Light and Shadows in cardiac regeneration.

Autores
Giménez, Carlos Sebastián
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Given that the adult human heart has an extremely limited regenerative capacity, diseases characterized by contractile cell loss, as myocardial infarction and cardiomyopathies, lead to ventricular remodeling and heart failure. Hence, diverse strategies to promote myocardial regeneration have been proposed and assessed in animals and humans with ischemic heart disease. Of these, gene transfer and especially stem cell therapy have been used. So far, the overall main outcome is a gross disparity between the promising results obtained in mammalian models and the poor, if any, benefit observed in randomized,controlled clinical trials. Many reasons may account for this disappointing scenario.Some, including flawed trial design and methodology, differences in cell type and dosing as well as in route of administration, erroneous end points selection and heterogeneous patient populations have been extensively discussed in comprehensive reviews. Others,more recently addressed, signal the use of inadequate or non-precise laboratorytechniques in cell identification and fate, this leading to precarious or misleadingconclusions. We hereby summarize part of the work done and quote some newapproaches, like the use of induced pluripotent stem cells and the promotion of selfregeneration by targeting the adult cardiomyocyte cell cycle, that may cast some light inthe otherwise shadowy field of cardiac regeneration.
Fil: Giménez, Carlos Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
Materia
GENE THERAPY
CELL THERAPY
CARDIAC REGENERATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/115600

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spelling Light and Shadows in cardiac regeneration.Giménez, Carlos SebastiánGENE THERAPYCELL THERAPYCARDIAC REGENERATIONhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Given that the adult human heart has an extremely limited regenerative capacity, diseases characterized by contractile cell loss, as myocardial infarction and cardiomyopathies, lead to ventricular remodeling and heart failure. Hence, diverse strategies to promote myocardial regeneration have been proposed and assessed in animals and humans with ischemic heart disease. Of these, gene transfer and especially stem cell therapy have been used. So far, the overall main outcome is a gross disparity between the promising results obtained in mammalian models and the poor, if any, benefit observed in randomized,controlled clinical trials. Many reasons may account for this disappointing scenario.Some, including flawed trial design and methodology, differences in cell type and dosing as well as in route of administration, erroneous end points selection and heterogeneous patient populations have been extensively discussed in comprehensive reviews. Others,more recently addressed, signal the use of inadequate or non-precise laboratorytechniques in cell identification and fate, this leading to precarious or misleadingconclusions. We hereby summarize part of the work done and quote some newapproaches, like the use of induced pluripotent stem cells and the promotion of selfregeneration by targeting the adult cardiomyocyte cell cycle, that may cast some light inthe otherwise shadowy field of cardiac regeneration.Fil: Giménez, Carlos Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; ArgentinaSociedad Argentina de Fisiología2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115600Giménez, Carlos Sebastián; Light and Shadows in cardiac regeneration.; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 12; 5-2019; 1-111669-54101669-5410CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/108info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:55:58Zoai:ri.conicet.gov.ar:11336/115600instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:55:59.062CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Light and Shadows in cardiac regeneration.
title Light and Shadows in cardiac regeneration.
spellingShingle Light and Shadows in cardiac regeneration.
Giménez, Carlos Sebastián
GENE THERAPY
CELL THERAPY
CARDIAC REGENERATION
title_short Light and Shadows in cardiac regeneration.
title_full Light and Shadows in cardiac regeneration.
title_fullStr Light and Shadows in cardiac regeneration.
title_full_unstemmed Light and Shadows in cardiac regeneration.
title_sort Light and Shadows in cardiac regeneration.
dc.creator.none.fl_str_mv Giménez, Carlos Sebastián
author Giménez, Carlos Sebastián
author_facet Giménez, Carlos Sebastián
author_role author
dc.subject.none.fl_str_mv GENE THERAPY
CELL THERAPY
CARDIAC REGENERATION
topic GENE THERAPY
CELL THERAPY
CARDIAC REGENERATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Given that the adult human heart has an extremely limited regenerative capacity, diseases characterized by contractile cell loss, as myocardial infarction and cardiomyopathies, lead to ventricular remodeling and heart failure. Hence, diverse strategies to promote myocardial regeneration have been proposed and assessed in animals and humans with ischemic heart disease. Of these, gene transfer and especially stem cell therapy have been used. So far, the overall main outcome is a gross disparity between the promising results obtained in mammalian models and the poor, if any, benefit observed in randomized,controlled clinical trials. Many reasons may account for this disappointing scenario.Some, including flawed trial design and methodology, differences in cell type and dosing as well as in route of administration, erroneous end points selection and heterogeneous patient populations have been extensively discussed in comprehensive reviews. Others,more recently addressed, signal the use of inadequate or non-precise laboratorytechniques in cell identification and fate, this leading to precarious or misleadingconclusions. We hereby summarize part of the work done and quote some newapproaches, like the use of induced pluripotent stem cells and the promotion of selfregeneration by targeting the adult cardiomyocyte cell cycle, that may cast some light inthe otherwise shadowy field of cardiac regeneration.
Fil: Giménez, Carlos Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
description Given that the adult human heart has an extremely limited regenerative capacity, diseases characterized by contractile cell loss, as myocardial infarction and cardiomyopathies, lead to ventricular remodeling and heart failure. Hence, diverse strategies to promote myocardial regeneration have been proposed and assessed in animals and humans with ischemic heart disease. Of these, gene transfer and especially stem cell therapy have been used. So far, the overall main outcome is a gross disparity between the promising results obtained in mammalian models and the poor, if any, benefit observed in randomized,controlled clinical trials. Many reasons may account for this disappointing scenario.Some, including flawed trial design and methodology, differences in cell type and dosing as well as in route of administration, erroneous end points selection and heterogeneous patient populations have been extensively discussed in comprehensive reviews. Others,more recently addressed, signal the use of inadequate or non-precise laboratorytechniques in cell identification and fate, this leading to precarious or misleadingconclusions. We hereby summarize part of the work done and quote some newapproaches, like the use of induced pluripotent stem cells and the promotion of selfregeneration by targeting the adult cardiomyocyte cell cycle, that may cast some light inthe otherwise shadowy field of cardiac regeneration.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/115600
Giménez, Carlos Sebastián; Light and Shadows in cardiac regeneration.; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 12; 5-2019; 1-11
1669-5410
1669-5410
CONICET Digital
CONICET
url http://hdl.handle.net/11336/115600
identifier_str_mv Giménez, Carlos Sebastián; Light and Shadows in cardiac regeneration.; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 12; 5-2019; 1-11
1669-5410
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/108
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Fisiología
publisher.none.fl_str_mv Sociedad Argentina de Fisiología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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