Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance

Autores
Helbling, Ignacio Marcelo; Cabrera, Maria Ines; Luna, Julio Alberto
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A mathematical modeling of controlled release of drug from one-layer and two-layer torus-shaped devices with external mass transfer resistance is presented. Analytical solutions based on the pseudosteady state approximation are derived. The validity of the equations is established in two stages. In the first stage, the validity of the models derived for more complex systems is determined by comparison with profiles predicted by the simplest model, in asymptotic cases. In the second stage, the reliability and usefulness of the models are ascertained by comparison of the simulation results with vaginal rings experimental release data reported in the literature. In order to measures quantitatively the fit of the theoretical models to the experimental data, the pair-wise procedure is used. A good agreement between the prediction of the models and the experimental data is observed. The models are applicable only to torusshaped systems in where the initial load of drug is higher than its solubility in the polymer.
Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Fil: Cabrera, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Materia
Vaginal Ring
Pseudo-Steady State Approximation
Mass Transfer Resistance
Mathematical Modeling
Moving Front
Drug Delivery
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13352
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistanceHelbling, Ignacio MarceloCabrera, Maria InesLuna, Julio AlbertoVaginal RingPseudo-Steady State ApproximationMass Transfer ResistanceMathematical ModelingMoving FrontDrug Deliveryhttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2A mathematical modeling of controlled release of drug from one-layer and two-layer torus-shaped devices with external mass transfer resistance is presented. Analytical solutions based on the pseudosteady state approximation are derived. The validity of the equations is established in two stages. In the first stage, the validity of the models derived for more complex systems is determined by comparison with profiles predicted by the simplest model, in asymptotic cases. In the second stage, the reliability and usefulness of the models are ascertained by comparison of the simulation results with vaginal rings experimental release data reported in the literature. In order to measures quantitatively the fit of the theoretical models to the experimental data, the pair-wise procedure is used. A good agreement between the prediction of the models and the experimental data is observed. The models are applicable only to torusshaped systems in where the initial load of drug is higher than its solubility in the polymer.Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Cabrera, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaElsevier Science2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13352Helbling, Ignacio Marcelo; Cabrera, Maria Ines; Luna, Julio Alberto; Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance; Elsevier Science; European Journal Of Pharmaceutical Sciences; 44; 3; 8-2011; 288-2980928-0987enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S092809871100265Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejps.2011.08.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:33:47Zoai:ri.conicet.gov.ar:11336/13352instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:33:48.043CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
title Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
spellingShingle Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
Helbling, Ignacio Marcelo
Vaginal Ring
Pseudo-Steady State Approximation
Mass Transfer Resistance
Mathematical Modeling
Moving Front
Drug Delivery
title_short Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
title_full Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
title_fullStr Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
title_full_unstemmed Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
title_sort Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance
dc.creator.none.fl_str_mv Helbling, Ignacio Marcelo
Cabrera, Maria Ines
Luna, Julio Alberto
author Helbling, Ignacio Marcelo
author_facet Helbling, Ignacio Marcelo
Cabrera, Maria Ines
Luna, Julio Alberto
author_role author
author2 Cabrera, Maria Ines
Luna, Julio Alberto
author2_role author
author
dc.subject.none.fl_str_mv Vaginal Ring
Pseudo-Steady State Approximation
Mass Transfer Resistance
Mathematical Modeling
Moving Front
Drug Delivery
topic Vaginal Ring
Pseudo-Steady State Approximation
Mass Transfer Resistance
Mathematical Modeling
Moving Front
Drug Delivery
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv A mathematical modeling of controlled release of drug from one-layer and two-layer torus-shaped devices with external mass transfer resistance is presented. Analytical solutions based on the pseudosteady state approximation are derived. The validity of the equations is established in two stages. In the first stage, the validity of the models derived for more complex systems is determined by comparison with profiles predicted by the simplest model, in asymptotic cases. In the second stage, the reliability and usefulness of the models are ascertained by comparison of the simulation results with vaginal rings experimental release data reported in the literature. In order to measures quantitatively the fit of the theoretical models to the experimental data, the pair-wise procedure is used. A good agreement between the prediction of the models and the experimental data is observed. The models are applicable only to torusshaped systems in where the initial load of drug is higher than its solubility in the polymer.
Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Fil: Cabrera, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina
description A mathematical modeling of controlled release of drug from one-layer and two-layer torus-shaped devices with external mass transfer resistance is presented. Analytical solutions based on the pseudosteady state approximation are derived. The validity of the equations is established in two stages. In the first stage, the validity of the models derived for more complex systems is determined by comparison with profiles predicted by the simplest model, in asymptotic cases. In the second stage, the reliability and usefulness of the models are ascertained by comparison of the simulation results with vaginal rings experimental release data reported in the literature. In order to measures quantitatively the fit of the theoretical models to the experimental data, the pair-wise procedure is used. A good agreement between the prediction of the models and the experimental data is observed. The models are applicable only to torusshaped systems in where the initial load of drug is higher than its solubility in the polymer.
publishDate 2011
dc.date.none.fl_str_mv 2011-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13352
Helbling, Ignacio Marcelo; Cabrera, Maria Ines; Luna, Julio Alberto; Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance; Elsevier Science; European Journal Of Pharmaceutical Sciences; 44; 3; 8-2011; 288-298
0928-0987
url http://hdl.handle.net/11336/13352
identifier_str_mv Helbling, Ignacio Marcelo; Cabrera, Maria Ines; Luna, Julio Alberto; Mathematical modeling of drug delivery from one-layer and two-layer torus-shaped devices with external mass transfer resistance; Elsevier Science; European Journal Of Pharmaceutical Sciences; 44; 3; 8-2011; 288-298
0928-0987
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S092809871100265X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejps.2011.08.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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