscious and unconscious states.Fil: Demertzi, A.. Université de Liège; Bélgica. Inserm; Francia. Hôpital Pitié Salpêtrière; FranciaFil: Tagliazucchi, Enzo Rodolfo. Hôpital Pitié Salpêtrière; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Dehaene, Stanislas. Inserm; Francia. Collège de France; FranciaFil: Deco, G.. Universitat Pompeu Fabra; EspañaFil: Barttfeld, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Raimondo, Federico. Université de Liège; Bélgica. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia. Universidad de Buenos Aires; Argentina. Sorbonne University; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martial, C.. Université de Liège; BélgicaFil: Fernández Espejo, D.. University of Birmingham; Reino Unido. Western University; CanadáFil: Rohaut, Benjamin. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia. Columbia University; Estados UnidosFil: Voss, H. U.. Weill Cornell Medical College; Estados UnidosFil: Schiff, N. D.. Weill Cornell Medical College; Estados UnidosFil: Owen, A. M.. Western University; CanadáFil: Laureys, S.. Université de Liège; BélgicaFil: Naccache, L.. Inserm; Francia. Hôpital Pitié Salpêtrière; FranciaFil: Sitt, J. D.. Inserm; Francia. Hôpital Pitié Salpêtrière; FranciaAmerican Association for the Advancement of Science2019-02-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147539Demertzi, A.; Tagliazucchi, Enzo Rodolfo; Dehaene, Stanislas; Deco, G.; Barttfeld, Pablo; et al.; Human consciousness is supported by dynamic complex patterns of brain signal coordination; American Association for the Advancement of Science; Science Advances; 5; 2; 6-2-2019; 1-122375-2548CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aat7603info:eu-repo/semantics/altIdentifier/doi/10.1126/sciadv.aat7603info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:47Zoai:ri.conicet.gov.ar:11336/147539instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:48.029CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Human consciousness is supported by dynamic complex patterns of brain signal coordination
title Human consciousness is supported by dynamic complex patterns of brain signal coordination
spellingShingle Human consciousness is supported by dynamic complex patterns of brain signal coordination
Demertzi, A.
Consciousness
Neuroimaging
Dynamics
Neurology
title_short Human consciousness is supported by dynamic complex patterns of brain signal coordination
title_full Human consciousness is supported by dynamic complex patterns of brain signal coordination
title_fullStr Human consciousness is supported by dynamic complex patterns of brain signal coordination
title_full_unstemmed Human consciousness is supported by dynamic complex patterns of brain signal coordination
title_sort Human consciousness is supported by dynamic complex patterns of brain signal coordination
dc.creator.none.fl_str_mv Demertzi, A.
Tagliazucchi, Enzo Rodolfo
Dehaene, Stanislas
Deco, G.
Barttfeld, Pablo
Raimondo, Federico
Martial, C.
Fernández Espejo, D.
Rohaut, Benjamin
Voss, H. U.
Schiff, N. D.
Owen, A. M.
Laureys, S.
Naccache, L.
Sitt, J. D.
author Demertzi, A.
author_facet Demertzi, A.
Tagliazucchi, Enzo Rodolfo
Dehaene, Stanislas
Deco, G.
Barttfeld, Pablo
Raimondo, Federico
Martial, C.
Fernández Espejo, D.
Rohaut, Benjamin
Voss, H. U.
Schiff, N. D.
Owen, A. M.
Laureys, S.
Naccache, L.
Sitt, J. D.
author_role author
author2 Tagliazucchi, Enzo Rodolfo
Dehaene, Stanislas
Deco, G.
Barttfeld, Pablo
Raimondo, Federico
Martial, C.
Fernández Espejo, D.
Rohaut, Benjamin
Voss, H. U.
Schiff, N. D.
Owen, A. M.
Laureys, S.
Naccache, L.
Sitt, J. D.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Consciousness
Neuroimaging
Dynamics
Neurology
topic Consciousness
Neuroimaging
Dynamics
Neurology
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined whether dynamic signal coordination provides specific and generalizable patterns pertaining to conscious and unconscious states after brain damage. A dynamic pattern of coordinated and anticoordinated functional magnetic resonance imaging signals characterized healthy individuals and minimally conscious patients. The brains of unresponsive patients showed primarily a pattern of low interareal phase coherence mainly mediated by structural connectivity, and had smaller chances to transition between patterns. The complex pattern was further corroborated in patients with covert cognition, who could perform neuroimaging mental imagery tasks, validating this pattern’s implication in consciousness. Anesthesia increased the probability of the less complex pattern to equal levels, validating its implication in unconsciousness. Our results establish that consciousness rests on the brain’s ability to sustain rich brain dynamics and pave the way for determining specific and generalizable fingerprints of conscious and unconscious states.
Fil: Demertzi, A.. Université de Liège; Bélgica. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia
Fil: Tagliazucchi, Enzo Rodolfo. Hôpital Pitié Salpêtrière; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Dehaene, Stanislas. Inserm; Francia. Collège de France; Francia
Fil: Deco, G.. Universitat Pompeu Fabra; España
Fil: Barttfeld, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Raimondo, Federico. Université de Liège; Bélgica. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia. Universidad de Buenos Aires; Argentina. Sorbonne University; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martial, C.. Université de Liège; Bélgica
Fil: Fernández Espejo, D.. University of Birmingham; Reino Unido. Western University; Canadá
Fil: Rohaut, Benjamin. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia. Columbia University; Estados Unidos
Fil: Voss, H. U.. Weill Cornell Medical College; Estados Unidos
Fil: Schiff, N. D.. Weill Cornell Medical College; Estados Unidos
Fil: Owen, A. M.. Western University; Canadá
Fil: Laureys, S.. Université de Liège; Bélgica
Fil: Naccache, L.. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia
Fil: Sitt, J. D.. Inserm; Francia. Hôpital Pitié Salpêtrière; Francia
description Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined whether dynamic signal coordination provides specific and generalizable patterns pertaining to conscious and unconscious states after brain damage. A dynamic pattern of coordinated and anticoordinated functional magnetic resonance imaging signals characterized healthy individuals and minimally conscious patients. The brains of unresponsive patients showed primarily a pattern of low interareal phase coherence mainly mediated by structural connectivity, and had smaller chances to transition between patterns. The complex pattern was further corroborated in patients with covert cognition, who could perform neuroimaging mental imagery tasks, validating this pattern’s implication in consciousness. Anesthesia increased the probability of the less complex pattern to equal levels, validating its implication in unconsciousness. Our results establish that consciousness rests on the brain’s ability to sustain rich brain dynamics and pave the way for determining specific and generalizable fingerprints of conscious and unconscious states.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147539
Demertzi, A.; Tagliazucchi, Enzo Rodolfo; Dehaene, Stanislas; Deco, G.; Barttfeld, Pablo; et al.; Human consciousness is supported by dynamic complex patterns of brain signal coordination; American Association for the Advancement of Science; Science Advances; 5; 2; 6-2-2019; 1-12
2375-2548
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147539
identifier_str_mv Demertzi, A.; Tagliazucchi, Enzo Rodolfo; Dehaene, Stanislas; Deco, G.; Barttfeld, Pablo; et al.; Human consciousness is supported by dynamic complex patterns of brain signal coordination; American Association for the Advancement of Science; Science Advances; 5; 2; 6-2-2019; 1-12
2375-2548
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aat7603
info:eu-repo/semantics/altIdentifier/doi/10.1126/sciadv.aat7603
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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