Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium

Autores
Helbling, Ignacio Marcelo; Ibarra, Juan Carlos Daniel; Luna, Julio Alberto; Cabrera, Maria Ines; Grau, Ricardo Jose Antonio
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Analytical solutions based on the pseudo-steady state approximation (PSSA) were derived for the case of controlled dispersed-drug release from erodible and non-erodible planar matrices, through a membrane, and taking into account the existence of a diffusion boundary layer and a finite release medium. The solutions can be applied to a broad range of situations from drug release into finite or infinite medium, from erodible or non-erodible matrices, in the presence or absence of a membrane, and in the presence or absence of a stagnant liquid layer. The prediction is accurate for the cases in which the initial drug load is higher than the drug solubility in the polymer (e.g. A/Cs mayor o igual a 3) till the entire dispersed drug is dissolved. The dependence on the release kinetics with different parameters was simulated and provides a theoretical platform for the design of dispersed drug release devices.
Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Cabrera, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
Mathematical Modeling
Dispersed Drug
Moving Front
Finite External Medium
Erodible Device
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21700
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/21700
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network_name_str CONICET Digital (CONICET)
spelling Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external mediumHelbling, Ignacio MarceloIbarra, Juan Carlos DanielLuna, Julio AlbertoCabrera, Maria InesGrau, Ricardo Jose AntonioMathematical ModelingDispersed DrugMoving FrontFinite External MediumErodible Devicehttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Analytical solutions based on the pseudo-steady state approximation (PSSA) were derived for the case of controlled dispersed-drug release from erodible and non-erodible planar matrices, through a membrane, and taking into account the existence of a diffusion boundary layer and a finite release medium. The solutions can be applied to a broad range of situations from drug release into finite or infinite medium, from erodible or non-erodible matrices, in the presence or absence of a membrane, and in the presence or absence of a stagnant liquid layer. The prediction is accurate for the cases in which the initial drug load is higher than the drug solubility in the polymer (e.g. A/Cs mayor o igual a 3) till the entire dispersed drug is dissolved. The dependence on the release kinetics with different parameters was simulated and provides a theoretical platform for the design of dispersed drug release devices.Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Cabrera, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaElsevier Science2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21700Helbling, Ignacio Marcelo; Ibarra, Juan Carlos Daniel; Luna, Julio Alberto; Cabrera, Maria Ines; Grau, Ricardo Jose Antonio; Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium; Elsevier Science; Journal Of Membrane Science; 350; 1-2; 3-2010; 10-180376-7388CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S037673880900903Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.memsci.2009.12.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:21:01Zoai:ri.conicet.gov.ar:11336/21700instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:21:01.862CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium
title Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium
spellingShingle Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium
Helbling, Ignacio Marcelo
Mathematical Modeling
Dispersed Drug
Moving Front
Finite External Medium
Erodible Device
title_short Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium
title_full Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium
title_fullStr Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium
title_full_unstemmed Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium
title_sort Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium
dc.creator.none.fl_str_mv Helbling, Ignacio Marcelo
Ibarra, Juan Carlos Daniel
Luna, Julio Alberto
Cabrera, Maria Ines
Grau, Ricardo Jose Antonio
author Helbling, Ignacio Marcelo
author_facet Helbling, Ignacio Marcelo
Ibarra, Juan Carlos Daniel
Luna, Julio Alberto
Cabrera, Maria Ines
Grau, Ricardo Jose Antonio
author_role author
author2 Ibarra, Juan Carlos Daniel
Luna, Julio Alberto
Cabrera, Maria Ines
Grau, Ricardo Jose Antonio
author2_role author
author
author
author
dc.subject.none.fl_str_mv Mathematical Modeling
Dispersed Drug
Moving Front
Finite External Medium
Erodible Device
topic Mathematical Modeling
Dispersed Drug
Moving Front
Finite External Medium
Erodible Device
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Analytical solutions based on the pseudo-steady state approximation (PSSA) were derived for the case of controlled dispersed-drug release from erodible and non-erodible planar matrices, through a membrane, and taking into account the existence of a diffusion boundary layer and a finite release medium. The solutions can be applied to a broad range of situations from drug release into finite or infinite medium, from erodible or non-erodible matrices, in the presence or absence of a membrane, and in the presence or absence of a stagnant liquid layer. The prediction is accurate for the cases in which the initial drug load is higher than the drug solubility in the polymer (e.g. A/Cs mayor o igual a 3) till the entire dispersed drug is dissolved. The dependence on the release kinetics with different parameters was simulated and provides a theoretical platform for the design of dispersed drug release devices.
Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Cabrera, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Grau, Ricardo Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description Analytical solutions based on the pseudo-steady state approximation (PSSA) were derived for the case of controlled dispersed-drug release from erodible and non-erodible planar matrices, through a membrane, and taking into account the existence of a diffusion boundary layer and a finite release medium. The solutions can be applied to a broad range of situations from drug release into finite or infinite medium, from erodible or non-erodible matrices, in the presence or absence of a membrane, and in the presence or absence of a stagnant liquid layer. The prediction is accurate for the cases in which the initial drug load is higher than the drug solubility in the polymer (e.g. A/Cs mayor o igual a 3) till the entire dispersed drug is dissolved. The dependence on the release kinetics with different parameters was simulated and provides a theoretical platform for the design of dispersed drug release devices.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21700
Helbling, Ignacio Marcelo; Ibarra, Juan Carlos Daniel; Luna, Julio Alberto; Cabrera, Maria Ines; Grau, Ricardo Jose Antonio; Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium; Elsevier Science; Journal Of Membrane Science; 350; 1-2; 3-2010; 10-18
0376-7388
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21700
identifier_str_mv Helbling, Ignacio Marcelo; Ibarra, Juan Carlos Daniel; Luna, Julio Alberto; Cabrera, Maria Ines; Grau, Ricardo Jose Antonio; Modeling of drug delivery from erodible and non-erodible laminated planar devices into a finite external medium; Elsevier Science; Journal Of Membrane Science; 350; 1-2; 3-2010; 10-18
0376-7388
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S037673880900903X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.memsci.2009.12.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082594016329728
score 13.22299

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