Light and Shadows in cardiac regeneration.
- Autores
- Giménez, Carlos Sebastián
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Given that the adult human heart has an extremely limited regenerative capacity, diseases characterized by contractile cell loss, as myocardial infarction and cardiomyopathies, lead to ventricular remodeling and heart failure. Hence, diverse strategies to promote myocardial regeneration have been proposed and assessed in animals and humans with ischemic heart disease. Of these, gene transfer and especially stem cell therapy have been used. So far, the overall main outcome is a gross disparity between the promising results obtained in mammalian models and the poor, if any, benefit observed in randomized,controlled clinical trials. Many reasons may account for this disappointing scenario.Some, including flawed trial design and methodology, differences in cell type and dosing as well as in route of administration, erroneous end points selection and heterogeneous patient populations have been extensively discussed in comprehensive reviews. Others,more recently addressed, signal the use of inadequate or non-precise laboratorytechniques in cell identification and fate, this leading to precarious or misleadingconclusions. We hereby summarize part of the work done and quote some newapproaches, like the use of induced pluripotent stem cells and the promotion of selfregeneration by targeting the adult cardiomyocyte cell cycle, that may cast some light inthe otherwise shadowy field of cardiac regeneration.
Fil: Giménez, Carlos Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina - Materia
-
GENE THERAPY
CELL THERAPY
CARDIAC REGENERATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/115600
Ver los metadatos del registro completo
id |
CONICETDig_ad5f0df2c0b8ba0a99e5e18778a8f55e |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/115600 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Light and Shadows in cardiac regeneration.Giménez, Carlos SebastiánGENE THERAPYCELL THERAPYCARDIAC REGENERATIONhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Given that the adult human heart has an extremely limited regenerative capacity, diseases characterized by contractile cell loss, as myocardial infarction and cardiomyopathies, lead to ventricular remodeling and heart failure. Hence, diverse strategies to promote myocardial regeneration have been proposed and assessed in animals and humans with ischemic heart disease. Of these, gene transfer and especially stem cell therapy have been used. So far, the overall main outcome is a gross disparity between the promising results obtained in mammalian models and the poor, if any, benefit observed in randomized,controlled clinical trials. Many reasons may account for this disappointing scenario.Some, including flawed trial design and methodology, differences in cell type and dosing as well as in route of administration, erroneous end points selection and heterogeneous patient populations have been extensively discussed in comprehensive reviews. Others,more recently addressed, signal the use of inadequate or non-precise laboratorytechniques in cell identification and fate, this leading to precarious or misleadingconclusions. We hereby summarize part of the work done and quote some newapproaches, like the use of induced pluripotent stem cells and the promotion of selfregeneration by targeting the adult cardiomyocyte cell cycle, that may cast some light inthe otherwise shadowy field of cardiac regeneration.Fil: Giménez, Carlos Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; ArgentinaSociedad Argentina de Fisiología2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115600Giménez, Carlos Sebastián; Light and Shadows in cardiac regeneration.; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 12; 5-2019; 1-111669-54101669-5410CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/108info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:55:58Zoai:ri.conicet.gov.ar:11336/115600instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:55:59.062CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Light and Shadows in cardiac regeneration. |
title |
Light and Shadows in cardiac regeneration. |
spellingShingle |
Light and Shadows in cardiac regeneration. Giménez, Carlos Sebastián GENE THERAPY CELL THERAPY CARDIAC REGENERATION |
title_short |
Light and Shadows in cardiac regeneration. |
title_full |
Light and Shadows in cardiac regeneration. |
title_fullStr |
Light and Shadows in cardiac regeneration. |
title_full_unstemmed |
Light and Shadows in cardiac regeneration. |
title_sort |
Light and Shadows in cardiac regeneration. |
dc.creator.none.fl_str_mv |
Giménez, Carlos Sebastián |
author |
Giménez, Carlos Sebastián |
author_facet |
Giménez, Carlos Sebastián |
author_role |
author |
dc.subject.none.fl_str_mv |
GENE THERAPY CELL THERAPY CARDIAC REGENERATION |
topic |
GENE THERAPY CELL THERAPY CARDIAC REGENERATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Given that the adult human heart has an extremely limited regenerative capacity, diseases characterized by contractile cell loss, as myocardial infarction and cardiomyopathies, lead to ventricular remodeling and heart failure. Hence, diverse strategies to promote myocardial regeneration have been proposed and assessed in animals and humans with ischemic heart disease. Of these, gene transfer and especially stem cell therapy have been used. So far, the overall main outcome is a gross disparity between the promising results obtained in mammalian models and the poor, if any, benefit observed in randomized,controlled clinical trials. Many reasons may account for this disappointing scenario.Some, including flawed trial design and methodology, differences in cell type and dosing as well as in route of administration, erroneous end points selection and heterogeneous patient populations have been extensively discussed in comprehensive reviews. Others,more recently addressed, signal the use of inadequate or non-precise laboratorytechniques in cell identification and fate, this leading to precarious or misleadingconclusions. We hereby summarize part of the work done and quote some newapproaches, like the use of induced pluripotent stem cells and the promotion of selfregeneration by targeting the adult cardiomyocyte cell cycle, that may cast some light inthe otherwise shadowy field of cardiac regeneration. Fil: Giménez, Carlos Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina |
description |
Given that the adult human heart has an extremely limited regenerative capacity, diseases characterized by contractile cell loss, as myocardial infarction and cardiomyopathies, lead to ventricular remodeling and heart failure. Hence, diverse strategies to promote myocardial regeneration have been proposed and assessed in animals and humans with ischemic heart disease. Of these, gene transfer and especially stem cell therapy have been used. So far, the overall main outcome is a gross disparity between the promising results obtained in mammalian models and the poor, if any, benefit observed in randomized,controlled clinical trials. Many reasons may account for this disappointing scenario.Some, including flawed trial design and methodology, differences in cell type and dosing as well as in route of administration, erroneous end points selection and heterogeneous patient populations have been extensively discussed in comprehensive reviews. Others,more recently addressed, signal the use of inadequate or non-precise laboratorytechniques in cell identification and fate, this leading to precarious or misleadingconclusions. We hereby summarize part of the work done and quote some newapproaches, like the use of induced pluripotent stem cells and the promotion of selfregeneration by targeting the adult cardiomyocyte cell cycle, that may cast some light inthe otherwise shadowy field of cardiac regeneration. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/115600 Giménez, Carlos Sebastián; Light and Shadows in cardiac regeneration.; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 12; 5-2019; 1-11 1669-5410 1669-5410 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/115600 |
identifier_str_mv |
Giménez, Carlos Sebastián; Light and Shadows in cardiac regeneration.; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 12; 5-2019; 1-11 1669-5410 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/108 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Sociedad Argentina de Fisiología |
publisher.none.fl_str_mv |
Sociedad Argentina de Fisiología |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613684615184384 |
score |
13.070432 |